CYTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS14_LEIMU

TriTrypDb:

LmxM.19.0620

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS14

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.675
CLV_NRD_NRD_1	318	320	PF00675	0.444
CLV_NRD_NRD_1	438	440	PF00675	0.484
CLV_NRD_NRD_1	459	461	PF00675	0.817
CLV_NRD_NRD_1	507	509	PF00675	0.529
CLV_NRD_NRD_1	515	517	PF00675	0.453
CLV_PCSK_KEX2_1	438	440	PF00082	0.484
CLV_PCSK_KEX2_1	459	461	PF00082	0.715
CLV_PCSK_KEX2_1	507	509	PF00082	0.529
CLV_PCSK_KEX2_1	517	519	PF00082	0.479
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.387
CLV_PCSK_SKI1_1	145	149	PF00082	0.457
CLV_PCSK_SKI1_1	319	323	PF00082	0.542
CLV_PCSK_SKI1_1	510	514	PF00082	0.586
CLV_PCSK_SKI1_1	523	527	PF00082	0.346
CLV_PCSK_SKI1_1	588	592	PF00082	0.458
DEG_APCC_DBOX_1	437	445	PF00400	0.501
DEG_COP1_1	165	172	PF00400	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.525
DOC_CDC14_PxL_1	652	660	PF14671	0.536
DOC_CYCLIN_yClb5_NLxxxL_5	438	445	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.496
DOC_MAPK_DCC_7	651	660	PF00069	0.527
DOC_MAPK_FxFP_2	37	40	PF00069	0.560
DOC_MAPK_gen_1	345	355	PF00069	0.517
DOC_MAPK_gen_1	438	446	PF00069	0.563
DOC_MAPK_gen_1	507	515	PF00069	0.494
DOC_MAPK_HePTP_8	648	660	PF00069	0.440
DOC_MAPK_MEF2A_6	348	355	PF00069	0.503
DOC_MAPK_MEF2A_6	47	55	PF00069	0.478
DOC_MAPK_MEF2A_6	651	660	PF00069	0.625
DOC_PP2B_LxvP_1	133	136	PF13499	0.629
DOC_PP2B_LxvP_1	369	372	PF13499	0.441
DOC_PP2B_LxvP_1	444	447	PF13499	0.580
DOC_PP2B_LxvP_1	53	56	PF13499	0.470
DOC_PP4_FxxP_1	37	40	PF00568	0.560
DOC_PP4_FxxP_1	499	502	PF00568	0.486
DOC_USP7_MATH_1	105	109	PF00917	0.787
DOC_USP7_MATH_1	222	226	PF00917	0.487
DOC_USP7_MATH_1	247	251	PF00917	0.701
DOC_USP7_MATH_1	254	258	PF00917	0.750
DOC_USP7_MATH_1	447	451	PF00917	0.660
DOC_USP7_MATH_1	453	457	PF00917	0.689
DOC_USP7_MATH_1	624	628	PF00917	0.687
DOC_USP7_MATH_1	71	75	PF00917	0.708
DOC_USP7_UBL2_3	145	149	PF12436	0.457
DOC_USP7_UBL2_3	289	293	PF12436	0.780
DOC_USP7_UBL2_3	575	579	PF12436	0.588
DOC_WW_Pin1_4	498	503	PF00397	0.494
LIG_14-3-3_CanoR_1	17	23	PF00244	0.505
LIG_14-3-3_CanoR_1	229	237	PF00244	0.468
LIG_14-3-3_CanoR_1	47	51	PF00244	0.590
LIG_14-3-3_CanoR_1	507	513	PF00244	0.506
