Vps53_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vps53-like domain protein

Species:

Leishmania mexicana

UniProt:

E9AS33_LEIMU

TriTrypDb:

LmxM.19.0810

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	12
GO:0005829	cytosol	2	12
GO:0010008	endosome membrane	5	12
GO:0012506	vesicle membrane	4	12
GO:0016020	membrane	2	12
GO:0030659	cytoplasmic vesicle membrane	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AS33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS33

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0016192	vesicle-mediated transport	4	12
GO:0016197	endosomal transport	4	12
GO:0016482	cytosolic transport	4	12
GO:0042147	retrograde transport, endosome to Golgi	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.549
CLV_MEL_PAP_1	93	99	PF00089	0.260
CLV_NRD_NRD_1	155	157	PF00675	0.264
CLV_NRD_NRD_1	267	269	PF00675	0.245
CLV_NRD_NRD_1	449	451	PF00675	0.343
CLV_NRD_NRD_1	474	476	PF00675	0.338
CLV_NRD_NRD_1	58	60	PF00675	0.408
CLV_NRD_NRD_1	617	619	PF00675	0.424
CLV_NRD_NRD_1	662	664	PF00675	0.363
CLV_NRD_NRD_1	713	715	PF00675	0.414
CLV_PCSK_FUR_1	252	256	PF00082	0.279
CLV_PCSK_FUR_1	615	619	PF00082	0.360
CLV_PCSK_KEX2_1	154	156	PF00082	0.279
CLV_PCSK_KEX2_1	254	256	PF00082	0.255
CLV_PCSK_KEX2_1	267	269	PF00082	0.225
CLV_PCSK_KEX2_1	352	354	PF00082	0.310
CLV_PCSK_KEX2_1	430	432	PF00082	0.332
CLV_PCSK_KEX2_1	449	451	PF00082	0.440
CLV_PCSK_KEX2_1	473	475	PF00082	0.346
CLV_PCSK_KEX2_1	617	619	PF00082	0.424
CLV_PCSK_KEX2_1	713	715	PF00082	0.410
CLV_PCSK_KEX2_1	726	728	PF00082	0.428
CLV_PCSK_KEX2_1	734	736	PF00082	0.366
CLV_PCSK_KEX2_1	868	870	PF00082	0.674
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.391
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.260
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.310
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.318
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.427
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.366
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.674
CLV_PCSK_SKI1_1	155	159	PF00082	0.257
CLV_PCSK_SKI1_1	161	165	PF00082	0.244
CLV_PCSK_SKI1_1	20	24	PF00082	0.563
CLV_PCSK_SKI1_1	268	272	PF00082	0.265
CLV_PCSK_SKI1_1	273	277	PF00082	0.227
CLV_PCSK_SKI1_1	284	288	PF00082	0.196
CLV_PCSK_SKI1_1	337	341	PF00082	0.245
CLV_PCSK_SKI1_1	384	388	PF00082	0.365
CLV_PCSK_SKI1_1	430	434	PF00082	0.398
CLV_PCSK_SKI1_1	514	518	PF00082	0.451
CLV_PCSK_SKI1_1	572	576	PF00082	0.432
CLV_PCSK_SKI1_1	595	599	PF00082	0.294
CLV_PCSK_SKI1_1	636	640	PF00082	0.380
CLV_PCSK_SKI1_1	671	675	PF00082	0.334
CLV_PCSK_SKI1_1	84	88	PF00082	0.307
DEG_APCC_DBOX_1	448	456	PF00400	0.433
DEG_APCC_DBOX_1	594	602	PF00400	0.286
DEG_SPOP_SBC_1	147	151	PF00917	0.279
DOC_CDC14_PxL_1	534	542	PF14671	0.376
DOC_CYCLIN_RxL_1	267	280	PF00134	0.245
DOC_CYCLIN_RxL_1	592	599	PF00134	0.287
DOC_MAPK_gen_1	264	272	PF00069	0.245
