Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AS42_LEIMU

TriTrypDb:

LmxM.19.0920

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AS42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS42

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.493
CLV_C14_Caspase3-7	659	663	PF00656	0.688
CLV_NRD_NRD_1	195	197	PF00675	0.213
CLV_NRD_NRD_1	41	43	PF00675	0.368
CLV_PCSK_KEX2_1	136	138	PF00082	0.274
CLV_PCSK_KEX2_1	194	196	PF00082	0.233
CLV_PCSK_KEX2_1	41	43	PF00082	0.412
CLV_PCSK_KEX2_1	523	525	PF00082	0.498
CLV_PCSK_KEX2_1	651	653	PF00082	0.268
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.274
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.498
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.283
CLV_PCSK_PC7_1	191	197	PF00082	0.202
CLV_PCSK_SKI1_1	119	123	PF00082	0.333
CLV_PCSK_SKI1_1	371	375	PF00082	0.243
CLV_PCSK_SKI1_1	652	656	PF00082	0.403
DEG_APCC_DBOX_1	96	104	PF00400	0.414
DEG_ODPH_VHL_1	622	634	PF01847	0.325
DEG_SPOP_SBC_1	300	304	PF00917	0.393
DEG_SPOP_SBC_1	505	509	PF00917	0.188
DOC_CDC14_PxL_1	609	617	PF14671	0.309
DOC_CKS1_1	602	607	PF01111	0.190
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.312
DOC_MAPK_gen_1	260	270	PF00069	0.527
DOC_MAPK_gen_1	288	295	PF00069	0.410
DOC_MAPK_gen_1	41	49	PF00069	0.470
DOC_MAPK_gen_1	523	531	PF00069	0.300
DOC_MAPK_HePTP_8	494	506	PF00069	0.390
DOC_MAPK_MEF2A_6	497	506	PF00069	0.456
DOC_MAPK_MEF2A_6	523	531	PF00069	0.337
DOC_PP1_RVXF_1	322	328	PF00149	0.515
DOC_PP2B_LxvP_1	444	447	PF13499	0.341
DOC_PP2B_LxvP_1	626	629	PF13499	0.331
DOC_PP2B_LxvP_1	632	635	PF13499	0.299
DOC_USP7_MATH_1	10	14	PF00917	0.646
DOC_USP7_MATH_1	159	163	PF00917	0.250
DOC_USP7_MATH_1	202	206	PF00917	0.291
DOC_USP7_MATH_1	449	453	PF00917	0.294
DOC_USP7_MATH_1	565	569	PF00917	0.464
DOC_USP7_MATH_1	59	63	PF00917	0.544
DOC_USP7_UBL2_3	651	655	PF12436	0.440
DOC_WW_Pin1_4	18	23	PF00397	0.763
DOC_WW_Pin1_4	601	606	PF00397	0.328
LIG_14-3-3_CanoR_1	107	114	PF00244	0.468
LIG_14-3-3_CanoR_1	501	505	PF00244	0.468
LIG_APCC_ABBA_1	251	256	PF00400	0.374
LIG_APCC_ABBA_1	53	58	PF00400	0.620
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.488
LIG_BIR_II_1	1	5	PF00653	0.763
LIG_BRCT_BRCA1_1	142	146	PF00533	0.252
LIG_BRCT_BRCA1_1	467	471	PF00533	0.294
LIG_CSL_BTD_1	552	555	PF09270	0.365
LIG_eIF4E_1	88	94	PF01652	0.390
LIG_EVH1_2	605	609	PF00568	0.340
LIG_FHA_1	120	126	PF00498	0.552
