Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARY6_LEIMU

TriTrypDb:

LmxM.19.0340

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ARY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.581
CLV_NRD_NRD_1	166	168	PF00675	0.621
CLV_NRD_NRD_1	194	196	PF00675	0.531
CLV_NRD_NRD_1	225	227	PF00675	0.499
CLV_NRD_NRD_1	292	294	PF00675	0.389
CLV_NRD_NRD_1	402	404	PF00675	0.413
CLV_PCSK_FUR_1	192	196	PF00082	0.545
CLV_PCSK_KEX2_1	166	168	PF00082	0.595
CLV_PCSK_KEX2_1	194	196	PF00082	0.531
CLV_PCSK_KEX2_1	292	294	PF00082	0.392
CLV_PCSK_KEX2_1	402	404	PF00082	0.406
CLV_PCSK_SKI1_1	226	230	PF00082	0.536
CLV_PCSK_SKI1_1	341	345	PF00082	0.495
CLV_PCSK_SKI1_1	447	451	PF00082	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SPOP_SBC_1	70	74	PF00917	0.683
DEG_SPOP_SBC_1	95	99	PF00917	0.703
DOC_CYCLIN_RxL_1	192	203	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.355
DOC_MAPK_gen_1	192	199	PF00069	0.491
DOC_MAPK_gen_1	314	324	PF00069	0.450
DOC_MAPK_gen_1	399	407	PF00069	0.266
DOC_MAPK_gen_1	7	17	PF00069	0.468
DOC_PP1_RVXF_1	315	322	PF00149	0.531
DOC_PP2B_LxvP_1	274	277	PF13499	0.467
DOC_PP4_FxxP_1	371	374	PF00568	0.541
DOC_PP4_FxxP_1	88	91	PF00568	0.487
DOC_USP7_MATH_1	147	151	PF00917	0.650
DOC_USP7_MATH_1	200	204	PF00917	0.589
DOC_USP7_MATH_1	329	333	PF00917	0.594
DOC_USP7_MATH_1	367	371	PF00917	0.518
DOC_USP7_MATH_1	432	436	PF00917	0.492
DOC_USP7_MATH_1	95	99	PF00917	0.740
DOC_USP7_UBL2_3	227	231	PF12436	0.400
DOC_USP7_UBL2_3	415	419	PF12436	0.575
DOC_USP7_UBL2_3	443	447	PF12436	0.492
DOC_WW_Pin1_4	305	310	PF00397	0.545
DOC_WW_Pin1_4	349	354	PF00397	0.511
LIG_14-3-3_CanoR_1	10	17	PF00244	0.748
LIG_14-3-3_CanoR_1	114	123	PF00244	0.694
LIG_14-3-3_CanoR_1	152	157	PF00244	0.454
LIG_14-3-3_CanoR_1	68	78	PF00244	0.681
LIG_AP2alpha_1	362	366	PF02296	0.515
LIG_eIF4E_1	38	44	PF01652	0.696
LIG_FHA_1	185	191	PF00498	0.515
LIG_FHA_1	208	214	PF00498	0.709
LIG_FHA_1	240	246	PF00498	0.561
LIG_FHA_1	352	358	PF00498	0.558
LIG_FHA_1	376	382	PF00498	0.496
LIG_FHA_1	38	44	PF00498	0.620
LIG_FHA_2	159	165	PF00498	0.479
LIG_FHA_2	412	418	PF00498	0.483
LIG_FHA_2	72	78	PF00498	0.683
LIG_Integrin_isoDGR_2	410	412	PF01839	0.480
LIG_LIR_Apic_2	158	163	PF02991	0.542
LIG_LIR_Apic_2	368	374	PF02991	0.524
LIG_LIR_Gen_1	121	127	PF02991	0.696
LIG_LIR_Gen_1	275	285	PF02991	0.522
LIG_LIR_Gen_1	320	329	PF02991	0.546
LIG_LIR_Nem_3	121	125	PF02991	0.696
LIG_LIR_Nem_3	275	281	PF02991	0.523
LIG_LIR_Nem_3	298	304	PF02991	0.390
LIG_LIR_Nem_3	320	324	PF02991	0.513
LIG_MYND_1	138	142	PF01753	0.670
LIG_NRBOX	432	438	PF00104	0.563
LIG_Pex14_1	71	75	PF04695	0.606
LIG_Pex14_2	344	348	PF04695	0.394
LIG_Pex14_2	362	366	PF04695	0.367
LIG_SH2_CRK	301	305	PF00017	0.530
LIG_SH2_NCK_1	160	164	PF00017	0.434
LIG_SH2_PTP2	173	176	PF00017	0.538
LIG_SH2_PTP2	278	281	PF00017	0.451
LIG_SH2_SRC	173	176	PF00017	0.621
LIG_SH2_SRC	27	30	PF00017	0.646
LIG_SH2_STAT5	160	163	PF00017	0.574
LIG_SH2_STAT5	173	176	PF00017	0.501