DOC_MAPK_gen_1	449	455	PF00069	0.334
DOC_MAPK_gen_1	473	480	PF00069	0.309
DOC_MAPK_MEF2A_6	369	376	PF00069	0.245
DOC_MAPK_NFAT4_5	369	377	PF00069	0.245
DOC_PP1_RVXF_1	504	511	PF00149	0.425
DOC_PP2B_LxvP_1	639	642	PF13499	0.325
DOC_PP2B_LxvP_1	785	788	PF13499	0.565
DOC_USP7_MATH_1	104	108	PF00917	0.279
DOC_USP7_MATH_1	565	569	PF00917	0.495
DOC_USP7_MATH_1	781	785	PF00917	0.658
DOC_USP7_MATH_1	822	826	PF00917	0.698
DOC_USP7_UBL2_3	178	182	PF12436	0.278
DOC_USP7_UBL2_3	426	430	PF12436	0.328
DOC_USP7_UBL2_3	862	866	PF12436	0.624
DOC_WW_Pin1_4	466	471	PF00397	0.389
LIG_14-3-3_CanoR_1	202	206	PF00244	0.330
LIG_14-3-3_CanoR_1	57	66	PF00244	0.263
LIG_14-3-3_CanoR_1	649	659	PF00244	0.441
LIG_14-3-3_CanoR_1	855	864	PF00244	0.545
LIG_Actin_WH2_2	414	432	PF00022	0.303
LIG_Actin_WH2_2	44	61	PF00022	0.296
LIG_APCC_ABBA_1	686	691	PF00400	0.316
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.279
LIG_BRCT_BRCA1_1	148	152	PF00533	0.281
LIG_BRCT_BRCA1_1	170	174	PF00533	0.288
LIG_BRCT_BRCA1_1	249	253	PF00533	0.279
LIG_BRCT_BRCA1_1	859	863	PF00533	0.576
LIG_BRCT_BRCA1_2	148	154	PF00533	0.391
LIG_Clathr_ClatBox_1	228	232	PF01394	0.146
LIG_DLG_GKlike_1	739	747	PF00625	0.456
LIG_FHA_1	127	133	PF00498	0.258
LIG_FHA_1	298	304	PF00498	0.245
LIG_FHA_1	324	330	PF00498	0.281
LIG_FHA_1	480	486	PF00498	0.327
LIG_FHA_1	523	529	PF00498	0.336
LIG_FHA_1	573	579	PF00498	0.397
LIG_FHA_1	654	660	PF00498	0.419
LIG_FHA_1	830	836	PF00498	0.692
LIG_FHA_2	303	309	PF00498	0.245
LIG_FHA_2	342	348	PF00498	0.310
LIG_FHA_2	487	493	PF00498	0.353
LIG_FHA_2	575	581	PF00498	0.450
LIG_FHA_2	731	737	PF00498	0.370
LIG_FHA_2	75	81	PF00498	0.381
LIG_LIR_Gen_1	171	181	PF02991	0.258
LIG_LIR_Gen_1	266	276	PF02991	0.245
LIG_LIR_Gen_1	277	287	PF02991	0.245
LIG_LIR_Gen_1	419	429	PF02991	0.303
LIG_LIR_Gen_1	507	517	PF02991	0.350
LIG_LIR_Gen_1	635	644	PF02991	0.311
LIG_LIR_Gen_1	656	666	PF02991	0.323
LIG_LIR_Gen_1	682	693	PF02991	0.347
LIG_LIR_Gen_1	848	858	PF02991	0.649
LIG_LIR_Nem_3	266	272	PF02991	0.245
LIG_LIR_Nem_3	27	31	PF02991	0.224
LIG_LIR_Nem_3	277	282	PF02991	0.245
LIG_LIR_Nem_3	413	417	PF02991	0.299
LIG_LIR_Nem_3	419	425	PF02991	0.269
LIG_LIR_Nem_3	507	513	PF02991	0.362
LIG_LIR_Nem_3	515	520	PF02991	0.310
LIG_LIR_Nem_3	635	641	PF02991	0.315
LIG_LIR_Nem_3	656	661	PF02991	0.339
LIG_LIR_Nem_3	665	669	PF02991	0.276
LIG_LIR_Nem_3	682	688	PF02991	0.321
LIG_NRBOX	271	277	PF00104	0.372
LIG_NRBOX	593	599	PF00104	0.285
LIG_PCNA_yPIPBox_3	697	710	PF02747	0.365
LIG_Pex14_1	345	349	PF04695	0.245
LIG_Pex14_2	283	287	PF04695	0.241
LIG_Pex14_2	773	777	PF04695	0.503
LIG_PTB_Apo_2	200	207	PF02174	0.391
LIG_PTB_Apo_2	32	39	PF02174	0.245
LIG_PTB_Apo_2	542	549	PF02174	0.345
LIG_PTB_Apo_2	608	615	PF02174	0.440
LIG_PTB_Phospho_1	608	614	PF10480	0.436
LIG_SH2_CRK	279	283	PF00017	0.391
LIG_SH2_GRB2like	33	36	PF00017	0.260
LIG_SH2_NCK_1	279	283	PF00017	0.255
