Putative nucleosome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARZ6_LEIMU

TriTrypDb:

LmxM.19.0440

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043231	intracellular membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:0000785	chromatin	2	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ARZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	15
GO:0006334	nucleosome assembly	7	15
GO:0006338	chromatin remodeling	5	15
GO:0009987	cellular process	1	15
GO:0016043	cellular component organization	3	15
GO:0022607	cellular component assembly	4	15
GO:0034728	nucleosome organization	6	15
GO:0043933	protein-containing complex organization	4	15
GO:0065003	protein-containing complex assembly	5	15
GO:0065004	protein-DNA complex assembly	6	15
GO:0071824	protein-DNA complex subunit organization	5	15
GO:0071840	cellular component organization or biogenesis	2	15

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.391
CLV_NRD_NRD_1	259	261	PF00675	0.152
CLV_NRD_NRD_1	81	83	PF00675	0.264
CLV_NRD_NRD_1	93	95	PF00675	0.294
CLV_PCSK_FUR_1	236	240	PF00082	0.311
CLV_PCSK_KEX2_1	238	240	PF00082	0.215
CLV_PCSK_KEX2_1	81	83	PF00082	0.223
CLV_PCSK_KEX2_1	93	95	PF00082	0.221
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.215
DEG_SPOP_SBC_1	243	247	PF00917	0.496
DOC_MAPK_gen_1	207	215	PF00069	0.448
DOC_MAPK_gen_1	70	79	PF00069	0.551
DOC_MAPK_MEF2A_6	207	215	PF00069	0.391
DOC_MAPK_MEF2A_6	248	255	PF00069	0.423
DOC_USP7_MATH_1	101	105	PF00917	0.448
DOC_USP7_MATH_1	202	206	PF00917	0.452
DOC_USP7_MATH_2	113	119	PF00917	0.352
DOC_USP7_UBL2_3	234	238	PF12436	0.431
DOC_WW_Pin1_4	187	192	PF00397	0.551
DOC_WW_Pin1_4	213	218	PF00397	0.437
LIG_14-3-3_CanoR_1	148	153	PF00244	0.391
LIG_14-3-3_CanoR_1	244	251	PF00244	0.535
LIG_14-3-3_CanoR_1	283	287	PF00244	0.511
LIG_APCC_ABBA_1	157	162	PF00400	0.448
LIG_BIR_III_4	135	139	PF00653	0.448
LIG_BRCT_BRCA1_1	39	43	PF00533	0.369
LIG_FHA_1	199	205	PF00498	0.481
LIG_FHA_1	245	251	PF00498	0.422
LIG_FHA_1	261	267	PF00498	0.423
LIG_FHA_1	290	296	PF00498	0.467
LIG_FHA_2	100	106	PF00498	0.434
LIG_FHA_2	149	155	PF00498	0.533
LIG_FHA_2	244	250	PF00498	0.423
LIG_LIR_Gen_1	140	147	PF02991	0.507
LIG_LIR_Gen_1	182	191	PF02991	0.444
LIG_LIR_Nem_3	140	146	PF02991	0.507
LIG_LIR_Nem_3	182	186	PF02991	0.424
LIG_LIR_Nem_3	254	259	PF02991	0.451
LIG_LIR_Nem_3	30	34	PF02991	0.420
LIG_LIR_Nem_3	84	90	PF02991	0.415
LIG_PCNA_yPIPBox_3	4	13	PF02747	0.458
LIG_Pex14_2	183	187	PF04695	0.427
LIG_Pex14_2	255	259	PF04695	0.454
LIG_Pex14_2	39	43	PF04695	0.416
LIG_SH2_CRK	83	87	PF00017	0.453
LIG_SH2_SRC	34	37	PF00017	0.531
LIG_SH2_STAP1	61	65	PF00017	0.448
LIG_SH2_STAP1	83	87	PF00017	0.415
LIG_SH2_STAT5	302	305	PF00017	0.454
LIG_SH2_STAT5	34	37	PF00017	0.414
LIG_SUMO_SIM_anti_2	114	121	PF11976	0.352
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.511
LIG_SUMO_SIM_par_1	118	123	PF11976	0.423
LIG_SUMO_SIM_par_1	167	173	PF11976	0.470
