Putative sarcoplasmic reticulum glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sarcalumenin, putative

Species:

Leishmania mexicana

UniProt:

E9ARX9_LEIMU

TriTrypDb:

LmxM.19.0280

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	20
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9ARX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0005488	binding	1	20
GO:0005525	GTP binding	5	20
GO:0017076	purine nucleotide binding	4	20
GO:0019001	guanyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032561	guanyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20
GO:0043167	ion binding	2	20
GO:0043168	anion binding	3	20
GO:0097159	organic cyclic compound binding	2	20
GO:0097367	carbohydrate derivative binding	2	20
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.369
CLV_NRD_NRD_1	171	173	PF00675	0.288
CLV_NRD_NRD_1	344	346	PF00675	0.317
CLV_NRD_NRD_1	552	554	PF00675	0.492
CLV_PCSK_KEX2_1	344	346	PF00082	0.317
CLV_PCSK_KEX2_1	552	554	PF00082	0.488
CLV_PCSK_SKI1_1	128	132	PF00082	0.274
CLV_PCSK_SKI1_1	206	210	PF00082	0.366
CLV_PCSK_SKI1_1	221	225	PF00082	0.317
CLV_PCSK_SKI1_1	309	313	PF00082	0.270
CLV_PCSK_SKI1_1	367	371	PF00082	0.295
CLV_Separin_Metazoa	234	238	PF03568	0.333
CLV_Separin_Metazoa	254	258	PF03568	0.345
DEG_APCC_DBOX_1	185	193	PF00400	0.255
DEG_APCC_DBOX_1	321	329	PF00400	0.296
DEG_SCF_FBW7_1	583	590	PF00400	0.709
DEG_SPOP_SBC_1	506	510	PF00917	0.571
DEG_SPOP_SBC_1	522	526	PF00917	0.452
DOC_CKS1_1	157	162	PF01111	0.254
DOC_CKS1_1	584	589	PF01111	0.651
DOC_CYCLIN_RxL_1	123	135	PF00134	0.385
DOC_CYCLIN_RxL_1	27	37	PF00134	0.132
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.244
DOC_MAPK_gen_1	172	179	PF00069	0.303
DOC_MAPK_MEF2A_6	186	194	PF00069	0.228
DOC_MAPK_MEF2A_6	322	329	PF00069	0.336
DOC_PP4_FxxP_1	144	147	PF00568	0.334
DOC_PP4_FxxP_1	193	196	PF00568	0.244
DOC_USP7_MATH_1	184	188	PF00917	0.255
DOC_USP7_MATH_1	365	369	PF00917	0.369
DOC_USP7_MATH_1	466	470	PF00917	0.624
DOC_USP7_MATH_1	476	480	PF00917	0.622
DOC_USP7_MATH_1	489	493	PF00917	0.637
DOC_USP7_MATH_1	506	510	PF00917	0.751
DOC_USP7_MATH_1	517	521	PF00917	0.530
DOC_USP7_MATH_1	522	526	PF00917	0.436
DOC_USP7_MATH_1	572	576	PF00917	0.750
DOC_USP7_MATH_1	578	582	PF00917	0.713
DOC_USP7_MATH_1	587	591	PF00917	0.715
DOC_USP7_UBL2_3	331	335	PF12436	0.275
DOC_WW_Pin1_4	156	161	PF00397	0.264
DOC_WW_Pin1_4	470	475	PF00397	0.677
