GtrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AS00_LEIMU

TriTrypDb:

LmxM.19.0480

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AS00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.732
CLV_NRD_NRD_1	142	144	PF00675	0.551
CLV_NRD_NRD_1	160	162	PF00675	0.353
CLV_NRD_NRD_1	168	170	PF00675	0.492
CLV_PCSK_KEX2_1	11	13	PF00082	0.752
CLV_PCSK_KEX2_1	110	112	PF00082	0.632
CLV_PCSK_KEX2_1	142	144	PF00082	0.551
CLV_PCSK_KEX2_1	160	162	PF00082	0.353
CLV_PCSK_KEX2_1	168	170	PF00082	0.492
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.632
CLV_PCSK_SKI1_1	110	114	PF00082	0.632
CLV_PCSK_SKI1_1	160	164	PF00082	0.562
CLV_PCSK_SKI1_1	29	33	PF00082	0.589
CLV_PCSK_SKI1_1	82	86	PF00082	0.724
DEG_APCC_DBOX_1	159	167	PF00400	0.762
DEG_SPOP_SBC_1	18	22	PF00917	0.625
DOC_CYCLIN_RxL_1	107	117	PF00134	0.432
DOC_MAPK_gen_1	160	167	PF00069	0.566
DOC_MAPK_gen_1	29	38	PF00069	0.361
DOC_MAPK_MEF2A_6	160	167	PF00069	0.566
DOC_MAPK_MEF2A_6	65	74	PF00069	0.339
DOC_MAPK_NFAT4_5	160	168	PF00069	0.569
DOC_MAPK_NFAT4_5	65	73	PF00069	0.339
DOC_MAPK_RevD_3	145	161	PF00069	0.766
DOC_PP2B_LxvP_1	60	63	PF13499	0.546
DOC_USP7_MATH_1	27	31	PF00917	0.389
LIG_14-3-3_CanoR_1	168	172	PF00244	0.787
LIG_14-3-3_CanoR_1	23	31	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.441
LIG_FHA_1	116	122	PF00498	0.524
LIG_LIR_Nem_3	81	87	PF02991	0.425
LIG_LIR_Nem_3	91	97	PF02991	0.516
LIG_PDZ_Class_1	167	172	PF00595	0.783
LIG_Pex14_1	98	102	PF04695	0.550
LIG_Pex14_2	129	133	PF04695	0.524
LIG_Pex14_2	134	138	PF04695	0.443
LIG_RPA_C_Fungi	138	150	PF08784	0.419
LIG_SH2_NCK_1	48	52	PF00017	0.694
LIG_SH2_PTP2	156	159	PF00017	0.713
LIG_SH2_STAT5	156	159	PF00017	0.713
LIG_SH2_STAT5	79	82	PF00017	0.659
LIG_SH3_3	12	18	PF00018	0.793
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.695
LIG_TYR_ITIM	92	97	PF00017	0.665
LIG_WRC_WIRS_1	126	131	PF05994	0.524
MOD_Cter_Amidation	140	143	PF01082	0.674
MOD_GlcNHglycan	135	138	PF01048	0.524
MOD_GSK3_1	19	26	PF00069	0.616
MOD_N-GLC_1	18	23	PF02516	0.523
MOD_NEK2_1	125	130	PF00069	0.524
MOD_NEK2_1	133	138	PF00069	0.394
MOD_NEK2_1	38	43	PF00069	0.696
MOD_NEK2_1	78	83	PF00069	0.662
MOD_NEK2_2	27	32	PF00069	0.454
MOD_Plk_4	104	110	PF00069	0.679
MOD_Plk_4	55	61	PF00069	0.712
TRG_DiLeu_BaEn_1	56	61	PF01217	0.718
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.670
TRG_ENDOCYTIC_2	94	97	PF00928	0.669
TRG_ER_diArg_1	11	13	PF00400	0.708
TRG_ER_diArg_1	159	161	PF00400	0.716
TRG_ER_diArg_1	167	169	PF00400	0.601
TRG_ER_diArg_1	42	45	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJZ2	Leishmania donovani	88%	67%
A4HY70	Leishmania infantum	89%	67%
Q4QDH3	Leishmania major	88%	100%