Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS27_LEIMU

TriTrypDb:

LmxM.19.0750

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS27

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.641
CLV_C14_Caspase3-7	501	505	PF00656	0.608
CLV_NRD_NRD_1	110	112	PF00675	0.558
CLV_NRD_NRD_1	312	314	PF00675	0.450
CLV_NRD_NRD_1	319	321	PF00675	0.608
CLV_NRD_NRD_1	394	396	PF00675	0.351
CLV_NRD_NRD_1	43	45	PF00675	0.544
CLV_PCSK_KEX2_1	109	111	PF00082	0.489
CLV_PCSK_KEX2_1	143	145	PF00082	0.727
CLV_PCSK_KEX2_1	312	314	PF00082	0.413
CLV_PCSK_KEX2_1	318	320	PF00082	0.551
CLV_PCSK_KEX2_1	394	396	PF00082	0.385
CLV_PCSK_KEX2_1	43	45	PF00082	0.559
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.466
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.727
CLV_PCSK_PC7_1	105	111	PF00082	0.406
CLV_PCSK_SKI1_1	105	109	PF00082	0.363
CLV_PCSK_SKI1_1	270	274	PF00082	0.442
CLV_PCSK_SKI1_1	312	316	PF00082	0.372
CLV_PCSK_SKI1_1	46	50	PF00082	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DOC_CYCLIN_RxL_1	267	276	PF00134	0.350
DOC_PP2B_LxvP_1	272	275	PF13499	0.357
DOC_PP4_FxxP_1	229	232	PF00568	0.358
DOC_USP7_MATH_1	152	156	PF00917	0.536
DOC_USP7_MATH_1	342	346	PF00917	0.426
DOC_USP7_MATH_1	359	363	PF00917	0.329
DOC_WW_Pin1_4	144	149	PF00397	0.666
DOC_WW_Pin1_4	404	409	PF00397	0.393
DOC_WW_Pin1_4	436	441	PF00397	0.618
LIG_14-3-3_CanoR_1	202	211	PF00244	0.511
LIG_14-3-3_CanoR_1	3	8	PF00244	0.645
LIG_BIR_III_4	433	437	PF00653	0.504
LIG_BRCT_BRCA1_1	352	356	PF00533	0.359
LIG_BRCT_BRCA1_1	399	403	PF00533	0.334
LIG_Clathr_ClatBox_1	294	298	PF01394	0.349
LIG_DLG_GKlike_1	3	11	PF00625	0.494
LIG_eIF4E_1	225	231	PF01652	0.309
LIG_FHA_1	15	21	PF00498	0.625
LIG_FHA_1	379	385	PF00498	0.358
LIG_FHA_1	416	422	PF00498	0.508
LIG_FHA_1	451	457	PF00498	0.396
LIG_FHA_2	114	120	PF00498	0.375
LIG_FHA_2	180	186	PF00498	0.222
LIG_FHA_2	380	386	PF00498	0.340
LIG_FHA_2	414	420	PF00498	0.415
LIG_FHA_2	83	89	PF00498	0.565
LIG_LIR_Apic_2	227	232	PF02991	0.308
LIG_LIR_Gen_1	300	311	PF02991	0.427
LIG_LIR_Gen_1	458	465	PF02991	0.486
LIG_LIR_LC3C_4	366	371	PF02991	0.363
LIG_LIR_Nem_3	300	306	PF02991	0.435
LIG_LIR_Nem_3	411	417	PF02991	0.383
LIG_PCNA_PIPBox_1	308	317	PF02747	0.406
LIG_PCNA_PIPBox_1	372	381	PF02747	0.387
LIG_PCNA_yPIPBox_3	305	315	PF02747	0.384
LIG_Pex14_1	262	266	PF04695	0.419
LIG_Pex14_1	443	447	PF04695	0.473
LIG_PTAP_UEV_1	55	60	PF05743	0.446
LIG_REV1ctd_RIR_1	312	322	PF16727	0.446
LIG_SH2_SRC	447	450	PF00017	0.388
LIG_SH2_STAP1	174	178	PF00017	0.374
LIG_SH2_STAT3	38	41	PF00017	0.454
LIG_SH2_STAT5	181	184	PF00017	0.278
LIG_SH2_STAT5	199	202	PF00017	0.455
LIG_SH2_STAT5	225	228	PF00017	0.301
LIG_SH2_STAT5	378	381	PF00017	0.359
LIG_SH2_STAT5	447	450	PF00017	0.388
LIG_SH2_STAT5	519	522	PF00017	0.379
LIG_SH3_3	114	120	PF00018	0.428
LIG_SH3_3	166	172	PF00018	0.501
LIG_SH3_3	402	408	PF00018	0.355
LIG_SH3_3	53	59	PF00018	0.498
LIG_SH3_3	67	73	PF00018	0.633
