TOG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centrosomal protein of 104 kDa

Species:

Leishmania mexicana

UniProt:

E9ARX6_LEIMU

TriTrypDb:

LmxM.19.0250

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ARX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.623
CLV_C14_Caspase3-7	90	94	PF00656	0.504
CLV_MEL_PAP_1	213	219	PF00089	0.377
CLV_NRD_NRD_1	313	315	PF00675	0.693
CLV_NRD_NRD_1	43	45	PF00675	0.339
CLV_NRD_NRD_1	437	439	PF00675	0.425
CLV_NRD_NRD_1	553	555	PF00675	0.446
CLV_NRD_NRD_1	673	675	PF00675	0.573
CLV_NRD_NRD_1	742	744	PF00675	0.413
CLV_NRD_NRD_1	800	802	PF00675	0.423
CLV_PCSK_KEX2_1	105	107	PF00082	0.449
CLV_PCSK_KEX2_1	313	315	PF00082	0.650
CLV_PCSK_KEX2_1	400	402	PF00082	0.539
CLV_PCSK_KEX2_1	553	555	PF00082	0.443
CLV_PCSK_KEX2_1	799	801	PF00082	0.415
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.489
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.391
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.452
CLV_PCSK_SKI1_1	101	105	PF00082	0.518
CLV_PCSK_SKI1_1	123	127	PF00082	0.323
CLV_PCSK_SKI1_1	138	142	PF00082	0.344
CLV_PCSK_SKI1_1	165	169	PF00082	0.298
CLV_PCSK_SKI1_1	270	274	PF00082	0.411
CLV_PCSK_SKI1_1	540	544	PF00082	0.454
CLV_PCSK_SKI1_1	631	635	PF00082	0.314
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DEG_SPOP_SBC_1	637	641	PF00917	0.493
DOC_CDC14_PxL_1	608	616	PF14671	0.376
DOC_CDC14_PxL_1	730	738	PF14671	0.518
DOC_CKS1_1	174	179	PF01111	0.489
DOC_CYCLIN_RxL_1	270	281	PF00134	0.382
DOC_CYCLIN_RxL_1	628	639	PF00134	0.328
DOC_MAPK_gen_1	105	112	PF00069	0.443
DOC_MAPK_gen_1	270	279	PF00069	0.514
DOC_MAPK_gen_1	553	561	PF00069	0.484
DOC_MAPK_MEF2A_6	132	141	PF00069	0.301
DOC_MAPK_MEF2A_6	270	279	PF00069	0.424
DOC_MAPK_MEF2A_6	553	560	PF00069	0.432
DOC_MAPK_MEF2A_6	7	14	PF00069	0.346
DOC_MAPK_MEF2A_6	74	83	PF00069	0.322
DOC_MAPK_RevD_3	541	554	PF00069	0.285
DOC_PP1_RVXF_1	629	635	PF00149	0.317
DOC_PP4_FxxP_1	307	310	PF00568	0.582
DOC_PP4_FxxP_1	634	637	PF00568	0.377
DOC_PP4_MxPP_1	193	196	PF00568	0.397
DOC_USP7_MATH_1	215	219	PF00917	0.449
DOC_USP7_MATH_1	290	294	PF00917	0.461
DOC_USP7_MATH_1	419	423	PF00917	0.265
DOC_USP7_MATH_1	450	454	PF00917	0.460
DOC_USP7_MATH_1	458	462	PF00917	0.379
DOC_USP7_MATH_1	491	495	PF00917	0.314
DOC_USP7_MATH_1	505	509	PF00917	0.383
DOC_USP7_MATH_1	575	579	PF00917	0.435
DOC_USP7_MATH_1	698	702	PF00917	0.664
DOC_USP7_MATH_1	70	74	PF00917	0.264
DOC_USP7_MATH_1	832	836	PF00917	0.273
DOC_USP7_UBL2_3	101	105	PF12436	0.484
DOC_USP7_UBL2_3	165	169	PF12436	0.239
DOC_USP7_UBL2_3	421	425	PF12436	0.472
DOC_USP7_UBL2_3	565	569	PF12436	0.528
