FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FYVE zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9AS48_LEIMU

TriTrypDb:

LmxM.19.0980

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.711
CLV_C14_Caspase3-7	449	453	PF00656	0.537
CLV_C14_Caspase3-7	76	80	PF00656	0.640
CLV_NRD_NRD_1	153	155	PF00675	0.479
CLV_NRD_NRD_1	184	186	PF00675	0.672
CLV_NRD_NRD_1	274	276	PF00675	0.717
CLV_NRD_NRD_1	342	344	PF00675	0.633
CLV_NRD_NRD_1	482	484	PF00675	0.516
CLV_NRD_NRD_1	486	488	PF00675	0.475
CLV_NRD_NRD_1	494	496	PF00675	0.437
CLV_NRD_NRD_1	522	524	PF00675	0.335
CLV_NRD_NRD_1	529	531	PF00675	0.335
CLV_NRD_NRD_1	537	539	PF00675	0.335
CLV_NRD_NRD_1	542	544	PF00675	0.183
CLV_NRD_NRD_1	612	614	PF00675	0.354
CLV_NRD_NRD_1	685	687	PF00675	0.548
CLV_NRD_NRD_1	854	856	PF00675	0.531
CLV_PCSK_FUR_1	527	531	PF00082	0.335
CLV_PCSK_FUR_1	683	687	PF00082	0.543
CLV_PCSK_KEX2_1	152	154	PF00082	0.494
CLV_PCSK_KEX2_1	184	186	PF00082	0.672
CLV_PCSK_KEX2_1	2	4	PF00082	0.634
CLV_PCSK_KEX2_1	274	276	PF00082	0.717
CLV_PCSK_KEX2_1	342	344	PF00082	0.633
CLV_PCSK_KEX2_1	482	484	PF00082	0.534
CLV_PCSK_KEX2_1	486	488	PF00082	0.488
CLV_PCSK_KEX2_1	494	496	PF00082	0.430
CLV_PCSK_KEX2_1	522	524	PF00082	0.335
CLV_PCSK_KEX2_1	529	531	PF00082	0.335
CLV_PCSK_KEX2_1	537	539	PF00082	0.335
CLV_PCSK_KEX2_1	542	544	PF00082	0.183
CLV_PCSK_KEX2_1	612	614	PF00082	0.354
CLV_PCSK_KEX2_1	685	687	PF00082	0.548
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.634
CLV_PCSK_PC7_1	149	155	PF00082	0.582
CLV_PCSK_PC7_1	482	488	PF00082	0.511
CLV_PCSK_PC7_1	538	544	PF00082	0.335
CLV_PCSK_SKI1_1	460	464	PF00082	0.685
CLV_PCSK_SKI1_1	495	499	PF00082	0.497
CLV_PCSK_SKI1_1	529	533	PF00082	0.347
CLV_PCSK_SKI1_1	800	804	PF00082	0.625
DEG_COP1_1	190	199	PF00400	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DEG_SPOP_SBC_1	384	388	PF00917	0.616
DEG_SPOP_SBC_1	41	45	PF00917	0.537
DEG_SPOP_SBC_1	74	78	PF00917	0.555
DOC_CKS1_1	303	308	PF01111	0.668
DOC_CKS1_1	359	364	PF01111	0.661
DOC_CKS1_1	61	66	PF01111	0.634
DOC_CKS1_1	764	769	PF01111	0.576
DOC_CYCLIN_RxL_1	523	536	PF00134	0.335
DOC_MAPK_gen_1	664	673	PF00069	0.335
DOC_MAPK_RevD_3	140	154	PF00069	0.601
DOC_MAPK_RevD_3	671	686	PF00069	0.335
DOC_PP2B_LxvP_1	312	315	PF13499	0.642
DOC_PP2B_LxvP_1	381	384	PF13499	0.650
DOC_USP7_MATH_1	194	198	PF00917	0.726
DOC_USP7_MATH_1	219	223	PF00917	0.729
DOC_USP7_MATH_1	34	38	PF00917	0.639
DOC_USP7_MATH_1	341	345	PF00917	0.753
DOC_USP7_MATH_1	366	370	PF00917	0.599
DOC_USP7_MATH_1	385	389	PF00917	0.778
DOC_USP7_MATH_1	391	395	PF00917	0.648
DOC_USP7_MATH_1	550	554	PF00917	0.335
DOC_USP7_MATH_1	74	78	PF00917	0.698
DOC_USP7_MATH_1	780	784	PF00917	0.562
DOC_USP7_MATH_1	823	827	PF00917	0.575
DOC_WW_Pin1_4	176	181	PF00397	0.620
DOC_WW_Pin1_4	184	189	PF00397	0.639
