Intraflagellar transport protein component,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 52

Species:

Leishmania mexicana

UniProt:

E9ARY4_LEIMU

TriTrypDb:

LmxM.19.0320

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARY4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	303	305	PF00675	0.472
CLV_NRD_NRD_1	60	62	PF00675	0.526
CLV_PCSK_KEX2_1	303	305	PF00082	0.473
CLV_PCSK_SKI1_1	148	152	PF00082	0.541
CLV_PCSK_SKI1_1	177	181	PF00082	0.562
CLV_PCSK_SKI1_1	201	205	PF00082	0.645
CLV_PCSK_SKI1_1	383	387	PF00082	0.483
CLV_PCSK_SKI1_1	503	507	PF00082	0.452
CLV_PCSK_SKI1_1	663	667	PF00082	0.527
CLV_Separin_Metazoa	380	384	PF03568	0.495
DEG_APCC_DBOX_1	461	469	PF00400	0.513
DEG_APCC_DBOX_1	502	510	PF00400	0.441
DEG_APCC_DBOX_1	662	670	PF00400	0.535
DEG_SCF_FBW7_2	92	98	PF00400	0.517
DOC_ANK_TNKS_1	104	111	PF00023	0.483
DOC_ANK_TNKS_1	217	224	PF00023	0.488
DOC_CKS1_1	425	430	PF01111	0.582
DOC_CKS1_1	92	97	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	420	423	PF00134	0.536
DOC_MAPK_DCC_7	410	420	PF00069	0.630
DOC_MAPK_DCC_7	442	451	PF00069	0.560
DOC_MAPK_FxFP_2	257	260	PF00069	0.353
DOC_MAPK_gen_1	303	312	PF00069	0.405
DOC_MAPK_gen_1	61	71	PF00069	0.420
DOC_MAPK_MEF2A_6	442	451	PF00069	0.549
DOC_MAPK_RevD_3	504	518	PF00069	0.462
DOC_PP1_RVXF_1	37	43	PF00149	0.431
DOC_PP2B_LxvP_1	420	423	PF13499	0.536
DOC_PP4_FxxP_1	257	260	PF00568	0.353
DOC_PP4_FxxP_1	425	428	PF00568	0.554
DOC_PP4_FxxP_1	89	92	PF00568	0.446
DOC_USP7_MATH_1	236	240	PF00917	0.673
DOC_USP7_MATH_1	523	527	PF00917	0.720
DOC_USP7_UBL2_3	173	177	PF12436	0.479
DOC_USP7_UBL2_3	410	414	PF12436	0.467
DOC_WW_Pin1_4	183	188	PF00397	0.621
DOC_WW_Pin1_4	3	8	PF00397	0.704
DOC_WW_Pin1_4	424	429	PF00397	0.588
DOC_WW_Pin1_4	493	498	PF00397	0.539
DOC_WW_Pin1_4	565	570	PF00397	0.466
DOC_WW_Pin1_4	91	96	PF00397	0.572
LIG_14-3-3_CanoR_1	601	609	PF00244	0.453
LIG_14-3-3_CanoR_1	80	90	PF00244	0.581
LIG_Actin_WH2_2	635	653	PF00022	0.427
LIG_BIR_III_2	566	570	PF00653	0.522
LIG_BRCT_BRCA1_1	187	191	PF00533	0.640
LIG_BRCT_BRCA1_1	253	257	PF00533	0.427
LIG_BRCT_BRCA1_1	275	279	PF00533	0.379
LIG_BRCT_BRCA1_1	332	336	PF00533	0.449
LIG_BRCT_BRCA1_1	598	602	PF00533	0.480
LIG_CaM_NSCaTE_8	625	632	PF13499	0.541
LIG_Clathr_ClatBox_1	388	392	PF01394	0.552
LIG_Clathr_ClatBox_1	451	455	PF01394	0.527
LIG_DLG_GKlike_1	619	627	PF00625	0.340
LIG_FHA_1	161	167	PF00498	0.497
LIG_FHA_1	193	199	PF00498	0.737
LIG_FHA_1	204	210	PF00498	0.785
LIG_FHA_1	251	257	PF00498	0.443
LIG_FHA_1	262	268	PF00498	0.383
LIG_FHA_1	362	368	PF00498	0.488
LIG_FHA_1	396	402	PF00498	0.484
LIG_FHA_1	489	495	PF00498	0.490
LIG_FHA_2	130	136	PF00498	0.426
LIG_FHA_2	138	144	PF00498	0.409
LIG_FHA_2	566	572	PF00498	0.492
LIG_FHA_2	666	672	PF00498	0.594
LIG_GBD_Chelix_1	331	339	PF00786	0.510
