Proteasome maturation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome maturation factor UMP1, putative

Species:

Leishmania mexicana

UniProt:

E9ARZ3_LEIMU

TriTrypDb:

LmxM.19.0410

Length:

124

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000502	proteasome complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

E9ARZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043248	proteasome assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.557
CLV_PCSK_KEX2_1	63	65	PF00082	0.557
DOC_CKS1_1	101	106	PF01111	0.644
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.637
DOC_MAPK_gen_1	13	23	PF00069	0.660
DOC_WW_Pin1_4	100	105	PF00397	0.702
DOC_WW_Pin1_4	83	88	PF00397	0.435
LIG_14-3-3_CanoR_1	79	87	PF00244	0.496
LIG_FHA_1	41	47	PF00498	0.570
LIG_FHA_2	84	90	PF00498	0.427
LIG_LIR_Nem_3	73	78	PF02991	0.470
LIG_LRP6_Inhibitor_1	35	41	PF00058	0.538
LIG_PDZ_Class_2	119	124	PF00595	0.712
LIG_SH2_STAT3	91	94	PF00017	0.401
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.642
LIG_TRAF2_1	12	15	PF00917	0.706
LIG_TRAF2_1	29	32	PF00917	0.632
MOD_CDK_SPK_2	100	105	PF00069	0.651
MOD_GlcNHglycan	26	29	PF01048	0.533
MOD_GSK3_1	55	62	PF00069	0.513
MOD_N-GLC_1	80	85	PF02516	0.543
MOD_NEK2_1	59	64	PF00069	0.578
MOD_PKA_2	40	46	PF00069	0.503
MOD_Plk_1	115	121	PF00069	0.550
MOD_Plk_1	55	61	PF00069	0.503
MOD_Plk_4	55	61	PF00069	0.499
MOD_Plk_4	70	76	PF00069	0.508
MOD_ProDKin_1	100	106	PF00069	0.696
MOD_ProDKin_1	83	89	PF00069	0.437
TRG_ER_diArg_1	63	65	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC2	Leptomonas seymouri	90%	100%
A0A0S4ISS2	Bodo saltans	39%	100%
A0A3S5H754	Leishmania donovani	96%	100%
A0A422P399	Trypanosoma rangeli	57%	100%
A4H9Z9	Leishmania braziliensis	92%	100%
A4HY63	Leishmania infantum	96%	100%
D0A0I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4QDI0	Leishmania major	97%	100%
V5BBY6	Trypanosoma cruzi	56%	100%