LIG_14-3-3_CanoR_1	588	593	PF00244	0.458
LIG_14-3-3_CanoR_1	596	600	PF00244	0.444
LIG_14-3-3_CanoR_1	65	71	PF00244	0.554
LIG_14-3-3_CanoR_1	677	686	PF00244	0.594
LIG_Actin_WH2_2	305	321	PF00022	0.468
LIG_APCC_ABBA_1	658	663	PF00400	0.447
LIG_BIR_III_4	11	15	PF00653	0.327
LIG_BIR_III_4	474	478	PF00653	0.477
LIG_BRCT_BRCA1_1	201	205	PF00533	0.626
LIG_DLG_GKlike_1	508	515	PF00625	0.597
LIG_EVH1_1	652	656	PF00568	0.581
LIG_FHA_1	169	175	PF00498	0.526
LIG_FHA_1	185	191	PF00498	0.517
LIG_FHA_1	559	565	PF00498	0.477
LIG_FHA_1	592	598	PF00498	0.443
LIG_FHA_1	691	697	PF00498	0.469
LIG_FHA_1	713	719	PF00498	0.491
LIG_FHA_1	724	730	PF00498	0.490
LIG_FHA_2	334	340	PF00498	0.676
LIG_FHA_2	363	369	PF00498	0.585
LIG_FHA_2	491	497	PF00498	0.463
LIG_FXI_DFP_1	36	40	PF00024	0.556
LIG_GBD_Chelix_1	710	718	PF00786	0.573
LIG_Integrin_RGD_1	476	478	PF01839	0.465
LIG_LIR_Apic_2	34	40	PF02991	0.550
LIG_LIR_Apic_2	356	362	PF02991	0.465
LIG_LIR_Apic_2	496	502	PF02991	0.480
LIG_LIR_Apic_2	665	670	PF02991	0.474
LIG_LIR_Gen_1	202	212	PF02991	0.591
LIG_LIR_Gen_1	258	269	PF02991	0.647
LIG_LIR_Gen_1	30	41	PF02991	0.449
LIG_LIR_Gen_1	511	519	PF02991	0.569
LIG_LIR_Gen_1	569	577	PF02991	0.506
LIG_LIR_Gen_1	734	742	PF02991	0.488
LIG_LIR_Gen_1	84	93	PF02991	0.618
LIG_LIR_Nem_3	202	208	PF02991	0.595
LIG_LIR_Nem_3	258	264	PF02991	0.648
LIG_LIR_Nem_3	29	35	PF02991	0.449
LIG_LIR_Nem_3	38	44	PF02991	0.465
LIG_LIR_Nem_3	401	407	PF02991	0.482
LIG_LIR_Nem_3	511	515	PF02991	0.463
LIG_LIR_Nem_3	569	574	PF02991	0.513
LIG_LIR_Nem_3	576	581	PF02991	0.509
LIG_LIR_Nem_3	734	739	PF02991	0.462
LIG_LIR_Nem_3	84	90	PF02991	0.619
LIG_LYPXL_yS_3	41	44	PF13949	0.489
LIG_MYND_3	306	310	PF01753	0.609
LIG_NRBOX	333	339	PF00104	0.414
LIG_NRBOX	440	446	PF00104	0.572
LIG_PAM2_1	232	244	PF00658	0.607
LIG_PCNA_TLS_4	730	737	PF02747	0.456
LIG_PCNA_yPIPBox_3	331	345	PF02747	0.388
LIG_SH2_CRK	324	328	PF00017	0.492
LIG_SH2_CRK	667	671	PF00017	0.499
LIG_SH2_SRC	241	244	PF00017	0.581
LIG_SH2_SRC	434	437	PF00017	0.584
LIG_SH2_SRC	567	570	PF00017	0.494
LIG_SH2_STAP1	33	37	PF00017	0.538
LIG_SH2_STAP1	367	371	PF00017	0.441
LIG_SH2_STAP1	407	411	PF00017	0.532
LIG_SH2_STAP1	567	571	PF00017	0.607
LIG_SH2_STAP1	63	67	PF00017	0.723
LIG_SH2_STAP1	694	698	PF00017	0.464
