Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9AS04_LEIMU

TriTrypDb:

LmxM.19.0520

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.577
CLV_C14_Caspase3-7	470	474	PF00656	0.535
CLV_NRD_NRD_1	176	178	PF00675	0.434
CLV_NRD_NRD_1	206	208	PF00675	0.394
CLV_NRD_NRD_1	214	216	PF00675	0.469
CLV_NRD_NRD_1	243	245	PF00675	0.387
CLV_NRD_NRD_1	287	289	PF00675	0.545
CLV_NRD_NRD_1	290	292	PF00675	0.526
CLV_NRD_NRD_1	331	333	PF00675	0.501
CLV_NRD_NRD_1	433	435	PF00675	0.488
CLV_PCSK_FUR_1	136	140	PF00082	0.679
CLV_PCSK_FUR_1	288	292	PF00082	0.653
CLV_PCSK_KEX2_1	138	140	PF00082	0.670
CLV_PCSK_KEX2_1	175	177	PF00082	0.441
CLV_PCSK_KEX2_1	205	207	PF00082	0.321
CLV_PCSK_KEX2_1	243	245	PF00082	0.399
CLV_PCSK_KEX2_1	289	291	PF00082	0.579
CLV_PCSK_KEX2_1	433	435	PF00082	0.522
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.619
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.633
CLV_PCSK_SKI1_1	170	174	PF00082	0.406
CLV_PCSK_SKI1_1	257	261	PF00082	0.389
CLV_PCSK_SKI1_1	284	288	PF00082	0.612
CLV_PCSK_SKI1_1	326	330	PF00082	0.664
CLV_PCSK_SKI1_1	408	412	PF00082	0.427
DEG_APCC_DBOX_1	204	212	PF00400	0.401
DEG_SCF_TRCP1_1	79	84	PF00400	0.577
DOC_CKS1_1	364	369	PF01111	0.494
DOC_CYCLIN_RxL_1	354	368	PF00134	0.337
DOC_MAPK_gen_1	424	432	PF00069	0.425
DOC_MAPK_gen_1	538	545	PF00069	0.504
DOC_MAPK_MEF2A_6	424	432	PF00069	0.495
DOC_MAPK_RevD_3	419	434	PF00069	0.437
DOC_PP1_RVXF_1	233	240	PF00149	0.435
DOC_PP1_RVXF_1	252	259	PF00149	0.486
DOC_PP2B_LxvP_1	123	126	PF13499	0.615
DOC_USP7_UBL2_3	216	220	PF12436	0.476
DOC_WW_Pin1_4	11	16	PF00397	0.700
DOC_WW_Pin1_4	363	368	PF00397	0.499
LIG_14-3-3_CanoR_1	441	450	PF00244	0.508
LIG_14-3-3_CanoR_1	524	529	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	1	5	PF00533	0.677
LIG_BRCT_BRCA1_1	12	16	PF00533	0.677
LIG_CaM_IQ_9	192	208	PF13499	0.501
LIG_CaM_IQ_9	249	265	PF13499	0.405
LIG_CaM_IQ_9	425	441	PF13499	0.458
LIG_FHA_1	323	329	PF00498	0.422
LIG_FHA_1	375	381	PF00498	0.616
LIG_FHA_1	405	411	PF00498	0.416
LIG_FHA_2	151	157	PF00498	0.443
LIG_FHA_2	181	187	PF00498	0.567
LIG_FHA_2	22	28	PF00498	0.571
LIG_FHA_2	363	369	PF00498	0.546
LIG_LIR_Apic_2	122	127	PF02991	0.574
LIG_LIR_Gen_1	84	91	PF02991	0.445
LIG_LIR_Nem_3	166	172	PF02991	0.504
LIG_LIR_Nem_3	84	90	PF02991	0.592
LIG_PCNA_yPIPBox_3	157	169	PF02747	0.449
LIG_PTB_Apo_2	112	119	PF02174	0.444
LIG_PTB_Apo_2	233	240	PF02174	0.298
LIG_PTB_Phospho_1	112	118	PF10480	0.428
LIG_RPA_C_Fungi	447	459	PF08784	0.312
LIG_SH2_CRK	124	128	PF00017	0.492
LIG_SH2_CRK	510	514	PF00017	0.460
LIG_SH2_CRK	87	91	PF00017	0.495
LIG_SH2_GRB2like	113	116	PF00017	0.488
LIG_SH2_GRB2like	147	150	PF00017	0.569
LIG_SH2_GRB2like	414	417	PF00017	0.303
