Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARZ7_LEIMU

TriTrypDb:

LmxM.19.0450

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.707
CLV_C14_Caspase3-7	64	68	PF00656	0.658
CLV_C14_Caspase3-7	810	814	PF00656	0.504
CLV_C14_Caspase3-7	830	834	PF00656	0.475
CLV_C14_Caspase3-7	938	942	PF00656	0.629
CLV_NRD_NRD_1	146	148	PF00675	0.766
CLV_NRD_NRD_1	171	173	PF00675	0.801
CLV_NRD_NRD_1	176	178	PF00675	0.707
CLV_NRD_NRD_1	223	225	PF00675	0.738
CLV_NRD_NRD_1	248	250	PF00675	0.758
CLV_NRD_NRD_1	275	277	PF00675	0.784
CLV_NRD_NRD_1	315	317	PF00675	0.722
CLV_NRD_NRD_1	341	343	PF00675	0.548
CLV_NRD_NRD_1	412	414	PF00675	0.752
CLV_NRD_NRD_1	48	50	PF00675	0.579
CLV_NRD_NRD_1	97	99	PF00675	0.766
CLV_PCSK_KEX2_1	146	148	PF00082	0.734
CLV_PCSK_KEX2_1	169	171	PF00082	0.788
CLV_PCSK_KEX2_1	176	178	PF00082	0.704
CLV_PCSK_KEX2_1	223	225	PF00082	0.738
CLV_PCSK_KEX2_1	248	250	PF00082	0.758
CLV_PCSK_KEX2_1	275	277	PF00082	0.784
CLV_PCSK_KEX2_1	315	317	PF00082	0.722
CLV_PCSK_KEX2_1	341	343	PF00082	0.548
CLV_PCSK_KEX2_1	97	99	PF00082	0.766
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.725
CLV_PCSK_PC7_1	165	171	PF00082	0.713
CLV_PCSK_PC7_1	172	178	PF00082	0.642
CLV_PCSK_PC7_1	337	343	PF00082	0.542
CLV_PCSK_SKI1_1	50	54	PF00082	0.543
DEG_APCC_DBOX_1	19	27	PF00400	0.527
DEG_APCC_DBOX_1	544	552	PF00400	0.656
DEG_APCC_DBOX_1	97	105	PF00400	0.518
DEG_ODPH_VHL_1	531	543	PF01847	0.521
DEG_SCF_TRCP1_1	486	491	PF00400	0.539
DEG_SPOP_SBC_1	148	152	PF00917	0.540
DEG_SPOP_SBC_1	367	371	PF00917	0.610
DEG_SPOP_SBC_1	855	859	PF00917	0.778
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.731
DOC_MAPK_gen_1	534	543	PF00069	0.520
DOC_MAPK_gen_1	611	620	PF00069	0.828
DOC_MAPK_gen_1	97	103	PF00069	0.522
DOC_MAPK_MEF2A_6	614	622	PF00069	0.541
DOC_MIT_MIM_1	14	24	PF04212	0.632
DOC_PP2B_LxvP_1	469	472	PF13499	0.760
DOC_PP4_FxxP_1	115	118	PF00568	0.710
DOC_PP4_FxxP_1	355	358	PF00568	0.713
DOC_USP7_MATH_1	141	145	PF00917	0.835
DOC_USP7_MATH_1	148	152	PF00917	0.650
DOC_USP7_MATH_1	264	268	PF00917	0.644
DOC_USP7_MATH_1	308	312	PF00917	0.791
DOC_USP7_MATH_1	365	369	PF00917	0.661
DOC_USP7_MATH_1	484	488	PF00917	0.602
DOC_USP7_MATH_1	510	514	PF00917	0.757
DOC_USP7_MATH_1	516	520	PF00917	0.677
DOC_USP7_MATH_1	7	11	PF00917	0.614
DOC_USP7_MATH_1	721	725	PF00917	0.791
DOC_USP7_MATH_1	829	833	PF00917	0.713
