Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARY1_LEIMU

TriTrypDb:

LmxM.19.0300

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

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Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ARY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARY1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.423
CLV_NRD_NRD_1	212	214	PF00675	0.686
CLV_PCSK_KEX2_1	212	214	PF00082	0.686
CLV_PCSK_KEX2_1	41	43	PF00082	0.607
CLV_PCSK_KEX2_1	97	99	PF00082	0.535
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.607
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.530
CLV_PCSK_SKI1_1	150	154	PF00082	0.477
CLV_PCSK_SKI1_1	160	164	PF00082	0.398
CLV_PCSK_SKI1_1	168	172	PF00082	0.393

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	30%	79%
A0A0N1PG85	Leptomonas seymouri	70%	99%
A0A0S4KEK3	Bodo saltans	29%	96%
A0A0S4KMM7	Bodo saltans	38%	82%
A0A1X0P6E1	Trypanosomatidae	39%	96%
A0A3Q8IA61	Leishmania donovani	96%	100%
A0A3R7RSV6	Trypanosoma rangeli	43%	100%
A0A3S7WVD2	Leishmania donovani	31%	80%
A4H9Y7	Leishmania braziliensis	80%	100%
A4H9Y8	Leishmania braziliensis	34%	80%

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