LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AS09_LEIMU
TriTrypDb:
LmxM.19.0540
Length:
530

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 18, no: 1
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

E9AS09
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS09

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 449 451 PF00675 0.494
CLV_PCSK_KEX2_1 449 451 PF00082 0.494
CLV_PCSK_SKI1_1 367 371 PF00082 0.607
DEG_SPOP_SBC_1 469 473 PF00917 0.314
DEG_SPOP_SBC_1 526 530 PF00917 0.557
DOC_MAPK_gen_1 449 456 PF00069 0.299
DOC_MAPK_MEF2A_6 106 115 PF00069 0.551
DOC_USP7_MATH_1 25 29 PF00917 0.466
DOC_USP7_UBL2_3 382 386 PF12436 0.307
DOC_WW_Pin1_4 522 527 PF00397 0.775
LIG_14-3-3_CanoR_1 470 475 PF00244 0.403
LIG_14-3-3_CanoR_1 53 62 PF00244 0.433
LIG_BRCT_BRCA1_1 175 179 PF00533 0.386
LIG_EH1_1 219 227 PF00400 0.490
LIG_EH1_1 479 487 PF00400 0.374
LIG_FHA_1 188 194 PF00498 0.415
LIG_FHA_1 204 210 PF00498 0.265
LIG_FHA_1 258 264 PF00498 0.459
LIG_FHA_1 3 9 PF00498 0.602
LIG_FHA_1 369 375 PF00498 0.386
LIG_FHA_1 469 475 PF00498 0.360
LIG_FHA_1 49 55 PF00498 0.389
LIG_FHA_1 511 517 PF00498 0.731
LIG_FHA_1 519 525 PF00498 0.758
LIG_FHA_2 456 462 PF00498 0.492
LIG_GBD_Chelix_1 250 258 PF00786 0.419
LIG_LIR_Apic_2 32 38 PF02991 0.258
LIG_LIR_Apic_2 363 368 PF02991 0.418
LIG_LIR_Apic_2 398 402 PF02991 0.438
LIG_LIR_Apic_2 428 432 PF02991 0.376
LIG_LIR_Gen_1 176 185 PF02991 0.345
LIG_LIR_Gen_1 190 200 PF02991 0.358
LIG_LIR_Gen_1 295 305 PF02991 0.397
LIG_LIR_Nem_3 176 182 PF02991 0.340
LIG_LIR_Nem_3 190 195 PF02991 0.331
LIG_LIR_Nem_3 198 203 PF02991 0.343
LIG_LIR_Nem_3 242 248 PF02991 0.334
LIG_LIR_Nem_3 295 301 PF02991 0.417
LIG_LIR_Nem_3 428 434 PF02991 0.446
LIG_LIR_Nem_3 56 61 PF02991 0.359
LIG_LYPXL_S_1 62 66 PF13949 0.530
LIG_MYND_1 402 406 PF01753 0.238
LIG_PCNA_yPIPBox_3 186 197 PF02747 0.302
LIG_Pex14_1 241 245 PF04695 0.572
LIG_Pex14_2 248 252 PF04695 0.396
LIG_SH2_CRK 129 133 PF00017 0.409
LIG_SH2_GRB2like 152 155 PF00017 0.388
LIG_SH2_NCK_1 277 281 PF00017 0.395
LIG_SH2_NCK_1 93 97 PF00017 0.509
LIG_SH2_PTP2 192 195 PF00017 0.444
LIG_SH2_PTP2 365 368 PF00017 0.418
LIG_SH2_PTP2 429 432 PF00017 0.416
LIG_SH2_SRC 61 64 PF00017 0.400
LIG_SH2_STAT5 152 155 PF00017 0.357
LIG_SH2_STAT5 192 195 PF00017 0.363
LIG_SH2_STAT5 200 203 PF00017 0.345
LIG_SH2_STAT5 245 248 PF00017 0.339
LIG_SH2_STAT5 264 267 PF00017 0.296
LIG_SH2_STAT5 323 326 PF00017 0.248
LIG_SH2_STAT5 365 368 PF00017 0.411
LIG_SH2_STAT5 429 432 PF00017 0.406
LIG_SH2_STAT5 462 465 PF00017 0.477
LIG_SH2_STAT5 61 64 PF00017 0.336
LIG_SH3_1 400 406 PF00018 0.405
LIG_SH3_3 168 174 PF00018 0.451
LIG_SH3_3 400 406 PF00018 0.405
LIG_SH3_3 513 519 PF00018 0.621
LIG_SH3_3 520 526 PF00018 0.597
LIG_SUMO_SIM_anti_2 355 364 PF11976 0.423
LIG_TRFH_1 60 64 PF08558 0.421
LIG_TYR_ITIM 127 132 PF00017 0.484
MOD_CK1_1 391 397 PF00069 0.351
MOD_CK1_1 40 46 PF00069 0.398
MOD_CK1_1 455 461 PF00069 0.531
MOD_CK2_1 40 46 PF00069 0.445
MOD_GlcNHglycan 167 170 PF01048 0.634
MOD_GlcNHglycan 178 182 PF01048 0.479
