Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS45_LEIMU

TriTrypDb:

LmxM.19.0950

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.409
CLV_C14_Caspase3-7	521	525	PF00656	0.454
CLV_C14_Caspase3-7	604	608	PF00656	0.676
CLV_C14_Caspase3-7	712	716	PF00656	0.649
CLV_NRD_NRD_1	121	123	PF00675	0.665
CLV_NRD_NRD_1	134	136	PF00675	0.558
CLV_NRD_NRD_1	323	325	PF00675	0.593
CLV_NRD_NRD_1	418	420	PF00675	0.562
CLV_NRD_NRD_1	581	583	PF00675	0.699
CLV_NRD_NRD_1	586	588	PF00675	0.673
CLV_NRD_NRD_1	610	612	PF00675	0.743
CLV_NRD_NRD_1	647	649	PF00675	0.653
CLV_PCSK_FUR_1	324	328	PF00082	0.541
CLV_PCSK_KEX2_1	121	123	PF00082	0.665
CLV_PCSK_KEX2_1	218	220	PF00082	0.648
CLV_PCSK_KEX2_1	326	328	PF00082	0.721
CLV_PCSK_KEX2_1	337	339	PF00082	0.598
CLV_PCSK_KEX2_1	454	456	PF00082	0.605
CLV_PCSK_KEX2_1	586	588	PF00082	0.733
CLV_PCSK_KEX2_1	610	612	PF00082	0.743
CLV_PCSK_KEX2_1	647	649	PF00082	0.527
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.539
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.721
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.598
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.583
CLV_PCSK_PC7_1	582	588	PF00082	0.692
CLV_PCSK_SKI1_1	530	534	PF00082	0.535
CLV_PCSK_SKI1_1	535	539	PF00082	0.477
CLV_PCSK_SKI1_1	592	596	PF00082	0.681
CLV_PCSK_SKI1_1	87	91	PF00082	0.537
DEG_APCC_DBOX_1	200	208	PF00400	0.522
DEG_APCC_DBOX_1	718	726	PF00400	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DEG_SPOP_SBC_1	564	568	PF00917	0.744
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.498
DOC_MAPK_gen_1	365	375	PF00069	0.625
DOC_MAPK_gen_1	647	658	PF00069	0.661
DOC_MAPK_MEF2A_6	169	178	PF00069	0.721
DOC_PP2B_LxvP_1	308	311	PF13499	0.682
DOC_PP2B_LxvP_1	682	685	PF13499	0.644
DOC_PP2B_LxvP_1	69	72	PF13499	0.571
DOC_USP7_MATH_1	143	147	PF00917	0.547
DOC_USP7_MATH_1	194	198	PF00917	0.610
DOC_USP7_MATH_1	203	207	PF00917	0.687
DOC_USP7_MATH_1	330	334	PF00917	0.716
DOC_USP7_MATH_1	414	418	PF00917	0.736
DOC_USP7_MATH_1	473	477	PF00917	0.596
DOC_USP7_MATH_1	482	486	PF00917	0.650
DOC_USP7_MATH_1	563	567	PF00917	0.696
DOC_USP7_MATH_1	594	598	PF00917	0.617
DOC_USP7_MATH_1	618	622	PF00917	0.745
DOC_USP7_MATH_1	627	631	PF00917	0.591
DOC_USP7_MATH_1	652	656	PF00917	0.663
DOC_USP7_MATH_1	733	737	PF00917	0.621
DOC_WW_Pin1_4	162	167	PF00397	0.728
DOC_WW_Pin1_4	199	204	PF00397	0.688
DOC_WW_Pin1_4	212	217	PF00397	0.594
DOC_WW_Pin1_4	272	277	PF00397	0.686
DOC_WW_Pin1_4	297	302	PF00397	0.669
