Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9ARX7_LEIMU

TriTrypDb:

LmxM.19.0260

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9ARX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0005543	phospholipid binding	3	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008289	lipid binding	2	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032182	ubiquitin-like protein binding	3	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035091	phosphatidylinositol binding	4	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043130	ubiquitin binding	4	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.812
CLV_C14_Caspase3-7	572	576	PF00656	0.378
CLV_MEL_PAP_1	252	258	PF00089	0.500
CLV_NRD_NRD_1	299	301	PF00675	0.684
CLV_NRD_NRD_1	305	307	PF00675	0.706
CLV_NRD_NRD_1	429	431	PF00675	0.579
CLV_NRD_NRD_1	473	475	PF00675	0.694
CLV_NRD_NRD_1	490	492	PF00675	0.518
CLV_NRD_NRD_1	51	53	PF00675	0.655
CLV_NRD_NRD_1	515	517	PF00675	0.293
CLV_NRD_NRD_1	620	622	PF00675	0.394
CLV_PCSK_FUR_1	302	306	PF00082	0.807
CLV_PCSK_KEX2_1	299	301	PF00082	0.683
CLV_PCSK_KEX2_1	304	306	PF00082	0.709
CLV_PCSK_KEX2_1	485	487	PF00082	0.637
CLV_PCSK_KEX2_1	51	53	PF00082	0.637
CLV_PCSK_KEX2_1	620	622	PF00082	0.436
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.599
CLV_PCSK_PC7_1	300	306	PF00082	0.780
CLV_PCSK_SKI1_1	104	108	PF00082	0.477
CLV_PCSK_SKI1_1	160	164	PF00082	0.596
CLV_PCSK_SKI1_1	176	180	PF00082	0.726
CLV_PCSK_SKI1_1	244	248	PF00082	0.702
CLV_PCSK_SKI1_1	357	361	PF00082	0.611
CLV_PCSK_SKI1_1	423	427	PF00082	0.689
CLV_PCSK_SKI1_1	434	438	PF00082	0.631
CLV_PCSK_SKI1_1	474	478	PF00082	0.606
CLV_PCSK_SKI1_1	486	490	PF00082	0.536
CLV_PCSK_SKI1_1	512	516	PF00082	0.413
CLV_PCSK_SKI1_1	591	595	PF00082	0.442
CLV_PCSK_SKI1_1	641	645	PF00082	0.378
CLV_PCSK_SKI1_1	834	838	PF00082	0.712
DEG_APCC_DBOX_1	338	346	PF00400	0.636
DEG_APCC_DBOX_1	422	430	PF00400	0.575
DOC_CDC14_PxL_1	391	399	PF14671	0.770
DOC_CYCLIN_RxL_1	794	805	PF00134	0.394
DOC_MAPK_gen_1	749	756	PF00069	0.487
DOC_MAPK_MEF2A_6	705	714	PF00069	0.378
DOC_MAPK_MEF2A_6	797	804	PF00069	0.413
DOC_MAPK_NFAT4_5	705	713	PF00069	0.378
DOC_PP1_RVXF_1	473	480	PF00149	0.587
DOC_PP1_RVXF_1	795	802	PF00149	0.378
DOC_PP1_RVXF_1	823	830	PF00149	0.524
DOC_USP7_MATH_1	404	408	PF00917	0.769
DOC_USP7_MATH_1	771	775	PF00917	0.446
DOC_USP7_UBL2_3	360	364	PF12436	0.649
DOC_USP7_UBL2_3	485	489	PF12436	0.516
DOC_WW_Pin1_4	2	7	PF00397	0.756
DOC_WW_Pin1_4	412	417	PF00397	0.719
DOC_WW_Pin1_4	802	807	PF00397	0.394
LIG_14-3-3_CanoR_1	131	140	PF00244	0.569
LIG_14-3-3_CanoR_1	244	253	PF00244	0.605
LIG_14-3-3_CanoR_1	255	263	PF00244	0.493
