Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

Flagellum attachment zone protein 7

Species:

Leishmania mexicana

UniProt:

E9AS21_LEIMU

TriTrypDb:

LmxM.19.0690

Length:

1034

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AS21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS21

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0009987	cellular process	1	15

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003824	catalytic activity	1	9
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.448
CLV_NRD_NRD_1	106	108	PF00675	0.763
CLV_NRD_NRD_1	124	126	PF00675	0.570
CLV_NRD_NRD_1	216	218	PF00675	0.487
CLV_NRD_NRD_1	343	345	PF00675	0.391
CLV_NRD_NRD_1	598	600	PF00675	0.750
CLV_NRD_NRD_1	653	655	PF00675	0.614
CLV_NRD_NRD_1	766	768	PF00675	0.638
CLV_NRD_NRD_1	859	861	PF00675	0.635
CLV_NRD_NRD_1	991	993	PF00675	0.692
CLV_PCSK_FUR_1	276	280	PF00082	0.492
CLV_PCSK_FUR_1	857	861	PF00082	0.719
CLV_PCSK_KEX2_1	1002	1004	PF00082	0.659
CLV_PCSK_KEX2_1	106	108	PF00082	0.763
CLV_PCSK_KEX2_1	124	126	PF00082	0.570
CLV_PCSK_KEX2_1	278	280	PF00082	0.442
CLV_PCSK_KEX2_1	653	655	PF00082	0.647
CLV_PCSK_KEX2_1	709	711	PF00082	0.594
CLV_PCSK_KEX2_1	768	770	PF00082	0.645
CLV_PCSK_KEX2_1	839	841	PF00082	0.744
CLV_PCSK_KEX2_1	859	861	PF00082	0.448
CLV_PCSK_KEX2_1	882	884	PF00082	0.644
CLV_PCSK_KEX2_1	991	993	PF00082	0.679
CLV_PCSK_PC1ET2_1	1002	1004	PF00082	0.570
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.442
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.601
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.638
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.678
CLV_PCSK_PC1ET2_1	882	884	PF00082	0.560
CLV_PCSK_SKI1_1	200	204	PF00082	0.487
CLV_PCSK_SKI1_1	278	282	PF00082	0.523
CLV_PCSK_SKI1_1	629	633	PF00082	0.630
CLV_PCSK_SKI1_1	672	676	PF00082	0.490
CLV_PCSK_SKI1_1	728	732	PF00082	0.570
CLV_PCSK_SKI1_1	999	1003	PF00082	0.566
DEG_APCC_DBOX_1	386	394	PF00400	0.503
DEG_Kelch_actinfilin_1	151	155	PF01344	0.780
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DEG_SPOP_SBC_1	208	212	PF00917	0.498
DOC_ANK_TNKS_1	799	806	PF00023	0.503
DOC_CYCLIN_yClb5_NLxxxL_5	447	455	PF00134	0.414
DOC_MAPK_gen_1	306	315	PF00069	0.404
DOC_MAPK_gen_1	360	370	PF00069	0.411
DOC_MAPK_gen_1	387	395	PF00069	0.457
DOC_MAPK_gen_1	510	519	PF00069	0.623
DOC_MAPK_gen_1	634	644	PF00069	0.488
DOC_MAPK_gen_1	670	677	PF00069	0.719
DOC_MAPK_gen_1	830	837	PF00069	0.547
DOC_MAPK_MEF2A_6	13	21	PF00069	0.454
DOC_MAPK_MEF2A_6	499	508	PF00069	0.484
DOC_PP1_RVXF_1	953	960	PF00149	0.568
DOC_PP2B_LxvP_1	442	445	PF13499	0.331
DOC_USP7_MATH_1	1015	1019	PF00917	0.552
DOC_USP7_MATH_1	105	109	PF00917	0.764
DOC_USP7_MATH_1	157	161	PF00917	0.704
DOC_USP7_MATH_1	209	213	PF00917	0.435
DOC_USP7_MATH_1	240	244	PF00917	0.426
DOC_USP7_MATH_1	280	284	PF00917	0.422
DOC_USP7_MATH_1	526	530	PF00917	0.759