DOC_WW_Pin1_4	190	195	PF00397	0.627
DOC_WW_Pin1_4	242	247	PF00397	0.650
DOC_WW_Pin1_4	258	263	PF00397	0.709
DOC_WW_Pin1_4	30	35	PF00397	0.606
DOC_WW_Pin1_4	302	307	PF00397	0.667
DOC_WW_Pin1_4	358	363	PF00397	0.649
DOC_WW_Pin1_4	367	372	PF00397	0.642
DOC_WW_Pin1_4	413	418	PF00397	0.633
DOC_WW_Pin1_4	429	434	PF00397	0.594
DOC_WW_Pin1_4	443	448	PF00397	0.560
DOC_WW_Pin1_4	47	52	PF00397	0.564
DOC_WW_Pin1_4	60	65	PF00397	0.502
DOC_WW_Pin1_4	618	623	PF00397	0.344
DOC_WW_Pin1_4	763	768	PF00397	0.579
LIG_14-3-3_CanoR_1	143	151	PF00244	0.599
LIG_14-3-3_CanoR_1	269	277	PF00244	0.772
LIG_14-3-3_CanoR_1	298	306	PF00244	0.783
LIG_14-3-3_CanoR_1	3	9	PF00244	0.594
LIG_14-3-3_CanoR_1	330	334	PF00244	0.716
LIG_14-3-3_CanoR_1	342	351	PF00244	0.580
LIG_14-3-3_CanoR_1	392	396	PF00244	0.762
LIG_14-3-3_CanoR_1	460	468	PF00244	0.679
LIG_14-3-3_CanoR_1	529	535	PF00244	0.494
LIG_14-3-3_CanoR_1	573	577	PF00244	0.457
LIG_14-3-3_CanoR_1	718	726	PF00244	0.684
LIG_14-3-3_CanoR_1	785	792	PF00244	0.566
LIG_BRCT_BRCA1_1	315	319	PF00533	0.774
LIG_Clathr_ClatBox_1	118	122	PF01394	0.708
LIG_Clathr_ClatBox_1	83	87	PF01394	0.651
LIG_Clathr_ClatBox_1	841	845	PF01394	0.764
LIG_eIF4E_1	492	498	PF01652	0.498
LIG_eIF4E_1	526	532	PF01652	0.335
LIG_FHA_1	113	119	PF00498	0.672
LIG_FHA_1	129	135	PF00498	0.538
LIG_FHA_1	143	149	PF00498	0.524
LIG_FHA_1	228	234	PF00498	0.707
LIG_FHA_1	303	309	PF00498	0.667
LIG_FHA_1	385	391	PF00498	0.645
LIG_FHA_1	417	423	PF00498	0.713
LIG_FHA_1	560	566	PF00498	0.335
LIG_FHA_1	587	593	PF00498	0.453
LIG_FHA_1	595	601	PF00498	0.345
LIG_FHA_1	633	639	PF00498	0.340
LIG_FHA_1	711	717	PF00498	0.658
LIG_FHA_1	764	770	PF00498	0.576
LIG_FHA_1	812	818	PF00498	0.553
LIG_FHA_2	227	233	PF00498	0.727
LIG_FHA_2	236	242	PF00498	0.625
LIG_FHA_2	447	453	PF00498	0.691
LIG_FHA_2	472	478	PF00498	0.603
LIG_FHA_2	591	597	PF00498	0.313
LIG_FHA_2	64	70	PF00498	0.697
LIG_FHA_2	710	716	PF00498	0.536
LIG_FHA_2	74	80	PF00498	0.586
LIG_FHA_2	785	791	PF00498	0.565
LIG_FHA_2	808	814	PF00498	0.531
LIG_FHA_2	871	877	PF00498	0.668
LIG_HCF-1_HBM_1	607	610	PF13415	0.335
LIG_KLC1_Yacidic_2	117	122	PF13176	0.707
LIG_LIR_Gen_1	117	125	PF02991	0.606
LIG_LIR_Nem_3	117	123	PF02991	0.614
LIG_LIR_Nem_3	702	708	PF02991	0.537
LIG_MYND_1	306	310	PF01753	0.654
LIG_MYND_1	429	433	PF01753	0.627
LIG_MYND_1	622	626	PF01753	0.374
LIG_PTB_Apo_2	247	254	PF02174	0.553
LIG_PTB_Phospho_1	247	253	PF10480	0.553
LIG_SH2_GRB2like	678	681	PF00017	0.335
LIG_SH2_PTP2	120	123	PF00017	0.608
LIG_SH2_SRC	253	256	PF00017	0.546
LIG_SH2_STAP1	345	349	PF00017	0.776
LIG_SH2_STAP1	588	592	PF00017	0.335
LIG_SH2_STAT3	276	279	PF00017	0.752
LIG_SH2_STAT5	120	123	PF00017	0.608
LIG_SH2_STAT5	345	348	PF00017	0.635
LIG_SH2_STAT5	534	537	PF00017	0.491
LIG_SH2_STAT5	555	558	PF00017	0.335
LIG_SH2_STAT5	564	567	PF00017	0.335
