Putative sarcoplasmic reticulum glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sarcalumenin, putative

Species:

Leishmania mexicana

UniProt:

E9ARX9_LEIMU

TriTrypDb:

LmxM.19.0280

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	20
GO:0016020	membrane	2	20
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	20

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Expansion

Sequence features

E9ARX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX9

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0005488	binding	1	20
GO:0005525	GTP binding	5	20
GO:0017076	purine nucleotide binding	4	20
GO:0019001	guanyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032561	guanyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.369
CLV_NRD_NRD_1	171	173	PF00675	0.288
CLV_NRD_NRD_1	344	346	PF00675	0.317
CLV_NRD_NRD_1	552	554	PF00675	0.492
CLV_PCSK_KEX2_1	344	346	PF00082	0.317
CLV_PCSK_KEX2_1	552	554	PF00082	0.488
CLV_PCSK_SKI1_1	128	132	PF00082	0.274
CLV_PCSK_SKI1_1	206	210	PF00082	0.366
CLV_PCSK_SKI1_1	221	225	PF00082	0.317
CLV_PCSK_SKI1_1	309	313	PF00082	0.270

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	79%	100%
A0A0N0P9A4	Leptomonas seymouri	44%	100%
A0A0S4KGM0	Bodo saltans	64%	100%
A0A1X0P6D7	Trypanosomatidae	65%	100%
A0A1X0P9Q8	Trypanosomatidae	47%	100%
A0A3R7LDF3	Trypanosoma rangeli	62%	100%
A0A3S7WV81	Leishmania donovani	87%	100%
A0A3S7X801	Leishmania donovani	41%	100%
A0A422P0G8	Trypanosoma rangeli	44%	100%
A4H9Y5	Leishmania braziliensis	75%	100%

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