LIG_14-3-3_CanoR_1	430	434	PF00244	0.551
LIG_14-3-3_CanoR_1	51	59	PF00244	0.359
LIG_14-3-3_CanoR_1	780	785	PF00244	0.394
LIG_Actin_WH2_2	418	436	PF00022	0.524
LIG_APCC_ABBA_1	560	565	PF00400	0.234
LIG_APCC_ABBA_1	633	638	PF00400	0.378
LIG_BIR_III_4	539	543	PF00653	0.446
LIG_BRCT_BRCA1_1	816	820	PF00533	0.378
LIG_CaM_IQ_9	477	493	PF13499	0.583
LIG_Clathr_ClatBox_1	546	550	PF01394	0.435
LIG_DCNL_PONY_1	1	4	PF03556	0.537
LIG_deltaCOP1_diTrp_1	99	106	PF00928	0.529
LIG_eIF4E_1	726	732	PF01652	0.435
LIG_FHA_1	100	106	PF00498	0.537
LIG_FHA_1	14	20	PF00498	0.691
LIG_FHA_1	169	175	PF00498	0.531
LIG_FHA_1	193	199	PF00498	0.537
LIG_FHA_1	322	328	PF00498	0.632
LIG_FHA_1	41	47	PF00498	0.608
LIG_FHA_1	478	484	PF00498	0.595
LIG_FHA_1	564	570	PF00498	0.378
LIG_FHA_1	605	611	PF00498	0.403
LIG_FHA_1	625	631	PF00498	0.195
LIG_FHA_1	652	658	PF00498	0.450
LIG_FHA_1	783	789	PF00498	0.378
LIG_FHA_2	265	271	PF00498	0.553
LIG_FHA_2	288	294	PF00498	0.843
LIG_FHA_2	495	501	PF00498	0.552
LIG_FHA_2	596	602	PF00498	0.492
LIG_FHA_2	644	650	PF00498	0.454
LIG_FHA_2	77	83	PF00498	0.495
LIG_LIR_Gen_1	152	162	PF02991	0.510
LIG_LIR_Gen_1	177	183	PF02991	0.721
LIG_LIR_Gen_1	261	271	PF02991	0.550
LIG_LIR_Gen_1	520	530	PF02991	0.389
LIG_LIR_Gen_1	548	557	PF02991	0.378
LIG_LIR_Gen_1	611	619	PF02991	0.364
LIG_LIR_Nem_3	152	157	PF02991	0.510
LIG_LIR_Nem_3	177	181	PF02991	0.718
LIG_LIR_Nem_3	520	526	PF02991	0.536
LIG_LIR_Nem_3	548	552	PF02991	0.378
LIG_LIR_Nem_3	611	617	PF02991	0.394
LIG_NRBOX	783	789	PF00104	0.378
LIG_PCNA_yPIPBox_3	67	81	PF02747	0.595
LIG_PDZ_Class_3	836	841	PF00595	0.488
LIG_Pex14_1	128	132	PF04695	0.483
LIG_Pex14_2	154	158	PF04695	0.602
LIG_PTAP_UEV_1	554	559	PF05743	0.525
LIG_SH2_CRK	495	499	PF00017	0.511
LIG_SH2_CRK	508	512	PF00017	0.378
LIG_SH2_CRK	68	72	PF00017	0.639
LIG_SH2_CRK	726	730	PF00017	0.435
LIG_SH2_GRB2like	494	497	PF00017	0.525
LIG_SH2_NCK_1	495	499	PF00017	0.511
LIG_SH2_NCK_1	68	72	PF00017	0.639
LIG_SH2_PTP2	711	714	PF00017	0.378
LIG_SH2_SRC	711	714	PF00017	0.435
LIG_SH2_STAP1	373	377	PF00017	0.632
LIG_SH2_STAP1	451	455	PF00017	0.593
LIG_SH2_STAP1	523	527	PF00017	0.448
LIG_SH2_STAT3	451	454	PF00017	0.565
LIG_SH2_STAT3	529	532	PF00017	0.525
LIG_SH2_STAT3	636	639	PF00017	0.463
LIG_SH2_STAT5	440	443	PF00017	0.604
LIG_SH2_STAT5	508	511	PF00017	0.417
LIG_SH2_STAT5	523	526	PF00017	0.391
LIG_SH2_STAT5	636	639	PF00017	0.365
LIG_SH2_STAT5	666	669	PF00017	0.378
LIG_SH2_STAT5	711	714	PF00017	0.378
LIG_SH3_3	549	555	PF00018	0.390
LIG_SUMO_SIM_anti_2	629	634	PF11976	0.390
LIG_SUMO_SIM_par_1	191	199	PF11976	0.617
LIG_SUMO_SIM_par_1	626	634	PF11976	0.388
LIG_SUMO_SIM_par_1	76	82	PF11976	0.493