LIG_SH2_STAT5	588	591	PF00017	0.335
LIG_SH2_STAT5	747	750	PF00017	0.709
LIG_SH2_STAT5	791	794	PF00017	0.596
LIG_SH2_STAT5	795	798	PF00017	0.622
LIG_SH3_2	180	185	PF14604	0.696
LIG_SH3_3	174	180	PF00018	0.716
LIG_SH3_3	307	313	PF00018	0.767
LIG_SH3_3	430	436	PF00018	0.656
LIG_SH3_3	562	568	PF00018	0.453
LIG_SH3_3	670	676	PF00018	0.453
LIG_SUMO_SIM_anti_2	837	843	PF11976	0.701
LIG_SUMO_SIM_par_1	54	59	PF11976	0.636
LIG_SUMO_SIM_par_1	82	88	PF11976	0.566
LIG_SUMO_SIM_par_1	885	893	PF11976	0.772
LIG_TRAF2_1	474	477	PF00917	0.547
LIG_TRAF2_1	712	715	PF00917	0.658
LIG_TYR_ITIM	118	123	PF00017	0.613
MOD_CDK_SPK_2	242	247	PF00069	0.715
MOD_CDK_SPK_2	258	263	PF00069	0.630
MOD_CDK_SPxxK_3	367	374	PF00069	0.683
MOD_CK1_1	187	193	PF00069	0.671
MOD_CK1_1	208	214	PF00069	0.707
MOD_CK1_1	296	302	PF00069	0.665
MOD_CK1_1	304	310	PF00069	0.652
MOD_CK1_1	332	338	PF00069	0.634
MOD_CK1_1	357	363	PF00069	0.680
MOD_CK1_1	37	43	PF00069	0.639
MOD_CK1_1	416	422	PF00069	0.630
MOD_CK1_1	438	444	PF00069	0.797
MOD_CK1_1	44	50	PF00069	0.644
MOD_CK1_1	533	539	PF00069	0.336
MOD_CK1_1	586	592	PF00069	0.335
MOD_CK1_1	755	761	PF00069	0.589
MOD_CK1_1	837	843	PF00069	0.661
MOD_CK2_1	40	46	PF00069	0.650
MOD_CK2_1	417	423	PF00069	0.631
MOD_CK2_1	438	444	PF00069	0.654
MOD_CK2_1	471	477	PF00069	0.497
MOD_CK2_1	63	69	PF00069	0.696
MOD_CK2_1	709	715	PF00069	0.527
MOD_CK2_1	807	813	PF00069	0.531
MOD_CK2_1	870	876	PF00069	0.551
MOD_Cter_Amidation	556	559	PF01082	0.335
MOD_GlcNHglycan	167	170	PF01048	0.570
MOD_GlcNHglycan	19	22	PF01048	0.613
MOD_GlcNHglycan	196	199	PF01048	0.685
MOD_GlcNHglycan	238	241	PF01048	0.718
MOD_GlcNHglycan	271	274	PF01048	0.815
MOD_GlcNHglycan	30	33	PF01048	0.602
MOD_GlcNHglycan	387	390	PF01048	0.611
MOD_GlcNHglycan	403	406	PF01048	0.507
MOD_GlcNHglycan	408	411	PF01048	0.625
MOD_GlcNHglycan	423	427	PF01048	0.526
MOD_GlcNHglycan	437	440	PF01048	0.617
MOD_GlcNHglycan	46	49	PF01048	0.521
MOD_GlcNHglycan	463	466	PF01048	0.682
MOD_GlcNHglycan	694	697	PF01048	0.670
MOD_GlcNHglycan	742	746	PF01048	0.619
MOD_GlcNHglycan	754	757	PF01048	0.566
MOD_GlcNHglycan	782	785	PF01048	0.584
MOD_GlcNHglycan	817	820	PF01048	0.725
MOD_GlcNHglycan	825	828	PF01048	0.623
MOD_GSK3_1	124	131	PF00069	0.716
MOD_GSK3_1	184	191	PF00069	0.684
MOD_GSK3_1	205	212	PF00069	0.691
MOD_GSK3_1	242	249	PF00069	0.728
MOD_GSK3_1	265	272	PF00069	0.650
MOD_GSK3_1	290	297	PF00069	0.659
MOD_GSK3_1	298	305	PF00069	0.665
MOD_GSK3_1	30	37	PF00069	0.598
MOD_GSK3_1	350	357	PF00069	0.660
MOD_GSK3_1	379	386	PF00069	0.774
MOD_GSK3_1	40	47	PF00069	0.606
MOD_GSK3_1	406	413	PF00069	0.678
MOD_GSK3_1	56	63	PF00069	0.510
MOD_GSK3_1	568	575	PF00069	0.482
MOD_GSK3_1	583	590	PF00069	0.252
MOD_GSK3_1	647	654	PF00069	0.453
MOD_GSK3_1	780	787	PF00069	0.564
MOD_GSK3_1	807	814	PF00069	0.552
