Signal recognition particle subunit SRP72

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS31_LEIMU

TriTrypDb:

LmxM.19.0790

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0048500	signal recognition particle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AS31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS31

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008312	7S RNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.410
CLV_C14_Caspase3-7	413	417	PF00656	0.616
CLV_NRD_NRD_1	11	13	PF00675	0.518
CLV_NRD_NRD_1	287	289	PF00675	0.504
CLV_NRD_NRD_1	324	326	PF00675	0.369
CLV_NRD_NRD_1	445	447	PF00675	0.527
CLV_NRD_NRD_1	631	633	PF00675	0.617
CLV_NRD_NRD_1	659	661	PF00675	0.234
CLV_NRD_NRD_1	663	665	PF00675	0.230
CLV_NRD_NRD_1	693	695	PF00675	0.476
CLV_NRD_NRD_1	699	701	PF00675	0.511
CLV_NRD_NRD_1	710	712	PF00675	0.496
CLV_PCSK_FUR_1	657	661	PF00082	0.259
CLV_PCSK_KEX2_1	287	289	PF00082	0.504
CLV_PCSK_KEX2_1	396	398	PF00082	0.347
CLV_PCSK_KEX2_1	447	449	PF00082	0.556
CLV_PCSK_KEX2_1	582	584	PF00082	0.515
CLV_PCSK_KEX2_1	631	633	PF00082	0.602
CLV_PCSK_KEX2_1	657	659	PF00082	0.240
CLV_PCSK_KEX2_1	663	665	PF00082	0.234
CLV_PCSK_KEX2_1	693	695	PF00082	0.476
CLV_PCSK_KEX2_1	699	701	PF00082	0.511
CLV_PCSK_KEX2_1	709	711	PF00082	0.494
CLV_PCSK_KEX2_1	721	723	PF00082	0.501
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.347
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.567
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.515
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.548
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.501
CLV_PCSK_PC7_1	659	665	PF00082	0.274
CLV_PCSK_SKI1_1	114	118	PF00082	0.298
CLV_PCSK_SKI1_1	221	225	PF00082	0.474
CLV_PCSK_SKI1_1	260	264	PF00082	0.319
CLV_PCSK_SKI1_1	325	329	PF00082	0.385
CLV_PCSK_SKI1_1	385	389	PF00082	0.387
CLV_PCSK_SKI1_1	391	395	PF00082	0.413
CLV_PCSK_SKI1_1	412	416	PF00082	0.590
CLV_PCSK_SKI1_1	525	529	PF00082	0.338
CLV_PCSK_SKI1_1	563	567	PF00082	0.393
CLV_PCSK_SKI1_1	631	635	PF00082	0.673
CLV_PCSK_SKI1_1	664	668	PF00082	0.297
CLV_PCSK_SKI1_1	75	79	PF00082	0.145
DEG_APCC_DBOX_1	113	121	PF00400	0.497
DOC_CYCLIN_RxL_1	28	38	PF00134	0.218
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.572
DOC_MAPK_gen_1	287	294	PF00069	0.453
DOC_MAPK_gen_1	325	335	PF00069	0.512
DOC_MAPK_gen_1	446	454	PF00069	0.517
DOC_MAPK_gen_1	561	570	PF00069	0.411
DOC_MAPK_MEF2A_6	287	294	PF00069	0.401
DOC_MAPK_RevD_3	384	397	PF00069	0.525
DOC_PP2B_LxvP_1	238	241	PF13499	0.531
DOC_USP7_MATH_1	228	232	PF00917	0.546
DOC_USP7_MATH_1	244	248	PF00917	0.437
DOC_USP7_MATH_1	301	305	PF00917	0.347
DOC_USP7_MATH_1	410	414	PF00917	0.669
DOC_USP7_MATH_1	438	442	PF00917	0.684
DOC_USP7_MATH_1	555	559	PF00917	0.427
DOC_USP7_MATH_1	623	627	PF00917	0.557
DOC_USP7_MATH_1	665	669	PF00917	0.551
DOC_USP7_MATH_1	714	718	PF00917	0.603
DOC_USP7_MATH_1	736	740	PF00917	0.734
DOC_USP7_UBL2_3	9	13	PF12436	0.525
DOC_WW_Pin1_4	177	182	PF00397	0.514
DOC_WW_Pin1_4	254	259	PF00397	0.439
DOC_WW_Pin1_4	400	405	PF00397	0.667