LIG_TRAF2_1	320	323	PF00917	0.733
LIG_TRAF2_1	497	500	PF00917	0.547
LIG_TYR_ITIM	709	714	PF00017	0.378
LIG_UBA3_1	157	163	PF00899	0.663
MOD_CDC14_SPxK_1	5	8	PF00782	0.641
MOD_CDK_SPxK_1	2	8	PF00069	0.646
MOD_CK1_1	10	16	PF00069	0.643
MOD_CK1_1	32	38	PF00069	0.632
MOD_CK1_1	421	427	PF00069	0.467
MOD_CK1_1	528	534	PF00069	0.499
MOD_CK1_1	589	595	PF00069	0.378
MOD_CK1_1	626	632	PF00069	0.393
MOD_CK1_1	703	709	PF00069	0.390
MOD_CK1_1	782	788	PF00069	0.390
MOD_CK1_1	805	811	PF00069	0.385
MOD_CK1_1	812	818	PF00069	0.373
MOD_CK2_1	14	20	PF00069	0.717
MOD_CK2_1	248	254	PF00069	0.670
MOD_CK2_1	258	264	PF00069	0.491
MOD_CK2_1	365	371	PF00069	0.513
MOD_CK2_1	429	435	PF00069	0.561
MOD_CK2_1	494	500	PF00069	0.550
MOD_CK2_1	528	534	PF00069	0.411
MOD_CK2_1	595	601	PF00069	0.448
MOD_CK2_1	628	634	PF00069	0.378
MOD_CK2_1	643	649	PF00069	0.378
MOD_CK2_1	740	746	PF00069	0.394
MOD_GlcNHglycan	134	137	PF01048	0.561
MOD_GlcNHglycan	16	19	PF01048	0.644
MOD_GlcNHglycan	238	241	PF01048	0.618
MOD_GlcNHglycan	406	409	PF01048	0.753
MOD_GlcNHglycan	451	454	PF01048	0.583
MOD_GlcNHglycan	539	543	PF01048	0.442
MOD_GlcNHglycan	55	58	PF01048	0.459
MOD_GlcNHglycan	588	591	PF01048	0.378
MOD_GlcNHglycan	741	745	PF01048	0.394
MOD_GlcNHglycan	760	763	PF01048	0.256
MOD_GlcNHglycan	767	770	PF01048	0.352
MOD_GlcNHglycan	87	90	PF01048	0.604
MOD_GlcNHglycan	9	12	PF01048	0.723
MOD_GSK3_1	10	17	PF00069	0.722
MOD_GSK3_1	244	251	PF00069	0.651
MOD_GSK3_1	25	32	PF00069	0.512
MOD_GSK3_1	254	261	PF00069	0.530
MOD_GSK3_1	412	419	PF00069	0.677
MOD_GSK3_1	421	428	PF00069	0.504
MOD_GSK3_1	449	456	PF00069	0.579
MOD_GSK3_1	521	528	PF00069	0.426
MOD_GSK3_1	591	598	PF00069	0.492
MOD_GSK3_1	620	627	PF00069	0.355
MOD_GSK3_1	690	697	PF00069	0.376
MOD_GSK3_1	714	721	PF00069	0.384
MOD_GSK3_1	805	812	PF00069	0.394
MOD_GSK3_1	95	102	PF00069	0.516
MOD_LATS_1	242	248	PF00433	0.630
MOD_N-GLC_1	258	263	PF02516	0.498
MOD_N-GLC_1	384	389	PF02516	0.623
MOD_N-GLC_1	53	58	PF02516	0.642
MOD_N-GLC_1	595	600	PF02516	0.448
MOD_N-GLC_1	756	761	PF02516	0.378
MOD_N-GLC_1	780	785	PF02516	0.234
MOD_N-GLC_1	809	814	PF02516	0.380
MOD_N-GLC_1	834	839	PF02516	0.725
MOD_N-GLC_2	224	226	PF02516	0.585
MOD_N-GLC_2	578	580	PF02516	0.378
MOD_NEK2_1	14	19	PF00069	0.552
MOD_NEK2_1	144	149	PF00069	0.487
MOD_NEK2_1	236	241	PF00069	0.598
MOD_NEK2_1	379	384	PF00069	0.746
MOD_NEK2_1	397	402	PF00069	0.607
MOD_NEK2_1	418	423	PF00069	0.468
MOD_NEK2_1	563	568	PF00069	0.378
MOD_NEK2_1	569	574	PF00069	0.378
MOD_NEK2_1	643	648	PF00069	0.439
MOD_NEK2_1	740	745	PF00069	0.235
MOD_NEK2_1	779	784	PF00069	0.394
MOD_NEK2_1	788	793	PF00069	0.409
MOD_NEK2_1	819	824	PF00069	0.499
MOD_NEK2_1	85	90	PF00069	0.588