DOC_WW_Pin1_4	352	357	PF00397	0.656
DOC_WW_Pin1_4	377	382	PF00397	0.706
DOC_WW_Pin1_4	403	408	PF00397	0.617
DOC_WW_Pin1_4	435	440	PF00397	0.629
DOC_WW_Pin1_4	565	570	PF00397	0.719
DOC_WW_Pin1_4	574	579	PF00397	0.604
LIG_14-3-3_CanoR_1	105	111	PF00244	0.626
LIG_14-3-3_CanoR_1	283	292	PF00244	0.678
LIG_14-3-3_CanoR_1	338	343	PF00244	0.711
LIG_14-3-3_CanoR_1	419	428	PF00244	0.587
LIG_14-3-3_CanoR_1	574	578	PF00244	0.640
LIG_14-3-3_CanoR_1	723	733	PF00244	0.692
LIG_14-3-3_CanoR_1	755	761	PF00244	0.597
LIG_Actin_WH2_2	463	480	PF00022	0.503
LIG_Actin_WH2_2	753	769	PF00022	0.580
LIG_APCC_ABBA_1	531	536	PF00400	0.350
LIG_APCC_ABBAyCdc20_2	530	536	PF00400	0.357
LIG_BRCT_BRCA1_1	654	658	PF00533	0.668
LIG_eIF4E_1	466	472	PF01652	0.497
LIG_FHA_1	152	158	PF00498	0.716
LIG_FHA_1	24	30	PF00498	0.593
LIG_FHA_1	353	359	PF00498	0.646
LIG_FHA_1	467	473	PF00498	0.540
LIG_FHA_1	484	490	PF00498	0.521
LIG_FHA_1	536	542	PF00498	0.370
LIG_FHA_1	555	561	PF00498	0.523
LIG_FHA_1	679	685	PF00498	0.629
LIG_FHA_1	773	779	PF00498	0.459
LIG_FHA_1	93	99	PF00498	0.631
LIG_FHA_2	113	119	PF00498	0.640
LIG_FHA_2	148	154	PF00498	0.636
LIG_FHA_2	597	603	PF00498	0.725
LIG_FHA_2	74	80	PF00498	0.497
LIG_HP1_1	203	207	PF01393	0.519
LIG_Integrin_isoDGR_2	130	132	PF01839	0.559
LIG_LIR_Apic_2	707	711	PF02991	0.790
LIG_LIR_Gen_1	22	32	PF02991	0.611
LIG_LIR_Gen_1	247	256	PF02991	0.722
LIG_LIR_Nem_3	20	24	PF02991	0.645
LIG_LIR_Nem_3	247	251	PF02991	0.825
LIG_LIR_Nem_3	786	792	PF02991	0.638
LIG_LYPXL_SIV_4	46	54	PF13949	0.555
LIG_MYND_3	693	697	PF01753	0.684
LIG_NRBOX	466	472	PF00104	0.497
LIG_PTAP_UEV_1	300	305	PF05743	0.640
LIG_SH2_CRK	104	108	PF00017	0.628
LIG_SH2_CRK	24	28	PF00017	0.612
LIG_SH2_NCK_1	88	92	PF00017	0.589
LIG_SH2_SRC	47	50	PF00017	0.555
LIG_SH2_SRC	791	794	PF00017	0.640
LIG_SH2_STAP1	47	51	PF00017	0.552
LIG_SH2_STAP1	527	531	PF00017	0.556
LIG_SH2_STAT5	269	272	PF00017	0.814
LIG_SH2_STAT5	466	469	PF00017	0.552
LIG_SH2_STAT5	708	711	PF00017	0.675
LIG_SH2_STAT5	791	794	PF00017	0.640
LIG_SH3_1	401	407	PF00018	0.592
LIG_SH3_2	382	387	PF14604	0.720
LIG_SH3_3	188	194	PF00018	0.601
LIG_SH3_3	268	274	PF00018	0.651
LIG_SH3_3	298	304	PF00018	0.730
LIG_SH3_3	379	385	PF00018	0.712
LIG_SH3_3	401	407	PF00018	0.592
LIG_SH3_3	766	772	PF00018	0.621
LIG_SUMO_SIM_anti_2	630	638	PF11976	0.607
LIG_SUMO_SIM_par_1	25	30	PF11976	0.605
LIG_TRAF2_1	677	680	PF00917	0.699
LIG_TRAF2_1	76	79	PF00917	0.574
LIG_UBA3_1	106	111	PF00899	0.623
MOD_CDC14_SPxK_1	384	387	PF00782	0.715
