LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AS01_LEIMU
TriTrypDb:
LmxM.19.0490
Length:
287

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005635 nuclear envelope 4 1
GO:0005783 endoplasmic reticulum 5 1
GO:0020016 ciliary pocket 2 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AS01
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS01

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.363
CLV_NRD_NRD_1 10 12 PF00675 0.535
CLV_NRD_NRD_1 112 114 PF00675 0.634
CLV_NRD_NRD_1 153 155 PF00675 0.652
CLV_NRD_NRD_1 254 256 PF00675 0.491
CLV_NRD_NRD_1 276 278 PF00675 0.653
CLV_PCSK_KEX2_1 10 12 PF00082 0.535
CLV_PCSK_KEX2_1 112 114 PF00082 0.634
CLV_PCSK_KEX2_1 254 256 PF00082 0.491
CLV_PCSK_KEX2_1 276 278 PF00082 0.552
CLV_PCSK_PC7_1 108 114 PF00082 0.638
CLV_PCSK_PC7_1 272 278 PF00082 0.571
CLV_PCSK_SKI1_1 113 117 PF00082 0.636
CLV_PCSK_SKI1_1 268 272 PF00082 0.495
CLV_PCSK_SKI1_1 82 86 PF00082 0.576
DEG_APCC_DBOX_1 76 84 PF00400 0.423
DEG_Nend_UBRbox_3 1 3 PF02207 0.368
DEG_SCF_FBW7_1 83 89 PF00400 0.375
DOC_CKS1_1 83 88 PF01111 0.429
DOC_MAPK_gen_1 10 18 PF00069 0.333
DOC_MAPK_gen_1 158 166 PF00069 0.422
DOC_MAPK_gen_1 276 284 PF00069 0.342
DOC_MAPK_gen_1 40 47 PF00069 0.352
DOC_MAPK_MEF2A_6 11 20 PF00069 0.334
DOC_PP1_RVXF_1 252 259 PF00149 0.306
DOC_PP2B_LxvP_1 20 23 PF13499 0.345
DOC_PP4_FxxP_1 176 179 PF00568 0.383
DOC_USP7_MATH_1 120 124 PF00917 0.438
DOC_USP7_MATH_1 171 175 PF00917 0.408
DOC_USP7_MATH_1 23 27 PF00917 0.336
DOC_USP7_MATH_1 4 8 PF00917 0.343
DOC_USP7_MATH_1 86 90 PF00917 0.512
DOC_USP7_MATH_1 95 99 PF00917 0.456
DOC_USP7_UBL2_3 117 121 PF12436 0.496
DOC_WW_Pin1_4 82 87 PF00397 0.426
LIG_14-3-3_CanoR_1 10 20 PF00244 0.334
LIG_14-3-3_CanoR_1 255 261 PF00244 0.267
LIG_14-3-3_CanoR_1 40 47 PF00244 0.352
LIG_14-3-3_CanoR_1 52 60 PF00244 0.286
LIG_14-3-3_CanoR_1 61 67 PF00244 0.410
LIG_14-3-3_CanoR_1 94 100 PF00244 0.558
LIG_BRCT_BRCA1_1 62 66 PF00533 0.300
LIG_deltaCOP1_diTrp_1 218 227 PF00928 0.467
LIG_FHA_2 114 120 PF00498 0.476
LIG_FHA_2 122 128 PF00498 0.517
LIG_FHA_2 157 163 PF00498 0.426
LIG_GBD_Chelix_1 180 188 PF00786 0.339
LIG_LIR_Apic_2 174 179 PF02991 0.386
LIG_LIR_Gen_1 240 248 PF02991 0.306
LIG_LIR_Nem_3 102 107 PF02991 0.353
LIG_LIR_Nem_3 240 244 PF02991 0.336
LIG_NRBOX 277 283 PF00104 0.397
LIG_SH2_CRK 104 108 PF00017 0.427
LIG_SH2_CRK 233 237 PF00017 0.325
LIG_SH2_CRK 241 245 PF00017 0.436
LIG_SH2_STAP1 241 245 PF00017 0.306
LIG_SH2_STAP1 5 9 PF00017 0.333
LIG_SH2_STAT5 165 168 PF00017 0.407
LIG_SH2_STAT5 199 202 PF00017 0.339
LIG_SH2_STAT5 207 210 PF00017 0.491
LIG_SH2_STAT5 233 236 PF00017 0.306
LIG_SUMO_SIM_anti_2 17 22 PF11976 0.341
LIG_TYR_ITIM 231 236 PF00017 0.335
LIG_WRC_WIRS_1 5 10 PF05994 0.334
MOD_CK1_1 14 20 PF00069 0.335
MOD_CK1_1 26 32 PF00069 0.348
MOD_CK1_1 97 103 PF00069 0.425
MOD_CK2_1 113 119 PF00069 0.434
MOD_CK2_1 121 127 PF00069 0.476
MOD_CK2_1 156 162 PF00069 0.470
MOD_Cter_Amidation 252 255 PF01082 0.339
MOD_GlcNHglycan 101 104 PF01048 0.591
MOD_GlcNHglycan 131 134 PF01048 0.773
MOD_GlcNHglycan 194 197 PF01048 0.366
MOD_GlcNHglycan 86 89 PF01048 0.639
MOD_GSK3_1 10 17 PF00069 0.336
MOD_GSK3_1 188 195 PF00069 0.306
MOD_GSK3_1 22 29 PF00069 0.391
MOD_GSK3_1 264 271 PF00069 0.310
MOD_GSK3_1 36 43 PF00069 0.389
MOD_GSK3_1 82 89 PF00069 0.528
MOD_GSK3_1 95 102 PF00069 0.428
MOD_N-GLC_1 272 277 PF02516 0.557
MOD_N-GLC_1 36 41 PF02516 0.556
MOD_NEK2_1 188 193 PF00069 0.328
MOD_NEK2_1 99 104 PF00069 0.483
MOD_NEK2_2 171 176 PF00069 0.407
MOD_OFUCOSY 44 50 PF10250 0.532
MOD_PIKK_1 141 147 PF00454 0.514
MOD_PKA_1 10 16 PF00069 0.332
MOD_PKA_2 45 51 PF00069 0.324
MOD_PKA_2 60 66 PF00069 0.397
MOD_PKA_2 9 15 PF00069 0.329
MOD_PKA_2 95 101 PF00069 0.542
MOD_Plk_1 36 42 PF00069 0.357
MOD_Plk_4 171 177 PF00069 0.430
MOD_Plk_4 239 245 PF00069 0.347
MOD_ProDKin_1 82 88 PF00069 0.429
MOD_SUMO_rev_2 134 143 PF00179 0.437
TRG_ENDOCYTIC_2 104 107 PF00928 0.353
TRG_ENDOCYTIC_2 229 232 PF00928 0.473
TRG_ENDOCYTIC_2 233 236 PF00928 0.306
TRG_ENDOCYTIC_2 241 244 PF00928 0.306
TRG_ENDOCYTIC_2 5 8 PF00928 0.340
TRG_ER_diArg_1 254 256 PF00400 0.271
TRG_ER_diArg_1 276 278 PF00400 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE20 Leptomonas seymouri 76% 100%
A0A3S7WVB3 Leishmania donovani 95% 100%
A4HA07 Leishmania braziliensis 88% 100%
A4HY71 Leishmania infantum 95% 100%
D0A0J0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
Q4QDH2 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS