Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS25_LEIMU

TriTrypDb:

LmxM.19.0730

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS25

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.306
CLV_NRD_NRD_1	22	24	PF00675	0.478
CLV_NRD_NRD_1	316	318	PF00675	0.563
CLV_NRD_NRD_1	374	376	PF00675	0.692
CLV_NRD_NRD_1	51	53	PF00675	0.393
CLV_NRD_NRD_1	78	80	PF00675	0.451
CLV_PCSK_KEX2_1	106	108	PF00082	0.160
CLV_PCSK_KEX2_1	162	164	PF00082	0.367
CLV_PCSK_KEX2_1	257	259	PF00082	0.443
CLV_PCSK_KEX2_1	374	376	PF00082	0.688
CLV_PCSK_KEX2_1	51	53	PF00082	0.393
CLV_PCSK_KEX2_1	56	58	PF00082	0.443
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.160
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.425
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.538
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.443
CLV_PCSK_PC7_1	158	164	PF00082	0.425
CLV_PCSK_PC7_1	253	259	PF00082	0.563
CLV_PCSK_PC7_1	52	58	PF00082	0.425
CLV_PCSK_SKI1_1	158	162	PF00082	0.305
CLV_PCSK_SKI1_1	226	230	PF00082	0.376
CLV_PCSK_SKI1_1	23	27	PF00082	0.401
CLV_PCSK_SKI1_1	258	262	PF00082	0.378
CLV_PCSK_SKI1_1	51	55	PF00082	0.401
DEG_APCC_DBOX_1	316	324	PF00400	0.546
DEG_APCC_DBOX_1	78	86	PF00400	0.354
DOC_CKS1_1	231	236	PF01111	0.383
DOC_MAPK_DCC_7	106	115	PF00069	0.320
DOC_MAPK_gen_1	56	63	PF00069	0.392
DOC_MAPK_MEF2A_6	106	115	PF00069	0.320
DOC_MAPK_MEF2A_6	56	65	PF00069	0.382
DOC_PP4_FxxP_1	128	131	PF00568	0.304
DOC_PP4_FxxP_1	217	220	PF00568	0.369
DOC_PP4_MxPP_1	108	111	PF00568	0.219
DOC_USP7_MATH_1	131	135	PF00917	0.389
DOC_USP7_MATH_1	301	305	PF00917	0.556
DOC_USP7_MATH_1	308	312	PF00917	0.527
DOC_WW_Pin1_4	123	128	PF00397	0.372
DOC_WW_Pin1_4	193	198	PF00397	0.424
DOC_WW_Pin1_4	230	235	PF00397	0.369
DOC_WW_Pin1_4	288	293	PF00397	0.383
DOC_WW_Pin1_4	32	37	PF00397	0.492
DOC_WW_Pin1_4	56	61	PF00397	0.407
LIG_14-3-3_CanoR_1	181	187	PF00244	0.376
LIG_14-3-3_CanoR_1	30	36	PF00244	0.507
LIG_BIR_III_4	361	365	PF00653	0.481
LIG_CSL_BTD_1	289	292	PF09270	0.407
LIG_eIF4E_1	272	278	PF01652	0.399
LIG_FHA_1	150	156	PF00498	0.320
LIG_FHA_1	187	193	PF00498	0.397
LIG_FHA_1	208	214	PF00498	0.354
LIG_FHA_1	219	225	PF00498	0.374
LIG_FHA_1	279	285	PF00498	0.353
LIG_FHA_1	57	63	PF00498	0.375
LIG_FHA_2	174	180	PF00498	0.343
LIG_LIR_Apic_2	126	131	PF02991	0.298
LIG_LIR_Gen_1	112	122	PF02991	0.319
LIG_LIR_Gen_1	232	243	PF02991	0.371
LIG_LIR_Gen_1	281	289	PF02991	0.354
LIG_LIR_Nem_3	112	118	PF02991	0.319
LIG_LIR_Nem_3	281	285	PF02991	0.338
LIG_LIR_Nem_3	341	347	PF02991	0.456
LIG_PTB_Apo_2	166	173	PF02174	0.437
LIG_Rb_LxCxE_1	114	136	PF01857	0.304
LIG_SH2_NCK_1	231	235	PF00017	0.421
LIG_SH2_SRC	102	105	PF00017	0.320
LIG_SH2_STAP1	268	272	PF00017	0.367
LIG_SH2_STAT3	251	254	PF00017	0.586
LIG_SH2_STAT5	72	75	PF00017	0.389
LIG_SH2_STAT5	88	91	PF00017	0.320