DOC_WW_Pin1_4	491	496	PF00397	0.716
DOC_WW_Pin1_4	497	502	PF00397	0.686
DOC_WW_Pin1_4	5	10	PF00397	0.452
DOC_WW_Pin1_4	511	516	PF00397	0.493
DOC_WW_Pin1_4	523	528	PF00397	0.652
DOC_WW_Pin1_4	567	572	PF00397	0.737
DOC_WW_Pin1_4	583	588	PF00397	0.569
LIG_14-3-3_CanoR_1	153	157	PF00244	0.333
LIG_14-3-3_CanoR_1	552	558	PF00244	0.527
LIG_14-3-3_CanoR_1	567	571	PF00244	0.502
LIG_14-3-3_CanoR_1	65	71	PF00244	0.351
LIG_Actin_WH2_2	209	227	PF00022	0.280
LIG_Actin_WH2_2	390	408	PF00022	0.339
LIG_APCC_ABBA_1	190	195	PF00400	0.244
LIG_APCC_ABBA_1	426	431	PF00400	0.503
LIG_BIR_III_4	200	204	PF00653	0.312
LIG_BRCT_BRCA1_1	273	277	PF00533	0.322
LIG_BRCT_BRCA1_1	493	497	PF00533	0.529
LIG_EH_1	414	418	PF12763	0.592
LIG_eIF4E_1	429	435	PF01652	0.284
LIG_FHA_1	157	163	PF00498	0.254
LIG_FHA_1	230	236	PF00498	0.335
LIG_FHA_1	35	41	PF00498	0.403
LIG_FHA_1	421	427	PF00498	0.566
LIG_FHA_1	445	451	PF00498	0.551
LIG_FHA_1	77	83	PF00498	0.408
LIG_FHA_2	153	159	PF00498	0.247
LIG_FHA_2	584	590	PF00498	0.539
LIG_FHA_2	617	623	PF00498	0.510
LIG_FHA_2	96	102	PF00498	0.240
LIG_FXI_DFP_1	357	361	PF00024	0.255
LIG_GBD_Chelix_1	317	325	PF00786	0.214
LIG_LIR_Apic_2	262	267	PF02991	0.342
LIG_LIR_Gen_1	175	184	PF02991	0.285
LIG_LIR_Gen_1	188	199	PF02991	0.258
LIG_LIR_Gen_1	272	278	PF02991	0.382
LIG_LIR_Gen_1	48	57	PF02991	0.415
LIG_LIR_Gen_1	64	73	PF02991	0.430
LIG_LIR_Gen_1	99	107	PF02991	0.264
LIG_LIR_Nem_3	175	179	PF02991	0.276
LIG_LIR_Nem_3	188	194	PF02991	0.220
LIG_LIR_Nem_3	211	216	PF02991	0.450
LIG_LIR_Nem_3	241	246	PF02991	0.360
LIG_LIR_Nem_3	272	276	PF02991	0.380
LIG_LIR_Nem_3	359	363	PF02991	0.291
LIG_LIR_Nem_3	419	425	PF02991	0.409
LIG_LIR_Nem_3	48	52	PF02991	0.433
LIG_LIR_Nem_3	64	70	PF02991	0.316
LIG_LIR_Nem_3	79	84	PF02991	0.272
LIG_LIR_Nem_3	99	105	PF02991	0.254
LIG_NRBOX	284	290	PF00104	0.422
LIG_Pex14_1	264	268	PF04695	0.345
LIG_Pex14_2	133	137	PF04695	0.264
LIG_Pex14_2	209	213	PF04695	0.296
LIG_Pex14_2	273	277	PF04695	0.356
LIG_Pex14_2	52	56	PF04695	0.283
LIG_Pex14_2	67	71	PF04695	0.229
LIG_SH2_CRK	174	178	PF00017	0.274
LIG_SH2_CRK	239	243	PF00017	0.326
LIG_SH2_NCK_1	346	350	PF00017	0.327
LIG_SH2_PTP2	176	179	PF00017	0.299
LIG_SH2_SRC	174	177	PF00017	0.336
LIG_SH2_STAP1	36	40	PF00017	0.403
LIG_SH2_STAP1	57	61	PF00017	0.345
LIG_SH2_STAT3	543	546	PF00017	0.452
LIG_SH2_STAT3	84	87	PF00017	0.299
LIG_SH2_STAT5	132	135	PF00017	0.150
