Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS05_LEIMU

TriTrypDb:

LmxM.19.0530

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1

Expansion

Sequence features

E9AS05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.752
CLV_C14_Caspase3-7	606	610	PF00656	0.562
CLV_C14_Caspase3-7	727	731	PF00656	0.787
CLV_C14_Caspase3-7	758	762	PF00656	0.734
CLV_NRD_NRD_1	159	161	PF00675	0.531
CLV_NRD_NRD_1	333	335	PF00675	0.560
CLV_NRD_NRD_1	381	383	PF00675	0.716
CLV_NRD_NRD_1	635	637	PF00675	0.794
CLV_NRD_NRD_1	750	752	PF00675	0.709
CLV_PCSK_FUR_1	217	221	PF00082	0.804
CLV_PCSK_KEX2_1	159	161	PF00082	0.531
CLV_PCSK_KEX2_1	219	221	PF00082	0.649
CLV_PCSK_KEX2_1	293	295	PF00082	0.829
CLV_PCSK_KEX2_1	333	335	PF00082	0.525
CLV_PCSK_KEX2_1	381	383	PF00082	0.646
CLV_PCSK_KEX2_1	634	636	PF00082	0.777
CLV_PCSK_KEX2_1	749	751	PF00082	0.707
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.649
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.801
CLV_PCSK_SKI1_1	394	398	PF00082	0.526
CLV_PCSK_SKI1_1	495	499	PF00082	0.469
CLV_PCSK_SKI1_1	556	560	PF00082	0.538
CLV_PCSK_SKI1_1	708	712	PF00082	0.783
CLV_PCSK_SKI1_1	751	755	PF00082	0.673
CLV_PCSK_SKI1_1	900	904	PF00082	0.601
DEG_APCC_DBOX_1	890	898	PF00400	0.678
DEG_Nend_UBRbox_2	1	3	PF02207	0.531
DEG_ODPH_VHL_1	64	76	PF01847	0.585
DEG_SCF_FBW7_1	752	758	PF00400	0.636
DEG_SIAH_1	149	157	PF03145	0.568
DEG_SPOP_SBC_1	66	70	PF00917	0.525
DEG_SPOP_SBC_1	803	807	PF00917	0.608
DEG_SPOP_SBC_1	852	856	PF00917	0.637
DOC_CKS1_1	361	366	PF01111	0.636
DOC_CKS1_1	37	42	PF01111	0.572
DOC_CKS1_1	752	757	PF01111	0.696
DOC_CYCLIN_RxL_1	459	468	PF00134	0.453
DOC_CYCLIN_RxL_1	550	561	PF00134	0.323
DOC_MAPK_gen_1	550	559	PF00069	0.335
DOC_MAPK_gen_1	713	721	PF00069	0.722
DOC_MAPK_MEF2A_6	116	123	PF00069	0.551
DOC_PIKK_1	649	656	PF02985	0.595
DOC_PP1_RVXF_1	258	265	PF00149	0.750
DOC_PP2B_LxvP_1	238	241	PF13499	0.742
DOC_PP2B_LxvP_1	487	490	PF13499	0.543
DOC_PP2B_LxvP_1	599	602	PF13499	0.597
DOC_PP2B_LxvP_1	637	640	PF13499	0.751
DOC_USP7_MATH_1	11	15	PF00917	0.665
DOC_USP7_MATH_1	186	190	PF00917	0.742
DOC_USP7_MATH_1	202	206	PF00917	0.569
DOC_USP7_MATH_1	271	275	PF00917	0.727
DOC_USP7_MATH_1	49	53	PF00917	0.588
DOC_USP7_MATH_1	66	70	PF00917	0.541
