Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS08_LEIMU

TriTrypDb:

LmxM.19.0570

Length:

518

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 19, no: 1
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9AS08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	516	518	PF00675	0.561
CLV_PCSK_SKI1_1	367	371	PF00082	0.649
DEG_SPOP_SBC_1	469	473	PF00917	0.326
DOC_MAPK_MEF2A_6	106	115	PF00069	0.569
DOC_USP7_MATH_1	25	29	PF00917	0.509
LIG_14-3-3_CanoR_1	157	163	PF00244	0.477
LIG_14-3-3_CanoR_1	470	475	PF00244	0.389
LIG_14-3-3_CanoR_1	53	62	PF00244	0.458
LIG_BRCT_BRCA1_1	175	179	PF00533	0.407
LIG_EH1_1	219	227	PF00400	0.536
LIG_EH1_1	479	487	PF00400	0.386
LIG_FHA_1	159	165	PF00498	0.462
LIG_FHA_1	188	194	PF00498	0.451
LIG_FHA_1	204	210	PF00498	0.348
LIG_FHA_1	258	264	PF00498	0.498
LIG_FHA_1	3	9	PF00498	0.629
LIG_FHA_1	369	375	PF00498	0.419
LIG_FHA_1	406	412	PF00498	0.399
LIG_FHA_1	442	448	PF00498	0.422
LIG_FHA_1	469	475	PF00498	0.383
LIG_FHA_1	49	55	PF00498	0.435
LIG_FHA_2	377	383	PF00498	0.523
LIG_FHA_2	456	462	PF00498	0.482
LIG_GBD_Chelix_1	250	258	PF00786	0.388
LIG_LIR_Apic_2	32	38	PF02991	0.293
LIG_LIR_Apic_2	363	368	PF02991	0.398
LIG_LIR_Apic_2	428	432	PF02991	0.396
LIG_LIR_Gen_1	176	185	PF02991	0.365
LIG_LIR_Gen_1	190	200	PF02991	0.388
LIG_LIR_Gen_1	295	305	PF02991	0.429
LIG_LIR_Gen_1	398	406	PF02991	0.489
LIG_LIR_Nem_3	176	182	PF02991	0.362
LIG_LIR_Nem_3	190	195	PF02991	0.358
LIG_LIR_Nem_3	198	203	PF02991	0.370
LIG_LIR_Nem_3	242	248	PF02991	0.343
LIG_LIR_Nem_3	295	301	PF02991	0.431
LIG_LIR_Nem_3	398	402	PF02991	0.521
LIG_LIR_Nem_3	428	434	PF02991	0.492
LIG_LIR_Nem_3	56	61	PF02991	0.382
LIG_LYPXL_S_1	62	66	PF13949	0.565
LIG_PCNA_yPIPBox_3	186	197	PF02747	0.323
LIG_Pex14_1	241	245	PF04695	0.614
LIG_Pex14_2	248	252	PF04695	0.406
LIG_SH2_CRK	129	133	PF00017	0.447
LIG_SH2_GRB2like	152	155	PF00017	0.406
LIG_SH2_NCK_1	277	281	PF00017	0.282
LIG_SH2_NCK_1	93	97	PF00017	0.549
LIG_SH2_PTP2	192	195	PF00017	0.488
LIG_SH2_PTP2	365	368	PF00017	0.398
LIG_SH2_PTP2	429	432	PF00017	0.453
LIG_SH2_SRC	492	495	PF00017	0.322
LIG_SH2_SRC	61	64	PF00017	0.436
LIG_SH2_STAP1	405	409	PF00017	0.470
LIG_SH2_STAT3	409	412	PF00017	0.358
LIG_SH2_STAT5	152	155	PF00017	0.376
LIG_SH2_STAT5	192	195	PF00017	0.396
LIG_SH2_STAT5	200	203	PF00017	0.375
LIG_SH2_STAT5	245	248	PF00017	0.365
LIG_SH2_STAT5	264	267	PF00017	0.304
LIG_SH2_STAT5	287	290	PF00017	0.337
LIG_SH2_STAT5	323	326	PF00017	0.282
LIG_SH2_STAT5	365	368	PF00017	0.451
LIG_SH2_STAT5	429	432	PF00017	0.441
LIG_SH2_STAT5	462	465	PF00017	0.528
LIG_SH2_STAT5	61	64	PF00017	0.368
LIG_SH3_3	168	174	PF00018	0.488
LIG_SUMO_SIM_anti_2	355	364	PF11976	0.463
LIG_TRFH_1	60	64	PF08558	0.468
LIG_TYR_ITIM	127	132	PF00017	0.507
LIG_TYR_ITIM	397	402	PF00017	0.313
MOD_CK1_1	391	397	PF00069	0.404
MOD_CK1_1	40	46	PF00069	0.433
MOD_CK1_1	455	461	PF00069	0.574
MOD_CK2_1	376	382	PF00069	0.492
MOD_CK2_1	40	46	PF00069	0.491
