Methionine aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan MG, Family M24

Species:

Leishmania mexicana

UniProt:

E9AS06_LEIMU

TriTrypDb:

LmxM.19.0550

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS06

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044238	primary metabolic process	2	13
GO:0070084	protein initiator methionine removal	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0016485	protein processing	5	1
GO:0035551	protein initiator methionine removal involved in protein maturation	6	1
GO:0051604	protein maturation	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004177	aminopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008235	metalloexopeptidase activity	5	13
GO:0008237	metallopeptidase activity	4	13
GO:0008238	exopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0070006	metalloaminopeptidase activity	6	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.289
CLV_C14_Caspase3-7	372	376	PF00656	0.391
CLV_C14_Caspase3-7	94	98	PF00656	0.476
CLV_NRD_NRD_1	130	132	PF00675	0.555
CLV_NRD_NRD_1	80	82	PF00675	0.413
CLV_PCSK_KEX2_1	130	132	PF00082	0.558
CLV_PCSK_KEX2_1	139	141	PF00082	0.379
CLV_PCSK_KEX2_1	351	353	PF00082	0.269
CLV_PCSK_KEX2_1	80	82	PF00082	0.413
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.412
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.283
CLV_PCSK_SKI1_1	146	150	PF00082	0.269
CLV_PCSK_SKI1_1	382	386	PF00082	0.341
DOC_CKS1_1	361	366	PF01111	0.412
DOC_CYCLIN_RxL_1	16	26	PF00134	0.447
DOC_MAPK_gen_1	130	138	PF00069	0.480
DOC_MAPK_gen_1	382	391	PF00069	0.443
DOC_PP2B_LxvP_1	21	24	PF13499	0.447
DOC_PP4_FxxP_1	68	71	PF00568	0.418
DOC_USP7_MATH_1	279	283	PF00917	0.372
DOC_USP7_MATH_2	392	398	PF00917	0.597
DOC_WW_Pin1_4	178	183	PF00397	0.283
DOC_WW_Pin1_4	310	315	PF00397	0.380
DOC_WW_Pin1_4	360	365	PF00397	0.412
DOC_WW_Pin1_4	75	80	PF00397	0.403
LIG_14-3-3_CanoR_1	130	138	PF00244	0.422
LIG_Actin_WH2_2	58	75	PF00022	0.536
LIG_deltaCOP1_diTrp_1	336	343	PF00928	0.269
LIG_deltaCOP1_diTrp_1	372	379	PF00928	0.478
LIG_EVH1_2	24	28	PF00568	0.435
LIG_FHA_1	160	166	PF00498	0.294
LIG_FHA_1	232	238	PF00498	0.283
LIG_FHA_1	38	44	PF00498	0.529
LIG_FHA_1	46	52	PF00498	0.622
LIG_FHA_1	67	73	PF00498	0.410
LIG_FHA_2	159	165	PF00498	0.318
LIG_FHA_2	331	337	PF00498	0.276
LIG_FHA_2	55	61	PF00498	0.454
LIG_LIR_Apic_2	386	390	PF02991	0.482
LIG_LIR_Gen_1	250	259	PF02991	0.344
LIG_LIR_Gen_1	333	340	PF02991	0.306
LIG_LIR_Nem_3	265	271	PF02991	0.301
LIG_LIR_Nem_3	333	337	PF02991	0.299
LIG_PDZ_Class_2	396	401	PF00595	0.641
LIG_Pex14_2	34	38	PF04695	0.435
LIG_SH2_CRK	186	190	PF00017	0.283
LIG_SH2_CRK	268	272	PF00017	0.319
LIG_SH2_GRB2like	185	188	PF00017	0.299
LIG_SH2_NCK_1	124	128	PF00017	0.444
LIG_SH2_SRC	223	226	PF00017	0.318
LIG_SH2_STAP1	252	256	PF00017	0.342
LIG_SH2_STAT3	380	383	PF00017	0.322
LIG_SH2_STAT5	223	226	PF00017	0.299
LIG_SH2_STAT5	270	273	PF00017	0.408
LIG_SH2_STAT5	290	293	PF00017	0.117
LIG_SH3_2	71	76	PF14604	0.457
LIG_SH3_3	234	240	PF00018	0.299
LIG_SH3_3	258	264	PF00018	0.299
LIG_SH3_3	334	340	PF00018	0.269
LIG_SH3_3	358	364	PF00018	0.372
LIG_SH3_3	68	74	PF00018	0.411
LIG_SUMO_SIM_anti_2	365	372	PF11976	0.483
LIG_TRAF2_1	209	212	PF00917	0.372
LIG_TRAF2_1	240	243	PF00917	0.399
