WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted coiled-coil domain-containing protein (DUF2360), putative

Species:

Leishmania mexicana

UniProt:

E9ARZ8_LEIMU

TriTrypDb:

LmxM.19.0460

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0071203	WASH complex	2	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006887	exocytosis	4	1
GO:0007015	actin filament organization	5	1
GO:0008154	actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0022607	cellular component assembly	4	1
GO:0030041	actin filament polymerization	7	1
GO:0032940	secretion by cell	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051258	protein polymerization	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.340
CLV_C14_Caspase3-7	273	277	PF00656	0.512
CLV_NRD_NRD_1	137	139	PF00675	0.310
CLV_NRD_NRD_1	140	142	PF00675	0.297
CLV_NRD_NRD_1	163	165	PF00675	0.396
CLV_NRD_NRD_1	175	177	PF00675	0.252
CLV_PCSK_FUR_1	135	139	PF00082	0.292
CLV_PCSK_KEX2_1	135	137	PF00082	0.321
CLV_PCSK_KEX2_1	140	142	PF00082	0.308
CLV_PCSK_KEX2_1	163	165	PF00082	0.400
CLV_PCSK_PC7_1	136	142	PF00082	0.326
CLV_PCSK_SKI1_1	200	204	PF00082	0.312
DOC_CDC14_PxL_1	206	214	PF14671	0.312
DOC_CKS1_1	272	277	PF01111	0.503
DOC_CYCLIN_yCln2_LP_2	212	215	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.291
DOC_MAPK_JIP1_4	230	236	PF00069	0.312
DOC_PP2B_LxvP_1	155	158	PF13499	0.376
DOC_PP2B_LxvP_1	212	215	PF13499	0.315
DOC_PP2B_LxvP_1	251	254	PF13499	0.312
DOC_SPAK_OSR1_1	38	42	PF12202	0.312
DOC_USP7_MATH_1	278	282	PF00917	0.603
DOC_WW_Pin1_4	271	276	PF00397	0.525
LIG_14-3-3_CanoR_1	200	205	PF00244	0.320
LIG_14-3-3_CanoR_1	38	47	PF00244	0.338
LIG_14-3-3_CanoR_1	57	65	PF00244	0.415
LIG_CtBP_PxDLS_1	226	230	PF00389	0.312
LIG_EVH1_1	155	159	PF00568	0.340
LIG_FHA_1	1	7	PF00498	0.580
LIG_FHA_1	201	207	PF00498	0.243
LIG_FHA_1	70	76	PF00498	0.312
LIG_MYND_1	210	214	PF01753	0.312
LIG_NRBOX	74	80	PF00104	0.340
LIG_PCNA_PIPBox_1	71	80	PF02747	0.340
LIG_Pex14_2	267	271	PF04695	0.388
LIG_Pex14_2	46	50	PF04695	0.312
LIG_SH2_SRC	130	133	PF00017	0.315
LIG_SH2_STAT5	109	112	PF00017	0.340
LIG_SH2_STAT5	245	248	PF00017	0.388
LIG_SH2_STAT5	257	260	PF00017	0.265
LIG_SH3_1	153	159	PF00018	0.315
LIG_SH3_1	176	182	PF00018	0.311
LIG_SH3_3	153	159	PF00018	0.496
LIG_SH3_3	165	171	PF00018	0.322
LIG_SH3_3	176	182	PF00018	0.334
LIG_SH3_3	204	210	PF00018	0.312
LIG_SH3_3	218	224	PF00018	0.312
LIG_SH3_3	272	278	PF00018	0.523
LIG_SH3_3	288	294	PF00018	0.626
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.243
LIG_TRAF2_1	192	195	PF00917	0.312
LIG_WW_3	178	182	PF00397	0.388
MOD_CK1_1	124	130	PF00069	0.505
MOD_CK1_1	281	287	PF00069	0.608
MOD_CK1_1	4	10	PF00069	0.543
MOD_CK1_1	97	103	PF00069	0.219
MOD_Cter_Amidation	138	141	PF01082	0.340
MOD_GlcNHglycan	125	129	PF01048	0.394
MOD_GlcNHglycan	15	18	PF01048	0.444
MOD_GlcNHglycan	164	167	PF01048	0.406
MOD_GlcNHglycan	216	219	PF01048	0.390
MOD_GlcNHglycan	280	283	PF01048	0.633
MOD_GlcNHglycan	3	6	PF01048	0.564
MOD_GlcNHglycan	81	84	PF01048	0.311
MOD_GSK3_1	9	16	PF00069	0.507
MOD_N-GLC_1	10	15	PF02516	0.506
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	39	44	PF00069	0.335
MOD_NEK2_1	78	83	PF00069	0.312
MOD_PIKK_1	69	75	PF00454	0.312
MOD_PKA_2	162	168	PF00069	0.321
MOD_PKA_2	48	54	PF00069	0.394
MOD_Plk_1	10	16	PF00069	0.375
MOD_Plk_1	61	67	PF00069	0.388
MOD_Plk_4	10	16	PF00069	0.375
MOD_Plk_4	105	111	PF00069	0.340
MOD_ProDKin_1	271	277	PF00069	0.522
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.388
TRG_ENDOCYTIC_2	245	248	PF00928	0.312
TRG_ER_diArg_1	135	138	PF00400	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y5	Leptomonas seymouri	56%	96%
A0A3Q8ID87	Leishmania donovani	91%	100%
A4HA04	Leishmania braziliensis	77%	100%
A4HY68	Leishmania infantum	91%	100%
Q4QDH5	Leishmania major	88%	100%