LIG_FHA_1	19	25	PF00498	0.629
LIG_FHA_1	256	262	PF00498	0.451
LIG_FHA_1	302	308	PF00498	0.410
LIG_FHA_1	386	392	PF00498	0.323
LIG_FHA_1	401	407	PF00498	0.240
LIG_FHA_1	501	507	PF00498	0.469
LIG_FHA_2	301	307	PF00498	0.553
LIG_HP1_1	555	559	PF01393	0.367
LIG_LIR_Apic_2	33	38	PF02991	0.588
LIG_LIR_Apic_2	421	426	PF02991	0.385
LIG_LIR_Gen_1	127	134	PF02991	0.497
LIG_LIR_Gen_1	186	197	PF02991	0.506
LIG_LIR_Gen_1	205	216	PF02991	0.495
LIG_LIR_Gen_1	470	479	PF02991	0.307
LIG_LIR_Gen_1	489	495	PF02991	0.362
LIG_LIR_Gen_1	515	522	PF02991	0.302
LIG_LIR_Gen_1	570	580	PF02991	0.493
LIG_LIR_Gen_1	608	617	PF02991	0.249
LIG_LIR_LC3C_4	503	506	PF02991	0.195
LIG_LIR_Nem_3	127	132	PF02991	0.472
LIG_LIR_Nem_3	135	141	PF02991	0.472
LIG_LIR_Nem_3	143	149	PF02991	0.325
LIG_LIR_Nem_3	186	192	PF02991	0.514
LIG_LIR_Nem_3	205	211	PF02991	0.265
LIG_LIR_Nem_3	361	367	PF02991	0.515
LIG_LIR_Nem_3	421	425	PF02991	0.352
LIG_LIR_Nem_3	468	472	PF02991	0.277
LIG_LIR_Nem_3	489	494	PF02991	0.310
LIG_LIR_Nem_3	515	520	PF02991	0.304
LIG_LIR_Nem_3	552	556	PF02991	0.272
LIG_LIR_Nem_3	596	602	PF02991	0.269
LIG_LIR_Nem_3	608	612	PF02991	0.245
LIG_Pex14_1	206	210	PF04695	0.342
LIG_Pex14_2	146	150	PF04695	0.188
LIG_Pex14_2	172	176	PF04695	0.332
LIG_Pex14_2	374	378	PF04695	0.468
LIG_Pex14_2	467	471	PF04695	0.287
LIG_Pex14_2	491	495	PF04695	0.339
LIG_PTB_Apo_2	489	496	PF02174	0.413
LIG_SH2_CRK	105	109	PF00017	0.489
LIG_SH2_CRK	189	193	PF00017	0.491
LIG_SH2_CRK	383	387	PF00017	0.313
LIG_SH2_CRK	44	48	PF00017	0.685
LIG_SH2_CRK	472	476	PF00017	0.280
LIG_SH2_NCK_1	472	476	PF00017	0.278
LIG_SH2_PTP2	35	38	PF00017	0.584
LIG_SH2_SRC	35	38	PF00017	0.590
LIG_SH2_STAP1	134	138	PF00017	0.478
LIG_SH2_STAP1	189	193	PF00017	0.468
LIG_SH2_STAP1	383	387	PF00017	0.361
LIG_SH2_STAP1	573	577	PF00017	0.307
LIG_SH2_STAT3	343	346	PF00017	0.382
LIG_SH2_STAT3	88	91	PF00017	0.404
LIG_SH2_STAT5	134	137	PF00017	0.479
LIG_SH2_STAT5	31	34	PF00017	0.652
LIG_SH2_STAT5	35	38	PF00017	0.579
LIG_SH2_STAT5	437	440	PF00017	0.322
LIG_SH2_STAT5	443	446	PF00017	0.315
LIG_SH2_STAT5	454	457	PF00017	0.265
LIG_SH2_STAT5	469	472	PF00017	0.243
LIG_SH2_STAT5	493	496	PF00017	0.433
LIG_SH2_STAT5	537	540	PF00017	0.271
LIG_SH2_STAT5	550	553	PF00017	0.346
LIG_SH2_STAT5	657	660	PF00017	0.562
LIG_SH2_STAT5	75	78	PF00017	0.502
LIG_SH3_3	353	359	PF00018	0.587
LIG_SH3_3	459	465	PF00018	0.263
LIG_SH3_3	599	605	PF00018	0.290
LIG_SUMO_SIM_par_1	502	509	PF11976	0.297
