CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS44_LEIMU

TriTrypDb:

LmxM.19.0940

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035371	microtubule plus-end	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

E9AS44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS44

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	568	572	PF00656	0.413
CLV_C14_Caspase3-7	633	637	PF00656	0.545
CLV_NRD_NRD_1	217	219	PF00675	0.481
CLV_NRD_NRD_1	304	306	PF00675	0.479
CLV_NRD_NRD_1	33	35	PF00675	0.346
CLV_NRD_NRD_1	535	537	PF00675	0.549
CLV_PCSK_KEX2_1	209	211	PF00082	0.591
CLV_PCSK_KEX2_1	32	34	PF00082	0.345
CLV_PCSK_KEX2_1	535	537	PF00082	0.513
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.588
CLV_PCSK_SKI1_1	191	195	PF00082	0.499
CLV_PCSK_SKI1_1	275	279	PF00082	0.464
CLV_PCSK_SKI1_1	34	38	PF00082	0.388
CLV_PCSK_SKI1_1	342	346	PF00082	0.489
CLV_PCSK_SKI1_1	643	647	PF00082	0.628
CLV_PCSK_SKI1_1	67	71	PF00082	0.460
DEG_SCF_FBW7_1	645	652	PF00400	0.645
DEG_SCF_FBW7_2	24	31	PF00400	0.365
DEG_SPOP_SBC_1	440	444	PF00917	0.693
DOC_CKS1_1	25	30	PF01111	0.373
DOC_CKS1_1	646	651	PF01111	0.654
DOC_CYCLIN_RxL_1	467	477	PF00134	0.599
DOC_CYCLIN_RxL_1	623	636	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.477
DOC_MAPK_gen_1	32	39	PF00069	0.312
DOC_MAPK_gen_1	610	619	PF00069	0.654
DOC_MAPK_MEF2A_6	613	621	PF00069	0.604
DOC_MAPK_RevD_3	21	34	PF00069	0.515
DOC_PP1_RVXF_1	626	633	PF00149	0.528
DOC_PP1_SILK_1	34	39	PF00149	0.388
DOC_PP2B_LxvP_1	86	89	PF13499	0.486
DOC_PP4_FxxP_1	646	649	PF00568	0.650
DOC_PP4_FxxP_1	81	84	PF00568	0.319
DOC_USP7_MATH_1	16	20	PF00917	0.511
DOC_USP7_MATH_1	193	197	PF00917	0.557
DOC_USP7_MATH_1	251	255	PF00917	0.549
DOC_USP7_MATH_1	265	269	PF00917	0.459
DOC_USP7_MATH_1	293	297	PF00917	0.513
DOC_USP7_MATH_1	326	330	PF00917	0.604
DOC_USP7_MATH_1	400	404	PF00917	0.562
DOC_USP7_MATH_1	440	444	PF00917	0.678
DOC_USP7_MATH_1	502	506	PF00917	0.580
DOC_USP7_MATH_1	565	569	PF00917	0.497
DOC_USP7_MATH_1	595	599	PF00917	0.438
DOC_USP7_MATH_1	6	10	PF00917	0.735
DOC_USP7_UBL2_3	154	158	PF12436	0.577
DOC_USP7_UBL2_3	191	195	PF12436	0.383
DOC_WW_Pin1_4	24	29	PF00397	0.384
DOC_WW_Pin1_4	447	452	PF00397	0.542
DOC_WW_Pin1_4	547	552	PF00397	0.466
DOC_WW_Pin1_4	645	650	PF00397	0.683
DOC_WW_Pin1_4	91	96	PF00397	0.532
LIG_14-3-3_CanoR_1	231	239	PF00244	0.358
LIG_14-3-3_CanoR_1	424	431	PF00244	0.610
LIG_14-3-3_CanoR_1	510	514	PF00244	0.596
LIG_14-3-3_CanoR_1	581	586	PF00244	0.599
LIG_14-3-3_CanoR_1	596	605	PF00244	0.431
LIG_14-3-3_CanoR_1	8	16	PF00244	0.611
LIG_Actin_WH2_2	130	147	PF00022	0.531
LIG_DLG_GKlike_1	581	588	PF00625	0.528
LIG_FHA_1	25	31	PF00498	0.379
LIG_FHA_1	281	287	PF00498	0.475
LIG_FHA_1	329	335	PF00498	0.534
LIG_FHA_1	378	384	PF00498	0.550
LIG_FHA_1	448	454	PF00498	0.466
LIG_FHA_1	640	646	PF00498	0.458
LIG_FHA_2	157	163	PF00498	0.565
LIG_FHA_2	341	347	PF00498	0.510
LIG_IRF3_LxIS_1	451	456	PF10401	0.436
LIG_LIR_Apic_2	599	605	PF02991	0.646
LIG_LIR_Gen_1	18	28	PF02991	0.453
LIG_LIR_Nem_3	18	23	PF02991	0.426
LIG_LIR_Nem_3	296	302	PF02991	0.402
LIG_LIR_Nem_3	47	53	PF02991	0.321
LIG_NRBOX	360	366	PF00104	0.468
LIG_NRBOX	584	590	PF00104	0.524
LIG_RPA_C_Fungi	213	225	PF08784	0.574
LIG_SH2_CRK	299	303	PF00017	0.418
LIG_SH2_NCK_1	90	94	PF00017	0.485