DOC_USP7_MATH_1	855	859	PF00917	0.778
DOC_USP7_UBL2_3	534	538	PF12436	0.711
DOC_WW_Pin1_4	106	111	PF00397	0.500
DOC_WW_Pin1_4	182	187	PF00397	0.490
DOC_WW_Pin1_4	299	304	PF00397	0.719
DOC_WW_Pin1_4	330	335	PF00397	0.711
DOC_WW_Pin1_4	353	358	PF00397	0.693
DOC_WW_Pin1_4	392	397	PF00397	0.787
DOC_WW_Pin1_4	412	417	PF00397	0.480
DOC_WW_Pin1_4	428	433	PF00397	0.691
DOC_WW_Pin1_4	521	526	PF00397	0.693
DOC_WW_Pin1_4	564	569	PF00397	0.727
DOC_WW_Pin1_4	595	600	PF00397	0.659
DOC_WW_Pin1_4	609	614	PF00397	0.717
DOC_WW_Pin1_4	638	643	PF00397	0.766
DOC_WW_Pin1_4	648	653	PF00397	0.649
DOC_WW_Pin1_4	841	846	PF00397	0.725
DOC_WW_Pin1_4	90	95	PF00397	0.778
LIG_14-3-3_CanoR_1	165	173	PF00244	0.648
LIG_14-3-3_CanoR_1	176	182	PF00244	0.646
LIG_14-3-3_CanoR_1	341	350	PF00244	0.594
LIG_14-3-3_CanoR_1	55	61	PF00244	0.483
LIG_14-3-3_CanoR_1	614	619	PF00244	0.707
LIG_14-3-3_CanoR_1	725	733	PF00244	0.638
LIG_14-3-3_CanoR_1	89	94	PF00244	0.782
LIG_14-3-3_CanoR_1	900	910	PF00244	0.576
LIG_14-3-3_CanoR_1	97	102	PF00244	0.732
LIG_Actin_WH2_2	684	702	PF00022	0.649
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BRCT_BRCA1_1	10	14	PF00533	0.573
LIG_BRCT_BRCA1_1	560	564	PF00533	0.751
LIG_EVH1_2	358	362	PF00568	0.620
LIG_FHA_1	333	339	PF00498	0.815
LIG_FHA_1	39	45	PF00498	0.577
LIG_FHA_1	445	451	PF00498	0.721
LIG_FHA_1	516	522	PF00498	0.818
LIG_FHA_1	600	606	PF00498	0.758
LIG_FHA_1	615	621	PF00498	0.723
LIG_FHA_1	762	768	PF00498	0.597
LIG_FHA_1	779	785	PF00498	0.678
LIG_FHA_1	902	908	PF00498	0.634
LIG_FHA_1	915	921	PF00498	0.465
LIG_FHA_1	94	100	PF00498	0.726
LIG_FHA_2	344	350	PF00498	0.744
LIG_FHA_2	393	399	PF00498	0.638
LIG_FHA_2	432	438	PF00498	0.751
LIG_FHA_2	499	505	PF00498	0.722
LIG_FHA_2	808	814	PF00498	0.602
LIG_Integrin_RGD_1	224	226	PF01839	0.824
LIG_LIR_Apic_2	352	358	PF02991	0.684
LIG_LIR_Apic_2	631	637	PF02991	0.809
LIG_LIR_Gen_1	11	21	PF02991	0.642
LIG_LIR_Gen_1	190	199	PF02991	0.650
LIG_LIR_Gen_1	661	671	PF02991	0.508
LIG_LIR_Gen_1	680	688	PF02991	0.618
LIG_LIR_Nem_3	11	17	PF02991	0.650
LIG_LIR_Nem_3	190	196	PF02991	0.639
LIG_LIR_Nem_3	480	485	PF02991	0.755
LIG_LIR_Nem_3	661	667	PF02991	0.513
LIG_LIR_Nem_3	680	684	PF02991	0.627
LIG_LIR_Nem_3	922	928	PF02991	0.527
LIG_MAD2	73	81	PF02301	0.734
LIG_MYND_1	851	855	PF01753	0.727
LIG_PCNA_yPIPBox_3	696	704	PF02747	0.558
