Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARY1_LEIMU

TriTrypDb:

LmxM.19.0300

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.423
CLV_NRD_NRD_1	212	214	PF00675	0.686
CLV_PCSK_KEX2_1	212	214	PF00082	0.686
CLV_PCSK_KEX2_1	41	43	PF00082	0.607
CLV_PCSK_KEX2_1	97	99	PF00082	0.535
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.607
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.530
CLV_PCSK_SKI1_1	150	154	PF00082	0.477
CLV_PCSK_SKI1_1	160	164	PF00082	0.398
CLV_PCSK_SKI1_1	168	172	PF00082	0.393
CLV_PCSK_SKI1_1	193	197	PF00082	0.591
CLV_PCSK_SKI1_1	65	69	PF00082	0.503
DOC_MAPK_gen_1	231	241	PF00069	0.503
DOC_MAPK_MEF2A_6	234	241	PF00069	0.400
DOC_PP1_RVXF_1	276	283	PF00149	0.455
DOC_PP2B_LxvP_1	155	158	PF13499	0.565
DOC_PP2B_PxIxI_1	236	242	PF00149	0.442
DOC_PP4_FxxP_1	282	285	PF00568	0.458
DOC_USP7_MATH_1	151	155	PF00917	0.464
DOC_USP7_MATH_1	158	162	PF00917	0.375
DOC_USP7_MATH_1	177	181	PF00917	0.579
DOC_USP7_MATH_1	305	309	PF00917	0.672
DOC_USP7_UBL2_3	268	272	PF12436	0.567
DOC_WW_Pin1_4	11	16	PF00397	0.699
DOC_WW_Pin1_4	139	144	PF00397	0.550
DOC_WW_Pin1_4	175	180	PF00397	0.615
LIG_14-3-3_CanoR_1	160	166	PF00244	0.554
LIG_14-3-3_CanoR_1	168	173	PF00244	0.584
LIG_14-3-3_CanoR_1	65	70	PF00244	0.572
LIG_APCC_ABBA_1	43	48	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.394
LIG_BRCT_BRCA1_1	118	122	PF00533	0.408
LIG_FHA_1	151	157	PF00498	0.461
LIG_FHA_1	66	72	PF00498	0.539
LIG_FHA_2	162	168	PF00498	0.512
LIG_KLC1_Yacidic_2	84	89	PF13176	0.437
LIG_LIR_Apic_2	281	285	PF02991	0.461
LIG_LIR_Nem_3	107	112	PF02991	0.561
LIG_LIR_Nem_3	250	256	PF02991	0.403
LIG_PCNA_yPIPBox_3	159	168	PF02747	0.466
LIG_PTAP_UEV_1	178	183	PF05743	0.465
LIG_SH2_PTP2	109	112	PF00017	0.512
LIG_SH2_SRC	132	135	PF00017	0.551
LIG_SH2_SRC	78	81	PF00017	0.544
LIG_SH2_STAP1	258	262	PF00017	0.416
LIG_SH2_STAP1	53	57	PF00017	0.424
LIG_SH2_STAP1	78	82	PF00017	0.425
LIG_SH2_STAT3	53	56	PF00017	0.424
LIG_SH2_STAT5	109	112	PF00017	0.473
LIG_SH2_STAT5	132	135	PF00017	0.431
LIG_SH2_STAT5	244	247	PF00017	0.398
LIG_SH2_STAT5	87	90	PF00017	0.514
LIG_SH3_3	176	182	PF00018	0.667
LIG_SH3_5	285	289	PF00018	0.596
LIG_TRAF2_1	299	302	PF00917	0.619
LIG_TRAF2_1	81	84	PF00917	0.571
MOD_CK1_1	145	151	PF00069	0.490
MOD_CK1_1	161	167	PF00069	0.433
MOD_CK2_1	128	134	PF00069	0.520
MOD_CK2_1	305	311	PF00069	0.490
MOD_GlcNHglycan	179	182	PF01048	0.494
MOD_GlcNHglycan	221	225	PF01048	0.614
MOD_GSK3_1	116	123	PF00069	0.418
MOD_GSK3_1	141	148	PF00069	0.532
MOD_GSK3_1	189	196	PF00069	0.727
MOD_LATS_1	191	197	PF00433	0.589
MOD_N-GLC_1	158	163	PF02516	0.449
MOD_N-GLC_1	201	206	PF02516	0.734
MOD_N-GLC_1	247	252	PF02516	0.526
MOD_N-GLC_1	303	308	PF02516	0.535
MOD_N-GLC_1	36	41	PF02516	0.554
MOD_N-GLC_2	267	269	PF02516	0.553
MOD_N-GLC_2	273	275	PF02516	0.583
MOD_NEK2_1	1	6	PF00069	0.620
MOD_NEK2_1	46	51	PF00069	0.488
MOD_NEK2_2	158	163	PF00069	0.420
MOD_OFUCOSY	245	251	PF10250	0.416
MOD_PIKK_1	36	42	PF00454	0.578
MOD_PKA_2	125	131	PF00069	0.541
MOD_PKA_2	46	52	PF00069	0.591
MOD_Plk_1	158	164	PF00069	0.470
MOD_Plk_1	201	207	PF00069	0.632
MOD_Plk_2-3	120	126	PF00069	0.428
MOD_Plk_4	128	134	PF00069	0.503
MOD_Plk_4	151	157	PF00069	0.429
MOD_Plk_4	161	167	PF00069	0.407
MOD_Plk_4	46	52	PF00069	0.570
MOD_ProDKin_1	11	17	PF00069	0.699
MOD_ProDKin_1	139	145	PF00069	0.542
MOD_ProDKin_1	175	181	PF00069	0.619
MOD_SUMO_for_1	230	233	PF00179	0.611
MOD_SUMO_rev_2	96	105	PF00179	0.549
TRG_DiLeu_BaEn_4	62	68	PF01217	0.391
TRG_ENDOCYTIC_2	109	112	PF00928	0.441
TRG_NES_CRM1_1	59	70	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	30%	79%
A0A0N1PG85	Leptomonas seymouri	70%	99%
A0A0S4KEK3	Bodo saltans	29%	96%
A0A0S4KMM7	Bodo saltans	38%	82%
A0A1X0P6E1	Trypanosomatidae	39%	96%
A0A3Q8IA61	Leishmania donovani	96%	100%
A0A3R7RSV6	Trypanosoma rangeli	43%	100%
A0A3S7WVD2	Leishmania donovani	31%	80%
A4H9Y7	Leishmania braziliensis	80%	100%
A4H9Y8	Leishmania braziliensis	34%	80%
A4HY39	Leishmania infantum	31%	80%
A4HY52	Leishmania infantum	96%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	73%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	80%
Q4QDJ1	Leishmania major	95%	100%
V5BWY8	Trypanosoma cruzi	44%	100%