LIG_SUMO_SIM_par_1	201	209	PF11976	0.448
LIG_TRAF2_1	104	107	PF00917	0.454
LIG_UBA3_1	86	95	PF00899	0.423
LIG_WRC_WIRS_1	186	191	PF05994	0.431
MOD_CK1_1	118	124	PF00069	0.532
MOD_CK1_1	216	222	PF00069	0.455
MOD_CK2_1	152	158	PF00069	0.444
MOD_CK2_1	282	288	PF00069	0.511
MOD_CK2_1	99	105	PF00069	0.455
MOD_GlcNHglycan	58	61	PF01048	0.311
MOD_GlcNHglycan	64	68	PF01048	0.223
MOD_GSK3_1	148	155	PF00069	0.415
MOD_GSK3_1	196	203	PF00069	0.457
MOD_NEK2_1	227	232	PF00069	0.575
MOD_NEK2_2	202	207	PF00069	0.452
MOD_NEK2_2	251	256	PF00069	0.509
MOD_PKA_1	260	266	PF00069	0.423
MOD_PKA_2	243	249	PF00069	0.459
MOD_PKA_2	282	288	PF00069	0.511
MOD_Plk_1	153	159	PF00069	0.448
MOD_Plk_1	196	202	PF00069	0.454
MOD_Plk_1	211	217	PF00069	0.473
MOD_Plk_4	115	121	PF00069	0.352
MOD_Plk_4	148	154	PF00069	0.452
MOD_Plk_4	251	257	PF00069	0.454
MOD_ProDKin_1	187	193	PF00069	0.551
MOD_ProDKin_1	213	219	PF00069	0.437
MOD_SUMO_rev_2	205	211	PF00179	0.578
TRG_DiLeu_BaEn_3	324	330	PF01217	0.694
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.470
TRG_ENDOCYTIC_2	83	86	PF00928	0.497
TRG_ER_diArg_1	331	334	PF00400	0.697
TRG_ER_diArg_1	51	54	PF00400	0.484
TRG_ER_diArg_1	80	82	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	68%	100%
A0A0N1IJI7	Leptomonas seymouri	30%	86%
A0A1X0P6J1	Trypanosomatidae	49%	84%
A0A3Q8IA70	Leishmania donovani	95%	100%
A0A3R7KRI5	Trypanosoma rangeli	47%	100%
A0A3S7X4M4	Leishmania donovani	30%	87%
A2ZX50	Oryza sativa subsp. japonica	25%	100%
A4HA02	Leishmania braziliensis	79%	100%
A4HJF7	Leishmania braziliensis	33%	100%
A4HY66	Leishmania infantum	94%	100%
A4I6V2	Leishmania infantum	30%	87%
A6H767	Bos taurus	28%	90%
B8AW64	Oryza sativa subsp. indica	26%	97%
B8B4K9	Oryza sativa subsp. indica	25%	100%
B9FU45	Oryza sativa subsp. japonica	25%	100%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	86%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	90%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	84%
P28656	Mus musculus	29%	90%
P51860	Mus musculus	26%	77%
P55209	Homo sapiens	28%	90%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
Q28EB4	Xenopus tropicalis	30%	90%
Q2TA40	Bos taurus	30%	91%
Q4Q687	Leishmania major	32%	100%
Q4QDH7	Leishmania major	92%	100%
Q4U0Y4	Xenopus laevis	28%	90%
Q53WK4	Oryza sativa subsp. japonica	26%	97%
Q55ED1	Dictyostelium discoideum	32%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	81%
Q5MGA9	Oryza sativa subsp. indica	25%	100%
Q5R4D4	Pongo abelii	28%	90%
Q5U2Z3	Rattus norvegicus	30%	91%
Q70Z16	Nicotiana tabacum	26%	99%
Q70Z17	Nicotiana tabacum	25%	93%
Q70Z18	Nicotiana tabacum	25%	93%
Q70Z19	Nicotiana tabacum	24%	94%
Q78ZA7	Mus musculus	30%	94%
Q7ZY81	Xenopus laevis	28%	90%
Q94K07	Arabidopsis thaliana	29%	94%
Q99733	Homo sapiens	30%	94%
Q9SZI2	Arabidopsis thaliana	29%	95%
Q9ULW6	Homo sapiens	25%	77%
Q9Z2G8	Rattus norvegicus	29%	90%
V5BX23	Trypanosoma cruzi	46%	99%