LIG_PTAP_UEV_1	415	420	PF05743	0.715
LIG_Rb_LxCxE_1	208	229	PF01857	0.733
LIG_REV1ctd_RIR_1	190	198	PF16727	0.646
LIG_SH2_CRK	634	638	PF00017	0.817
LIG_SH2_CRK	802	806	PF00017	0.559
LIG_SH2_SRC	255	258	PF00017	0.482
LIG_SH2_SRC	789	792	PF00017	0.452
LIG_SH2_SRC	939	942	PF00017	0.529
LIG_SH2_STAP1	327	331	PF00017	0.749
LIG_SH2_STAP1	789	793	PF00017	0.542
LIG_SH2_STAT5	173	176	PF00017	0.675
LIG_SH2_STAT5	282	285	PF00017	0.507
LIG_SH2_STAT5	763	766	PF00017	0.585
LIG_SH2_STAT5	802	805	PF00017	0.517
LIG_SH2_STAT5	939	942	PF00017	0.529
LIG_SH3_1	293	299	PF00018	0.729
LIG_SH3_1	413	419	PF00018	0.724
LIG_SH3_2	107	112	PF14604	0.633
LIG_SH3_3	104	110	PF00018	0.676
LIG_SH3_3	293	299	PF00018	0.753
LIG_SH3_3	413	419	PF00018	0.697
LIG_SH3_3	426	432	PF00018	0.469
LIG_SH3_3	445	451	PF00018	0.712
LIG_SH3_3	461	467	PF00018	0.622
LIG_SH3_3	607	613	PF00018	0.745
LIG_SH3_3	649	655	PF00018	0.675
LIG_SH3_3	781	787	PF00018	0.486
LIG_TRAF2_1	680	683	PF00917	0.587
LIG_TYR_ITIM	800	805	PF00017	0.562
LIG_WW_3	109	113	PF00397	0.702
MOD_CDC14_SPxK_1	109	112	PF00782	0.623
MOD_CDK_SPK_2	521	526	PF00069	0.693
MOD_CDK_SPK_2	609	614	PF00069	0.717
MOD_CDK_SPxK_1	106	112	PF00069	0.703
MOD_CDK_SPxxK_3	182	189	PF00069	0.481
MOD_CDK_SPxxK_3	330	337	PF00069	0.636
MOD_CDK_SPxxK_3	841	848	PF00069	0.728
MOD_CDK_SPxxK_3	90	97	PF00069	0.629
MOD_CK1_1	368	374	PF00069	0.637
MOD_CK1_1	431	437	PF00069	0.734
MOD_CK1_1	453	459	PF00069	0.678
MOD_CK1_1	491	497	PF00069	0.710
MOD_CK1_1	515	521	PF00069	0.723
MOD_CK1_1	567	573	PF00069	0.656
MOD_CK1_1	674	680	PF00069	0.675
MOD_CK1_1	710	716	PF00069	0.554
MOD_CK1_1	724	730	PF00069	0.762
MOD_CK1_1	741	747	PF00069	0.653
MOD_CK1_1	856	862	PF00069	0.721
MOD_CK1_1	905	911	PF00069	0.573
MOD_CK1_1	93	99	PF00069	0.809
MOD_CK2_1	130	136	PF00069	0.747
MOD_CK2_1	182	188	PF00069	0.749
MOD_CK2_1	367	373	PF00069	0.705
MOD_CK2_1	392	398	PF00069	0.754
MOD_CK2_1	403	409	PF00069	0.633
MOD_CK2_1	498	504	PF00069	0.723
MOD_CK2_1	56	62	PF00069	0.698
MOD_CK2_1	677	683	PF00069	0.670
MOD_CK2_1	7	13	PF00069	0.587
MOD_CK2_1	741	747	PF00069	0.716
MOD_Cter_Amidation	221	224	PF01082	0.633
MOD_Cter_Amidation	246	249	PF01082	0.541
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.681
MOD_DYRK1A_RPxSP_1	595	599	PF00069	0.527
MOD_GlcNHglycan	10	13	PF01048	0.576
MOD_GlcNHglycan	119	122	PF01048	0.693