LIG_SUMO_SIM_par_1	555	561	PF11976	0.297
LIG_TRAF2_1	456	459	PF00917	0.190
LIG_TYR_ITIM	103	108	PF00017	0.272
LIG_TYR_ITIM	441	446	PF00017	0.302
LIG_TYR_ITSM	468	475	PF00017	0.372
LIG_UBA3_1	152	160	PF00899	0.301
LIG_Vh1_VBS_1	392	410	PF01044	0.422
LIG_Vh1_VBS_1	471	489	PF01044	0.354
LIG_WRC_WIRS_1	450	455	PF05994	0.303
MOD_CK1_1	109	115	PF00069	0.329
MOD_CK1_1	163	169	PF00069	0.243
MOD_CK1_1	226	232	PF00069	0.263
MOD_CK1_1	302	308	PF00069	0.270
MOD_CK1_1	496	502	PF00069	0.319
MOD_CK1_1	589	595	PF00069	0.288
MOD_CK1_1	663	669	PF00069	0.550
MOD_CK2_1	300	306	PF00069	0.393
MOD_GlcNHglycan	100	103	PF01048	0.260
MOD_GlcNHglycan	161	165	PF01048	0.326
MOD_GlcNHglycan	326	330	PF01048	0.381
MOD_GlcNHglycan	475	478	PF01048	0.401
MOD_GSK3_1	106	113	PF00069	0.376
MOD_GSK3_1	159	166	PF00069	0.268
MOD_GSK3_1	381	388	PF00069	0.342
MOD_GSK3_1	467	474	PF00069	0.346
MOD_GSK3_1	496	503	PF00069	0.331
MOD_GSK3_1	54	61	PF00069	0.351
MOD_GSK3_1	582	589	PF00069	0.341
MOD_GSK3_1	656	663	PF00069	0.558
MOD_NEK2_1	114	119	PF00069	0.343
MOD_NEK2_1	132	137	PF00069	0.258
MOD_NEK2_1	140	145	PF00069	0.306
MOD_NEK2_1	225	230	PF00069	0.335
MOD_NEK2_1	325	330	PF00069	0.425
MOD_NEK2_1	381	386	PF00069	0.339
MOD_NEK2_1	400	405	PF00069	0.270
MOD_NEK2_1	467	472	PF00069	0.330
MOD_NEK2_1	504	509	PF00069	0.334
MOD_NEK2_1	582	587	PF00069	0.322
MOD_NEK2_2	449	454	PF00069	0.305
MOD_NEK2_2	486	491	PF00069	0.188
MOD_OFUCOSY	389	396	PF10250	0.365
MOD_PK_1	107	113	PF00069	0.428
MOD_PKA_2	106	112	PF00069	0.344
MOD_PKA_2	500	506	PF00069	0.317
MOD_PKA_2	565	571	PF00069	0.303
MOD_Plk_1	226	232	PF00069	0.251
MOD_Plk_2-3	344	350	PF00069	0.273
MOD_Plk_4	202	208	PF00069	0.313
MOD_Plk_4	226	232	PF00069	0.305
MOD_Plk_4	381	387	PF00069	0.323
MOD_Plk_4	411	417	PF00069	0.387
MOD_Plk_4	418	424	PF00069	0.362
MOD_Plk_4	449	455	PF00069	0.307
MOD_Plk_4	467	473	PF00069	0.442
MOD_Plk_4	500	506	PF00069	0.313
MOD_Plk_4	512	518	PF00069	0.296
MOD_Plk_4	549	555	PF00069	0.288
MOD_Plk_4	567	573	PF00069	0.349
MOD_Plk_4	589	595	PF00069	0.307
MOD_Plk_4	628	634	PF00069	0.349
MOD_Plk_4	81	87	PF00069	0.288
MOD_ProDKin_1	18	24	PF00069	0.713
MOD_ProDKin_1	601	607	PF00069	0.387
MOD_SUMO_for_1	650	653	PF00179	0.345
TRG_ENDOCYTIC_2	105	108	PF00928	0.295
TRG_ENDOCYTIC_2	189	192	PF00928	0.312
TRG_ENDOCYTIC_2	383	386	PF00928	0.315
TRG_ENDOCYTIC_2	437	440	PF00928	0.326
TRG_ENDOCYTIC_2	44	47	PF00928	0.472
