Putative extracellular receptor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

extracellular receptor, putative

Species:

Leishmania mexicana

UniProt:

E9AS16_LEIMU

TriTrypDb:

LmxM.19.0640

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AS16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS16

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	5
GO:0004930	G protein-coupled receptor activity	4	5
GO:0004965	G protein-coupled GABA receptor activity	5	3
GO:0016917	GABA receptor activity	4	3
GO:0038023	signaling receptor activity	2	5
GO:0060089	molecular transducer activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.325
CLV_C14_Caspase3-7	608	612	PF00656	0.205
CLV_C14_Caspase3-7	846	850	PF00656	0.415
CLV_NRD_NRD_1	10	12	PF00675	0.401
CLV_NRD_NRD_1	261	263	PF00675	0.638
CLV_NRD_NRD_1	717	719	PF00675	0.445
CLV_PCSK_KEX2_1	10	12	PF00082	0.401
CLV_PCSK_KEX2_1	261	263	PF00082	0.573
CLV_PCSK_SKI1_1	176	180	PF00082	0.464
CLV_PCSK_SKI1_1	433	437	PF00082	0.475
CLV_PCSK_SKI1_1	912	916	PF00082	0.455
DEG_APCC_DBOX_1	175	183	PF00400	0.271
DEG_APCC_DBOX_1	282	290	PF00400	0.312
DEG_SPOP_SBC_1	230	234	PF00917	0.490
DOC_CDC14_PxL_1	286	294	PF14671	0.300
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.306
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.234
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.303
DOC_MAPK_gen_1	269	279	PF00069	0.321
DOC_MAPK_gen_1	680	689	PF00069	0.258
DOC_MAPK_gen_1	8	16	PF00069	0.437
DOC_MAPK_HePTP_8	622	634	PF00069	0.278
DOC_MAPK_MEF2A_6	625	634	PF00069	0.250
DOC_MAPK_MEF2A_6	821	828	PF00069	0.304
DOC_PP1_RVXF_1	361	368	PF00149	0.276
DOC_PP4_FxxP_1	523	526	PF00568	0.276
DOC_USP7_MATH_1	124	128	PF00917	0.317
DOC_USP7_MATH_1	148	152	PF00917	0.311
DOC_USP7_MATH_1	207	211	PF00917	0.352
DOC_USP7_MATH_1	273	277	PF00917	0.293
DOC_USP7_MATH_1	3	7	PF00917	0.621
DOC_USP7_MATH_1	375	379	PF00917	0.433
DOC_USP7_MATH_1	440	444	PF00917	0.290
DOC_USP7_MATH_1	670	674	PF00917	0.316
DOC_USP7_MATH_2	314	320	PF00917	0.305
DOC_USP7_UBL2_3	621	625	PF12436	0.245
DOC_WW_Pin1_4	309	314	PF00397	0.325
DOC_WW_Pin1_4	427	432	PF00397	0.297
DOC_WW_Pin1_4	438	443	PF00397	0.270
DOC_WW_Pin1_4	514	519	PF00397	0.238
DOC_WW_Pin1_4	736	741	PF00397	0.319
DOC_WW_Pin1_4	820	825	PF00397	0.323
DOC_WW_Pin1_4	858	863	PF00397	0.384
LIG_14-3-3_CanoR_1	10	17	PF00244	0.436
LIG_14-3-3_CanoR_1	272	278	PF00244	0.358
LIG_14-3-3_CanoR_1	499	504	PF00244	0.238
LIG_14-3-3_CanoR_1	54	62	PF00244	0.319
LIG_14-3-3_CanoR_1	586	591	PF00244	0.278
LIG_14-3-3_CanoR_1	647	655	PF00244	0.245