MOD_GlcNHglycan	132	135	PF01048	0.592
MOD_GlcNHglycan	266	269	PF01048	0.803
MOD_GlcNHglycan	299	302	PF01048	0.728
MOD_GlcNHglycan	363	366	PF01048	0.560
MOD_GlcNHglycan	416	419	PF01048	0.651
MOD_GlcNHglycan	452	455	PF01048	0.691
MOD_GlcNHglycan	475	478	PF01048	0.689
MOD_GlcNHglycan	486	489	PF01048	0.756
MOD_GlcNHglycan	490	493	PF01048	0.794
MOD_GlcNHglycan	494	497	PF01048	0.841
MOD_GlcNHglycan	512	515	PF01048	0.677
MOD_GlcNHglycan	554	557	PF01048	0.634
MOD_GlcNHglycan	560	563	PF01048	0.655
MOD_GlcNHglycan	575	578	PF01048	0.690
MOD_GlcNHglycan	602	605	PF01048	0.739
MOD_GlcNHglycan	673	676	PF01048	0.586
MOD_GlcNHglycan	685	688	PF01048	0.622
MOD_GlcNHglycan	712	715	PF01048	0.547
MOD_GlcNHglycan	735	738	PF01048	0.586
MOD_GlcNHglycan	778	781	PF01048	0.575
MOD_GlcNHglycan	791	794	PF01048	0.649
MOD_GlcNHglycan	848	851	PF01048	0.542
MOD_GSK3_1	184	191	PF00069	0.653
MOD_GSK3_1	361	368	PF00069	0.750
MOD_GSK3_1	414	421	PF00069	0.789
MOD_GSK3_1	427	434	PF00069	0.545
MOD_GSK3_1	437	444	PF00069	0.753
MOD_GSK3_1	484	491	PF00069	0.777
MOD_GSK3_1	498	505	PF00069	0.678
MOD_GSK3_1	510	517	PF00069	0.770
MOD_GSK3_1	552	559	PF00069	0.648
MOD_GSK3_1	560	567	PF00069	0.695
MOD_GSK3_1	569	576	PF00069	0.669
MOD_GSK3_1	591	598	PF00069	0.693
MOD_GSK3_1	641	648	PF00069	0.737
MOD_GSK3_1	673	680	PF00069	0.621
MOD_GSK3_1	703	710	PF00069	0.656
MOD_GSK3_1	733	740	PF00069	0.666
MOD_GSK3_1	774	781	PF00069	0.742
MOD_GSK3_1	829	836	PF00069	0.702
MOD_GSK3_1	85	92	PF00069	0.682
MOD_GSK3_1	853	860	PF00069	0.721
MOD_GSK3_1	901	908	PF00069	0.574
MOD_GSK3_1	914	921	PF00069	0.526
MOD_GSK3_1	93	100	PF00069	0.794
MOD_N-GLC_1	238	243	PF02516	0.732
MOD_N-GLC_1	342	347	PF02516	0.754
MOD_N-GLC_1	902	907	PF02516	0.577
MOD_NEK2_1	38	43	PF00069	0.564
MOD_NEK2_1	441	446	PF00069	0.733
MOD_NEK2_1	558	563	PF00069	0.794
MOD_NEK2_1	600	605	PF00069	0.596
MOD_NEK2_1	645	650	PF00069	0.570
MOD_NEK2_1	800	805	PF00069	0.513
MOD_NEK2_1	846	851	PF00069	0.655
MOD_NEK2_1	85	90	PF00069	0.752
MOD_NEK2_1	901	906	PF00069	0.576
MOD_NEK2_2	141	146	PF00069	0.837
MOD_PIKK_1	502	508	PF00454	0.636
MOD_PIKK_1	516	522	PF00454	0.802
MOD_PIKK_1	703	709	PF00454	0.415
MOD_PIKK_1	724	730	PF00454	0.635
MOD_PIKK_1	747	753	PF00454	0.510
MOD_PIKK_1	800	806	PF00454	0.559
MOD_PIKK_1	807	813	PF00454	0.549
MOD_PIKK_1	905	911	PF00454	0.573