DOC_USP7_MATH_1	687	691	PF00917	0.698
DOC_USP7_MATH_1	709	713	PF00917	0.679
DOC_USP7_MATH_1	744	748	PF00917	0.681
DOC_USP7_MATH_1	753	757	PF00917	0.724
DOC_USP7_MATH_1	81	85	PF00917	0.525
DOC_USP7_MATH_1	820	824	PF00917	0.657
DOC_USP7_MATH_1	859	863	PF00917	0.710
DOC_USP7_MATH_1	876	880	PF00917	0.689
DOC_USP7_MATH_1	902	906	PF00917	0.731
DOC_WW_Pin1_4	13	18	PF00397	0.569
DOC_WW_Pin1_4	24	29	PF00397	0.501
DOC_WW_Pin1_4	36	41	PF00397	0.719
DOC_WW_Pin1_4	360	365	PF00397	0.637
DOC_WW_Pin1_4	495	500	PF00397	0.465
DOC_WW_Pin1_4	54	59	PF00397	0.492
DOC_WW_Pin1_4	575	580	PF00397	0.699
DOC_WW_Pin1_4	620	625	PF00397	0.546
DOC_WW_Pin1_4	626	631	PF00397	0.503
DOC_WW_Pin1_4	68	73	PF00397	0.609
DOC_WW_Pin1_4	7	12	PF00397	0.579
DOC_WW_Pin1_4	751	756	PF00397	0.676
DOC_WW_Pin1_4	788	793	PF00397	0.539
LIG_14-3-3_CanoR_1	242	252	PF00244	0.757
LIG_14-3-3_CanoR_1	307	313	PF00244	0.682
LIG_14-3-3_CanoR_1	318	322	PF00244	0.640
LIG_14-3-3_CanoR_1	35	40	PF00244	0.679
LIG_14-3-3_CanoR_1	394	401	PF00244	0.595
LIG_14-3-3_CanoR_1	50	54	PF00244	0.604
LIG_14-3-3_CanoR_1	534	539	PF00244	0.454
LIG_14-3-3_CanoR_1	686	696	PF00244	0.702
LIG_14-3-3_CanoR_1	796	802	PF00244	0.538
LIG_14-3-3_CanoR_1	837	847	PF00244	0.791
LIG_BRCT_BRCA1_1	90	94	PF00533	0.579
LIG_deltaCOP1_diTrp_1	403	407	PF00928	0.506
LIG_deltaCOP1_diTrp_1	824	831	PF00928	0.754
LIG_FHA_1	204	210	PF00498	0.700
LIG_FHA_1	235	241	PF00498	0.623
LIG_FHA_1	267	273	PF00498	0.694
LIG_FHA_1	356	362	PF00498	0.746
LIG_FHA_1	395	401	PF00498	0.573
LIG_FHA_1	413	419	PF00498	0.398
LIG_FHA_1	504	510	PF00498	0.487
LIG_FHA_1	69	75	PF00498	0.581
LIG_FHA_1	734	740	PF00498	0.691
LIG_FHA_1	743	749	PF00498	0.695
LIG_FHA_1	804	810	PF00498	0.708
LIG_FHA_2	183	189	PF00498	0.741
LIG_FHA_2	387	393	PF00498	0.684
LIG_FHA_2	403	409	PF00498	0.482
LIG_FHA_2	604	610	PF00498	0.516
LIG_FHA_2	641	647	PF00498	0.761
LIG_FHA_2	78	84	PF00498	0.526
LIG_FHA_2	867	873	PF00498	0.775
LIG_LIR_Gen_1	405	414	PF02991	0.511
LIG_LIR_Gen_1	456	466	PF02991	0.439
LIG_LIR_Gen_1	667	676	PF02991	0.630
LIG_LIR_Gen_1	825	836	PF02991	0.749
LIG_LIR_Nem_3	2	6	PF02991	0.510
LIG_LIR_Nem_3	405	410	PF02991	0.511
LIG_LIR_Nem_3	456	461	PF02991	0.447
LIG_LIR_Nem_3	486	491	PF02991	0.456
LIG_LIR_Nem_3	553	558	PF02991	0.505