LIG_14-3-3_CanoR_1	718	727	PF00244	0.280
LIG_14-3-3_CanoR_1	777	784	PF00244	0.246
LIG_Actin_WH2_2	419	435	PF00022	0.298
LIG_BRCT_BRCA1_1	318	322	PF00533	0.317
LIG_BRCT_BRCA1_1	452	456	PF00533	0.255
LIG_BRCT_BRCA1_1	810	814	PF00533	0.378
LIG_BRCT_BRCA1_1	854	858	PF00533	0.409
LIG_Clathr_ClatBox_1	346	350	PF01394	0.340
LIG_DLG_GKlike_1	848	856	PF00625	0.369
LIG_EH_1	634	638	PF12763	0.245
LIG_EH1_1	885	893	PF00400	0.553
LIG_eIF4E_1	886	892	PF01652	0.518
LIG_FHA_1	103	109	PF00498	0.356
LIG_FHA_1	121	127	PF00498	0.243
LIG_FHA_1	138	144	PF00498	0.294
LIG_FHA_1	207	213	PF00498	0.423
LIG_FHA_1	216	222	PF00498	0.337
LIG_FHA_1	258	264	PF00498	0.422
LIG_FHA_1	291	297	PF00498	0.404
LIG_FHA_1	401	407	PF00498	0.308
LIG_FHA_1	421	427	PF00498	0.255
LIG_FHA_1	432	438	PF00498	0.271
LIG_FHA_1	515	521	PF00498	0.237
LIG_FHA_1	536	542	PF00498	0.352
LIG_FHA_1	602	608	PF00498	0.287
LIG_FHA_1	65	71	PF00498	0.370
LIG_FHA_1	873	879	PF00498	0.291
LIG_FHA_2	137	143	PF00498	0.312
LIG_FHA_2	231	237	PF00498	0.329
LIG_FHA_2	327	333	PF00498	0.434
LIG_FHA_2	403	409	PF00498	0.269
LIG_FHA_2	54	60	PF00498	0.284
LIG_FHA_2	553	559	PF00498	0.284
LIG_FHA_2	575	581	PF00498	0.245
LIG_FHA_2	612	618	PF00498	0.245
LIG_FHA_2	638	644	PF00498	0.279
LIG_FHA_2	704	710	PF00498	0.236
LIG_FHA_2	711	717	PF00498	0.227
LIG_FHA_2	777	783	PF00498	0.258
LIG_FHA_2	844	850	PF00498	0.386
LIG_FHA_2	902	908	PF00498	0.575
LIG_GBD_Chelix_1	44	52	PF00786	0.530
LIG_LIR_Apic_2	309	314	PF02991	0.344
LIG_LIR_Apic_2	522	526	PF02991	0.264
LIG_LIR_Gen_1	19	29	PF02991	0.237
LIG_LIR_Gen_1	378	388	PF02991	0.321
LIG_LIR_Gen_1	555	564	PF02991	0.251
LIG_LIR_Gen_1	620	631	PF02991	0.319
LIG_LIR_Gen_1	747	756	PF02991	0.249
LIG_LIR_Gen_1	830	841	PF02991	0.303
LIG_LIR_Nem_3	113	117	PF02991	0.360
LIG_LIR_Nem_3	19	25	PF02991	0.237
LIG_LIR_Nem_3	332	337	PF02991	0.311
LIG_LIR_Nem_3	378	384	PF02991	0.330
LIG_LIR_Nem_3	385	391	PF02991	0.268
LIG_LIR_Nem_3	471	477	PF02991	0.305
LIG_LIR_Nem_3	543	547	PF02991	0.262
LIG_LIR_Nem_3	555	559	PF02991	0.244
LIG_LIR_Nem_3	643	648	PF02991	0.278
LIG_LIR_Nem_3	649	654	PF02991	0.256
LIG_LIR_Nem_3	739	744	PF02991	0.259
LIG_LIR_Nem_3	747	753	PF02991	0.235
LIG_LIR_Nem_3	830	836	PF02991	0.327
LIG_LIR_Nem_3	880	886	PF02991	0.331
LIG_LYPXL_S_1	689	693	PF13949	0.445
LIG_LYPXL_yS_3	690	693	PF13949	0.245
LIG_NRBOX	24	30	PF00104	0.237
LIG_NRBOX	338	344	PF00104	0.329
LIG_OCRL_FandH_1	880	892	PF00620	0.369
LIG_PDZ_Class_3	913	918	PF00595	0.665
LIG_Pex14_1	303	307	PF04695	0.272
LIG_Pex14_2	814	818	PF04695	0.274
LIG_PTB_Apo_2	113	120	PF02174	0.232
LIG_PTB_Apo_2	194	201	PF02174	0.318