MOD_GlcNHglycan	167	170	PF01048	0.668
MOD_GlcNHglycan	178	182	PF01048	0.616
MOD_GlcNHglycan	23	26	PF01048	0.612
MOD_GlcNHglycan	233	236	PF01048	0.511
MOD_GlcNHglycan	266	269	PF01048	0.634
MOD_GlcNHglycan	314	317	PF01048	0.642
MOD_GlcNHglycan	466	469	PF01048	0.673
MOD_GSK3_1	142	149	PF00069	0.473
MOD_GSK3_1	158	165	PF00069	0.318
MOD_GSK3_1	173	180	PF00069	0.389
MOD_GSK3_1	21	28	PF00069	0.511
MOD_GSK3_1	346	353	PF00069	0.418
MOD_GSK3_1	36	43	PF00069	0.348
MOD_GSK3_1	421	428	PF00069	0.395
MOD_GSK3_1	464	471	PF00069	0.456
MOD_N-GLC_1	153	158	PF02516	0.569
MOD_N-GLC_1	165	170	PF02516	0.587
MOD_N-GLC_1	185	190	PF02516	0.572
MOD_N-GLC_1	376	381	PF02516	0.720
MOD_N-GLC_1	40	45	PF02516	0.675
MOD_N-GLC_1	421	426	PF02516	0.579
MOD_N-GLC_1	452	457	PF02516	0.688
MOD_N-GLC_2	322	324	PF02516	0.642
MOD_NEK2_1	153	158	PF00069	0.453
MOD_NEK2_1	162	167	PF00069	0.444
MOD_NEK2_1	18	23	PF00069	0.552
MOD_NEK2_1	275	280	PF00069	0.336
MOD_NEK2_1	370	375	PF00069	0.435
MOD_NEK2_1	475	480	PF00069	0.399
MOD_NEK2_1	510	515	PF00069	0.639
MOD_NEK2_1	71	76	PF00069	0.444
MOD_OFUCOSY	236	243	PF10250	0.435
MOD_OFUCOSY	387	392	PF10250	0.572
MOD_PIKK_1	304	310	PF00454	0.483
MOD_PIKK_1	346	352	PF00454	0.446
MOD_PIKK_1	455	461	PF00454	0.478
MOD_PIKK_1	53	59	PF00454	0.450
MOD_PK_1	407	413	PF00069	0.351
MOD_PK_1	470	476	PF00069	0.363
MOD_PK_1	496	502	PF00069	0.512
MOD_PKA_2	231	237	PF00069	0.640
MOD_PKA_2	469	475	PF00069	0.436
MOD_Plk_1	158	164	PF00069	0.422
MOD_Plk_1	177	183	PF00069	0.360
MOD_Plk_1	185	191	PF00069	0.386
MOD_Plk_1	40	46	PF00069	0.474
MOD_Plk_1	452	458	PF00069	0.503
MOD_Plk_1	508	514	PF00069	0.702
MOD_Plk_2-3	146	152	PF00069	0.499
MOD_Plk_4	128	134	PF00069	0.385
MOD_Plk_4	2	8	PF00069	0.577
MOD_Plk_4	30	36	PF00069	0.454
MOD_Plk_4	361	367	PF00069	0.374
MOD_Plk_4	40	46	PF00069	0.492
MOD_Plk_4	425	431	PF00069	0.429
MOD_Plk_4	470	476	PF00069	0.333
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.386
TRG_ENDOCYTIC_2	129	132	PF00928	0.448
TRG_ENDOCYTIC_2	192	195	PF00928	0.457
TRG_ENDOCYTIC_2	245	248	PF00928	0.333
TRG_ENDOCYTIC_2	399	402	PF00928	0.352
TRG_ENDOCYTIC_2	63	66	PF00928	0.322
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y8	Leptomonas seymouri	52%	100%
A0A0S4ITY9	Bodo saltans	26%	100%
A0A0S4IXB1	Bodo saltans	27%	100%
A0A0S4IXU4	Bodo saltans	28%	98%
A0A1X0NVP9	Trypanosomatidae	38%	100%
A0A1X0NWC8	Trypanosomatidae	35%	100%
A0A1X0P6A6	Trypanosomatidae	31%	100%
A0A3Q8IB78	Leishmania donovani	84%	100%
A0A3S7WVB2	Leishmania donovani	83%	98%
A0A422N059	Trypanosoma rangeli	39%	100%
A4HA16	Leishmania braziliensis	70%	100%
A4HY78	Leishmania infantum	84%	100%
A4HY79	Leishmania infantum	82%	98%
C9ZWF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
D0A5X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	91%
E9AS09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
Q4QDG4	Leishmania major	82%	100%
Q4QDG5	Leishmania major	82%	100%
V5C1U9	Trypanosoma cruzi	31%	100%