LIG_SH3_3	30	36	PF00018	0.422
LIG_SH3_3	377	383	PF00018	0.609
LIG_SUMO_SIM_anti_2	239	247	PF11976	0.486
LIG_SUMO_SIM_par_1	220	225	PF11976	0.458
LIG_SUMO_SIM_par_1	3	8	PF11976	0.595
LIG_SUMO_SIM_par_1	58	64	PF11976	0.369
LIG_TRFH_1	327	331	PF08558	0.624
MOD_CK1_1	140	146	PF00069	0.304
MOD_CK1_1	31	37	PF00069	0.513
MOD_CK1_1	311	317	PF00069	0.518
MOD_CK2_1	173	179	PF00069	0.341
MOD_GlcNHglycan	246	249	PF01048	0.368
MOD_GlcNHglycan	303	306	PF01048	0.508
MOD_GlcNHglycan	349	353	PF01048	0.478
MOD_GSK3_1	182	189	PF00069	0.360
MOD_GSK3_1	193	200	PF00069	0.412
MOD_GSK3_1	28	35	PF00069	0.502
MOD_GSK3_1	284	291	PF00069	0.371
MOD_GSK3_1	307	314	PF00069	0.537
MOD_NEK2_1	137	142	PF00069	0.304
MOD_NEK2_1	150	155	PF00069	0.304
MOD_NEK2_1	244	249	PF00069	0.357
MOD_NEK2_1	28	33	PF00069	0.463
MOD_NEK2_1	5	10	PF00069	0.604
MOD_NEK2_2	173	178	PF00069	0.344
MOD_PIKK_1	292	298	PF00454	0.450
MOD_PKA_2	301	307	PF00069	0.508
MOD_Plk_1	131	137	PF00069	0.291
MOD_Plk_1	150	156	PF00069	0.385
MOD_Plk_4	150	156	PF00069	0.381
MOD_Plk_4	173	179	PF00069	0.366
MOD_Plk_4	207	213	PF00069	0.366
MOD_Plk_4	239	245	PF00069	0.334
MOD_Plk_4	267	273	PF00069	0.511
MOD_Plk_4	319	325	PF00069	0.577
MOD_ProDKin_1	123	129	PF00069	0.372
MOD_ProDKin_1	193	199	PF00069	0.418
MOD_ProDKin_1	230	236	PF00069	0.371
MOD_ProDKin_1	288	294	PF00069	0.396
MOD_ProDKin_1	32	38	PF00069	0.485
MOD_ProDKin_1	56	62	PF00069	0.398
MOD_SUMO_rev_2	103	108	PF00179	0.310
MOD_SUMO_rev_2	371	381	PF00179	0.709
TRG_DiLeu_BaEn_1	350	355	PF01217	0.505
TRG_DiLeu_BaEn_4	371	377	PF01217	0.670
TRG_ENDOCYTIC_2	102	105	PF00928	0.320
TRG_ENDOCYTIC_2	268	271	PF00928	0.371
TRG_ER_diArg_1	374	376	PF00400	0.737
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I2	Leptomonas seymouri	87%	100%
A0A0S4ISY2	Bodo saltans	61%	99%
A0A1X0P6A4	Trypanosomatidae	79%	98%
A0A3S7WVD3	Leishmania donovani	97%	100%
A0A422NMU6	Trypanosoma rangeli	71%	100%
A1WVM4	Halorhodospira halophila (strain DSM 244 / SL1)	26%	100%
A2APY7	Mus musculus	39%	100%
A3KP37	Danio rerio	37%	100%
A4HA30	Leishmania braziliensis	92%	100%
A4HY93	Leishmania infantum	97%	100%
B2GV71	Rattus norvegicus	39%	100%
B2IAI0	Xylella fastidiosa (strain M23)	26%	100%
C1D5S5	Laribacter hongkongensis (strain HLHK9)	26%	100%
D0A0M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	99%
D9SJ16	Gallionella capsiferriformans (strain ES-2)	26%	100%
E4QJB8	Methylovorus sp. (strain MP688)	28%	100%
O80543	Arabidopsis thaliana	32%	100%
Q2Y9Y6	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	26%	100%
Q4QDE8	Leishmania major	97%	100%
Q54JW0	Dictyostelium discoideum	31%	88%
Q5RBS1	Pongo abelii	37%	100%
Q5TEU4	Homo sapiens	38%	100%
Q83E64	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	24%	100%
Q9K623	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	25%	100%
V5AMS7	Trypanosoma cruzi	77%	98%