LIG_PTB_Apo_2	531	538	PF02174	0.302
LIG_PTB_Phospho_1	194	200	PF10480	0.319
LIG_REV1ctd_RIR_1	643	651	PF16727	0.425
LIG_RPA_C_Fungi	6	18	PF08784	0.235
LIG_SH2_CRK	311	315	PF00017	0.401
LIG_SH2_NCK_1	311	315	PF00017	0.356
LIG_SH2_PTP2	750	753	PF00017	0.366
LIG_SH2_STAP1	189	193	PF00017	0.336
LIG_SH2_STAP1	409	413	PF00017	0.483
LIG_SH2_STAP1	623	627	PF00017	0.306
LIG_SH2_STAP1	801	805	PF00017	0.366
LIG_SH2_STAT3	654	657	PF00017	0.263
LIG_SH2_STAT3	886	889	PF00017	0.371
LIG_SH2_STAT5	311	314	PF00017	0.315
LIG_SH2_STAT5	536	539	PF00017	0.308
LIG_SH2_STAT5	546	549	PF00017	0.244
LIG_SH2_STAT5	600	603	PF00017	0.263
LIG_SH2_STAT5	606	609	PF00017	0.244
LIG_SH2_STAT5	651	654	PF00017	0.285
LIG_SH2_STAT5	658	661	PF00017	0.235
LIG_SH2_STAT5	705	708	PF00017	0.322
LIG_SH2_STAT5	750	753	PF00017	0.279
LIG_SH2_STAT5	775	778	PF00017	0.366
LIG_SH2_STAT5	79	82	PF00017	0.413
LIG_SH3_3	394	400	PF00018	0.320
LIG_SH3_5	526	530	PF00018	0.309
LIG_Sin3_3	13	20	PF02671	0.233
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.417
LIG_SUMO_SIM_anti_2	12	19	PF11976	0.252
LIG_SUMO_SIM_anti_2	138	147	PF11976	0.359
LIG_SUMO_SIM_anti_2	571	578	PF11976	0.253
LIG_SUMO_SIM_anti_2	628	634	PF11976	0.281
LIG_SUMO_SIM_par_1	138	147	PF11976	0.461
LIG_SUMO_SIM_par_1	177	183	PF11976	0.399
LIG_SUMO_SIM_par_1	344	350	PF11976	0.392
LIG_SUMO_SIM_par_1	477	483	PF11976	0.323
LIG_SUMO_SIM_par_1	571	578	PF11976	0.309
LIG_SUMO_SIM_par_1	87	93	PF11976	0.366
LIG_SUMO_SIM_par_1	874	880	PF11976	0.229
LIG_SxIP_EBH_1	488	499	PF03271	0.406
LIG_TRAF2_1	713	716	PF00917	0.463
LIG_TRAF2_1	904	907	PF00917	0.460
LIG_TYR_ITIM	379	384	PF00017	0.359
LIG_UBA3_1	346	353	PF00899	0.296
LIG_WRC_WIRS_1	553	558	PF05994	0.233
LIG_WRC_WIRS_1	844	849	PF05994	0.472
LIG_WRC_WIRS_1	878	883	PF05994	0.207
MOD_CDC14_SPxK_1	430	433	PF00782	0.326
MOD_CDK_SPxK_1	427	433	PF00069	0.334
MOD_CK1_1	147	153	PF00069	0.350
MOD_CK1_1	187	193	PF00069	0.275
MOD_CK1_1	282	288	PF00069	0.387
MOD_CK1_1	309	315	PF00069	0.355
MOD_CK1_1	389	395	PF00069	0.324
MOD_CK1_1	486	492	PF00069	0.403
MOD_CK1_1	53	59	PF00069	0.412
MOD_CK1_1	589	595	PF00069	0.531
MOD_CK1_1	729	735	PF00069	0.320
MOD_CK1_1	736	742	PF00069	0.264
MOD_CK1_1	820	826	PF00069	0.362
MOD_CK2_1	229	235	PF00069	0.355
MOD_CK2_1	53	59	PF00069	0.412
MOD_CK2_1	637	643	PF00069	0.226
MOD_CK2_1	710	716	PF00069	0.251
MOD_CK2_1	725	731	PF00069	0.215
MOD_CK2_1	777	783	PF00069	0.257
MOD_CK2_1	901	907	PF00069	0.453
MOD_GlcNHglycan	11	14	PF01048	0.244
MOD_GlcNHglycan	125	129	PF01048	0.362
MOD_GlcNHglycan	146	149	PF01048	0.332