LIG_LIR_Apic_2	14	19	PF02991	0.701
LIG_LIR_Apic_2	254	260	PF02991	0.381
LIG_LIR_Apic_2	424	428	PF02991	0.556
LIG_LIR_Gen_1	333	343	PF02991	0.391
LIG_LIR_Gen_1	356	365	PF02991	0.476
LIG_LIR_Gen_1	384	391	PF02991	0.499
LIG_LIR_Gen_1	406	415	PF02991	0.477
LIG_LIR_Nem_3	134	139	PF02991	0.392
LIG_LIR_Nem_3	276	282	PF02991	0.390
LIG_LIR_Nem_3	333	339	PF02991	0.473
LIG_LIR_Nem_3	356	361	PF02991	0.504
LIG_LIR_Nem_3	384	388	PF02991	0.492
LIG_LIR_Nem_3	406	411	PF02991	0.469
LIG_LIR_Nem_3	476	482	PF02991	0.447
LIG_LIR_Nem_3	507	513	PF02991	0.442
LIG_LIR_Nem_3	515	519	PF02991	0.481
LIG_LIR_Nem_3	622	628	PF02991	0.433
LIG_PDZ_Class_3	667	672	PF00595	0.467
LIG_Pex14_2	318	322	PF04695	0.536
LIG_Pex14_2	385	389	PF04695	0.475
LIG_SH2_CRK	126	130	PF00017	0.428
LIG_SH2_CRK	408	412	PF00017	0.493
LIG_SH2_CRK	516	520	PF00017	0.531
LIG_SH2_PTP2	639	642	PF00017	0.522
LIG_SH2_SRC	107	110	PF00017	0.452
LIG_SH2_SRC	154	157	PF00017	0.439
LIG_SH2_SRC	338	341	PF00017	0.509
LIG_SH2_SRC	579	582	PF00017	0.536
LIG_SH2_STAP1	621	625	PF00017	0.322
LIG_SH2_STAT3	480	483	PF00017	0.463
LIG_SH2_STAT5	107	110	PF00017	0.392
LIG_SH2_STAT5	128	131	PF00017	0.444
LIG_SH2_STAT5	154	157	PF00017	0.423
LIG_SH2_STAT5	338	341	PF00017	0.460
LIG_SH2_STAT5	480	483	PF00017	0.427
LIG_SH2_STAT5	508	511	PF00017	0.473
LIG_SH2_STAT5	579	582	PF00017	0.536
LIG_SH2_STAT5	639	642	PF00017	0.522
LIG_SH2_STAT5	667	670	PF00017	0.523
LIG_SH3_2	428	433	PF14604	0.562
LIG_SH3_3	1	7	PF00018	0.646
LIG_SH3_3	264	270	PF00018	0.424
LIG_SH3_3	425	431	PF00018	0.560
LIG_SH3_3	433	439	PF00018	0.605
LIG_SH3_3	441	447	PF00018	0.654
LIG_SH3_3	84	90	PF00018	0.524
LIG_SUMO_SIM_anti_2	416	422	PF11976	0.517
LIG_SUMO_SIM_par_1	113	120	PF11976	0.474
LIG_SUMO_SIM_par_1	308	314	PF11976	0.371
LIG_TRAF2_1	248	251	PF00917	0.726
LIG_TRAF2_1	603	606	PF00917	0.366
LIG_TRAF2_1	668	671	PF00917	0.549
LIG_TYR_ITIM	477	482	PF00017	0.573
LIG_TYR_ITIM	514	519	PF00017	0.508
LIG_TYR_ITIM	637	642	PF00017	0.531
LIG_UBA3_1	335	344	PF00899	0.388
LIG_UBA3_1	388	395	PF00899	0.526
LIG_WRC_WIRS_1	391	396	PF05994	0.498
MOD_CDC14_SPxK_1	6	9	PF00782	0.642
MOD_CDK_SPK_2	493	498	PF00069	0.539
MOD_CDK_SPxK_1	3	9	PF00069	0.646
MOD_CDK_SPxxK_3	493	500	PF00069	0.531
MOD_CK1_1	127	133	PF00069	0.315
MOD_CK1_1	186	192	PF00069	0.743
MOD_CK1_1	409	415	PF00069	0.548
MOD_CK1_1	466	472	PF00069	0.459
MOD_CK1_1	600	606	PF00069	0.352
MOD_CK2_1	137	143	PF00069	0.405
MOD_CK2_1	363	369	PF00069	0.472
MOD_CK2_1	600	606	PF00069	0.559
MOD_CK2_1	665	671	PF00069	0.598
MOD_Cter_Amidation	175	178	PF01082	0.484
MOD_Cter_Amidation	301	304	PF01082	0.536
MOD_GlcNHglycan	112	115	PF01048	0.400
MOD_GlcNHglycan	188	191	PF01048	0.757
MOD_GlcNHglycan	233	236	PF01048	0.667
MOD_GlcNHglycan	238	241	PF01048	0.656
MOD_GlcNHglycan	276	279	PF01048	0.394
MOD_GlcNHglycan	313	316	PF01048	0.381