MOD_PIKK_1	442	448	PF00454	0.586
MOD_PIKK_1	477	483	PF00454	0.615
MOD_PIKK_1	528	534	PF00454	0.525
MOD_PIKK_1	70	76	PF00454	0.604
MOD_PKA_1	620	626	PF00069	0.394
MOD_PKA_2	168	174	PF00069	0.751
MOD_PKA_2	254	260	PF00069	0.521
MOD_PKA_2	429	435	PF00069	0.575
MOD_PKA_2	463	469	PF00069	0.566
MOD_PKA_2	620	626	PF00069	0.348
MOD_PKA_2	7	13	PF00069	0.523
MOD_PKA_2	714	720	PF00069	0.394
MOD_PKA_2	779	785	PF00069	0.365
MOD_Plk_1	176	182	PF00069	0.806
MOD_Plk_1	192	198	PF00069	0.520
MOD_Plk_1	258	264	PF00069	0.373
MOD_Plk_1	311	317	PF00069	0.786
MOD_Plk_1	40	46	PF00069	0.666
MOD_Plk_1	53	59	PF00069	0.396
MOD_Plk_1	623	629	PF00069	0.378
MOD_Plk_1	756	762	PF00069	0.378
MOD_Plk_1	780	786	PF00069	0.234
MOD_Plk_2-3	203	209	PF00069	0.524
MOD_Plk_2-3	248	254	PF00069	0.672
MOD_Plk_2-3	258	264	PF00069	0.491
MOD_Plk_2-3	289	295	PF00069	0.813
MOD_Plk_2-3	365	371	PF00069	0.513
MOD_Plk_4	121	127	PF00069	0.474
MOD_Plk_4	192	198	PF00069	0.540
MOD_Plk_4	248	254	PF00069	0.679
MOD_Plk_4	258	264	PF00069	0.491
MOD_Plk_4	365	371	PF00069	0.664
MOD_Plk_4	569	575	PF00069	0.378
MOD_Plk_4	628	634	PF00069	0.396
MOD_Plk_4	662	668	PF00069	0.387
MOD_Plk_4	727	733	PF00069	0.365
MOD_Plk_4	76	82	PF00069	0.475
MOD_Plk_4	782	788	PF00069	0.392
MOD_Plk_4	814	820	PF00069	0.495
MOD_ProDKin_1	2	8	PF00069	0.756
MOD_ProDKin_1	412	418	PF00069	0.714
MOD_ProDKin_1	802	808	PF00069	0.394
MOD_SUMO_rev_2	225	232	PF00179	0.590
MOD_SUMO_rev_2	432	439	PF00179	0.642
MOD_SUMO_rev_2	467	477	PF00179	0.604
MOD_SUMO_rev_2	482	490	PF00179	0.505
MOD_SUMO_rev_2	528	538	PF00179	0.327
MOD_SUMO_rev_2	599	605	PF00179	0.429
TRG_DiLeu_BaEn_1	193	198	PF01217	0.662
TRG_DiLeu_BaEn_1	22	27	PF01217	0.627
TRG_DiLeu_BaEn_1	248	253	PF01217	0.554
TRG_DiLeu_BaEn_1	323	328	PF01217	0.738
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.378
TRG_ENDOCYTIC_2	495	498	PF00928	0.519
TRG_ENDOCYTIC_2	508	511	PF00928	0.414
TRG_ENDOCYTIC_2	523	526	PF00928	0.394
TRG_ENDOCYTIC_2	711	714	PF00928	0.378
TRG_ENDOCYTIC_2	726	729	PF00928	0.378
TRG_ER_diArg_1	299	302	PF00400	0.677
TRG_ER_diArg_1	304	306	PF00400	0.683
TRG_ER_diArg_1	50	52	PF00400	0.628
TRG_ER_diArg_1	510	513	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.787
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X9	Leptomonas seymouri	76%	100%
A0A0S4KHP9	Bodo saltans	51%	93%
A0A1X0P6D6	Trypanosomatidae	61%	100%
A0A3S5H751	Leishmania donovani	92%	100%
A0A422P3A3	Trypanosoma rangeli	59%	100%
A4H9Y3	Leishmania braziliensis	79%	100%
A4HY48	Leishmania infantum	92%	100%
D0A0E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q4QDJ5	Leishmania major	92%	100%
V5BWY3	Trypanosoma cruzi	61%	100%