LIG_LIR_Nem_3	667	672	PF02991	0.599
LIG_LIR_Nem_3	825	831	PF02991	0.652
LIG_LIR_Nem_3	862	866	PF02991	0.792
LIG_MYND_1	696	700	PF01753	0.685
LIG_MYND_3	601	605	PF01753	0.539
LIG_Pex14_2	710	714	PF04695	0.789
LIG_SH2_CRK	176	180	PF00017	0.768
LIG_SH2_CRK	555	559	PF00017	0.346
LIG_SH2_CRK	684	688	PF00017	0.687
LIG_SH2_NCK_1	176	180	PF00017	0.640
LIG_SH2_NCK_1	684	688	PF00017	0.670
LIG_SH2_STAP1	176	180	PF00017	0.516
LIG_SH2_STAP1	391	395	PF00017	0.607
LIG_SH2_STAT5	279	282	PF00017	0.693
LIG_SH2_STAT5	30	33	PF00017	0.595
LIG_SH2_STAT5	463	466	PF00017	0.450
LIG_SH2_STAT5	488	491	PF00017	0.462
LIG_SH2_STAT5	684	687	PF00017	0.668
LIG_SH2_STAT5	797	800	PF00017	0.741
LIG_SH2_STAT5	868	871	PF00017	0.711
LIG_SH3_1	55	61	PF00018	0.643
LIG_SH3_2	58	63	PF14604	0.601
LIG_SH3_3	34	40	PF00018	0.620
LIG_SH3_3	358	364	PF00018	0.744
LIG_SH3_3	55	61	PF00018	0.599
LIG_SH3_3	573	579	PF00018	0.790
LIG_SH3_3	69	75	PF00018	0.563
LIG_SH3_3	703	709	PF00018	0.671
LIG_SUMO_SIM_anti_2	408	415	PF11976	0.498
LIG_SUMO_SIM_anti_2	506	511	PF11976	0.474
LIG_SUMO_SIM_par_1	504	511	PF11976	0.483
LIG_SUMO_SIM_par_1	556	561	PF11976	0.341
LIG_TRAF2_1	629	632	PF00917	0.765
LIG_TRAF2_1	823	826	PF00917	0.749
LIG_TYR_ITIM	461	466	PF00017	0.455
LIG_UBA3_1	211	219	PF00899	0.801
MOD_CK1_1	13	19	PF00069	0.742
MOD_CK1_1	178	184	PF00069	0.791
MOD_CK1_1	189	195	PF00069	0.646
MOD_CK1_1	226	232	PF00069	0.714
MOD_CK1_1	24	30	PF00069	0.558
MOD_CK1_1	299	305	PF00069	0.690
MOD_CK1_1	313	319	PF00069	0.714
MOD_CK1_1	355	361	PF00069	0.756
MOD_CK1_1	436	442	PF00069	0.478
MOD_CK1_1	615	621	PF00069	0.732
MOD_CK1_1	68	74	PF00069	0.581
MOD_CK1_1	712	718	PF00069	0.690
MOD_CK1_1	732	738	PF00069	0.679
MOD_CK1_1	756	762	PF00069	0.765
MOD_CK1_1	768	774	PF00069	0.696
MOD_CK1_1	838	844	PF00069	0.775
MOD_CK1_1	88	94	PF00069	0.579
MOD_CK2_1	121	127	PF00069	0.550
MOD_CK2_1	386	392	PF00069	0.693
MOD_CK2_1	402	408	PF00069	0.479
MOD_CK2_1	480	486	PF00069	0.559
MOD_CK2_1	625	631	PF00069	0.786
MOD_CK2_1	77	83	PF00069	0.587
MOD_CK2_1	820	826	PF00069	0.758
MOD_CK2_1	866	872	PF00069	0.677
MOD_CMANNOS	404	407	PF00535	0.438
MOD_GlcNHglycan	123	126	PF01048	0.546
MOD_GlcNHglycan	13	16	PF01048	0.782
MOD_GlcNHglycan	191	194	PF01048	0.784
