Nuclear cap binding complex subunit CBP30

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding complex subunit CBP30, putative

Species:

Leishmania mexicana

UniProt:

E9ARZ9_LEIMU

TriTrypDb:

LmxM.19.0470

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.267
CLV_NRD_NRD_1	105	107	PF00675	0.404
CLV_NRD_NRD_1	278	280	PF00675	0.353
CLV_NRD_NRD_1	307	309	PF00675	0.471
CLV_NRD_NRD_1	320	322	PF00675	0.394
CLV_NRD_NRD_1	44	46	PF00675	0.268
CLV_PCSK_KEX2_1	104	106	PF00082	0.291
CLV_PCSK_KEX2_1	307	309	PF00082	0.399
CLV_PCSK_KEX2_1	320	322	PF00082	0.270
CLV_PCSK_SKI1_1	280	284	PF00082	0.292
CLV_PCSK_SKI1_1	62	66	PF00082	0.271
DEG_SPOP_SBC_1	148	152	PF00917	0.289
DEG_SPOP_SBC_1	158	162	PF00917	0.223
DOC_CKS1_1	23	28	PF01111	0.271
DOC_CYCLIN_RxL_1	32	40	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.289
DOC_MAPK_DCC_7	240	249	PF00069	0.335
DOC_MAPK_FxFP_2	209	212	PF00069	0.271
DOC_MAPK_gen_1	320	327	PF00069	0.292
DOC_MAPK_gen_1	45	54	PF00069	0.248
DOC_PP2B_PxIxI_1	223	229	PF00149	0.335
DOC_PP4_FxxP_1	209	212	PF00568	0.271
DOC_USP7_MATH_1	133	137	PF00917	0.422
DOC_USP7_MATH_1	149	153	PF00917	0.382
DOC_USP7_MATH_1	157	161	PF00917	0.403
DOC_USP7_MATH_1	174	178	PF00917	0.363
DOC_USP7_MATH_1	179	183	PF00917	0.351
DOC_USP7_MATH_1	196	200	PF00917	0.437
DOC_USP7_MATH_1	288	292	PF00917	0.342
DOC_WW_Pin1_4	120	125	PF00397	0.458
DOC_WW_Pin1_4	22	27	PF00397	0.271
DOC_WW_Pin1_4	242	247	PF00397	0.289
LIG_14-3-3_CanoR_1	267	274	PF00244	0.404
LIG_Actin_WH2_2	344	361	PF00022	0.404
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	2	6	PF00533	0.470
LIG_BRCT_BRCA1_1	269	273	PF00533	0.404
LIG_CtBP_PxDLS_1	55	59	PF00389	0.404
LIG_DLG_GKlike_1	269	277	PF00625	0.404
LIG_FHA_1	142	148	PF00498	0.240
LIG_FHA_1	34	40	PF00498	0.404
LIG_FHA_2	227	233	PF00498	0.360
LIG_FHA_2	246	252	PF00498	0.351
LIG_FHA_2	333	339	PF00498	0.355
LIG_LIR_Gen_1	18	27	PF02991	0.314
LIG_LIR_Gen_1	71	81	PF02991	0.405
LIG_LIR_Nem_3	18	23	PF02991	0.314
LIG_LIR_Nem_3	213	217	PF02991	0.292
LIG_LIR_Nem_3	63	68	PF02991	0.326
LIG_LIR_Nem_3	71	77	PF02991	0.297
LIG_MYND_1	90	94	PF01753	0.289
LIG_Pex14_1	61	65	PF04695	0.271
LIG_SH2_CRK	214	218	PF00017	0.292
LIG_SH2_NCK_1	330	334	PF00017	0.335
LIG_SH2_PTP2	243	246	PF00017	0.314
LIG_SH2_SRC	330	333	PF00017	0.335
LIG_SH2_STAP1	74	78	PF00017	0.370
LIG_SH2_STAT5	243	246	PF00017	0.309
LIG_SH2_STAT5	31	34	PF00017	0.404
LIG_SH3_2	303	308	PF14604	0.292
LIG_SH3_2	94	99	PF14604	0.335
LIG_SH3_3	300	306	PF00018	0.467
LIG_SH3_3	322	328	PF00018	0.279