MOD_GlcNHglycan	520	523	PF01048	0.586
MOD_GlcNHglycan	535	538	PF01048	0.625
MOD_GlcNHglycan	602	605	PF01048	0.394
MOD_GlcNHglycan	81	84	PF01048	0.464
MOD_GSK3_1	160	167	PF00069	0.494
MOD_GSK3_1	208	215	PF00069	0.652
MOD_GSK3_1	326	333	PF00069	0.526
MOD_GSK3_1	361	368	PF00069	0.490
MOD_GSK3_1	557	564	PF00069	0.622
MOD_GSK3_1	596	603	PF00069	0.417
MOD_N-GLC_1	216	221	PF02516	0.614
MOD_N-GLC_1	327	332	PF02516	0.502
MOD_N-GLC_2	43	45	PF02516	0.433
MOD_N-GLC_2	470	472	PF02516	0.449
MOD_NEK2_1	216	221	PF00069	0.638
MOD_NEK2_1	231	236	PF00069	0.553
MOD_NEK2_1	274	279	PF00069	0.490
MOD_NEK2_1	311	316	PF00069	0.324
MOD_NEK2_1	488	493	PF00069	0.484
MOD_NEK2_1	596	601	PF00069	0.523
MOD_NEK2_2	194	199	PF00069	0.715
MOD_PIKK_1	383	389	PF00454	0.622
MOD_PIKK_1	463	469	PF00454	0.456
MOD_PIKK_1	523	529	PF00454	0.717
MOD_PKA_2	463	469	PF00069	0.446
MOD_PKA_2	557	563	PF00069	0.523
MOD_PKA_2	596	602	PF00069	0.473
MOD_PKA_2	79	85	PF00069	0.593
MOD_Plk_1	216	222	PF00069	0.642
MOD_Plk_1	250	256	PF00069	0.611
MOD_Plk_1	326	332	PF00069	0.483
MOD_Plk_1	383	389	PF00069	0.586
MOD_Plk_1	597	603	PF00069	0.586
MOD_Plk_1	619	625	PF00069	0.409
MOD_Plk_1	74	80	PF00069	0.464
MOD_Plk_2-3	363	369	PF00069	0.452
MOD_Plk_2-3	74	80	PF00069	0.464
MOD_Plk_4	124	130	PF00069	0.505
MOD_Plk_4	209	215	PF00069	0.700
MOD_Plk_4	251	257	PF00069	0.445
MOD_Plk_4	330	336	PF00069	0.402
MOD_Plk_4	416	422	PF00069	0.529
MOD_ProDKin_1	183	189	PF00069	0.621
MOD_ProDKin_1	3	9	PF00069	0.706
MOD_ProDKin_1	424	430	PF00069	0.585
MOD_ProDKin_1	493	499	PF00069	0.533
MOD_ProDKin_1	565	571	PF00069	0.471
MOD_ProDKin_1	91	97	PF00069	0.574
MOD_SUMO_for_1	413	416	PF00179	0.470
MOD_SUMO_rev_2	337	343	PF00179	0.416
MOD_SUMO_rev_2	606	616	PF00179	0.621
TRG_DiLeu_BaEn_1	251	256	PF01217	0.583
TRG_DiLeu_BaEn_1	416	421	PF01217	0.515
TRG_DiLeu_BaEn_4	326	332	PF01217	0.396
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.516
TRG_ENDOCYTIC_2	126	129	PF00928	0.425
TRG_ENDOCYTIC_2	358	361	PF00928	0.505
TRG_ENDOCYTIC_2	408	411	PF00928	0.473
TRG_ENDOCYTIC_2	479	482	PF00928	0.561
TRG_ENDOCYTIC_2	516	519	PF00928	0.524
TRG_ENDOCYTIC_2	56	59	PF00928	0.461
TRG_ENDOCYTIC_2	639	642	PF00928	0.522
TRG_ER_diArg_1	370	373	PF00400	0.585
TRG_ER_diArg_1	462	465	PF00400	0.516
TRG_ER_diArg_1	497	500	PF00400	0.589
TRG_ER_diArg_1	8	11	PF00400	0.658
TRG_NES_CRM1_1	379	392	PF08389	0.625
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDM4	Leptomonas seymouri	77%	99%
A0A0S4KG78	Bodo saltans	55%	100%
A0A1X0P7F0	Trypanosomatidae	66%	100%
A0A3R7NUY6	Trypanosoma rangeli	65%	100%
A0A3S5H752	Leishmania donovani	94%	100%
A4H9Z0	Leishmania braziliensis	88%	100%
A4HY54	Leishmania infantum	94%	100%
D0A0G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
Q4QDI9	Leishmania major	95%	100%
V5DTK4	Trypanosoma cruzi	65%	100%