MOD_GSK3_1	867	874	PF00069	0.776
MOD_N-GLC_1	208	213	PF02516	0.742
MOD_N-GLC_1	283	288	PF02516	0.759
MOD_N-GLC_1	367	372	PF02516	0.622
MOD_N-GLC_2	697	699	PF02516	0.545
MOD_N-GLC_2	862	864	PF02516	0.525
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	17	22	PF00069	0.526
MOD_NEK2_1	294	299	PF00069	0.668
MOD_NEK2_1	334	339	PF00069	0.749
MOD_NEK2_1	422	427	PF00069	0.675
MOD_NEK2_1	56	61	PF00069	0.632
MOD_NEK2_1	796	801	PF00069	0.612
MOD_PIKK_1	142	148	PF00454	0.640
MOD_PIKK_1	451	457	PF00454	0.626
MOD_PKA_1	482	488	PF00069	0.574
MOD_PKA_2	142	148	PF00069	0.548
MOD_PKA_2	165	171	PF00069	0.569
MOD_PKA_2	202	208	PF00069	0.664
MOD_PKA_2	246	252	PF00069	0.690
MOD_PKA_2	294	300	PF00069	0.605
MOD_PKA_2	329	335	PF00069	0.636
MOD_PKA_2	341	347	PF00069	0.640
MOD_PKA_2	391	397	PF00069	0.762
MOD_PKA_2	482	488	PF00069	0.542
MOD_PKA_2	572	578	PF00069	0.482
MOD_PKA_2	717	723	PF00069	0.676
MOD_PKA_2	784	790	PF00069	0.560
MOD_PKB_1	348	356	PF00069	0.662
MOD_Plk_1	550	556	PF00069	0.335
MOD_Plk_1	560	566	PF00069	0.335
MOD_Plk_1	606	612	PF00069	0.370
MOD_Plk_1	837	843	PF00069	0.647
MOD_Plk_2-3	877	883	PF00069	0.633
MOD_Plk_4	329	335	PF00069	0.754
MOD_Plk_4	446	452	PF00069	0.693
MOD_Plk_4	560	566	PF00069	0.335
MOD_Plk_4	837	843	PF00069	0.765
MOD_ProDKin_1	176	182	PF00069	0.624
MOD_ProDKin_1	184	190	PF00069	0.639
MOD_ProDKin_1	242	248	PF00069	0.650
MOD_ProDKin_1	258	264	PF00069	0.710
MOD_ProDKin_1	30	36	PF00069	0.602
MOD_ProDKin_1	302	308	PF00069	0.667
MOD_ProDKin_1	358	364	PF00069	0.650
MOD_ProDKin_1	367	373	PF00069	0.638
MOD_ProDKin_1	413	419	PF00069	0.637
MOD_ProDKin_1	429	435	PF00069	0.592
MOD_ProDKin_1	443	449	PF00069	0.556
MOD_ProDKin_1	47	53	PF00069	0.566
MOD_ProDKin_1	60	66	PF00069	0.503
MOD_ProDKin_1	618	624	PF00069	0.344
MOD_ProDKin_1	763	769	PF00069	0.579
MOD_SUMO_for_1	584	587	PF00179	0.335
MOD_SUMO_rev_2	476	481	PF00179	0.568
TRG_DiLeu_BaEn_4	476	482	PF01217	0.455
TRG_DiLeu_BaEn_4	714	720	PF01217	0.664
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.742
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.614
TRG_ENDOCYTIC_2	120	123	PF00928	0.608
TRG_ENDOCYTIC_2	707	710	PF00928	0.510
TRG_ER_diArg_1	151	154	PF00400	0.484
TRG_ER_diArg_1	164	167	PF00400	0.542
TRG_ER_diArg_1	183	185	PF00400	0.680
TRG_ER_diArg_1	274	276	PF00400	0.717
TRG_ER_diArg_1	481	483	PF00400	0.522
TRG_ER_diArg_1	486	488	PF00400	0.469
TRG_ER_diArg_1	526	529	PF00400	0.335
TRG_ER_diArg_1	611	613	PF00400	0.335
TRG_ER_diArg_1	682	685	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	495	500	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R7	Leptomonas seymouri	52%	100%
A0A3S7WVE0	Leishmania donovani	93%	100%
A4HA51	Leishmania braziliensis	79%	100%
A4HYB5	Leishmania infantum	93%	100%
Q4QDB8	Leishmania major	89%	100%