DOC_USP7_MATH_1	594	598	PF00917	0.552
DOC_USP7_UBL2_3	331	335	PF12436	0.477
DOC_USP7_UBL2_3	600	604	PF12436	0.589
DOC_USP7_UBL2_3	768	772	PF12436	0.645
DOC_WW_Pin1_4	315	320	PF00397	0.510
DOC_WW_Pin1_4	469	474	PF00397	0.390
DOC_WW_Pin1_4	5	10	PF00397	0.767
LIG_14-3-3_CanoR_1	109	114	PF00244	0.757
LIG_14-3-3_CanoR_1	24	31	PF00244	0.527
LIG_14-3-3_CanoR_1	266	275	PF00244	0.393
LIG_14-3-3_CanoR_1	309	315	PF00244	0.566
LIG_14-3-3_CanoR_1	350	357	PF00244	0.398
LIG_14-3-3_CanoR_1	360	370	PF00244	0.367
LIG_14-3-3_CanoR_1	61	68	PF00244	0.582
LIG_14-3-3_CanoR_1	653	662	PF00244	0.718
LIG_14-3-3_CanoR_1	70	76	PF00244	0.464
LIG_14-3-3_CanoR_1	755	765	PF00244	0.557
LIG_Actin_WH2_2	509	526	PF00022	0.583
LIG_Actin_WH2_2	690	708	PF00022	0.752
LIG_Actin_WH2_2	824	841	PF00022	0.546
LIG_APCC_ABBA_1	23	28	PF00400	0.502
LIG_BRCT_BRCA1_1	320	324	PF00533	0.510
LIG_DLG_GKlike_1	109	117	PF00625	0.757
LIG_EH1_1	935	943	PF00400	0.544
LIG_FHA_1	209	215	PF00498	0.500
LIG_FHA_1	284	290	PF00498	0.561
LIG_FHA_1	327	333	PF00498	0.297
LIG_FHA_1	367	373	PF00498	0.386
LIG_FHA_1	38	44	PF00498	0.528
LIG_FHA_1	450	456	PF00498	0.394
LIG_FHA_1	463	469	PF00498	0.403
LIG_FHA_1	706	712	PF00498	0.773
LIG_FHA_2	136	142	PF00498	0.741
LIG_FHA_2	251	257	PF00498	0.400
LIG_FHA_2	50	56	PF00498	0.494
LIG_FHA_2	571	577	PF00498	0.789
LIG_FHA_2	662	668	PF00498	0.691
LIG_FHA_2	716	722	PF00498	0.663
LIG_FHA_2	81	87	PF00498	0.664
LIG_GBD_Chelix_1	339	347	PF00786	0.402
LIG_LIR_Apic_2	3	9	PF02991	0.783
LIG_LIR_Apic_2	576	581	PF02991	0.652
LIG_LIR_Gen_1	168	179	PF02991	0.404
LIG_LIR_Gen_1	201	209	PF02991	0.400
LIG_LIR_Gen_1	299	307	PF02991	0.397
LIG_LIR_Gen_1	369	377	PF02991	0.494
LIG_LIR_Gen_1	475	485	PF02991	0.497
LIG_LIR_Gen_1	657	666	PF02991	0.630
LIG_LIR_Gen_1	944	954	PF02991	0.681
LIG_LIR_Nem_3	168	174	PF02991	0.404
LIG_LIR_Nem_3	201	205	PF02991	0.400
LIG_LIR_Nem_3	269	275	PF02991	0.403
LIG_LIR_Nem_3	290	296	PF02991	0.441
LIG_LIR_Nem_3	299	305	PF02991	0.396
LIG_LIR_Nem_3	329	333	PF02991	0.510
LIG_LIR_Nem_3	369	373	PF02991	0.491
LIG_LIR_Nem_3	565	569	PF02991	0.585
LIG_LIR_Nem_3	657	662	PF02991	0.657
LIG_LIR_Nem_3	944	950	PF02991	0.675
LIG_PCNA_yPIPBox_3	298	309	PF02747	0.404
LIG_PCNA_yPIPBox_3	897	907	PF02747	0.703
LIG_Pex14_2	68	72	PF04695	0.456
LIG_PTB_Apo_2	66	73	PF02174	0.417
LIG_SH2_GRB2like	531	534	PF00017	0.737
LIG_SH2_NCK_1	171	175	PF00017	0.297
LIG_SH2_NCK_1	6	10	PF00017	0.650
LIG_SH2_PTP2	20	23	PF00017	0.453
LIG_SH2_SRC	207	210	PF00017	0.498
LIG_SH2_SRC	578	581	PF00017	0.653
LIG_SH2_STAP1	487	491	PF00017	0.390
LIG_SH2_STAP1	531	535	PF00017	0.722
LIG_SH2_STAP1	943	947	PF00017	0.579
LIG_SH2_STAT3	164	167	PF00017	0.400
LIG_SH2_STAT3	899	902	PF00017	0.563
LIG_SH2_STAT3	994	997	PF00017	0.551
LIG_SH2_STAT5	171	174	PF00017	0.462
LIG_SH2_STAT5	20	23	PF00017	0.453
LIG_SH2_STAT5	531	534	PF00017	0.648