LIG_SH2_STAP1	87	91	PF00017	0.609
LIG_SH2_STAT3	211	214	PF00017	0.608
LIG_SH2_STAT3	275	278	PF00017	0.631
LIG_SH2_STAT3	637	640	PF00017	0.689
LIG_SH2_STAT5	275	278	PF00017	0.567
LIG_SH2_STAT5	359	362	PF00017	0.549
LIG_SH2_STAT5	410	413	PF00017	0.549
LIG_SH2_STAT5	489	492	PF00017	0.611
LIG_SH2_STAT5	524	527	PF00017	0.447
LIG_SH2_STAT5	63	66	PF00017	0.475
LIG_SH2_STAT5	631	634	PF00017	0.671
LIG_SH2_STAT5	637	640	PF00017	0.616
LIG_SH2_STAT5	736	739	PF00017	0.462
LIG_SH3_1	651	657	PF00018	0.558
LIG_SH3_3	237	243	PF00018	0.422
LIG_SH3_3	53	59	PF00018	0.584
LIG_SH3_3	650	656	PF00018	0.579
LIG_SH3_3	673	679	PF00018	0.705
LIG_SH3_3	701	707	PF00018	0.628
LIG_SUMO_SIM_anti_2	593	601	PF11976	0.258
LIG_SUMO_SIM_par_1	333	339	PF11976	0.414
LIG_TRAF2_1	43	46	PF00917	0.481
LIG_UBA3_1	525	529	PF00899	0.555
MOD_CK1_1	108	114	PF00069	0.666
MOD_CK1_1	184	190	PF00069	0.517
MOD_CK1_1	194	200	PF00069	0.631
MOD_CK1_1	232	238	PF00069	0.486
MOD_CK1_1	283	289	PF00069	0.703
MOD_CK1_1	449	455	PF00069	0.616
MOD_CK1_1	541	547	PF00069	0.529
MOD_CK1_1	61	67	PF00069	0.696
MOD_CK1_1	69	75	PF00069	0.565
MOD_CK2_1	333	339	PF00069	0.686
MOD_CK2_1	340	346	PF00069	0.558
MOD_CK2_1	362	368	PF00069	0.601
MOD_CK2_1	460	466	PF00069	0.710
MOD_CK2_1	728	734	PF00069	0.566
MOD_GlcNHglycan	108	111	PF01048	0.667
MOD_GlcNHglycan	193	196	PF01048	0.497
MOD_GlcNHglycan	198	202	PF01048	0.573
MOD_GlcNHglycan	208	211	PF01048	0.562
MOD_GlcNHglycan	224	227	PF01048	0.485
MOD_GlcNHglycan	234	237	PF01048	0.447
MOD_GlcNHglycan	249	252	PF01048	0.553
MOD_GlcNHglycan	449	452	PF01048	0.637
MOD_GlcNHglycan	534	537	PF01048	0.620
MOD_GlcNHglycan	620	623	PF01048	0.753
MOD_GlcNHglycan	65	68	PF01048	0.622
MOD_GlcNHglycan	71	74	PF01048	0.707
MOD_GSK3_1	105	112	PF00069	0.665
MOD_GSK3_1	181	188	PF00069	0.506
MOD_GSK3_1	279	286	PF00069	0.741
MOD_GSK3_1	445	452	PF00069	0.577
MOD_GSK3_1	477	484	PF00069	0.626
MOD_GSK3_1	498	505	PF00069	0.497
MOD_GSK3_1	586	593	PF00069	0.553
MOD_GSK3_1	607	614	PF00069	0.567
MOD_GSK3_1	632	639	PF00069	0.768
MOD_GSK3_1	678	685	PF00069	0.739
MOD_NEK2_1	185	190	PF00069	0.497
MOD_NEK2_1	280	285	PF00069	0.740
MOD_NEK2_1	392	397	PF00069	0.392
MOD_NEK2_1	426	431	PF00069	0.511
MOD_NEK2_1	586	591	PF00069	0.516
MOD_NEK2_1	611	616	PF00069	0.639