MOD_GlcNHglycan	298	301	PF01048	0.519
MOD_GlcNHglycan	308	311	PF01048	0.455
MOD_GlcNHglycan	31	34	PF01048	0.447
MOD_GlcNHglycan	359	362	PF01048	0.354
MOD_GlcNHglycan	370	373	PF01048	0.311
MOD_GlcNHglycan	41	44	PF01048	0.386
MOD_GlcNHglycan	423	426	PF01048	0.464
MOD_GlcNHglycan	485	488	PF01048	0.354
MOD_GlcNHglycan	5	8	PF01048	0.501
MOD_GlcNHglycan	663	666	PF01048	0.263
MOD_GlcNHglycan	73	76	PF01048	0.462
MOD_GlcNHglycan	741	744	PF01048	0.218
MOD_GlcNHglycan	858	861	PF01048	0.477
MOD_GSK3_1	120	127	PF00069	0.289
MOD_GSK3_1	144	151	PF00069	0.349
MOD_GSK3_1	157	164	PF00069	0.384
MOD_GSK3_1	180	187	PF00069	0.401
MOD_GSK3_1	189	196	PF00069	0.313
MOD_GSK3_1	207	214	PF00069	0.485
MOD_GSK3_1	27	34	PF00069	0.479
MOD_GSK3_1	322	329	PF00069	0.526
MOD_GSK3_1	35	42	PF00069	0.658
MOD_GSK3_1	386	393	PF00069	0.319
MOD_GSK3_1	427	434	PF00069	0.379
MOD_GSK3_1	479	486	PF00069	0.309
MOD_GSK3_1	502	509	PF00069	0.320
MOD_GSK3_1	582	589	PF00069	0.261
MOD_GSK3_1	60	67	PF00069	0.423
MOD_GSK3_1	601	608	PF00069	0.215
MOD_GSK3_1	637	644	PF00069	0.525
MOD_GSK3_1	646	653	PF00069	0.349
MOD_GSK3_1	700	707	PF00069	0.494
MOD_GSK3_1	725	732	PF00069	0.257
MOD_GSK3_1	782	789	PF00069	0.284
MOD_GSK3_1	848	855	PF00069	0.459
MOD_N-GLC_1	136	141	PF02516	0.462
MOD_N-GLC_1	290	295	PF02516	0.429
MOD_N-GLC_1	296	301	PF02516	0.538
MOD_N-GLC_1	357	362	PF02516	0.365
MOD_N-GLC_1	39	44	PF02516	0.498
MOD_N-GLC_1	420	425	PF02516	0.412
MOD_N-GLC_1	467	472	PF02516	0.499
MOD_N-GLC_1	611	616	PF02516	0.315
MOD_N-GLC_1	691	696	PF02516	0.371
MOD_N-GLC_1	71	76	PF02516	0.488
MOD_N-GLC_1	762	767	PF02516	0.272
MOD_N-GLC_1	808	813	PF02516	0.352
MOD_N-GLC_1	837	842	PF02516	0.484
MOD_NEK2_1	144	149	PF00069	0.387
MOD_NEK2_1	16	21	PF00069	0.243
MOD_NEK2_1	29	34	PF00069	0.596
MOD_NEK2_1	337	342	PF00069	0.399
MOD_NEK2_1	390	395	PF00069	0.260
MOD_NEK2_1	450	455	PF00069	0.444
MOD_NEK2_1	456	461	PF00069	0.559
MOD_NEK2_1	52	57	PF00069	0.332
MOD_NEK2_1	547	552	PF00069	0.263
MOD_NEK2_1	582	587	PF00069	0.351
MOD_NEK2_1	637	642	PF00069	0.359
MOD_NEK2_1	661	666	PF00069	0.487
MOD_NEK2_1	70	75	PF00069	0.483
MOD_NEK2_1	752	757	PF00069	0.328
MOD_NEK2_1	808	813	PF00069	0.466
MOD_NEK2_1	814	819	PF00069	0.318
MOD_NEK2_1	836	841	PF00069	0.460
MOD_NEK2_1	852	857	PF00069	0.411
MOD_NEK2_1	872	877	PF00069	0.229
MOD_NEK2_2	273	278	PF00069	0.417
MOD_NEK2_2	375	380	PF00069	0.537
MOD_NEK2_2	700	705	PF00069	0.248
MOD_NEK2_2	79	84	PF00069	0.336
MOD_NEK2_2	843	848	PF00069	0.341
MOD_PIKK_1	207	213	PF00454	0.388
MOD_PIKK_1	316	322	PF00454	0.365
MOD_PIKK_1	445	451	PF00454	0.301
MOD_PIKK_1	559	565	PF00454	0.248