LIG_UBA3_1	135	139	PF00899	0.412
LIG_UBA3_1	255	263	PF00899	0.372
MOD_CDK_SPK_2	75	80	PF00069	0.402
MOD_CDK_SPxK_1	75	81	PF00069	0.401
MOD_CK1_1	191	197	PF00069	0.269
MOD_CK1_1	282	288	PF00069	0.372
MOD_CK2_1	158	164	PF00069	0.319
MOD_CK2_1	192	198	PF00069	0.274
MOD_CK2_1	54	60	PF00069	0.549
MOD_CK2_1	97	103	PF00069	0.410
MOD_Cter_Amidation	349	352	PF01082	0.269
MOD_GlcNHglycan	344	347	PF01048	0.306
MOD_GSK3_1	188	195	PF00069	0.281
MOD_GSK3_1	19	26	PF00069	0.449
MOD_GSK3_1	282	289	PF00069	0.299
MOD_GSK3_1	356	363	PF00069	0.292
MOD_N-GLC_1	231	236	PF02516	0.283
MOD_N-GLC_1	310	315	PF02516	0.274
MOD_N-GLC_1	341	346	PF02516	0.299
MOD_N-GLC_1	66	71	PF02516	0.433
MOD_N-GLC_2	304	306	PF02516	0.387
MOD_NEK2_1	231	236	PF00069	0.304
MOD_NEK2_1	298	303	PF00069	0.275
MOD_NEK2_1	356	361	PF00069	0.272
MOD_NEK2_1	66	71	PF00069	0.385
MOD_PIKK_1	27	33	PF00454	0.426
MOD_PKA_1	130	136	PF00069	0.475
MOD_PKA_1	19	25	PF00069	0.510
MOD_PKA_2	106	112	PF00069	0.449
MOD_PKA_2	129	135	PF00069	0.478
MOD_Plk_1	218	224	PF00069	0.293
MOD_Plk_1	231	237	PF00069	0.259
MOD_Plk_1	241	247	PF00069	0.283
MOD_Plk_1	282	288	PF00069	0.201
MOD_Plk_1	335	341	PF00069	0.269
MOD_Plk_1	356	362	PF00069	0.283
MOD_Plk_2-3	97	103	PF00069	0.500
MOD_Plk_4	23	29	PF00069	0.445
MOD_Plk_4	231	237	PF00069	0.338
MOD_Plk_4	282	288	PF00069	0.283
MOD_Plk_4	356	362	PF00069	0.283
MOD_ProDKin_1	178	184	PF00069	0.283
MOD_ProDKin_1	310	316	PF00069	0.380
MOD_ProDKin_1	360	366	PF00069	0.412
MOD_ProDKin_1	75	81	PF00069	0.402
MOD_SUMO_rev_2	345	353	PF00179	0.299
MOD_SUMO_rev_2	394	401	PF00179	0.622
TRG_DiLeu_BaEn_1	365	370	PF01217	0.506
TRG_DiLeu_BaEn_3	242	248	PF01217	0.323
TRG_ENDOCYTIC_2	185	188	PF00928	0.269
TRG_ENDOCYTIC_2	252	255	PF00928	0.280
TRG_ENDOCYTIC_2	268	271	PF00928	0.232
TRG_ER_diArg_1	129	131	PF00400	0.494
TRG_ER_diArg_1	79	81	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB6	Leptomonas seymouri	85%	97%
A0A0S4IW90	Bodo saltans	65%	100%
A0A0S4IXB9	Bodo saltans	54%	100%
A0A1X0P6I6	Trypanosomatidae	72%	100%
A0A3R7P3I2	Trypanosoma rangeli	72%	100%
A0A3S7WVI9	Leishmania donovani	98%	100%
A4HA12	Leishmania braziliensis	92%	100%
A4HY76	Leishmania infantum	98%	100%
A6QLA4	Bos taurus	52%	100%
D0A0J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
O31689	Bacillus subtilis (strain 168)	24%	100%
O59730	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P0A5J3	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	43%	100%
P53582	Homo sapiens	52%	100%
P9WK18	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WK19	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q01662	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q4QDG7	Leishmania major	96%	100%
Q4QRK0	Danio rerio	53%	100%
Q4VBS4	Danio rerio	41%	100%
Q54VU7	Dictyostelium discoideum	40%	99%
Q54WU3	Dictyostelium discoideum	50%	100%
Q5I0A0	Xenopus tropicalis	52%	100%
Q5RBF3	Pongo abelii	52%	100%
Q5ZIM5	Gallus gallus	52%	100%
Q6UB28	Homo sapiens	37%	100%
Q7ZWV9	Xenopus laevis	53%	100%
Q8BP48	Mus musculus	52%	100%
Q8IJP2	Plasmodium falciparum (isolate 3D7)	46%	78%
Q9CPW9	Mus musculus	38%	100%
Q9FV50	Arabidopsis thaliana	45%	100%
Q9FV51	Arabidopsis thaliana	41%	100%
Q9FV52	Arabidopsis thaliana	45%	100%
Q9SLN5	Arabidopsis thaliana	47%	100%
V5DTM6	Trypanosoma cruzi	71%	100%