MOD_NEK2_1	662	667	PF00069	0.450
MOD_NEK2_2	314	319	PF00069	0.431
MOD_NEK2_2	362	367	PF00069	0.613
MOD_NEK2_2	502	507	PF00069	0.508
MOD_PIKK_1	229	235	PF00454	0.349
MOD_PIKK_1	259	265	PF00454	0.630
MOD_PIKK_1	273	279	PF00454	0.661
MOD_PIKK_1	280	286	PF00454	0.658
MOD_PIKK_1	453	459	PF00454	0.804
MOD_PIKK_1	558	564	PF00454	0.480
MOD_PIKK_1	624	630	PF00454	0.663
MOD_PIKK_1	636	642	PF00454	0.663
MOD_PIKK_1	678	684	PF00454	0.737
MOD_PKA_2	426	432	PF00069	0.517
MOD_PKA_2	46	52	PF00069	0.491
MOD_PKA_2	595	601	PF00069	0.552
MOD_PKB_1	516	524	PF00069	0.395
MOD_Plk_1	355	361	PF00069	0.450
MOD_Plk_1	45	51	PF00069	0.533
MOD_Plk_1	477	483	PF00069	0.611
MOD_Plk_1	502	508	PF00069	0.516
MOD_Plk_1	662	668	PF00069	0.460
MOD_Plk_1	712	718	PF00069	0.548
MOD_Plk_1	723	729	PF00069	0.416
MOD_Plk_4	158	164	PF00069	0.451
MOD_Plk_4	181	187	PF00069	0.553
MOD_Plk_4	333	339	PF00069	0.414
MOD_Plk_4	355	361	PF00069	0.410
MOD_Plk_4	362	368	PF00069	0.423
MOD_Plk_4	46	52	PF00069	0.491
MOD_Plk_4	477	483	PF00069	0.601
MOD_Plk_4	508	514	PF00069	0.503
MOD_Plk_4	573	579	PF00069	0.474
MOD_Plk_4	58	64	PF00069	0.540
MOD_Plk_4	595	601	PF00069	0.261
MOD_Plk_4	632	638	PF00069	0.650
MOD_Plk_4	713	719	PF00069	0.515
MOD_ProDKin_1	498	504	PF00069	0.493
MOD_SUMO_for_1	27	30	PF00179	0.469
MOD_SUMO_rev_2	395	405	PF00179	0.497
MOD_SUMO_rev_2	418	426	PF00179	0.641
TRG_DiLeu_BaEn_1	86	91	PF01217	0.712
TRG_DiLeu_BaEn_2	383	389	PF01217	0.565
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.511
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.492
TRG_ENDOCYTIC_2	32	35	PF00928	0.432
TRG_ENDOCYTIC_2	324	327	PF00928	0.481
TRG_ENDOCYTIC_2	41	44	PF00928	0.465
TRG_ENDOCYTIC_2	434	437	PF00928	0.584
TRG_ENDOCYTIC_2	736	739	PF00928	0.462
TRG_ENDOCYTIC_2	87	90	PF00928	0.613
TRG_ER_diArg_1	351	354	PF00400	0.474
TRG_ER_diArg_1	437	439	PF00400	0.472
TRG_ER_diArg_1	506	508	PF00400	0.504
TRG_ER_diArg_1	51	54	PF00400	0.466
TRG_ER_diArg_1	513	516	PF00400	0.454
TRG_NES_CRM1_1	713	724	PF08389	0.495
TRG_NLS_MonoExtN_4	514	520	PF00514	0.400
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD6	Leptomonas seymouri	54%	93%
A0A3S7WVE7	Leishmania donovani	91%	100%
A4HA20	Leishmania braziliensis	80%	100%
A4HY83	Leishmania infantum	92%	100%
Q4QDF9	Leishmania major	92%	100%