LIG_SH2_NCK_1	644	648	PF00017	0.379
LIG_SH2_PTP2	269	272	PF00017	0.225
LIG_SH2_PTP2	658	661	PF00017	0.327
LIG_SH2_PTP2	94	97	PF00017	0.310
LIG_SH2_SRC	33	36	PF00017	0.304
LIG_SH2_SRC	414	417	PF00017	0.364
LIG_SH2_STAP1	170	174	PF00017	0.260
LIG_SH2_STAP1	249	253	PF00017	0.260
LIG_SH2_STAP1	279	283	PF00017	0.452
LIG_SH2_STAP1	5	9	PF00017	0.567
LIG_SH2_STAP1	690	694	PF00017	0.337
LIG_SH2_STAT3	327	330	PF00017	0.245
LIG_SH2_STAT5	200	203	PF00017	0.246
LIG_SH2_STAT5	269	272	PF00017	0.288
LIG_SH2_STAT5	327	330	PF00017	0.288
LIG_SH2_STAT5	33	36	PF00017	0.260
LIG_SH2_STAT5	414	417	PF00017	0.428
LIG_SH2_STAT5	521	524	PF00017	0.377
LIG_SH2_STAT5	658	661	PF00017	0.475
LIG_SH2_STAT5	94	97	PF00017	0.310
LIG_SH3_3	13	19	PF00018	0.470
LIG_SH3_3	585	591	PF00018	0.334
LIG_SH3_3	689	695	PF00018	0.416
LIG_Sin3_3	222	229	PF02671	0.310
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.247
LIG_SUMO_SIM_par_1	224	230	PF11976	0.458
LIG_SUMO_SIM_par_1	321	326	PF11976	0.252
LIG_SUMO_SIM_par_1	331	336	PF11976	0.233
LIG_TRAF2_1	163	166	PF00917	0.391
LIG_TRAF2_1	305	308	PF00917	0.391
LIG_TRAF2_1	840	843	PF00917	0.597
LIG_TYR_ITIM	688	693	PF00017	0.456
LIG_UBA3_1	173	182	PF00899	0.279
LIG_UBA3_1	421	430	PF00899	0.318
LIG_WW_3	17	21	PF00397	0.484
LIG_WW_3	503	507	PF00397	0.485
LIG_WW_3	786	790	PF00397	0.576
MOD_CDK_SPxxK_3	466	473	PF00069	0.462
MOD_CK1_1	131	137	PF00069	0.265
MOD_CK1_1	302	308	PF00069	0.293
MOD_CK1_1	394	400	PF00069	0.483
MOD_CK1_1	524	530	PF00069	0.471
MOD_CK1_1	653	659	PF00069	0.445
MOD_CK1_1	74	80	PF00069	0.367
MOD_CK1_1	764	770	PF00069	0.629
MOD_CK1_1	856	862	PF00069	0.583
MOD_CK2_1	102	108	PF00069	0.297
MOD_CK2_1	147	153	PF00069	0.269
MOD_CK2_1	302	308	PF00069	0.260
MOD_CK2_1	401	407	PF00069	0.517
MOD_CK2_1	466	472	PF00069	0.467
MOD_CK2_1	74	80	PF00069	0.393
MOD_GlcNHglycan	365	368	PF01048	0.339
MOD_GlcNHglycan	393	396	PF01048	0.532
MOD_GlcNHglycan	560	563	PF01048	0.432
MOD_GlcNHglycan	652	655	PF01048	0.479
MOD_GlcNHglycan	750	753	PF01048	0.596
MOD_GlcNHglycan	766	769	PF01048	0.432
MOD_GlcNHglycan	77	80	PF01048	0.316
MOD_GlcNHglycan	780	784	PF01048	0.520
MOD_GlcNHglycan	794	797	PF01048	0.493
MOD_GSK3_1	123	130	PF00069	0.351
MOD_GSK3_1	337	344	PF00069	0.310
MOD_GSK3_1	406	413	PF00069	0.498
MOD_GSK3_1	515	522	PF00069	0.345
MOD_GSK3_1	71	78	PF00069	0.322
MOD_GSK3_1	739	746	PF00069	0.483
MOD_GSK3_1	775	782	PF00069	0.498
MOD_GSK3_1	805	812	PF00069	0.563
MOD_GSK3_1	845	852	PF00069	0.599
MOD_GSK3_1	853	860	PF00069	0.527
MOD_GSK3_1	95	102	PF00069	0.435
MOD_N-GLC_1	126	131	PF02516	0.245
MOD_N-GLC_1	696	701	PF02516	0.376
MOD_N-GLC_1	74	79	PF02516	0.391
MOD_N-GLC_1	791	796	PF02516	0.592
MOD_NEK2_1	128	133	PF00069	0.279
MOD_NEK2_1	168	173	PF00069	0.308
MOD_NEK2_1	297	302	PF00069	0.269
MOD_NEK2_1	363	368	PF00069	0.263
MOD_NEK2_1	485	490	PF00069	0.340
MOD_NEK2_1	601	606	PF00069	0.426
MOD_NEK2_1	634	639	PF00069	0.334