LIG_SH2_STAT5	267	270	PF00017	0.564
LIG_SH2_STAT5	27	30	PF00017	0.646
LIG_SH2_STAT5	278	281	PF00017	0.217
LIG_SH3_3	451	457	PF00018	0.585
LIG_SH3_3	79	85	PF00018	0.715
LIG_SH3_4	181	188	PF00018	0.622
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.451
LIG_SUMO_SIM_par_1	403	409	PF11976	0.390
LIG_TRAF2_1	143	146	PF00917	0.667
LIG_TRAF2_1	414	417	PF00917	0.420
LIG_WRC_WIRS_1	304	309	PF05994	0.474
MOD_CK1_1	118	124	PF00069	0.659
MOD_CK1_1	158	164	PF00069	0.655
MOD_CK1_1	183	189	PF00069	0.580
MOD_CK1_1	203	209	PF00069	0.489
MOD_CK1_1	98	104	PF00069	0.704
MOD_CK2_1	411	417	PF00069	0.454
MOD_CK2_1	71	77	PF00069	0.609
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.563
MOD_GlcNHglycan	106	109	PF01048	0.647
MOD_GlcNHglycan	207	210	PF01048	0.592
MOD_GlcNHglycan	214	217	PF01048	0.477
MOD_GlcNHglycan	331	334	PF01048	0.501
MOD_GlcNHglycan	335	338	PF01048	0.448
MOD_GlcNHglycan	389	392	PF01048	0.408
MOD_GlcNHglycan	92	95	PF01048	0.735
MOD_GSK3_1	108	115	PF00069	0.725
MOD_GSK3_1	147	154	PF00069	0.563
MOD_GSK3_1	180	187	PF00069	0.623
MOD_GSK3_1	200	207	PF00069	0.450
MOD_GSK3_1	28	35	PF00069	0.634
MOD_GSK3_1	329	336	PF00069	0.445
MOD_GSK3_1	351	358	PF00069	0.519
MOD_GSK3_1	375	382	PF00069	0.471
MOD_GSK3_1	9	16	PF00069	0.740
MOD_GSK3_1	90	97	PF00069	0.749
MOD_GSK3_1	99	106	PF00069	0.703
MOD_N-GLC_1	397	402	PF02516	0.419
MOD_N-GLC_1	45	50	PF02516	0.636
MOD_N-GLC_2	110	112	PF02516	0.454
MOD_NEK2_1	156	161	PF00069	0.607
MOD_NEK2_1	204	209	PF00069	0.463
MOD_NEK2_1	296	301	PF00069	0.510
MOD_NEK2_1	303	308	PF00069	0.488
MOD_NEK2_1	379	384	PF00069	0.483
MOD_OFUCOSY	396	401	PF10250	0.538
MOD_PIKK_1	112	118	PF00454	0.671
MOD_PIKK_1	181	187	PF00454	0.602
MOD_PIKK_1	355	361	PF00454	0.553
MOD_PKA_2	104	110	PF00069	0.473
MOD_PKA_2	151	157	PF00069	0.476
MOD_PKA_2	411	417	PF00069	0.444
MOD_PKA_2	9	15	PF00069	0.643
MOD_Plk_1	112	118	PF00069	0.716
MOD_Plk_1	367	373	PF00069	0.361
MOD_Plk_1	375	381	PF00069	0.518
MOD_Plk_4	118	124	PF00069	0.595
MOD_Plk_4	209	215	PF00069	0.612
MOD_Plk_4	296	302	PF00069	0.373
MOD_Plk_4	39	45	PF00069	0.690
MOD_Plk_4	432	438	PF00069	0.563
MOD_ProDKin_1	305	311	PF00069	0.541
MOD_ProDKin_1	349	355	PF00069	0.503
MOD_SUMO_rev_2	164	172	PF00179	0.651
MOD_SUMO_rev_2	53	62	PF00179	0.595
TRG_DiLeu_BaEn_1	260	265	PF01217	0.410
TRG_ENDOCYTIC_2	278	281	PF00928	0.500
TRG_ENDOCYTIC_2	301	304	PF00928	0.426
TRG_ENDOCYTIC_2	75	78	PF00928	0.593
TRG_ER_diArg_1	165	167	PF00400	0.659
TRG_ER_diArg_1	191	194	PF00400	0.479
TRG_ER_diArg_1	402	404	PF00400	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K5	Leptomonas seymouri	58%	100%
A0A0S4J8I1	Bodo saltans	38%	100%
A0A0S4J9L9	Bodo saltans	38%	100%
A0A1X0P6D5	Trypanosomatidae	46%	100%
A0A3R7KYH1	Trypanosoma rangeli	44%	100%
A0A3S5H753	Leishmania donovani	91%	100%
A4H9Z2	Leishmania braziliensis	82%	97%
A4HY56	Leishmania infantum	91%	100%
D0A0G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QDI7	Leishmania major	91%	100%
V5C1T2	Trypanosoma cruzi	45%	100%