LIG_SH2_STAT5	176	179	PF00017	0.286
LIG_SH2_STAT5	259	262	PF00017	0.310
LIG_SH2_STAT5	36	39	PF00017	0.290
LIG_SH2_STAT5	84	87	PF00017	0.273
LIG_SH3_3	143	149	PF00018	0.322
LIG_SH3_3	264	270	PF00018	0.369
LIG_SH3_3	513	519	PF00018	0.717
LIG_SH3_3	581	587	PF00018	0.661
LIG_SH3_3	602	608	PF00018	0.635
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.278
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.406
LIG_TRAF2_1	231	234	PF00917	0.482
LIG_TRAF2_1	416	419	PF00917	0.414
LIG_TRAF2_1	42	45	PF00917	0.385
LIG_TRAF2_1	586	589	PF00917	0.569
LIG_TRAF2_2	293	298	PF00917	0.340
LIG_WRC_WIRS_1	260	265	PF05994	0.323
LIG_WRC_WIRS_1	366	371	PF05994	0.220
LIG_WRC_WIRS_1	46	51	PF05994	0.214
LIG_WW_2	516	519	PF00397	0.458
LIG_WW_3	254	258	PF00397	0.345
MOD_CK1_1	24	30	PF00069	0.400
MOD_CK1_1	48	54	PF00069	0.197
MOD_CK1_1	491	497	PF00069	0.614
MOD_CK1_1	521	527	PF00069	0.559
MOD_CK1_1	563	569	PF00069	0.578
MOD_CK2_1	228	234	PF00069	0.459
MOD_CK2_1	365	371	PF00069	0.262
MOD_CK2_1	52	58	PF00069	0.267
MOD_CK2_1	583	589	PF00069	0.718
MOD_CK2_1	95	101	PF00069	0.240
MOD_DYRK1A_RPxSP_1	567	571	PF00069	0.479
MOD_GlcNHglycan	164	167	PF01048	0.361
MOD_GlcNHglycan	460	463	PF01048	0.593
MOD_GlcNHglycan	491	494	PF01048	0.672
MOD_GlcNHglycan	520	523	PF01048	0.702
MOD_GlcNHglycan	555	558	PF01048	0.714
MOD_GlcNHglycan	574	577	PF01048	0.708
MOD_GlcNHglycan	74	77	PF01048	0.264
MOD_GSK3_1	152	159	PF00069	0.303
MOD_GSK3_1	17	24	PF00069	0.541
MOD_GSK3_1	396	403	PF00069	0.398
MOD_GSK3_1	420	427	PF00069	0.466
MOD_GSK3_1	460	467	PF00069	0.628
MOD_GSK3_1	48	55	PF00069	0.157
MOD_GSK3_1	489	496	PF00069	0.534
MOD_GSK3_1	507	514	PF00069	0.703
MOD_GSK3_1	517	524	PF00069	0.668
MOD_GSK3_1	553	560	PF00069	0.736
MOD_GSK3_1	563	570	PF00069	0.695
MOD_GSK3_1	579	586	PF00069	0.590
MOD_GSK3_1	587	594	PF00069	0.603
MOD_GSK3_1	72	79	PF00069	0.278
MOD_GSK3_1	96	103	PF00069	0.278
MOD_N-GLC_1	244	249	PF02516	0.345
MOD_N-GLC_1	250	255	PF02516	0.370
MOD_NEK2_1	119	124	PF00069	0.344
MOD_NEK2_1	133	138	PF00069	0.279
MOD_NEK2_1	208	213	PF00069	0.355
MOD_NEK2_1	329	334	PF00069	0.405
MOD_NEK2_1	34	39	PF00069	0.225
MOD_NEK2_1	396	401	PF00069	0.422
MOD_NEK2_1	505	510	PF00069	0.755
MOD_NEK2_1	85	90	PF00069	0.392
MOD_NEK2_2	424	429	PF00069	0.411
MOD_NEK2_2	66	71	PF00069	0.255
MOD_PIKK_1	229	235	PF00454	0.338
MOD_PIKK_1	34	40	PF00454	0.244
MOD_PIKK_1	495	501	PF00454	0.568
MOD_PIKK_1	610	616	PF00454	0.536
