Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania mexicana

UniProt:

E9AS46_LEIMU

TriTrypDb:

LmxM.19.0960

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	10
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	10
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

E9AS46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS46

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	9	17	PF00069	0.498
DOC_USP7_MATH_1	100	104	PF00917	0.556
LIG_APCC_ABBA_1	74	79	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_FHA_1	29	35	PF00498	0.518
LIG_GBD_Chelix_1	40	48	PF00786	0.298
LIG_LIR_Gen_1	72	83	PF02991	0.433
LIG_LIR_Nem_3	71	77	PF02991	0.430
LIG_PCNA_yPIPBox_3	33	44	PF02747	0.424
LIG_Pex14_2	74	78	PF04695	0.439
LIG_Pex14_2	84	88	PF04695	0.470
LIG_SH2_STAT3	52	55	PF00017	0.470
LIG_SH2_STAT5	77	80	PF00017	0.441
LIG_UBA3_1	29	33	PF00899	0.470
MOD_CK1_1	63	69	PF00069	0.453
MOD_GlcNHglycan	1	4	PF01048	0.458
MOD_GlcNHglycan	10	13	PF01048	0.214
MOD_GlcNHglycan	102	105	PF01048	0.498
MOD_GSK3_1	100	107	PF00069	0.440
MOD_NEK2_2	28	33	PF00069	0.507
MOD_Plk_1	90	96	PF00069	0.480
MOD_SUMO_for_1	44	47	PF00179	0.433
MOD_SUMO_rev_2	91	99	PF00179	0.443
TRG_DiLeu_BaEn_2	38	44	PF01217	0.375
TRG_ENDOCYTIC_2	77	80	PF00928	0.415
TRG_NES_CRM1_1	81	95	PF08389	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z7	Leptomonas seymouri	31%	100%
A0A0N1PBY8	Leptomonas seymouri	34%	100%
A0A0N1PCF1	Leptomonas seymouri	71%	100%
A0A0S4IS05	Bodo saltans	37%	100%
A0A0S4J005	Bodo saltans	34%	85%
A0A0S4JE57	Bodo saltans	33%	100%
A0A0S4JKR9	Bodo saltans	52%	100%
A0A0S4JQ28	Bodo saltans	36%	100%
A0A1X0P6I9	Trypanosomatidae	50%	93%
A0A3Q8IDB7	Leishmania donovani	93%	100%
A0A3Q8IDX2	Leishmania donovani	44%	100%
A0A3S5H7E1	Leishmania donovani	33%	100%
A0A3S5H7R1	Leishmania donovani	42%	100%
A0A3S7WNY4	Leishmania donovani	34%	100%
A0A422NC25	Trypanosoma rangeli	30%	100%
A0A422NHE2	Trypanosoma rangeli	57%	100%
A4H453	Leishmania braziliensis	38%	100%
A4HA47	Leishmania braziliensis	86%	100%
A4HDX3	Leishmania braziliensis	31%	100%
A4HGR7	Leishmania braziliensis	44%	100%
A4HK04	Leishmania braziliensis	42%	100%
A4HSD6	Leishmania infantum	34%	100%
A4HYB3	Leishmania infantum	93%	100%
A4I168	Leishmania infantum	33%	100%
A4I3U2	Leishmania infantum	44%	100%
A4I7I7	Leishmania infantum	42%	100%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	86%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O02414	Heliocidaris crassispina	50%	100%
O96860	Drosophila melanogaster	49%	100%
P61273	Macaca fascicularis	45%	100%
P61285	Bos taurus	45%	100%
P63167	Homo sapiens	45%	100%
P63168	Mus musculus	45%	100%
P63169	Oryctolagus cuniculus	45%	100%
P63170	Rattus norvegicus	45%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
Q22799	Caenorhabditis elegans	47%	100%
Q24117	Drosophila melanogaster	47%	100%
Q39579	Chlamydomonas reinhardtii	32%	93%
Q39580	Chlamydomonas reinhardtii	44%	100%
Q3MHR3	Bos taurus	47%	100%
Q4Q5R2	Leishmania major	42%	100%
Q4Q852	Leishmania major	44%	100%
Q4QA70	Leishmania major	33%	100%
Q4QDC0	Leishmania major	92%	100%
Q4QJJ6	Leishmania major	32%	100%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	100%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	43%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q78P75	Rattus norvegicus	47%	100%
Q86A88	Dictyostelium discoideum	43%	100%
Q94748	Schistosoma mansoni	38%	100%
Q94758	Schistosoma mansoni	39%	100%
Q96FJ2	Homo sapiens	47%	100%
Q9D0M5	Mus musculus	47%	100%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
V5AV01	Trypanosoma cruzi	32%	100%
V5BXL9	Trypanosoma cruzi	29%	100%