LIG_SH2_STAT5	535	538	PF00017	0.567
LIG_SH2_STAT5	578	581	PF00017	0.764
LIG_SH3_3	156	162	PF00018	0.643
LIG_SH3_3	171	177	PF00018	0.400
LIG_SUMO_SIM_anti_2	420	425	PF11976	0.547
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.588
LIG_SUMO_SIM_par_1	150	156	PF11976	0.794
LIG_SUMO_SIM_par_1	49	55	PF11976	0.521
LIG_SUMO_SIM_par_1	505	511	PF11976	0.501
LIG_SUMO_SIM_par_1	514	520	PF11976	0.433
LIG_SUMO_SIM_par_1	641	648	PF11976	0.512
LIG_TRAF2_1	334	337	PF00917	0.441
LIG_TRAF2_1	551	554	PF00917	0.742
LIG_TYR_ITIM	291	296	PF00017	0.408
LIG_UBA3_1	271	278	PF00899	0.442
LIG_WRC_WIRS_1	367	372	PF05994	0.494
MOD_CK1_1	1018	1024	PF00069	0.670
MOD_CK1_1	112	118	PF00069	0.737
MOD_CK1_1	198	204	PF00069	0.383
MOD_CK1_1	283	289	PF00069	0.523
MOD_CK1_1	318	324	PF00069	0.510
MOD_CK1_1	361	367	PF00069	0.386
MOD_CK1_1	398	404	PF00069	0.414
MOD_CK1_1	449	455	PF00069	0.390
MOD_CK1_1	463	469	PF00069	0.390
MOD_CK1_1	472	478	PF00069	0.396
MOD_CK1_1	49	55	PF00069	0.467
MOD_CK1_1	529	535	PF00069	0.721
MOD_CK1_1	841	847	PF00069	0.565
MOD_CK2_1	135	141	PF00069	0.771
MOD_CK2_1	223	229	PF00069	0.474
MOD_CK2_1	24	30	PF00069	0.522
MOD_CK2_1	289	295	PF00069	0.505
MOD_CK2_1	331	337	PF00069	0.493
MOD_CK2_1	49	55	PF00069	0.443
MOD_CK2_1	570	576	PF00069	0.784
MOD_CK2_1	661	667	PF00069	0.731
MOD_CK2_1	696	702	PF00069	0.648
MOD_CK2_1	71	77	PF00069	0.475
MOD_CK2_1	715	721	PF00069	0.459
MOD_CK2_1	890	896	PF00069	0.501
MOD_CK2_1	919	925	PF00069	0.572
MOD_CK2_1	926	932	PF00069	0.530
MOD_GlcNHglycan	103	106	PF01048	0.704
MOD_GlcNHglycan	149	152	PF01048	0.787
MOD_GlcNHglycan	197	200	PF01048	0.400
MOD_GlcNHglycan	229	233	PF01048	0.520
MOD_GlcNHglycan	320	323	PF01048	0.429
MOD_GlcNHglycan	689	692	PF01048	0.680
MOD_GlcNHglycan	812	815	PF01048	0.581
MOD_GlcNHglycan	921	924	PF01048	0.582
MOD_GlcNHglycan	928	931	PF01048	0.522
MOD_GSK3_1	101	108	PF00069	0.723
MOD_GSK3_1	1015	1022	PF00069	0.600
MOD_GSK3_1	135	142	PF00069	0.633
MOD_GSK3_1	224	231	PF00069	0.526
MOD_GSK3_1	373	380	PF00069	0.504
MOD_GSK3_1	449	456	PF00069	0.477
MOD_GSK3_1	463	470	PF00069	0.313
MOD_GSK3_1	5	12	PF00069	0.736
MOD_LATS_1	652	658	PF00433	0.596
MOD_N-GLC_1	157	162	PF02516	0.743
MOD_N-GLC_1	417	422	PF02516	0.414
MOD_N-GLC_1	449	454	PF02516	0.414
MOD_N-GLC_1	529	534	PF02516	0.768
MOD_N-GLC_1	687	692	PF02516	0.533
MOD_N-GLC_1	914	919	PF02516	0.588
MOD_N-GLC_1	925	930	PF02516	0.572
MOD_N-GLC_1	997	1002	PF02516	0.612
MOD_N-GLC_2	187	189	PF02516	0.400
MOD_N-GLC_2	69	71	PF02516	0.420
MOD_NEK2_1	228	233	PF00069	0.511
MOD_NEK2_1	455	460	PF00069	0.414
MOD_NEK2_1	467	472	PF00069	0.387
MOD_NEK2_1	481	486	PF00069	0.357
MOD_NEK2_1	705	710	PF00069	0.697
MOD_NEK2_1	914	919	PF00069	0.587
MOD_NEK2_2	37	42	PF00069	0.641
MOD_NEK2_2	594	599	PF00069	0.551
MOD_NEK2_2	71	76	PF00069	0.580
MOD_PIKK_1	432	438	PF00454	0.448
MOD_PIKK_1	460	466	PF00454	0.547
MOD_PIKK_1	715	721	PF00454	0.603