MOD_GlcNHglycan 23 26 PF01048 0.580
MOD_GlcNHglycan 233 236 PF01048 0.455
MOD_GlcNHglycan 266 269 PF01048 0.585
MOD_GlcNHglycan 314 317 PF01048 0.584
MOD_GlcNHglycan 466 469 PF01048 0.633
MOD_GlcNHglycan 502 505 PF01048 0.355
MOD_GSK3_1 142 149 PF00069 0.437
MOD_GSK3_1 155 162 PF00069 0.309
MOD_GSK3_1 173 180 PF00069 0.362
MOD_GSK3_1 21 28 PF00069 0.481
MOD_GSK3_1 346 353 PF00069 0.384
MOD_GSK3_1 36 43 PF00069 0.306
MOD_GSK3_1 421 428 PF00069 0.375
MOD_GSK3_1 464 471 PF00069 0.421
MOD_GSK3_1 496 503 PF00069 0.552
MOD_GSK3_1 518 525 PF00069 0.766
MOD_LATS_1 405 411 PF00433 0.223
MOD_N-GLC_1 153 158 PF02516 0.548
MOD_N-GLC_1 165 170 PF02516 0.564
MOD_N-GLC_1 187 192 PF02516 0.565
MOD_N-GLC_1 376 381 PF02516 0.704
MOD_N-GLC_1 40 45 PF02516 0.634
MOD_N-GLC_1 421 426 PF02516 0.559
MOD_N-GLC_1 452 457 PF02516 0.678
MOD_N-GLC_2 322 324 PF02516 0.604
MOD_NEK2_1 153 158 PF00069 0.400
MOD_NEK2_1 18 23 PF00069 0.514
MOD_NEK2_1 275 280 PF00069 0.306
MOD_NEK2_1 370 375 PF00069 0.395
MOD_NEK2_1 475 480 PF00069 0.354
MOD_NEK2_1 71 76 PF00069 0.436
MOD_OFUCOSY 237 243 PF10250 0.390
MOD_OFUCOSY 387 392 PF10250 0.535
MOD_PIKK_1 304 310 PF00454 0.441
MOD_PIKK_1 346 352 PF00454 0.434
MOD_PIKK_1 455 461 PF00454 0.455
MOD_PIKK_1 53 59 PF00454 0.433
MOD_PK_1 407 413 PF00069 0.318
MOD_PK_1 470 476 PF00069 0.378
MOD_PK_1 496 502 PF00069 0.618
MOD_PKA_2 231 237 PF00069 0.594
MOD_PKA_2 469 475 PF00069 0.400
MOD_Plk_1 177 183 PF00069 0.338
MOD_Plk_1 187 193 PF00069 0.376
MOD_Plk_1 40 46 PF00069 0.433
MOD_Plk_1 452 458 PF00069 0.519
MOD_Plk_2-3 146 152 PF00069 0.458
MOD_Plk_4 128 134 PF00069 0.352
MOD_Plk_4 159 165 PF00069 0.304
MOD_Plk_4 2 8 PF00069 0.581
MOD_Plk_4 30 36 PF00069 0.413
MOD_Plk_4 361 367 PF00069 0.342
MOD_Plk_4 385 391 PF00069 0.356
MOD_Plk_4 40 46 PF00069 0.448
MOD_Plk_4 425 431 PF00069 0.394
MOD_Plk_4 470 476 PF00069 0.299
MOD_Plk_4 496 502 PF00069 0.486
MOD_ProDKin_1 522 528 PF00069 0.775
MOD_SUMO_for_1 406 409 PF00179 0.220
MOD_SUMO_rev_2 394 402 PF00179 0.350
TRG_DiLeu_BaEn_1 385 390 PF01217 0.320
TRG_DiLeu_BaLyEn_6 429 434 PF01217 0.365
TRG_ENDOCYTIC_2 129 132 PF00928 0.391
TRG_ENDOCYTIC_2 192 195 PF00928 0.415
TRG_ENDOCYTIC_2 245 248 PF00928 0.315
TRG_ENDOCYTIC_2 63 66 PF00928 0.289
TRG_Pf-PMV_PEXEL_1 27 32 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y8 Leptomonas seymouri 53% 100%
A0A0S4ITY9 Bodo saltans 26% 100%
A0A0S4IXB1 Bodo saltans 27% 100%
A0A0S4IXU4 Bodo saltans 28% 100%
A0A1X0NVP9 Trypanosomatidae 38% 100%
A0A1X0NWC8 Trypanosomatidae 35% 100%
A0A1X0P6A6 Trypanosomatidae 31% 100%
A0A3Q8IB78 Leishmania donovani 81% 100%
A0A3S7WVB2 Leishmania donovani 84% 100%
A0A422N059 Trypanosoma rangeli 39% 100%
A4HA16 Leishmania braziliensis 71% 100%
A4HY78 Leishmania infantum 83% 100%
A4HY79 Leishmania infantum 84% 100%
C9ZWF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 97%
E9AS08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QDG4 Leishmania major 82% 100%
Q4QDG5 Leishmania major 81% 100%
V5C1U9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS