Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS02_LEIMU

TriTrypDb:

LmxM.19.0500

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.508
CLV_NRD_NRD_1	215	217	PF00675	0.786
CLV_NRD_NRD_1	42	44	PF00675	0.497
CLV_NRD_NRD_1	93	95	PF00675	0.443
CLV_PCSK_KEX2_1	106	108	PF00082	0.523
CLV_PCSK_KEX2_1	215	217	PF00082	0.738
CLV_PCSK_KEX2_1	41	43	PF00082	0.499
CLV_PCSK_KEX2_1	75	77	PF00082	0.488
CLV_PCSK_KEX2_1	93	95	PF00082	0.410
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.502
CLV_PCSK_PC7_1	211	217	PF00082	0.780
CLV_PCSK_SKI1_1	144	148	PF00082	0.518
CLV_PCSK_SKI1_1	166	170	PF00082	0.457
CLV_PCSK_SKI1_1	244	248	PF00082	0.580
DEG_APCC_DBOX_1	150	158	PF00400	0.523
DEG_APCC_DBOX_1	83	91	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.623
DOC_ANK_TNKS_1	184	191	PF00023	0.509
DOC_MAPK_gen_1	153	163	PF00069	0.353
DOC_MAPK_MEF2A_6	156	163	PF00069	0.337
DOC_MIT_MIM_1	162	171	PF04212	0.529
DOC_PP4_FxxP_1	117	120	PF00568	0.516
DOC_USP7_MATH_1	189	193	PF00917	0.534
DOC_USP7_UBL2_3	260	264	PF12436	0.384
DOC_USP7_UBL2_3	57	61	PF12436	0.486
DOC_WW_Pin1_4	225	230	PF00397	0.699
DOC_WW_Pin1_4	234	239	PF00397	0.633
DOC_WW_Pin1_4	9	14	PF00397	0.599
LIG_14-3-3_CanoR_1	171	177	PF00244	0.419
LIG_14-3-3_CanoR_1	185	189	PF00244	0.400
LIG_14-3-3_CterR_2	294	299	PF00244	0.486
LIG_BRCT_BRCA1_1	113	117	PF00533	0.608
LIG_FHA_1	2	8	PF00498	0.642
LIG_FHA_2	121	127	PF00498	0.477
LIG_FHA_2	171	177	PF00498	0.555
LIG_FHA_2	76	82	PF00498	0.494
LIG_IRF3_LxIS_1	292	298	PF10401	0.455
LIG_LIR_Apic_2	114	120	PF02991	0.572
LIG_LIR_Gen_1	164	174	PF02991	0.423
LIG_LIR_Gen_1	228	238	PF02991	0.462
LIG_LIR_Nem_3	16	22	PF02991	0.480
LIG_LIR_Nem_3	164	170	PF02991	0.411
LIG_LIR_Nem_3	228	233	PF02991	0.470
LIG_MAD2	200	208	PF02301	0.523
LIG_NRBOX	34	40	PF00104	0.550
LIG_SH2_PTP2	22	25	PF00017	0.539
LIG_SH2_STAT5	22	25	PF00017	0.539
LIG_SH3_1	22	28	PF00018	0.538
LIG_SH3_3	106	112	PF00018	0.529
LIG_SH3_3	202	208	PF00018	0.543
LIG_SH3_3	22	28	PF00018	0.538
LIG_SH3_3	63	69	PF00018	0.562
LIG_SH3_4	57	64	PF00018	0.507
LIG_TRAF2_1	101	104	PF00917	0.504
LIG_TRAF2_1	173	176	PF00917	0.417
LIG_TRAF2_1	77	80	PF00917	0.456
MOD_CK1_1	194	200	PF00069	0.687
MOD_CK1_1	222	228	PF00069	0.751
MOD_CK1_1	234	240	PF00069	0.674
MOD_CK1_1	26	32	PF00069	0.536
MOD_CK2_1	120	126	PF00069	0.486
MOD_CK2_1	170	176	PF00069	0.474
MOD_CK2_1	260	266	PF00069	0.615
MOD_CK2_1	75	81	PF00069	0.468
MOD_Cter_Amidation	73	76	PF01082	0.531
MOD_GlcNHglycan	186	189	PF01048	0.538
MOD_GlcNHglycan	191	194	PF01048	0.592
MOD_GlcNHglycan	196	199	PF01048	0.574
MOD_GlcNHglycan	233	236	PF01048	0.703
MOD_GSK3_1	203	210	PF00069	0.636
MOD_GSK3_1	219	226	PF00069	0.734
MOD_GSK3_1	23	30	PF00069	0.578
MOD_GSK3_1	245	252	PF00069	0.603
MOD_GSK3_1	273	280	PF00069	0.473
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	170	175	PF00069	0.490
MOD_NEK2_1	184	189	PF00069	0.562
MOD_PIKK_1	210	216	PF00454	0.763
MOD_PKA_1	260	266	PF00069	0.378
MOD_PKA_1	75	81	PF00069	0.501
MOD_PKA_2	170	176	PF00069	0.472
MOD_PKA_2	184	190	PF00069	0.432
MOD_PKA_2	210	216	PF00069	0.691
MOD_PKA_2	75	81	PF00069	0.468
MOD_PKA_2	92	98	PF00069	0.480
MOD_Plk_1	1	7	PF00069	0.650
MOD_Plk_1	290	296	PF00069	0.378
MOD_Plk_4	277	283	PF00069	0.534
MOD_ProDKin_1	225	231	PF00069	0.702
MOD_ProDKin_1	234	240	PF00069	0.633
MOD_ProDKin_1	9	15	PF00069	0.586
MOD_SUMO_rev_2	258	263	PF00179	0.462
TRG_ER_diArg_1	106	108	PF00400	0.377
TRG_ER_diArg_1	151	154	PF00400	0.524
TRG_ER_diArg_1	41	43	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK6	Leptomonas seymouri	64%	98%
A0A1X0P771	Trypanosomatidae	40%	100%
A0A3S5H756	Leishmania donovani	90%	100%
A4HA08	Leishmania braziliensis	80%	100%
A4HY72	Leishmania infantum	89%	100%
D0A0J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QDH1	Leishmania major	90%	100%
V5DTM1	Trypanosoma cruzi	39%	100%