TRG_ENDOCYTIC_2	443	446	PF00928	0.328
TRG_ENDOCYTIC_2	472	475	PF00928	0.323
TRG_ENDOCYTIC_2	573	576	PF00928	0.308
TRG_ER_diArg_1	193	196	PF00400	0.240
TRG_ER_diArg_1	353	356	PF00400	0.395
TRG_ER_diArg_1	41	43	PF00400	0.577
TRG_NES_CRM1_1	242	256	PF08389	0.339
TRG_NES_CRM1_1	358	372	PF08389	0.212
TRG_NES_CRM1_1	445	459	PF08389	0.273
TRG_NES_CRM1_1	584	596	PF08389	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	51%	95%
A0A0N1HY49	Leptomonas seymouri	53%	100%
A0A0N1HZ06	Leptomonas seymouri	43%	100%
A0A0N1IHL1	Leptomonas seymouri	45%	94%
A0A0N1PAY4	Leptomonas seymouri	50%	76%
A0A0N1PB77	Leptomonas seymouri	41%	100%
A0A0N1PBZ2	Leptomonas seymouri	53%	100%
A0A0N1PCC1	Leptomonas seymouri	47%	100%
A0A381MBI0	Leishmania infantum	45%	100%
A0A3Q8I8X7	Leishmania donovani	45%	100%
A0A3Q8IAZ0	Leishmania donovani	52%	96%
A0A3Q8IH50	Leishmania donovani	61%	93%
A0A3Q8IVN0	Leishmania donovani	42%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	50%	99%
A0A3S5H5V2	Leishmania donovani	46%	100%
A0A3S5H6F6	Leishmania donovani	51%	96%
A0A3S5H763	Leishmania donovani	94%	100%
A0A3S7WR10	Leishmania donovani	49%	90%
A0A3S7WR14	Leishmania donovani	55%	98%
A0A3S7WR15	Leishmania donovani	52%	79%
A0A3S7WR24	Leishmania donovani	52%	95%
A4H4T8	Leishmania braziliensis	46%	100%
A4H5Y4	Leishmania braziliensis	48%	100%
A4H617	Leishmania braziliensis	50%	100%
A4H618	Leishmania braziliensis	50%	100%
A4H619	Leishmania braziliensis	50%	100%
A4H620	Leishmania braziliensis	60%	100%
A4H6C3	Leishmania braziliensis	47%	100%
A4HNH7	Leishmania braziliensis	40%	96%
A4HSS2	Leishmania infantum	50%	99%
A4HUE4	Leishmania infantum	50%	90%
A4HUE5	Leishmania infantum	51%	97%
A4HUE6	Leishmania infantum	55%	98%
A4HUE7	Leishmania infantum	52%	96%
A4HUE8	Leishmania infantum	51%	95%
A4HUF4	Leishmania infantum	51%	96%
A4HUF5	Leishmania infantum	62%	100%
A4HYA9	Leishmania infantum	94%	100%
A4IC33	Leishmania infantum	43%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AG72	Leishmania infantum	47%	100%
E9AI40	Leishmania braziliensis	54%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q4QDC4	Leishmania major	94%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	50%	100%
Q4QHH9	Leishmania major	50%	100%
Q4QHI0	Leishmania major	52%	100%
Q4QHI1	Leishmania major	54%	100%
Q4QHI2	Leishmania major	52%	100%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	52%	100%
Q7KIP2	Leishmania major	41%	100%