LIG_SH3_3	49	55	PF00018	0.245
LIG_SH3_3	87	93	PF00018	0.271
LIG_SUMO_SIM_anti_2	289	296	PF11976	0.323
LIG_SUMO_SIM_par_1	35	40	PF11976	0.404
LIG_TRAF2_1	229	232	PF00917	0.301
LIG_TRAF2_1	250	253	PF00917	0.299
LIG_TRAF2_1	256	259	PF00917	0.283
LIG_TRAF2_1	336	339	PF00917	0.477
LIG_TRAF2_1	69	72	PF00917	0.335
LIG_WRC_WIRS_1	74	79	PF05994	0.292
MOD_CK1_1	160	166	PF00069	0.434
MOD_CK1_1	182	188	PF00069	0.347
MOD_CK1_1	2	8	PF00069	0.630
MOD_CK1_1	245	251	PF00069	0.384
MOD_CK1_1	316	322	PF00069	0.482
MOD_CK2_1	226	232	PF00069	0.273
MOD_CK2_1	245	251	PF00069	0.336
MOD_CK2_1	332	338	PF00069	0.390
MOD_CK2_1	44	50	PF00069	0.330
MOD_CK2_1	66	72	PF00069	0.335
MOD_GlcNHglycan	11	14	PF01048	0.547
MOD_GlcNHglycan	131	134	PF01048	0.319
MOD_GlcNHglycan	135	138	PF01048	0.282
MOD_GlcNHglycan	17	20	PF01048	0.237
MOD_GlcNHglycan	218	221	PF01048	0.319
MOD_GlcNHglycan	39	42	PF01048	0.404
MOD_GSK3_1	125	132	PF00069	0.458
MOD_GSK3_1	159	166	PF00069	0.427
MOD_GSK3_1	179	186	PF00069	0.306
MOD_GSK3_1	25	32	PF00069	0.345
MOD_GSK3_1	263	270	PF00069	0.299
MOD_GSK3_1	309	316	PF00069	0.331
MOD_GSK3_1	33	40	PF00069	0.355
MOD_N-GLC_1	167	172	PF02516	0.465
MOD_N-GLC_1	9	14	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.750
MOD_NEK2_1	118	123	PF00069	0.493
MOD_NEK2_1	263	268	PF00069	0.271
MOD_NEK2_1	37	42	PF00069	0.404
MOD_PKA_2	15	21	PF00069	0.314
MOD_PKA_2	163	169	PF00069	0.294
MOD_PKA_2	44	50	PF00069	0.402
MOD_PKA_2	66	72	PF00069	0.335
MOD_PKB_1	267	275	PF00069	0.317
MOD_Plk_1	333	339	PF00069	0.293
MOD_Plk_4	269	275	PF00069	0.349
MOD_Plk_4	56	62	PF00069	0.349
MOD_ProDKin_1	120	126	PF00069	0.458
MOD_ProDKin_1	22	28	PF00069	0.271
MOD_ProDKin_1	242	248	PF00069	0.289
MOD_SUMO_rev_2	334	343	PF00179	0.292
TRG_DiLeu_BaEn_3	192	198	PF01217	0.171
TRG_DiLeu_BaEn_4	258	264	PF01217	0.311
TRG_DiLeu_BaEn_4	338	344	PF01217	0.335
TRG_ENDOCYTIC_2	214	217	PF00928	0.292
TRG_ENDOCYTIC_2	74	77	PF00928	0.410
TRG_ER_diArg_1	103	106	PF00400	0.388
TRG_ER_diArg_1	306	308	PF00400	0.355
TRG_ER_diArg_1	42	45	PF00400	0.269
TRG_NLS_MonoExtC_3	44	50	PF00514	0.378
TRG_NLS_MonoExtN_4	43	49	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD4	Leptomonas seymouri	59%	100%
A0A1X0P6J9	Trypanosomatidae	40%	100%
A0A3R7N3C2	Trypanosoma rangeli	42%	100%
A0A3S5H755	Leishmania donovani	91%	100%
A4HA05	Leishmania braziliensis	76%	100%
A4HY69	Leishmania infantum	91%	100%
D0A0I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QDH4	Leishmania major	90%	100%
V5BBW3	Trypanosoma cruzi	38%	100%