LIG_SH2_PTP2	603	606	PF00017	0.514
LIG_SH2_SRC	603	606	PF00017	0.459
LIG_SH2_SRC	90	93	PF00017	0.547
LIG_SH2_STAP1	578	582	PF00017	0.490
LIG_SH2_STAT5	603	606	PF00017	0.514
LIG_SH2_STAT5	71	74	PF00017	0.352
LIG_SH3_3	10	16	PF00018	0.613
LIG_SH3_3	22	28	PF00018	0.374
LIG_SH3_3	86	92	PF00018	0.563
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.415
LIG_TRAF2_1	108	111	PF00917	0.530
LIG_TRAF2_1	315	318	PF00917	0.446
LIG_TRAF2_1	404	407	PF00917	0.484
LIG_TYR_ITIM	601	606	PF00017	0.455
LIG_WRC_WIRS_1	17	22	PF05994	0.422
MOD_CDK_SPK_2	547	552	PF00069	0.457
MOD_CK1_1	133	139	PF00069	0.614
MOD_CK1_1	254	260	PF00069	0.483
MOD_CK1_1	261	267	PF00069	0.370
MOD_CK1_1	340	346	PF00069	0.503
MOD_CK1_1	441	447	PF00069	0.754
MOD_CK1_1	94	100	PF00069	0.516
MOD_CK2_1	156	162	PF00069	0.483
MOD_CK2_1	16	22	PF00069	0.427
MOD_CK2_1	193	199	PF00069	0.555
MOD_CK2_1	340	346	PF00069	0.509
MOD_CK2_1	43	49	PF00069	0.207
MOD_CK2_1	94	100	PF00069	0.505
MOD_GlcNHglycan	102	105	PF01048	0.712
MOD_GlcNHglycan	195	198	PF01048	0.637
MOD_GlcNHglycan	215	218	PF01048	0.589
MOD_GlcNHglycan	266	270	PF01048	0.432
MOD_GlcNHglycan	402	405	PF01048	0.576
MOD_GlcNHglycan	554	557	PF01048	0.571
MOD_GlcNHglycan	598	601	PF01048	0.593
MOD_GlcNHglycan	9	12	PF01048	0.717
MOD_GSK3_1	126	133	PF00069	0.588
MOD_GSK3_1	230	237	PF00069	0.450
MOD_GSK3_1	253	260	PF00069	0.605
MOD_GSK3_1	261	268	PF00069	0.461
MOD_GSK3_1	373	380	PF00069	0.566
MOD_GSK3_1	434	441	PF00069	0.722
MOD_GSK3_1	449	456	PF00069	0.478
MOD_GSK3_1	552	559	PF00069	0.644
MOD_GSK3_1	608	615	PF00069	0.671
MOD_GSK3_1	645	652	PF00069	0.634
MOD_GSK3_1	91	98	PF00069	0.540
MOD_N-GLC_1	258	263	PF02516	0.624
MOD_NEK2_1	130	135	PF00069	0.523
MOD_NEK2_1	295	300	PF00069	0.386
MOD_NEK2_1	453	458	PF00069	0.613
MOD_NEK2_1	472	477	PF00069	0.507
MOD_NEK2_1	630	635	PF00069	0.524
MOD_PIKK_1	251	257	PF00454	0.521
MOD_PIKK_1	474	480	PF00454	0.495
MOD_PKA_1	218	224	PF00069	0.440
MOD_PKA_2	230	236	PF00069	0.386
MOD_PKA_2	423	429	PF00069	0.562
MOD_PKA_2	438	444	PF00069	0.658
MOD_PKA_2	509	515	PF00069	0.584
MOD_PKA_2	595	601	PF00069	0.581
MOD_PKA_2	612	618	PF00069	0.524
MOD_PKA_2	7	13	PF00069	0.661
MOD_Plk_1	130	136	PF00069	0.482
MOD_Plk_1	237	243	PF00069	0.521
MOD_Plk_1	453	459	PF00069	0.423
MOD_Plk_2-3	156	162	PF00069	0.587
MOD_Plk_2-3	449	455	PF00069	0.587
MOD_Plk_4	16	22	PF00069	0.448
MOD_ProDKin_1	24	30	PF00069	0.389
MOD_ProDKin_1	447	453	PF00069	0.539
MOD_ProDKin_1	547	553	PF00069	0.466
MOD_ProDKin_1	645	651	PF00069	0.684
MOD_ProDKin_1	91	97	PF00069	0.533
MOD_SUMO_for_1	104	107	PF00179	0.533
MOD_SUMO_for_1	157	160	PF00179	0.591
MOD_SUMO_rev_2	184	193	PF00179	0.534
MOD_SUMO_rev_2	366	374	PF00179	0.466
TRG_DiLeu_BaEn_1	360	365	PF01217	0.469
TRG_DiLeu_BaEn_1	407	412	PF01217	0.516
TRG_DiLeu_BaEn_4	356	362	PF01217	0.540
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.612
TRG_DiLeu_LyEn_5	407	412	PF01217	0.455
TRG_ENDOCYTIC_2	299	302	PF00928	0.411
TRG_ENDOCYTIC_2	603	606	PF00928	0.459
TRG_ER_diArg_1	32	34	PF00400	0.350
TRG_ER_diArg_1	408	411	PF00400	0.493
TRG_ER_diArg_1	468	471	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	37%	91%
A0A3Q8IEJ2	Leishmania donovani	85%	98%
A4HA45	Leishmania braziliensis	71%	97%
A4HYB1	Leishmania infantum	85%	98%
Q4QDC2	Leishmania major	84%	100%