MOD_CDK_SPxK_1	212	218	PF00069	0.581
MOD_CDK_SPxK_1	381	387	PF00069	0.718
MOD_CDK_SPxxK_3	162	169	PF00069	0.729
MOD_CDK_SPxxK_3	212	219	PF00069	0.522
MOD_CK1_1	148	154	PF00069	0.708
MOD_CK1_1	199	205	PF00069	0.673
MOD_CK1_1	228	234	PF00069	0.666
MOD_CK1_1	247	253	PF00069	0.571
MOD_CK1_1	293	299	PF00069	0.601
MOD_CK1_1	3	9	PF00069	0.700
MOD_CK1_1	380	386	PF00069	0.697
MOD_CK1_1	518	524	PF00069	0.524
MOD_CK1_1	57	63	PF00069	0.578
MOD_CK1_1	585	591	PF00069	0.706
MOD_CK1_1	621	627	PF00069	0.642
MOD_CK1_1	637	643	PF00069	0.535
MOD_CK1_1	660	666	PF00069	0.669
MOD_CK1_1	674	680	PF00069	0.542
MOD_CK1_1	727	733	PF00069	0.681
MOD_CK2_1	112	118	PF00069	0.638
MOD_CK2_1	143	149	PF00069	0.550
MOD_CK2_1	194	200	PF00069	0.652
MOD_CK2_1	627	633	PF00069	0.612
MOD_CK2_1	661	667	PF00069	0.638
MOD_CK2_1	674	680	PF00069	0.528
MOD_CK2_1	73	79	PF00069	0.573
MOD_CMANNOS	400	403	PF00535	0.603
MOD_Cter_Amidation	417	420	PF01082	0.526
MOD_GlcNHglycan	188	191	PF01048	0.609
MOD_GlcNHglycan	21	24	PF01048	0.480
MOD_GlcNHglycan	222	225	PF01048	0.675
MOD_GlcNHglycan	230	233	PF01048	0.600
MOD_GlcNHglycan	292	295	PF01048	0.739
MOD_GlcNHglycan	301	304	PF01048	0.713
MOD_GlcNHglycan	320	323	PF01048	0.591
MOD_GlcNHglycan	415	419	PF01048	0.656
MOD_GlcNHglycan	421	424	PF01048	0.675
MOD_GlcNHglycan	479	482	PF01048	0.558
MOD_GlcNHglycan	5	8	PF01048	0.698
MOD_GlcNHglycan	524	527	PF01048	0.644
MOD_GlcNHglycan	544	547	PF01048	0.407
MOD_GlcNHglycan	554	557	PF01048	0.566
MOD_GlcNHglycan	56	59	PF01048	0.534
MOD_GlcNHglycan	578	581	PF01048	0.660
MOD_GlcNHglycan	619	623	PF01048	0.669
MOD_GlcNHglycan	629	632	PF01048	0.590
MOD_GlcNHglycan	664	667	PF01048	0.762
MOD_GlcNHglycan	726	729	PF01048	0.632
MOD_GlcNHglycan	742	745	PF01048	0.524
MOD_GSK3_1	143	150	PF00069	0.667
MOD_GSK3_1	19	26	PF00069	0.641
MOD_GSK3_1	199	206	PF00069	0.683
MOD_GSK3_1	208	215	PF00069	0.628
MOD_GSK3_1	27	34	PF00069	0.517
MOD_GSK3_1	293	300	PF00069	0.593
MOD_GSK3_1	352	359	PF00069	0.569
MOD_GSK3_1	377	384	PF00069	0.669
MOD_GSK3_1	473	480	PF00069	0.491
MOD_GSK3_1	496	503	PF00069	0.609
MOD_GSK3_1	518	525	PF00069	0.539
MOD_GSK3_1	550	557	PF00069	0.622
MOD_GSK3_1	564	571	PF00069	0.741
MOD_GSK3_1	57	64	PF00069	0.564
MOD_GSK3_1	572	579	PF00069	0.578
MOD_GSK3_1	582	589	PF00069	0.728
MOD_GSK3_1	592	599	PF00069	0.613
MOD_GSK3_1	617	624	PF00069	0.648
MOD_GSK3_1	637	644	PF00069	0.521
MOD_GSK3_1	657	664	PF00069	0.715
MOD_GSK3_1	671	678	PF00069	0.683
MOD_LATS_1	793	799	PF00433	0.653