LIG_SH2_NCK_1	245	249	PF00017	0.454
LIG_SH2_SRC	113	116	PF00017	0.639
LIG_SH2_SRC	124	127	PF00017	0.673
LIG_SH2_SRC	245	248	PF00017	0.456
LIG_SH2_SRC	547	550	PF00017	0.665
LIG_SH2_STAP1	147	151	PF00017	0.540
LIG_SH2_STAP1	218	222	PF00017	0.347
LIG_SH2_STAP1	245	249	PF00017	0.461
LIG_SH2_STAP1	87	91	PF00017	0.512
LIG_SH2_STAT5	226	229	PF00017	0.473
LIG_SH2_STAT5	293	296	PF00017	0.434
LIG_SH2_STAT5	414	417	PF00017	0.407
LIG_SH2_STAT5	544	547	PF00017	0.576
LIG_SH3_1	12	18	PF00018	0.579
LIG_SH3_1	124	130	PF00018	0.469
LIG_SH3_3	12	18	PF00018	0.579
LIG_SH3_3	123	129	PF00018	0.586
LIG_SH3_3	331	337	PF00018	0.570
LIG_SH3_3	502	508	PF00018	0.497
LIG_SH3_3	559	565	PF00018	0.506
LIG_TRAF2_1	341	344	PF00917	0.399
MOD_CK1_1	26	32	PF00069	0.601
MOD_CK2_1	150	156	PF00069	0.442
MOD_CK2_1	362	368	PF00069	0.529
MOD_GlcNHglycan	41	44	PF01048	0.537
MOD_GlcNHglycan	473	477	PF01048	0.542
MOD_GlcNHglycan	59	62	PF01048	0.740
MOD_GlcNHglycan	79	82	PF01048	0.588
MOD_GSK3_1	21	28	PF00069	0.798
MOD_GSK3_1	315	322	PF00069	0.470
MOD_GSK3_1	404	411	PF00069	0.369
MOD_GSK3_1	77	84	PF00069	0.592
MOD_GSK3_1	89	96	PF00069	0.642
MOD_N-GLC_2	95	97	PF02516	0.562
MOD_NEK2_1	362	367	PF00069	0.568
MOD_NEK2_1	395	400	PF00069	0.509
MOD_NEK2_1	472	477	PF00069	0.529
MOD_NEK2_1	77	82	PF00069	0.642
MOD_NEK2_1	89	94	PF00069	0.720
MOD_PIKK_1	339	345	PF00454	0.607
MOD_PIKK_1	441	447	PF00454	0.375
MOD_PK_1	34	40	PF00069	0.584
MOD_PKA_2	299	305	PF00069	0.438
MOD_PKB_1	406	414	PF00069	0.455
MOD_PKB_1	439	447	PF00069	0.539
MOD_Plk_1	163	169	PF00069	0.503
MOD_Plk_1	26	32	PF00069	0.584
MOD_Plk_2-3	313	319	PF00069	0.519
MOD_Plk_4	549	555	PF00069	0.509
MOD_ProDKin_1	11	17	PF00069	0.703
MOD_ProDKin_1	363	369	PF00069	0.494
MOD_SUMO_for_1	461	464	PF00179	0.512
MOD_SUMO_rev_2	368	377	PF00179	0.593
TRG_ENDOCYTIC_2	113	116	PF00928	0.659
TRG_ENDOCYTIC_2	510	513	PF00928	0.461
TRG_ENDOCYTIC_2	87	90	PF00928	0.497
TRG_ER_diArg_1	175	177	PF00400	0.441
TRG_ER_diArg_1	205	207	PF00400	0.431
TRG_ER_diArg_1	243	245	PF00400	0.387
TRG_ER_diArg_1	288	291	PF00400	0.536
TRG_ER_diArg_1	432	434	PF00400	0.495
TRG_ER_diArg_1	439	442	PF00400	0.469
TRG_NLS_MonoCore_2	287	292	PF00514	0.619
TRG_NLS_MonoExtC_3	287	292	PF00514	0.619
TRG_NLS_MonoExtN_4	285	292	PF00514	0.550
TRG_NLS_MonoExtN_4	433	440	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9S0	Leptomonas seymouri	45%	95%
A0A1X0P7R9	Trypanosomatidae	32%	100%
A0A3S7WVD7	Leishmania donovani	83%	100%
A0A422P367	Trypanosoma rangeli	35%	100%
A4HA10	Leishmania braziliensis	63%	100%
A4HY74	Leishmania infantum	82%	100%
D0A0J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QDG9	Leishmania major	83%	100%
V5BSD1	Trypanosoma cruzi	35%	100%