MOD_PKA_1	275	281	PF00069	0.729
MOD_PKA_1	97	103	PF00069	0.735
MOD_PKA_2	116	122	PF00069	0.533
MOD_PKA_2	164	170	PF00069	0.623
MOD_PKA_2	175	181	PF00069	0.644
MOD_PKA_2	188	194	PF00069	0.645
MOD_PKA_2	275	281	PF00069	0.683
MOD_PKA_2	710	716	PF00069	0.554
MOD_PKA_2	724	730	PF00069	0.723
MOD_PKA_2	761	767	PF00069	0.587
MOD_PKA_2	914	920	PF00069	0.526
MOD_PKA_2	97	103	PF00069	0.759
MOD_Plk_1	228	234	PF00069	0.528
MOD_Plk_1	327	333	PF00069	0.742
MOD_Plk_1	66	72	PF00069	0.796
MOD_Plk_1	767	773	PF00069	0.801
MOD_Plk_1	902	908	PF00069	0.600
MOD_Plk_2-3	228	234	PF00069	0.625
MOD_Plk_2-3	749	755	PF00069	0.516
MOD_Plk_2-3	931	937	PF00069	0.615
MOD_Plk_4	188	194	PF00069	0.651
MOD_Plk_4	418	424	PF00069	0.554
MOD_Plk_4	444	450	PF00069	0.555
MOD_Plk_4	641	647	PF00069	0.758
MOD_Plk_4	931	937	PF00069	0.615
MOD_ProDKin_1	106	112	PF00069	0.504
MOD_ProDKin_1	182	188	PF00069	0.482
MOD_ProDKin_1	299	305	PF00069	0.723
MOD_ProDKin_1	330	336	PF00069	0.714
MOD_ProDKin_1	353	359	PF00069	0.692
MOD_ProDKin_1	392	398	PF00069	0.790
MOD_ProDKin_1	412	418	PF00069	0.478
MOD_ProDKin_1	428	434	PF00069	0.690
MOD_ProDKin_1	521	527	PF00069	0.691
MOD_ProDKin_1	564	570	PF00069	0.727
MOD_ProDKin_1	595	601	PF00069	0.659
MOD_ProDKin_1	609	615	PF00069	0.716
MOD_ProDKin_1	638	644	PF00069	0.766
MOD_ProDKin_1	648	654	PF00069	0.647
MOD_ProDKin_1	841	847	PF00069	0.726
MOD_ProDKin_1	90	96	PF00069	0.777
MOD_SUMO_for_1	637	640	PF00179	0.523
MOD_SUMO_rev_2	431	441	PF00179	0.636
MOD_SUMO_rev_2	65	75	PF00179	0.724
TRG_DiLeu_BaEn_1	13	18	PF01217	0.534
TRG_DiLeu_BaEn_1	796	801	PF01217	0.560
TRG_ENDOCYTIC_2	294	297	PF00928	0.712
TRG_ENDOCYTIC_2	802	805	PF00928	0.562
TRG_ER_diArg_1	145	147	PF00400	0.746
TRG_ER_diArg_1	170	172	PF00400	0.804
TRG_ER_diArg_1	175	177	PF00400	0.703
TRG_ER_diArg_1	199	202	PF00400	0.787
TRG_ER_diArg_1	248	251	PF00400	0.715
TRG_ER_diArg_1	275	277	PF00400	0.676
TRG_ER_diArg_1	472	475	PF00400	0.538
TRG_ER_diArg_1	81	84	PF00400	0.705
TRG_ER_diArg_1	97	99	PF00400	0.774
TRG_NES_CRM1_1	682	694	PF08389	0.645
TRG_NES_CRM1_1	811	822	PF08389	0.674
TRG_NLS_MonoCore_2	168	173	PF00514	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K8	Leptomonas seymouri	35%	95%
A0A3S7WVC5	Leishmania donovani	82%	100%
A4HA03	Leishmania braziliensis	58%	100%
A4HY67	Leishmania infantum	82%	100%
Q4QDH6	Leishmania major	81%	100%