MOD_N-GLC_1	220	225	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.580
MOD_NEK2_1	106	111	PF00069	0.623
MOD_NEK2_1	285	290	PF00069	0.504
MOD_NEK2_1	32	37	PF00069	0.412
MOD_NEK2_1	477	482	PF00069	0.606
MOD_NEK2_1	634	639	PF00069	0.660
MOD_NEK2_1	784	789	PF00069	0.525
MOD_NEK2_2	473	478	PF00069	0.458
MOD_PIKK_1	330	336	PF00454	0.709
MOD_PIKK_1	356	362	PF00454	0.550
MOD_PIKK_1	39	45	PF00454	0.415
MOD_PIKK_1	568	574	PF00454	0.700
MOD_PIKK_1	671	677	PF00454	0.709
MOD_PIKK_1	761	767	PF00454	0.614
MOD_PK_1	225	231	PF00069	0.611
MOD_PK_1	338	344	PF00069	0.712
MOD_PKA_1	419	425	PF00069	0.542
MOD_PKA_1	582	588	PF00069	0.692
MOD_PKA_2	477	483	PF00069	0.492
MOD_PKA_2	573	579	PF00069	0.659
MOD_PKA_2	585	591	PF00069	0.679
MOD_PKA_2	652	658	PF00069	0.665
MOD_Plk_1	148	154	PF00069	0.636
MOD_Plk_1	194	200	PF00069	0.525
MOD_Plk_1	497	503	PF00069	0.627
MOD_Plk_1	666	672	PF00069	0.659
MOD_Plk_1	678	684	PF00069	0.621
MOD_Plk_1	733	739	PF00069	0.619
MOD_Plk_1	785	791	PF00069	0.459
MOD_Plk_4	203	209	PF00069	0.516
MOD_Plk_4	23	29	PF00069	0.614
MOD_Plk_4	244	250	PF00069	0.712
MOD_Plk_4	466	472	PF00069	0.546
MOD_Plk_4	641	647	PF00069	0.655
MOD_Plk_4	774	780	PF00069	0.635
MOD_Plk_4	785	791	PF00069	0.527
MOD_Plk_4	795	801	PF00069	0.598
MOD_ProDKin_1	162	168	PF00069	0.728
MOD_ProDKin_1	199	205	PF00069	0.688
MOD_ProDKin_1	212	218	PF00069	0.596
MOD_ProDKin_1	272	278	PF00069	0.684
MOD_ProDKin_1	297	303	PF00069	0.670
MOD_ProDKin_1	352	358	PF00069	0.651
MOD_ProDKin_1	377	383	PF00069	0.709
MOD_ProDKin_1	403	409	PF00069	0.624
MOD_ProDKin_1	435	441	PF00069	0.626
MOD_ProDKin_1	565	571	PF00069	0.719
MOD_ProDKin_1	574	580	PF00069	0.604
MOD_SUMO_for_1	178	181	PF00179	0.706
MOD_SUMO_for_1	217	220	PF00179	0.664
MOD_SUMO_for_1	251	254	PF00179	0.724
MOD_SUMO_rev_2	181	189	PF00179	0.593
TRG_DiLeu_BaEn_2	370	376	PF01217	0.640
TRG_DiLeu_BaEn_4	679	685	PF01217	0.694
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.613
TRG_ENDOCYTIC_2	104	107	PF00928	0.623
TRG_ENDOCYTIC_2	24	27	PF00928	0.618
TRG_ER_diArg_1	434	437	PF00400	0.454
TRG_ER_diArg_1	646	648	PF00400	0.487
TRG_NLS_Bipartite_1	324	341	PF00514	0.709
TRG_NLS_MonoCore_2	323	328	PF00514	0.610
TRG_NLS_MonoExtC_3	323	328	PF00514	0.610
TRG_NLS_MonoExtN_4	324	329	PF00514	0.660
TRG_NLS_MonoExtN_4	336	341	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAA0	Leishmania donovani	85%	100%
A4HA46	Leishmania braziliensis	69%	100%
A4HYB2	Leishmania infantum	86%	100%
Q4QDC1	Leishmania major	85%	100%