MOD_GlcNHglycan	200	203	PF01048	0.739
MOD_GlcNHglycan	225	228	PF01048	0.700
MOD_GlcNHglycan	23	26	PF01048	0.588
MOD_GlcNHglycan	246	249	PF01048	0.775
MOD_GlcNHglycan	255	258	PF01048	0.597
MOD_GlcNHglycan	296	299	PF01048	0.755
MOD_GlcNHglycan	312	315	PF01048	0.629
MOD_GlcNHglycan	341	345	PF01048	0.780
MOD_GlcNHglycan	383	386	PF01048	0.514
MOD_GlcNHglycan	503	506	PF01048	0.522
MOD_GlcNHglycan	572	575	PF01048	0.689
MOD_GlcNHglycan	691	694	PF01048	0.651
MOD_GlcNHglycan	766	770	PF01048	0.805
MOD_GlcNHglycan	772	775	PF01048	0.727
MOD_GlcNHglycan	783	786	PF01048	0.591
MOD_GlcNHglycan	841	844	PF01048	0.797
MOD_GlcNHglycan	849	852	PF01048	0.674
MOD_GlcNHglycan	855	858	PF01048	0.727
MOD_GSK3_1	140	147	PF00069	0.619
MOD_GSK3_1	174	181	PF00069	0.705
MOD_GSK3_1	182	189	PF00069	0.676
MOD_GSK3_1	194	201	PF00069	0.708
MOD_GSK3_1	211	218	PF00069	0.738
MOD_GSK3_1	222	229	PF00069	0.753
MOD_GSK3_1	244	251	PF00069	0.797
MOD_GSK3_1	294	301	PF00069	0.720
MOD_GSK3_1	308	315	PF00069	0.616
MOD_GSK3_1	31	38	PF00069	0.769
MOD_GSK3_1	381	388	PF00069	0.682
MOD_GSK3_1	390	397	PF00069	0.624
MOD_GSK3_1	433	440	PF00069	0.524
MOD_GSK3_1	465	472	PF00069	0.446
MOD_GSK3_1	6	13	PF00069	0.596
MOD_GSK3_1	612	619	PF00069	0.706
MOD_GSK3_1	682	689	PF00069	0.659
MOD_GSK3_1	708	715	PF00069	0.700
MOD_GSK3_1	720	727	PF00069	0.745
MOD_GSK3_1	729	736	PF00069	0.740
MOD_GSK3_1	751	758	PF00069	0.734
MOD_GSK3_1	77	84	PF00069	0.656
MOD_GSK3_1	797	804	PF00069	0.623
MOD_GSK3_1	831	838	PF00069	0.665
MOD_GSK3_1	847	854	PF00069	0.548
MOD_N-GLC_1	299	304	PF02516	0.697
MOD_N-GLC_1	443	448	PF02516	0.474
MOD_N-GLC_1	742	747	PF02516	0.792
MOD_N-GLC_2	467	469	PF02516	0.467
MOD_NEK2_1	211	216	PF00069	0.736
MOD_NEK2_1	233	238	PF00069	0.815
MOD_NEK2_1	264	269	PF00069	0.811
MOD_NEK2_1	31	36	PF00069	0.626
MOD_NEK2_1	340	345	PF00069	0.692
MOD_NEK2_1	390	395	PF00069	0.604
MOD_NEK2_1	412	417	PF00069	0.458
MOD_NEK2_1	443	448	PF00069	0.474
MOD_NEK2_1	501	506	PF00069	0.591
MOD_NEK2_1	625	630	PF00069	0.774
MOD_NEK2_1	831	836	PF00069	0.662
MOD_NEK2_1	853	858	PF00069	0.801
MOD_NEK2_1	866	871	PF00069	0.622
MOD_NEK2_2	465	470	PF00069	0.448
MOD_NEK2_2	744	749	PF00069	0.678
MOD_NEK2_2	81	86	PF00069	0.518
MOD_PIKK_1	226	232	PF00454	0.714
MOD_PIKK_1	255	261	PF00454	0.558
