Putative synaptobrevin-type transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vesicle-trafficking protein SEC22, putative

Species:

Leishmania mexicana

UniProt:

E9ARZ2_LEIMU

TriTrypDb:

LmxM.19.0400

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	1
GO:0005737	cytoplasm	2	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031201	SNARE complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ARZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	12
GO:0009987	cellular process	1	12
GO:0016192	vesicle-mediated transport	4	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048280	vesicle fusion with Golgi apparatus	6	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	12
GO:0030674	protein-macromolecule adaptor activity	2	12
GO:0060090	molecular adaptor activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.588
CLV_NRD_NRD_1	144	146	PF00675	0.403
CLV_NRD_NRD_1	193	195	PF00675	0.435
CLV_NRD_NRD_1	214	216	PF00675	0.263
CLV_PCSK_KEX2_1	193	195	PF00082	0.435
CLV_PCSK_SKI1_1	146	150	PF00082	0.410
CLV_PCSK_SKI1_1	256	260	PF00082	0.362
CLV_PCSK_SKI1_1	91	95	PF00082	0.339
DEG_APCC_DBOX_1	214	222	PF00400	0.458
DOC_CKS1_1	121	126	PF01111	0.630
DOC_CYCLIN_RxL_1	88	97	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.436
DOC_USP7_MATH_1	179	183	PF00917	0.764
DOC_USP7_MATH_1	20	24	PF00917	0.504
DOC_USP7_MATH_1	58	62	PF00917	0.613
DOC_WW_Pin1_4	120	125	PF00397	0.629
DOC_WW_Pin1_4	45	50	PF00397	0.592
LIG_14-3-3_CanoR_1	256	262	PF00244	0.368
LIG_Actin_WH2_2	79	97	PF00022	0.514
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_FHA_1	187	193	PF00498	0.751
LIG_FHA_1	82	88	PF00498	0.559
LIG_FHA_2	121	127	PF00498	0.575
LIG_FHA_2	155	161	PF00498	0.700
LIG_FHA_2	221	227	PF00498	0.463
LIG_LIR_Apic_2	260	264	PF02991	0.390
LIG_LIR_Gen_1	112	122	PF02991	0.499
LIG_LIR_Gen_1	61	70	PF02991	0.543
LIG_LIR_LC3C_4	82	87	PF02991	0.567
LIG_LIR_Nem_3	112	118	PF02991	0.489
LIG_LIR_Nem_3	61	66	PF02991	0.526
LIG_LIR_Nem_3	70	76	PF02991	0.474
LIG_MAD2	41	49	PF02301	0.560
LIG_PDZ_Class_2	275	280	PF00595	0.304
LIG_Pex14_2	270	274	PF04695	0.398
LIG_Pex14_2	275	279	PF04695	0.380
LIG_PTB_Apo_2	194	201	PF02174	0.636
LIG_PTB_Phospho_1	194	200	PF10480	0.638
LIG_SH2_CRK	135	139	PF00017	0.583
LIG_SH2_CRK	200	204	PF00017	0.443
LIG_SH2_CRK	261	265	PF00017	0.304
LIG_SH2_GRB2like	29	32	PF00017	0.557
LIG_SH2_NCK_1	122	126	PF00017	0.651
LIG_SH2_NCK_1	29	33	PF00017	0.615
LIG_SH2_STAP1	234	238	PF00017	0.513
LIG_SH2_STAT5	122	125	PF00017	0.570
LIG_SH2_STAT5	24	27	PF00017	0.526
LIG_SH2_STAT5	276	279	PF00017	0.320
LIG_SH2_STAT5	73	76	PF00017	0.490
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.486
LIG_WRC_WIRS_1	63	68	PF05994	0.500
MOD_CK1_1	166	172	PF00069	0.756
MOD_CK2_1	120	126	PF00069	0.555
MOD_CK2_1	220	226	PF00069	0.463
MOD_CK2_1	58	64	PF00069	0.640
MOD_GlcNHglycan	165	168	PF01048	0.481
MOD_GlcNHglycan	172	175	PF01048	0.483
MOD_GlcNHglycan	181	184	PF01048	0.412
MOD_GlcNHglycan	234	237	PF01048	0.249
MOD_GlcNHglycan	96	99	PF01048	0.379
MOD_GSK3_1	165	172	PF00069	0.747
MOD_GSK3_1	58	65	PF00069	0.590
MOD_N-GLC_1	232	237	PF02516	0.322
MOD_N-GLC_1	27	32	PF02516	0.437
MOD_N-GLC_2	4	6	PF02516	0.376
MOD_NEK2_1	140	145	PF00069	0.530
MOD_NEK2_1	257	262	PF00069	0.425
MOD_PKA_2	155	161	PF00069	0.657
MOD_PKA_2	94	100	PF00069	0.547
MOD_Plk_1	140	146	PF00069	0.521
MOD_Plk_1	81	87	PF00069	0.511
MOD_Plk_4	58	64	PF00069	0.579
MOD_Plk_4	81	87	PF00069	0.486
MOD_ProDKin_1	120	126	PF00069	0.630
MOD_ProDKin_1	45	51	PF00069	0.599
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.463
TRG_ENDOCYTIC_2	135	138	PF00928	0.565
TRG_ENDOCYTIC_2	200	203	PF00928	0.452
TRG_ENDOCYTIC_2	276	279	PF00928	0.308
TRG_ENDOCYTIC_2	63	66	PF00928	0.497
TRG_ENDOCYTIC_2	73	76	PF00928	0.479
TRG_ER_diArg_1	192	194	PF00400	0.725
TRG_ER_diArg_1	254	257	PF00400	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I327	Leptomonas seymouri	85%	100%
A0A0S4ITE2	Bodo saltans	51%	100%
A0A1X0P6D4	Trypanosomatidae	65%	100%
A0A3S7WVE2	Leishmania donovani	99%	100%
A0A422P3A7	Trypanosoma rangeli	67%	100%
A4H9Z8	Leishmania braziliensis	94%	100%
A4HY62	Leishmania infantum	99%	100%
D0A0I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
P22214	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q4QDI1	Leishmania major	99%	100%
Q6C880	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6CJA0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FWT0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q74ZD2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
V5BBV8	Trypanosoma cruzi	68%	100%