Putative SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS29_LEIMU

TriTrypDb:

LmxM.19.0770

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005794	Golgi apparatus	5	3
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	1
GO:0031902	late endosome membrane	6	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AS29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS29

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.545
CLV_NRD_NRD_1	183	185	PF00675	0.345
CLV_NRD_NRD_1	211	213	PF00675	0.258
CLV_NRD_NRD_1	96	98	PF00675	0.422
CLV_PCSK_KEX2_1	183	185	PF00082	0.362
CLV_PCSK_KEX2_1	211	213	PF00082	0.258
CLV_PCSK_KEX2_1	95	97	PF00082	0.434
CLV_PCSK_SKI1_1	114	118	PF00082	0.474
CLV_PCSK_SKI1_1	16	20	PF00082	0.441
CLV_PCSK_SKI1_1	172	176	PF00082	0.317
DEG_APCC_DBOX_1	171	179	PF00400	0.569
DEG_SPOP_SBC_1	70	74	PF00917	0.724
DOC_USP7_MATH_1	166	170	PF00917	0.538
DOC_USP7_MATH_1	84	88	PF00917	0.741
DOC_USP7_UBL2_3	19	23	PF12436	0.722
DOC_WW_Pin1_4	88	93	PF00397	0.713
LIG_BIR_III_4	6	10	PF00653	0.741
LIG_eIF4E_1	221	227	PF01652	0.423
LIG_FHA_1	196	202	PF00498	0.517
LIG_FHA_1	66	72	PF00498	0.689
LIG_FHA_2	1	7	PF00498	0.546
LIG_FHA_2	25	31	PF00498	0.692
LIG_LIR_Nem_3	216	221	PF02991	0.310
LIG_SH2_CRK	221	225	PF00017	0.312
LIG_SH2_NCK_1	40	44	PF00017	0.631
LIG_SH2_STAP1	115	119	PF00017	0.663
LIG_SH2_STAT3	159	162	PF00017	0.538
LIG_SH2_STAT5	125	128	PF00017	0.632
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.353
LIG_TYR_ITIM	219	224	PF00017	0.312
LIG_UBA3_1	206	214	PF00899	0.473
LIG_WRC_WIRS_1	62	67	PF05994	0.691
MOD_CDK_SPxxK_3	88	95	PF00069	0.717
MOD_CK1_1	202	208	PF00069	0.504
MOD_CK1_1	74	80	PF00069	0.721
MOD_CK2_1	24	30	PF00069	0.663
MOD_CMANNOS	232	235	PF00535	0.521
MOD_Cter_Amidation	181	184	PF01082	0.362
MOD_GlcNHglycan	6	10	PF01048	0.483
MOD_GlcNHglycan	73	76	PF01048	0.491
MOD_GSK3_1	124	131	PF00069	0.620
MOD_GSK3_1	195	202	PF00069	0.504
MOD_GSK3_1	61	68	PF00069	0.678
MOD_GSK3_1	70	77	PF00069	0.668
MOD_GSK3_1	84	91	PF00069	0.696
MOD_N-GLC_1	202	207	PF02516	0.247
MOD_N-GLC_1	88	93	PF02516	0.544
MOD_NEK2_1	107	112	PF00069	0.559
MOD_NEK2_1	195	200	PF00069	0.479
MOD_NEK2_1	65	70	PF00069	0.740
MOD_PIKK_1	84	90	PF00454	0.737
MOD_Plk_1	108	114	PF00069	0.583
MOD_Plk_1	202	208	PF00069	0.447
MOD_Plk_4	121	127	PF00069	0.637
MOD_Plk_4	128	134	PF00069	0.627
MOD_Plk_4	202	208	PF00069	0.468
MOD_Plk_4	66	72	PF00069	0.635
MOD_ProDKin_1	88	94	PF00069	0.710
MOD_SUMO_rev_2	127	132	PF00179	0.623
MOD_SUMO_rev_2	148	157	PF00179	0.495
MOD_SUMO_rev_2	99	108	PF00179	0.682
TRG_ENDOCYTIC_2	144	147	PF00928	0.670
TRG_ENDOCYTIC_2	221	224	PF00928	0.301
TRG_ER_diArg_1	161	164	PF00400	0.458
TRG_ER_diArg_1	183	185	PF00400	0.562
TRG_ER_diArg_1	210	212	PF00400	0.458
TRG_ER_diArg_1	53	56	PF00400	0.695
TRG_ER_diArg_1	95	97	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH9	Leptomonas seymouri	75%	99%
A0A1X0P6J5	Trypanosomatidae	44%	99%
A0A3R7K7L0	Trypanosoma rangeli	44%	99%
A0A3S7WVD1	Leishmania donovani	94%	100%
A4HA34	Leishmania braziliensis	85%	100%
A4HY97	Leishmania infantum	94%	100%
D0A0N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
Q4QDE4	Leishmania major	95%	100%
Q9SJL6	Arabidopsis thaliana	24%	100%
V5BNJ6	Trypanosoma cruzi	45%	99%