MOD_PKA_1	552	558	PF00069	0.440
MOD_PKA_2	14	20	PF00069	0.706
MOD_PKA_2	152	158	PF00069	0.299
MOD_PKA_2	52	58	PF00069	0.274
MOD_PKA_2	551	557	PF00069	0.516
MOD_PKA_2	566	572	PF00069	0.472
MOD_Plk_1	100	106	PF00069	0.241
MOD_Plk_1	57	63	PF00069	0.353
MOD_Plk_1	579	585	PF00069	0.704
MOD_Plk_2-3	152	158	PF00069	0.356
MOD_Plk_2-3	45	51	PF00069	0.367
MOD_Plk_4	133	139	PF00069	0.274
MOD_Plk_4	152	158	PF00069	0.296
MOD_Plk_4	238	244	PF00069	0.362
MOD_Plk_4	24	30	PF00069	0.414
MOD_Plk_4	259	265	PF00069	0.335
MOD_Plk_4	300	306	PF00069	0.274
MOD_Plk_4	396	402	PF00069	0.306
MOD_Plk_4	424	430	PF00069	0.479
MOD_Plk_4	477	483	PF00069	0.555
MOD_Plk_4	52	58	PF00069	0.281
MOD_Plk_4	77	83	PF00069	0.276
MOD_ProDKin_1	156	162	PF00069	0.264
MOD_ProDKin_1	470	476	PF00069	0.672
MOD_ProDKin_1	491	497	PF00069	0.692
MOD_ProDKin_1	5	11	PF00069	0.450
MOD_ProDKin_1	511	517	PF00069	0.517
MOD_ProDKin_1	523	529	PF00069	0.647
MOD_ProDKin_1	567	573	PF00069	0.737
MOD_ProDKin_1	583	589	PF00069	0.570
MOD_SUMO_rev_2	274	282	PF00179	0.404
MOD_SUMO_rev_2	418	423	PF00179	0.513
TRG_DiLeu_BaEn_1	152	157	PF01217	0.397
TRG_DiLeu_BaEn_1	185	190	PF01217	0.274
TRG_DiLeu_BaEn_1	280	285	PF01217	0.307
TRG_DiLeu_BaEn_1	385	390	PF01217	0.447
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.245
TRG_ENDOCYTIC_2	174	177	PF00928	0.269
TRG_ENDOCYTIC_2	239	242	PF00928	0.327
TRG_ENDOCYTIC_2	346	349	PF00928	0.272
TRG_ENDOCYTIC_2	366	369	PF00928	0.117
TRG_ER_diArg_1	219	222	PF00400	0.421
TRG_ER_diArg_1	343	345	PF00400	0.433
TRG_ER_diArg_1	39	42	PF00400	0.267
TRG_NES_CRM1_1	280	295	PF08389	0.452
TRG_NLS_MonoExtC_3	334	340	PF00514	0.274
TRG_NLS_MonoExtN_4	333	339	PF00514	0.255
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	79%	100%
A0A0N0P9A4	Leptomonas seymouri	44%	100%
A0A0S4KGM0	Bodo saltans	64%	100%
A0A1X0P6D7	Trypanosomatidae	65%	100%
A0A1X0P9Q8	Trypanosomatidae	47%	100%
A0A3R7LDF3	Trypanosoma rangeli	62%	100%
A0A3S7WV81	Leishmania donovani	87%	100%
A0A3S7X801	Leishmania donovani	41%	100%
A0A422P0G8	Trypanosoma rangeli	44%	100%
A4H9Y5	Leishmania braziliensis	75%	100%
A4HAT9	Leishmania braziliensis	45%	100%
A4HY50	Leishmania infantum	87%	100%
A4IA07	Leishmania infantum	41%	100%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4Q2X3	Leishmania major	43%	100%
Q4QDJ3	Leishmania major	86%	100%
Q4V8H8	Rattus norvegicus	35%	100%
V5BSA9	Trypanosoma cruzi	60%	100%