MOD_PIKK_1	637	643	PF00454	0.508
MOD_PIKK_1	691	697	PF00454	0.404
MOD_PIKK_1	99	105	PF00454	0.524
MOD_PK_1	777	783	PF00069	0.276
MOD_PKA_2	268	274	PF00069	0.321
MOD_PKA_2	282	288	PF00069	0.294
MOD_PKA_2	326	332	PF00069	0.295
MOD_PKA_2	53	59	PF00069	0.331
MOD_PKA_2	646	652	PF00069	0.263
MOD_PKA_2	776	782	PF00069	0.253
MOD_PKA_2	9	15	PF00069	0.252
MOD_Plk_1	357	363	PF00069	0.387
MOD_Plk_1	407	413	PF00069	0.320
MOD_Plk_1	58	64	PF00069	0.387
MOD_Plk_1	601	607	PF00069	0.272
MOD_Plk_1	611	617	PF00069	0.267
MOD_Plk_1	733	739	PF00069	0.256
MOD_Plk_1	762	768	PF00069	0.288
MOD_Plk_1	786	792	PF00069	0.418
MOD_Plk_1	829	835	PF00069	0.493
MOD_Plk_1	837	843	PF00069	0.552
MOD_Plk_1	848	854	PF00069	0.388
MOD_Plk_2-3	611	617	PF00069	0.222
MOD_Plk_4	126	132	PF00069	0.379
MOD_Plk_4	184	190	PF00069	0.514
MOD_Plk_4	217	223	PF00069	0.389
MOD_Plk_4	239	245	PF00069	0.318
MOD_Plk_4	273	279	PF00069	0.464
MOD_Plk_4	375	381	PF00069	0.376
MOD_Plk_4	383	389	PF00069	0.281
MOD_Plk_4	450	456	PF00069	0.300
MOD_Plk_4	490	496	PF00069	0.422
MOD_Plk_4	499	505	PF00069	0.247
MOD_Plk_4	601	607	PF00069	0.337
MOD_Plk_4	641	647	PF00069	0.329
MOD_Plk_4	650	656	PF00069	0.285
MOD_Plk_4	700	706	PF00069	0.403
MOD_Plk_4	79	85	PF00069	0.383
MOD_Plk_4	809	815	PF00069	0.313
MOD_Plk_4	829	835	PF00069	0.317
MOD_Plk_4	848	854	PF00069	0.510
MOD_ProDKin_1	309	315	PF00069	0.386
MOD_ProDKin_1	427	433	PF00069	0.333
MOD_ProDKin_1	438	444	PF00069	0.301
MOD_ProDKin_1	514	520	PF00069	0.253
MOD_ProDKin_1	736	742	PF00069	0.366
MOD_ProDKin_1	820	826	PF00069	0.365
MOD_ProDKin_1	858	864	PF00069	0.451
MOD_SUMO_rev_2	151	160	PF00179	0.370
TRG_DiLeu_BaEn_1	716	721	PF01217	0.248
TRG_DiLeu_BaEn_4	906	912	PF01217	0.459
TRG_ENDOCYTIC_2	334	337	PF00928	0.323
TRG_ENDOCYTIC_2	381	384	PF00928	0.335
TRG_ENDOCYTIC_2	544	547	PF00928	0.253
TRG_ENDOCYTIC_2	623	626	PF00928	0.366
TRG_ENDOCYTIC_2	658	661	PF00928	0.253
TRG_ENDOCYTIC_2	690	693	PF00928	0.263
TRG_ENDOCYTIC_2	741	744	PF00928	0.277
TRG_ENDOCYTIC_2	750	753	PF00928	0.242
TRG_ER_diArg_1	246	249	PF00400	0.525
TRG_ER_diArg_1	261	263	PF00400	0.363
TRG_NES_CRM1_1	171	185	PF08389	0.356
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	912	916	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK8	Leptomonas seymouri	66%	93%
A0A0S4ITA9	Bodo saltans	37%	100%
A0A1X0P7Q8	Trypanosomatidae	43%	100%
A0A3S7WVK2	Leishmania donovani	94%	100%
A0A422NN34	Trypanosoma rangeli	41%	100%
A4HA22	Leishmania braziliensis	79%	100%
A4HY85	Leishmania infantum	93%	100%
Q4QDF7	Leishmania major	93%	100%
V5C1V3	Trypanosoma cruzi	42%	100%