MOD_PKA_1	124	130	PF00069	0.791
MOD_PKA_1	217	223	PF00069	0.494
MOD_PKA_1	859	865	PF00069	0.582
MOD_PKA_2	105	111	PF00069	0.807
MOD_PKA_2	124	130	PF00069	0.783
MOD_PKA_2	308	314	PF00069	0.510
MOD_PKA_2	349	355	PF00069	0.392
MOD_PKA_2	359	365	PF00069	0.398
MOD_PKA_2	446	452	PF00069	0.405
MOD_PKA_2	481	487	PF00069	0.414
MOD_PKA_2	705	711	PF00069	0.738
MOD_PKA_2	859	865	PF00069	0.584
MOD_PKB_1	107	115	PF00069	0.756
MOD_PKB_1	215	223	PF00069	0.498
MOD_PKB_1	22	30	PF00069	0.507
MOD_PKB_1	857	865	PF00069	0.572
MOD_Plk_1	1022	1028	PF00069	0.660
MOD_Plk_1	283	289	PF00069	0.523
MOD_Plk_1	417	423	PF00069	0.414
MOD_Plk_1	449	455	PF00069	0.414
MOD_Plk_1	594	600	PF00069	0.601
MOD_Plk_1	647	653	PF00069	0.725
MOD_Plk_1	890	896	PF00069	0.481
MOD_Plk_1	997	1003	PF00069	0.614
MOD_Plk_2-3	891	897	PF00069	0.647
MOD_Plk_4	109	115	PF00069	0.637
MOD_Plk_4	289	295	PF00069	0.523
MOD_Plk_4	419	425	PF00069	0.547
MOD_Plk_4	449	455	PF00069	0.406
MOD_Plk_4	46	52	PF00069	0.596
MOD_Plk_4	463	469	PF00069	0.350
MOD_Plk_4	661	667	PF00069	0.621
MOD_ProDKin_1	315	321	PF00069	0.510
MOD_ProDKin_1	469	475	PF00069	0.390
MOD_ProDKin_1	5	11	PF00069	0.762
MOD_SUMO_for_1	592	595	PF00179	0.631
MOD_SUMO_for_1	612	615	PF00179	0.427
MOD_SUMO_rev_2	534	543	PF00179	0.503
MOD_SUMO_rev_2	877	884	PF00179	0.546
MOD_SUMO_rev_2	886	894	PF00179	0.586
MOD_SUMO_rev_2	922	929	PF00179	0.592
MOD_SUMO_rev_2	961	969	PF00179	0.565
TRG_AP2beta_CARGO_1	270	279	PF09066	0.408
TRG_DiLeu_BaLyEn_6	869	874	PF01217	0.605
TRG_ENDOCYTIC_2	171	174	PF00928	0.400
TRG_ENDOCYTIC_2	20	23	PF00928	0.453
TRG_ENDOCYTIC_2	293	296	PF00928	0.408
TRG_ENDOCYTIC_2	478	481	PF00928	0.486
TRG_ENDOCYTIC_2	947	950	PF00928	0.590
TRG_ER_diArg_1	106	109	PF00400	0.776
TRG_ER_diArg_1	123	125	PF00400	0.799
TRG_ER_diArg_1	21	24	PF00400	0.458
TRG_ER_diArg_1	214	217	PF00400	0.490
TRG_ER_diArg_1	313	316	PF00400	0.439
TRG_ER_diArg_1	653	656	PF00400	0.598
TRG_ER_diArg_1	777	780	PF00400	0.632
TRG_ER_diArg_1	799	802	PF00400	0.650
TRG_ER_diArg_1	857	860	PF00400	0.707
TRG_NES_CRM1_1	385	399	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	709	713	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	872	877	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	904	909	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	939	944	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NPH9	Trypanosomatidae	26%	100%
A0A1X0P696	Trypanosomatidae	42%	89%
A0A3Q8IBD8	Leishmania donovani	94%	100%
A0A3R7L3H0	Trypanosoma rangeli	40%	89%
A0A3S5H759	Leishmania donovani	59%	97%
A4HA26	Leishmania braziliensis	81%	100%
A4HA40	Leishmania braziliensis	48%	100%
A4HY89	Leishmania infantum	94%	94%
A4HYA2	Leishmania infantum	59%	92%
E9AS20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4QDF2	Leishmania major	93%	100%
Q4QDF3	Leishmania major	56%	99%
V5C1V7	Trypanosoma cruzi	42%	88%