Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Species:

Leishmania mexicana

UniProt:

E9AS47_LEIMU

TriTrypDb:

LmxM.19.0970

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS47

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.325
CLV_NRD_NRD_1	71	73	PF00675	0.620
CLV_PCSK_KEX2_1	110	112	PF00082	0.325
CLV_PCSK_KEX2_1	71	73	PF00082	0.629
CLV_PCSK_SKI1_1	185	189	PF00082	0.618
CLV_PCSK_SKI1_1	51	55	PF00082	0.561
DEG_SCF_FBW7_2	187	193	PF00400	0.406
DOC_CKS1_1	187	192	PF01111	0.439
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.318
DOC_PP2B_LxvP_1	135	138	PF13499	0.288
DOC_USP7_MATH_1	56	60	PF00917	0.581
DOC_USP7_UBL2_3	145	149	PF12436	0.275
DOC_WW_Pin1_4	109	114	PF00397	0.299
DOC_WW_Pin1_4	186	191	PF00397	0.402
LIG_14-3-3_CanoR_1	3	8	PF00244	0.565
LIG_14-3-3_CanoR_1	39	44	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.425
LIG_Clathr_ClatBox_1	66	70	PF01394	0.556
LIG_FHA_1	14	20	PF00498	0.515
LIG_FHA_1	193	199	PF00498	0.462
LIG_FHA_2	173	179	PF00498	0.486
LIG_LIR_Gen_1	131	142	PF02991	0.273
LIG_LIR_Gen_1	199	203	PF02991	0.585
LIG_LIR_Gen_1	42	49	PF02991	0.540
LIG_LIR_Nem_3	131	137	PF02991	0.262
LIG_LIR_Nem_3	199	203	PF02991	0.585
LIG_LIR_Nem_3	42	46	PF02991	0.543
LIG_LYPXL_yS_3	95	98	PF13949	0.188
LIG_NRBOX	16	22	PF00104	0.485
LIG_OCRL_FandH_1	3	15	PF00620	0.467
LIG_PDZ_Class_1	198	203	PF00595	0.540
LIG_SH2_CRK	43	47	PF00017	0.496
LIG_SH2_NCK_1	43	47	PF00017	0.496
LIG_SH2_SRC	134	137	PF00017	0.274
LIG_SH2_STAT5	134	137	PF00017	0.297
LIG_SH2_STAT5	182	185	PF00017	0.581
LIG_SH2_STAT5	200	203	PF00017	0.616
LIG_SH2_STAT5	89	92	PF00017	0.254
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.465
LIG_SUMO_SIM_par_1	16	22	PF11976	0.482
LIG_SUMO_SIM_par_1	24	29	PF11976	0.449
LIG_TYR_ITIM	198	203	PF00017	0.583
LIG_Vh1_VBS_1	10	28	PF01044	0.389
MOD_CK1_1	172	178	PF00069	0.554
MOD_CK1_1	31	37	PF00069	0.581
MOD_CK1_1	6	12	PF00069	0.511
MOD_CK2_1	172	178	PF00069	0.490
MOD_CK2_1	94	100	PF00069	0.199
MOD_GlcNHglycan	169	172	PF01048	0.666
MOD_GlcNHglycan	175	178	PF01048	0.569
MOD_GlcNHglycan	62	65	PF01048	0.560
MOD_GSK3_1	169	176	PF00069	0.675
MOD_GSK3_1	2	9	PF00069	0.470
MOD_GSK3_1	24	31	PF00069	0.455
MOD_GSK3_1	56	63	PF00069	0.612
MOD_N-GLC_1	56	61	PF02516	0.595
MOD_NEK2_1	19	24	PF00069	0.438
MOD_NEK2_1	87	92	PF00069	0.318
MOD_NEK2_1	99	104	PF00069	0.188
MOD_PIKK_1	111	117	PF00454	0.347
MOD_PK_1	94	100	PF00069	0.188
MOD_PKA_2	2	8	PF00069	0.577
MOD_PKB_1	92	100	PF00069	0.254
MOD_Plk_1	28	34	PF00069	0.617
MOD_Plk_1	56	62	PF00069	0.596
MOD_Plk_4	13	19	PF00069	0.482
MOD_Plk_4	28	34	PF00069	0.565
MOD_Plk_4	6	12	PF00069	0.522
MOD_Plk_4	94	100	PF00069	0.162
MOD_ProDKin_1	109	115	PF00069	0.299
MOD_ProDKin_1	186	192	PF00069	0.402
TRG_DiLeu_BaEn_1	122	127	PF01217	0.254
TRG_ENDOCYTIC_2	134	137	PF00928	0.275
TRG_ENDOCYTIC_2	200	203	PF00928	0.587
TRG_ENDOCYTIC_2	43	46	PF00928	0.545
TRG_ENDOCYTIC_2	95	98	PF00928	0.188
TRG_ER_diArg_1	109	111	PF00400	0.276
TRG_ER_diArg_1	91	94	PF00400	0.235
TRG_NES_CRM1_1	115	129	PF08389	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II12	Leptomonas seymouri	66%	100%
A0A1X0P7N1	Trypanosomatidae	40%	96%
A0A3Q8IB31	Leishmania donovani	31%	100%
A0A3S5H764	Leishmania donovani	88%	100%
A0A3S5IR72	Trypanosoma rangeli	39%	100%
A4H677	Leishmania braziliensis	32%	100%
A4HA48	Leishmania braziliensis	76%	100%
A4HUK1	Leishmania infantum	31%	100%
A4HYB4	Leishmania infantum	88%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
P0A9L3	Escherichia coli (strain K12)	32%	99%
P0A9L4	Shigella flexneri	32%	99%
Q09734	Trypanosoma cruzi	38%	100%
Q4QDB9	Leishmania major	90%	100%
Q4QHC5	Leishmania major	30%	100%
Q9JYI8	Neisseria meningitidis serogroup B (strain MC58)	29%	75%