DOC_WW_Pin1_4	68	73	PF00397	0.515
DOC_WW_Pin1_4	732	737	PF00397	0.615
LIG_14-3-3_CanoR_1	106	116	PF00244	0.498
LIG_14-3-3_CanoR_1	12	20	PF00244	0.554
LIG_14-3-3_CanoR_1	31	36	PF00244	0.528
LIG_14-3-3_CanoR_1	338	345	PF00244	0.400
LIG_14-3-3_CanoR_1	363	369	PF00244	0.493
LIG_14-3-3_CanoR_1	412	421	PF00244	0.631
LIG_14-3-3_CanoR_1	44	49	PF00244	0.517
LIG_14-3-3_CanoR_1	484	489	PF00244	0.474
LIG_14-3-3_CanoR_1	511	521	PF00244	0.505
LIG_14-3-3_CanoR_1	664	670	PF00244	0.345
LIG_Actin_WH2_2	534	552	PF00022	0.437
LIG_BIR_II_1	1	5	PF00653	0.409
LIG_BRCT_BRCA1_1	316	320	PF00533	0.524
LIG_BRCT_BRCA1_1	75	79	PF00533	0.515
LIG_CtBP_PxDLS_1	680	684	PF00389	0.470
LIG_eIF4E_1	85	91	PF01652	0.497
LIG_FHA_1	155	161	PF00498	0.373
LIG_FHA_1	178	184	PF00498	0.463
LIG_FHA_1	187	193	PF00498	0.333
LIG_FHA_1	301	307	PF00498	0.342
LIG_FHA_1	349	355	PF00498	0.341
LIG_FHA_1	379	385	PF00498	0.399
LIG_FHA_1	454	460	PF00498	0.488
LIG_FHA_1	564	570	PF00498	0.450
LIG_FHA_1	76	82	PF00498	0.470
LIG_FHA_2	13	19	PF00498	0.552
LIG_FHA_2	254	260	PF00498	0.450
LIG_FHA_2	632	638	PF00498	0.674
LIG_GBD_Chelix_1	306	314	PF00786	0.456
LIG_LIR_Nem_3	627	633	PF02991	0.626
LIG_PDZ_Class_1	736	741	PF00595	0.641
LIG_SH2_CRK	134	138	PF00017	0.510
LIG_SH2_CRK	311	315	PF00017	0.481
LIG_SH2_CRK	542	546	PF00017	0.433
LIG_SH2_CRK	630	634	PF00017	0.553
LIG_SH2_NCK_1	127	131	PF00017	0.497
LIG_SH2_NCK_1	542	546	PF00017	0.451
LIG_SH2_SRC	127	130	PF00017	0.528
LIG_SH2_STAP1	127	131	PF00017	0.451
LIG_SH2_STAP1	134	138	PF00017	0.409
LIG_SH2_STAP1	156	160	PF00017	0.442
LIG_SH2_STAP1	428	432	PF00017	0.540
LIG_SH2_STAP1	519	523	PF00017	0.519
LIG_SH2_STAT5	156	159	PF00017	0.401
LIG_SH2_STAT5	275	278	PF00017	0.338
LIG_SH2_STAT5	311	314	PF00017	0.352
LIG_SH2_STAT5	686	689	PF00017	0.443
LIG_SH2_STAT5	85	88	PF00017	0.431
LIG_SH2_STAT5	93	96	PF00017	0.431
LIG_Sin3_3	567	574	PF02671	0.469
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.241
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.510
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.429
LIG_SUMO_SIM_par_1	386	392	PF11976	0.509
LIG_TYR_ITIM	309	314	PF00017	0.351
LIG_TYR_ITIM	628	633	PF00017	0.572
MOD_CDC14_SPxK_1	257	260	PF00782	0.380
MOD_CDK_SPxK_1	254	260	PF00069	0.431
MOD_CDK_SPxxK_3	68	75	PF00069	0.154
MOD_CK1_1	253	259	PF00069	0.586
MOD_CK1_1	300	306	PF00069	0.344
MOD_CK1_1	337	343	PF00069	0.476
MOD_CK1_1	378	384	PF00069	0.365
MOD_CK1_1	403	409	PF00069	0.680
MOD_CK1_1	682	688	PF00069	0.310
MOD_CK2_1	24	30	PF00069	0.426
MOD_CK2_1	253	259	PF00069	0.493
MOD_CK2_1	58	64	PF00069	0.410
MOD_GlcNHglycan	160	163	PF01048	0.381
MOD_GlcNHglycan	299	302	PF01048	0.370
MOD_GlcNHglycan	303	306	PF01048	0.372
MOD_GlcNHglycan	316	319	PF01048	0.442
MOD_GlcNHglycan	356	359	PF01048	0.509
MOD_GlcNHglycan	405	408	PF01048	0.697
MOD_GlcNHglycan	412	415	PF01048	0.644
MOD_GlcNHglycan	416	419	PF01048	0.607
MOD_GlcNHglycan	52	55	PF01048	0.408
MOD_GlcNHglycan	596	599	PF01048	0.599
MOD_GlcNHglycan	738	741	PF01048	0.704
MOD_GlcNHglycan	75	78	PF01048	0.468
MOD_GSK3_1	154	161	PF00069	0.352