MOD_NEK2_1	650	655	PF00069	0.367
MOD_NEK2_1	743	748	PF00069	0.535
MOD_NEK2_1	805	810	PF00069	0.622
MOD_NEK2_1	853	858	PF00069	0.520
MOD_NEK2_2	516	521	PF00069	0.334
MOD_NEK2_2	609	614	PF00069	0.435
MOD_PIKK_1	188	194	PF00454	0.391
MOD_PIKK_1	337	343	PF00454	0.370
MOD_PIKK_1	487	493	PF00454	0.389
MOD_PIKK_1	522	528	PF00454	0.204
MOD_PIKK_1	99	105	PF00454	0.310
MOD_PK_1	278	284	PF00069	0.266
MOD_PK_1	845	851	PF00069	0.538
MOD_PKA_1	254	260	PF00069	0.260
MOD_PKA_2	201	207	PF00069	0.279
MOD_PKA_2	254	260	PF00069	0.242
MOD_PKA_2	58	64	PF00069	0.261
MOD_PKA_2	854	860	PF00069	0.531
MOD_PKA_2	95	101	PF00069	0.260
MOD_Plk_1	337	343	PF00069	0.245
MOD_Plk_1	40	46	PF00069	0.262
MOD_Plk_1	634	640	PF00069	0.331
MOD_Plk_1	696	702	PF00069	0.359
MOD_Plk_1	739	745	PF00069	0.431
MOD_Plk_4	169	175	PF00069	0.223
MOD_Plk_4	201	207	PF00069	0.279
MOD_Plk_4	278	284	PF00069	0.293
MOD_Plk_4	323	329	PF00069	0.245
MOD_Plk_4	410	416	PF00069	0.416
MOD_Plk_4	458	464	PF00069	0.282
MOD_Plk_4	516	522	PF00069	0.311
MOD_Plk_4	524	530	PF00069	0.294
MOD_Plk_4	601	607	PF00069	0.339
MOD_Plk_4	609	615	PF00069	0.328
MOD_Plk_4	634	640	PF00069	0.385
MOD_Plk_4	845	851	PF00069	0.581
MOD_ProDKin_1	466	472	PF00069	0.389
MOD_SUMO_for_1	260	263	PF00179	0.279
MOD_SUMO_for_1	351	354	PF00179	0.146
MOD_SUMO_rev_2	258	262	PF00179	0.264
MOD_SUMO_rev_2	561	571	PF00179	0.547
MOD_SUMO_rev_2	78	86	PF00179	0.356
MOD_SUMO_rev_2	98	102	PF00179	0.187
TRG_DiLeu_BaEn_2	152	158	PF01217	0.201
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.506
TRG_ENDOCYTIC_2	170	173	PF00928	0.301
TRG_ENDOCYTIC_2	269	272	PF00928	0.245
TRG_ENDOCYTIC_2	279	282	PF00928	0.245
TRG_ENDOCYTIC_2	360	363	PF00928	0.245
TRG_ENDOCYTIC_2	414	417	PF00928	0.428
TRG_ENDOCYTIC_2	658	661	PF00928	0.306
TRG_ENDOCYTIC_2	689	692	PF00928	0.319
TRG_ENDOCYTIC_2	94	97	PF00928	0.260
TRG_ER_diArg_1	155	157	PF00400	0.391
TRG_ER_diArg_1	267	269	PF00400	0.245
TRG_ER_diArg_1	448	450	PF00400	0.440
TRG_ER_diArg_1	473	475	PF00400	0.358
TRG_ER_diArg_1	614	617	PF00400	0.399
TRG_ER_diArg_1	712	714	PF00400	0.380
TRG_NES_CRM1_1	667	679	PF08389	0.345
TRG_NLS_MonoExtC_3	233	238	PF00514	0.391
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSX2	Leptomonas seymouri	80%	99%
A0A0S4J071	Bodo saltans	51%	100%
A0A1X0P670	Trypanosomatidae	59%	96%
A0A3R7KBJ1	Trypanosoma rangeli	58%	99%
A0A3S7WVF6	Leishmania donovani	95%	100%
A4HA38	Leishmania braziliensis	89%	100%
A4HYA1	Leishmania infantum	95%	100%
D0A0N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
P34561	Caenorhabditis elegans	22%	100%
P47061	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P87129	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q0WQF4	Arabidopsis thaliana	26%	100%
Q4QDE0	Leishmania major	94%	99%
Q5R5J4	Pongo abelii	23%	100%
Q5VIR6	Homo sapiens	23%	100%
Q5ZLD7	Gallus gallus	23%	100%
Q8CCB4	Mus musculus	23%	100%
V5AZ39	Trypanosoma cruzi	60%	100%