RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA binding protein

Species:

Leishmania mexicana

UniProt:

E9ARY2_LEIMU

TriTrypDb:

LmxM.19.0295

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ARY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARY2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.481
CLV_NRD_NRD_1	144	146	PF00675	0.479
CLV_NRD_NRD_1	39	41	PF00675	0.524
CLV_NRD_NRD_1	71	73	PF00675	0.549
CLV_NRD_NRD_1	88	90	PF00675	0.571
CLV_PCSK_KEX2_1	144	146	PF00082	0.419
CLV_PCSK_KEX2_1	39	41	PF00082	0.548
CLV_PCSK_KEX2_1	71	73	PF00082	0.507
CLV_PCSK_KEX2_1	88	90	PF00082	0.518
DEG_APCC_DBOX_1	38	46	PF00400	0.360
DOC_CYCLIN_RxL_1	37	47	PF00134	0.380
DOC_MAPK_MEF2A_6	211	220	PF00069	0.542
DOC_MAPK_MEF2A_6	245	254	PF00069	0.450
DOC_MAPK_MEF2A_6	39	46	PF00069	0.382
DOC_MAPK_NFAT4_5	39	47	PF00069	0.381
DOC_USP7_MATH_1	187	191	PF00917	0.668
DOC_USP7_MATH_1	333	337	PF00917	0.723
DOC_USP7_MATH_2	183	189	PF00917	0.465
DOC_USP7_UBL2_3	119	123	PF12436	0.559
DOC_USP7_UBL2_3	368	372	PF12436	0.655
DOC_WW_Pin1_4	14	19	PF00397	0.539
DOC_WW_Pin1_4	2	7	PF00397	0.540
LIG_14-3-3_CanoR_1	283	293	PF00244	0.515
LIG_14-3-3_CanoR_1	39	43	PF00244	0.584
LIG_BIR_II_1	1	5	PF00653	0.405
LIG_FHA_1	14	20	PF00498	0.583
LIG_FHA_1	22	28	PF00498	0.500
LIG_FHA_1	317	323	PF00498	0.712
LIG_FHA_2	127	133	PF00498	0.434
LIG_FHA_2	285	291	PF00498	0.560
LIG_GBD_Chelix_1	44	52	PF00786	0.442
LIG_LIR_Gen_1	57	64	PF02991	0.550
LIG_LIR_Nem_3	263	269	PF02991	0.393
LIG_LIR_Nem_3	57	62	PF02991	0.551
LIG_LIR_Nem_3	68	73	PF02991	0.551
LIG_LRP6_Inhibitor_1	273	279	PF00058	0.390
LIG_NRBOX	145	151	PF00104	0.501
LIG_PTB_Apo_2	265	272	PF02174	0.408
LIG_PTB_Phospho_1	265	271	PF10480	0.429
LIG_SH2_CRK	235	239	PF00017	0.539
LIG_SH2_CRK	59	63	PF00017	0.450
LIG_SH2_CRK	70	74	PF00017	0.460
LIG_SH2_GRB2like	300	303	PF00017	0.546
LIG_SH2_SRC	90	93	PF00017	0.496
LIG_SH2_STAP1	271	275	PF00017	0.407
LIG_SH2_STAT3	125	128	PF00017	0.536
LIG_SH2_STAT5	103	106	PF00017	0.448
LIG_SH2_STAT5	113	116	PF00017	0.409
LIG_SH3_3	153	159	PF00018	0.668
LIG_SH3_3	172	178	PF00018	0.489
LIG_SH3_3	292	298	PF00018	0.570
LIG_SH3_3	90	96	PF00018	0.379
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.426
LIG_TRAF2_1	129	132	PF00917	0.457
MOD_CK1_1	126	132	PF00069	0.476
MOD_CK1_1	2	8	PF00069	0.472
MOD_CK1_1	336	342	PF00069	0.634
MOD_CK1_1	346	352	PF00069	0.799
MOD_CK2_1	126	132	PF00069	0.455
MOD_CK2_1	284	290	PF00069	0.560
MOD_CK2_1	353	359	PF00069	0.747
MOD_CK2_1	44	50	PF00069	0.479
MOD_GlcNHglycan	1	4	PF01048	0.587
MOD_GlcNHglycan	189	192	PF01048	0.672
MOD_GlcNHglycan	228	232	PF01048	0.628
MOD_GlcNHglycan	348	351	PF01048	0.709
MOD_GlcNHglycan	378	381	PF01048	0.740
MOD_GSK3_1	108	115	PF00069	0.425
MOD_GSK3_1	119	126	PF00069	0.488
MOD_GSK3_1	23	30	PF00069	0.574
MOD_GSK3_1	332	339	PF00069	0.593
MOD_GSK3_1	97	104	PF00069	0.424
MOD_N-GLC_1	139	144	PF02516	0.436
MOD_N-GLC_1	333	338	PF02516	0.754
MOD_NEK2_1	27	32	PF00069	0.512
MOD_NEK2_1	284	289	PF00069	0.480
MOD_NEK2_1	44	49	PF00069	0.429
MOD_OFUCOSY	282	288	PF10250	0.548
MOD_PIKK_1	123	129	PF00454	0.402
MOD_PIKK_1	21	27	PF00454	0.564
MOD_PIKK_1	333	339	PF00454	0.614
MOD_PKA_2	346	352	PF00069	0.621
MOD_PKA_2	373	379	PF00069	0.536
MOD_PKA_2	38	44	PF00069	0.581
MOD_Plk_1	108	114	PF00069	0.448
MOD_Plk_1	139	145	PF00069	0.458
MOD_Plk_1	262	268	PF00069	0.432
MOD_Plk_2-3	101	107	PF00069	0.426
MOD_Plk_4	27	33	PF00069	0.588
MOD_Plk_4	353	359	PF00069	0.473
MOD_ProDKin_1	14	20	PF00069	0.533
MOD_ProDKin_1	2	8	PF00069	0.542
MOD_SUMO_rev_2	111	120	PF00179	0.529
MOD_SUMO_rev_2	75	80	PF00179	0.551
TRG_ENDOCYTIC_2	59	62	PF00928	0.417
TRG_ENDOCYTIC_2	70	73	PF00928	0.421
TRG_ENDOCYTIC_2	90	93	PF00928	0.389
TRG_ER_diArg_1	143	145	PF00400	0.466
TRG_ER_diArg_1	38	40	PF00400	0.537
TRG_ER_diArg_1	70	72	PF00400	0.563
TRG_ER_diArg_1	87	89	PF00400	0.546
TRG_ER_diLys_1	389	393	PF00400	0.726
TRG_NES_CRM1_1	148	160	PF08389	0.628
TRG_NES_CRM1_1	37	50	PF08389	0.559
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	70%	99%
A0A0N1PG85	Leptomonas seymouri	32%	100%
A0A0S4KEK3	Bodo saltans	38%	100%
A0A1X0P6E1	Trypanosomatidae	36%	100%
A0A3Q8IA61	Leishmania donovani	31%	100%
A0A3R7RSV6	Trypanosoma rangeli	34%	100%
A0A3S7WVD2	Leishmania donovani	95%	100%
A0A422P3A2	Trypanosoma rangeli	40%	96%
A4H9Y7	Leishmania braziliensis	31%	100%
A4H9Y8	Leishmania braziliensis	71%	100%
A4HY39	Leishmania infantum	94%	100%
A4HY52	Leishmania infantum	33%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
Q4QDJ1	Leishmania major	30%	97%
V5BSB1	Trypanosoma cruzi	36%	82%
V5BWY8	Trypanosoma cruzi	33%	100%