MOD_PIKK_1	866	872	PF00454	0.780
MOD_PKA_1	381	387	PF00069	0.686
MOD_PKA_2	244	250	PF00069	0.758
MOD_PKA_2	31	37	PF00069	0.747
MOD_PKA_2	317	323	PF00069	0.654
MOD_PKA_2	381	387	PF00069	0.680
MOD_PKA_2	49	55	PF00069	0.595
MOD_PKA_2	685	691	PF00069	0.693
MOD_PKA_2	712	718	PF00069	0.690
MOD_PKA_2	847	853	PF00069	0.526
MOD_PKB_1	220	228	PF00069	0.818
MOD_Plk_1	264	270	PF00069	0.674
MOD_Plk_1	352	358	PF00069	0.655
MOD_Plk_1	385	391	PF00069	0.659
MOD_Plk_1	612	618	PF00069	0.647
MOD_Plk_1	729	735	PF00069	0.684
MOD_Plk_1	892	898	PF00069	0.559
MOD_Plk_2-3	386	392	PF00069	0.655
MOD_Plk_4	126	132	PF00069	0.493
MOD_Plk_4	386	392	PF00069	0.655
MOD_Plk_4	480	486	PF00069	0.559
MOD_Plk_4	534	540	PF00069	0.586
MOD_Plk_4	729	735	PF00069	0.667
MOD_Plk_4	831	837	PF00069	0.648
MOD_Plk_4	876	882	PF00069	0.469
MOD_ProDKin_1	24	30	PF00069	0.504
MOD_ProDKin_1	36	42	PF00069	0.717
MOD_ProDKin_1	360	366	PF00069	0.636
MOD_ProDKin_1	495	501	PF00069	0.468
MOD_ProDKin_1	54	60	PF00069	0.491
MOD_ProDKin_1	575	581	PF00069	0.696
MOD_ProDKin_1	620	626	PF00069	0.550
MOD_ProDKin_1	68	74	PF00069	0.608
MOD_ProDKin_1	7	13	PF00069	0.580
MOD_ProDKin_1	751	757	PF00069	0.677
MOD_ProDKin_1	788	794	PF00069	0.542
MOD_SUMO_for_1	370	373	PF00179	0.675
MOD_SUMO_rev_2	584	589	PF00179	0.526
TRG_DiLeu_BaEn_1	408	413	PF01217	0.496
TRG_DiLeu_BaEn_1	654	659	PF01217	0.586
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.591
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.519
TRG_ENDOCYTIC_2	176	179	PF00928	0.743
TRG_ENDOCYTIC_2	463	466	PF00928	0.450
TRG_ENDOCYTIC_2	488	491	PF00928	0.462
TRG_ENDOCYTIC_2	555	558	PF00928	0.506
TRG_ENDOCYTIC_2	863	866	PF00928	0.794
TRG_ER_diArg_1	158	160	PF00400	0.535
TRG_ER_diArg_1	220	223	PF00400	0.712
TRG_ER_diArg_1	44	47	PF00400	0.615
TRG_ER_diArg_1	634	636	PF00400	0.777
TRG_ER_diArg_1	748	751	PF00400	0.705
TRG_ER_diArg_1	896	899	PF00400	0.598
TRG_NES_CRM1_1	408	423	PF08389	0.499
TRG_NES_CRM1_1	646	661	PF08389	0.599
TRG_NLS_MonoExtN_4	217	223	PF00514	0.810
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I334	Leptomonas seymouri	43%	100%
A0A3Q8IBC8	Leishmania donovani	89%	100%
A4HA11	Leishmania braziliensis	71%	98%
A4HY75	Leishmania infantum	88%	100%
Q4QDG8	Leishmania major	89%	100%