MOD_GSK3_1	20	27	PF00069	0.483
MOD_GSK3_1	215	222	PF00069	0.358
MOD_GSK3_1	244	251	PF00069	0.724
MOD_GSK3_1	292	299	PF00069	0.446
MOD_GSK3_1	31	38	PF00069	0.367
MOD_GSK3_1	334	341	PF00069	0.486
MOD_GSK3_1	408	415	PF00069	0.618
MOD_GSK3_1	472	479	PF00069	0.396
MOD_GSK3_1	483	490	PF00069	0.487
MOD_GSK3_1	513	520	PF00069	0.468
MOD_GSK3_1	594	601	PF00069	0.509
MOD_GSK3_1	645	652	PF00069	0.517
MOD_GSK3_1	71	78	PF00069	0.156
MOD_GSK3_1	732	739	PF00069	0.726
MOD_LATS_1	332	338	PF00433	0.533
MOD_N-GLC_1	154	159	PF02516	0.379
MOD_NEK2_1	210	215	PF00069	0.212
MOD_NEK2_1	242	247	PF00069	0.576
MOD_NEK2_1	248	253	PF00069	0.603
MOD_NEK2_1	292	297	PF00069	0.474
MOD_NEK2_1	320	325	PF00069	0.384
MOD_NEK2_1	354	359	PF00069	0.376
MOD_NEK2_1	380	385	PF00069	0.390
MOD_NEK2_1	476	481	PF00069	0.509
MOD_NEK2_1	50	55	PF00069	0.415
MOD_NEK2_1	512	517	PF00069	0.474
MOD_NEK2_1	7	12	PF00069	0.515
MOD_NEK2_1	73	78	PF00069	0.410
MOD_NEK2_2	469	474	PF00069	0.351
MOD_PIKK_1	714	720	PF00454	0.432
MOD_PK_1	44	50	PF00069	0.275
MOD_PKA_1	12	18	PF00069	0.528
MOD_PKA_1	395	401	PF00069	0.484
MOD_PKA_1	631	637	PF00069	0.671
MOD_PKA_2	337	343	PF00069	0.382
MOD_PKA_2	408	414	PF00069	0.667
MOD_PKA_2	483	489	PF00069	0.503
MOD_PKA_2	510	516	PF00069	0.501
MOD_PKA_2	631	637	PF00069	0.583
MOD_Plk_1	476	482	PF00069	0.549
MOD_Plk_1	555	561	PF00069	0.476
MOD_Plk_1	563	569	PF00069	0.376
MOD_Plk_1	7	13	PF00069	0.456
MOD_Plk_4	200	206	PF00069	0.456
MOD_Plk_4	210	216	PF00069	0.460
MOD_Plk_4	484	490	PF00069	0.400
MOD_Plk_4	58	64	PF00069	0.346
MOD_ProDKin_1	177	183	PF00069	0.506
MOD_ProDKin_1	254	260	PF00069	0.429
MOD_ProDKin_1	400	406	PF00069	0.670
MOD_ProDKin_1	68	74	PF00069	0.393
MOD_ProDKin_1	732	738	PF00069	0.619
MOD_SUMO_for_1	96	99	PF00179	0.218
MOD_SUMO_rev_2	174	181	PF00179	0.428
MOD_SUMO_rev_2	668	673	PF00179	0.154
TRG_DiLeu_BaEn_1	148	153	PF01217	0.335
TRG_DiLeu_BaEn_1	564	569	PF01217	0.369
TRG_ENDOCYTIC_2	134	137	PF00928	0.275
TRG_ENDOCYTIC_2	275	278	PF00928	0.457
TRG_ENDOCYTIC_2	311	314	PF00928	0.449
TRG_ENDOCYTIC_2	542	545	PF00928	0.456
TRG_ENDOCYTIC_2	630	633	PF00928	0.558
TRG_ENDOCYTIC_2	88	91	PF00928	0.291
TRG_ER_diArg_1	279	282	PF00400	0.429
TRG_ER_diArg_1	287	289	PF00400	0.332
TRG_ER_diArg_1	630	632	PF00400	0.653
TRG_ER_diArg_1	657	660	PF00400	0.276
TRG_ER_diArg_1	662	664	PF00400	0.275
TRG_ER_diArg_1	698	700	PF00400	0.521
TRG_NES_CRM1_1	379	392	PF08389	0.389
TRG_NES_CRM1_1	497	510	PF08389	0.474
TRG_NLS_Bipartite_1	693	713	PF00514	0.559
TRG_NLS_MonoCore_2	393	398	PF00514	0.447
TRG_NLS_MonoExtN_4	391	398	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I027	Leptomonas seymouri	63%	100%
A0A0S4J0A8	Bodo saltans	33%	100%
A0A1X0P6G4	Trypanosomatidae	42%	100%
A0A3Q8IDA7	Leishmania donovani	92%	100%
A0A422NHC6	Trypanosoma rangeli	42%	100%
A4HA36	Leishmania braziliensis	84%	100%
A4HY99	Leishmania infantum	92%	100%
D0A0N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
O76094	Homo sapiens	23%	100%
P33731	Canis lupus familiaris	23%	100%
Q4QDE2	Leishmania major	92%	100%
V5BJ44	Trypanosoma cruzi	43%	100%