LIG_SUMO_SIM_anti_2	27	32	PF11976	0.373
LIG_SUMO_SIM_anti_2	365	373	PF11976	0.417
LIG_SUMO_SIM_par_1	245	252	PF11976	0.399
LIG_TRAF2_1	85	88	PF00917	0.628
LIG_UBA3_1	7	12	PF00899	0.484
LIG_WRC_WIRS_1	414	419	PF05994	0.463
LIG_WRC_WIRS_1	448	453	PF05994	0.350
MOD_CK1_1	136	142	PF00069	0.633
MOD_CK1_1	155	161	PF00069	0.607
MOD_CK1_1	362	368	PF00069	0.465
MOD_CK1_1	450	456	PF00069	0.303
MOD_CK1_1	6	12	PF00069	0.540
MOD_CK1_1	61	67	PF00069	0.778
MOD_CK1_1	71	77	PF00069	0.542
MOD_CK2_1	113	119	PF00069	0.308
MOD_CK2_1	379	385	PF00069	0.345
MOD_CK2_1	443	449	PF00069	0.381
MOD_CK2_1	494	500	PF00069	0.627
MOD_CK2_1	82	88	PF00069	0.715
MOD_DYRK1A_RPxSP_1	144	148	PF00069	0.693
MOD_GlcNHglycan	135	138	PF01048	0.564
MOD_GlcNHglycan	148	151	PF01048	0.585
MOD_GlcNHglycan	154	157	PF01048	0.530
MOD_GlcNHglycan	164	167	PF01048	0.379
MOD_GlcNHglycan	326	329	PF01048	0.450
MOD_GlcNHglycan	361	364	PF01048	0.466
MOD_GlcNHglycan	399	402	PF01048	0.543
MOD_GlcNHglycan	497	500	PF01048	0.467
MOD_GlcNHglycan	65	68	PF01048	0.603
MOD_GlcNHglycan	73	76	PF01048	0.807
MOD_GlcNHglycan	8	11	PF01048	0.568
MOD_GSK3_1	146	153	PF00069	0.699
MOD_GSK3_1	158	165	PF00069	0.679
MOD_GSK3_1	212	219	PF00069	0.311
MOD_GSK3_1	238	245	PF00069	0.497
MOD_GSK3_1	406	413	PF00069	0.218
MOD_GSK3_1	443	450	PF00069	0.350
MOD_GSK3_1	54	61	PF00069	0.691
MOD_N-GLC_1	472	477	PF02516	0.601
MOD_N-GLC_1	82	87	PF02516	0.466
MOD_NEK2_1	299	304	PF00069	0.487
MOD_NEK2_1	364	369	PF00069	0.442
MOD_NEK2_1	379	384	PF00069	0.487
MOD_NEK2_1	410	415	PF00069	0.336
MOD_NEK2_1	62	67	PF00069	0.745
MOD_PIKK_1	304	310	PF00454	0.399
MOD_PK_1	246	252	PF00069	0.397
MOD_PKB_1	144	152	PF00069	0.640
MOD_Plk_1	275	281	PF00069	0.372
MOD_Plk_1	299	305	PF00069	0.397
MOD_Plk_1	365	371	PF00069	0.323
MOD_Plk_1	410	416	PF00069	0.362
MOD_Plk_2-3	472	478	PF00069	0.565
MOD_Plk_2-3	82	88	PF00069	0.542
MOD_Plk_4	113	119	PF00069	0.392
MOD_Plk_4	299	305	PF00069	0.545
MOD_Plk_4	3	9	PF00069	0.632
MOD_Plk_4	365	371	PF00069	0.465
MOD_Plk_4	443	449	PF00069	0.369
MOD_Plk_4	58	64	PF00069	0.473
MOD_ProDKin_1	144	150	PF00069	0.666
MOD_ProDKin_1	404	410	PF00069	0.391
MOD_ProDKin_1	436	442	PF00069	0.614
MOD_SUMO_rev_2	185	195	PF00179	0.406
MOD_SUMO_rev_2	335	342	PF00179	0.453
TRG_ER_diArg_1	110	112	PF00400	0.562
TRG_ER_diArg_1	311	313	PF00400	0.490
TRG_ER_diArg_1	318	320	PF00400	0.640
TRG_ER_diArg_1	393	395	PF00400	0.400
TRG_ER_diArg_1	463	466	PF00400	0.360
TRG_NLS_MonoExtC_3	108	113	PF00514	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I161	Leptomonas seymouri	46%	100%
A0A0S4IWK0	Bodo saltans	29%	100%
A0A1X0P685	Trypanosomatidae	33%	99%
A0A3R7KFJ2	Trypanosoma rangeli	31%	100%
A0A3S5H760	Leishmania donovani	90%	100%
A4HA32	Leishmania braziliensis	75%	99%
A4HY95	Leishmania infantum	91%	100%
D0A0M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QDE6	Leishmania major	86%	100%
V5B315	Trypanosoma cruzi	32%	100%