DOC_WW_Pin1_4	173	178	PF00397	0.476
DOC_WW_Pin1_4	199	204	PF00397	0.660
DOC_WW_Pin1_4	306	311	PF00397	0.620
DOC_WW_Pin1_4	312	317	PF00397	0.778
DOC_WW_Pin1_4	407	412	PF00397	0.439
DOC_WW_Pin1_4	545	550	PF00397	0.461
DOC_WW_Pin1_4	690	695	PF00397	0.616
DOC_WW_Pin1_4	855	860	PF00397	0.397
LIG_14-3-3_CanoR_1	132	137	PF00244	0.376
LIG_14-3-3_CanoR_1	185	189	PF00244	0.547
LIG_14-3-3_CanoR_1	216	223	PF00244	0.511
LIG_14-3-3_CanoR_1	401	406	PF00244	0.412
LIG_14-3-3_CanoR_1	44	50	PF00244	0.431
LIG_14-3-3_CanoR_1	603	609	PF00244	0.384
LIG_14-3-3_CanoR_1	814	822	PF00244	0.404
LIG_AP2alpha_1	586	590	PF02296	0.448
LIG_BIR_III_2	305	309	PF00653	0.539
LIG_BIR_III_4	361	365	PF00653	0.654
LIG_CaM_NSCaTE_8	391	398	PF13499	0.249
LIG_Clathr_ClatBox_1	558	562	PF01394	0.468
LIG_Clathr_ClatBox_1	632	636	PF01394	0.447
LIG_eIF4E_1	430	436	PF01652	0.276
LIG_eIF4E_1	662	668	PF01652	0.365
LIG_EVH1_1	307	311	PF00568	0.525
LIG_FHA_1	125	131	PF00498	0.337
LIG_FHA_1	185	191	PF00498	0.482
LIG_FHA_1	208	214	PF00498	0.595
LIG_FHA_1	279	285	PF00498	0.495
LIG_FHA_1	361	367	PF00498	0.666
LIG_FHA_1	495	501	PF00498	0.415
LIG_FHA_1	515	521	PF00498	0.451
LIG_FHA_1	522	528	PF00498	0.498
LIG_FHA_1	600	606	PF00498	0.505
LIG_FHA_1	63	69	PF00498	0.386
LIG_FHA_1	681	687	PF00498	0.716
LIG_FHA_1	831	837	PF00498	0.331
LIG_FHA_2	375	381	PF00498	0.594
LIG_FHA_2	583	589	PF00498	0.422
LIG_FHA_2	793	799	PF00498	0.418
LIG_FHA_2	85	91	PF00498	0.411
LIG_GBD_Chelix_1	512	520	PF00786	0.220
LIG_LIR_Apic_2	304	310	PF02991	0.587
LIG_LIR_Gen_1	135	144	PF02991	0.363
LIG_LIR_Gen_1	148	157	PF02991	0.283
LIG_LIR_Gen_1	464	474	PF02991	0.308
LIG_LIR_Nem_3	135	139	PF02991	0.344
LIG_LIR_Nem_3	148	152	PF02991	0.318
LIG_LIR_Nem_3	464	470	PF02991	0.345
LIG_LIR_Nem_3	739	745	PF02991	0.509
LIG_MYND_1	772	776	PF01753	0.299
LIG_NRBOX	628	634	PF00104	0.382
LIG_Pex14_2	586	590	PF04695	0.448
LIG_PTAP_UEV_1	724	729	PF05743	0.495
LIG_SH2_CRK	473	477	PF00017	0.358
LIG_SH2_CRK	742	746	PF00017	0.499
LIG_SH2_NCK_1	99	103	PF00017	0.366
LIG_SH2_STAP1	99	103	PF00017	0.410
LIG_SH2_STAT5	136	139	PF00017	0.336
LIG_SH2_STAT5	15	18	PF00017	0.388
LIG_SH2_STAT5	201	204	PF00017	0.685
LIG_SH2_STAT5	423	426	PF00017	0.339
LIG_SH2_STAT5	430	433	PF00017	0.246
LIG_SH2_STAT5	643	646	PF00017	0.459
LIG_SH2_STAT5	767	770	PF00017	0.431
LIG_SH3_1	691	697	PF00018	0.570
LIG_SH3_2	203	208	PF14604	0.539
LIG_SH3_2	308	313	PF14604	0.465
LIG_SH3_3	171	177	PF00018	0.312
LIG_SH3_3	200	206	PF00018	0.695
LIG_SH3_3	305	311	PF00018	0.530
LIG_SH3_3	315	321	PF00018	0.534
LIG_SH3_3	332	338	PF00018	0.660
LIG_SH3_3	403	409	PF00018	0.513
LIG_SH3_3	606	612	PF00018	0.411
LIG_SH3_3	691	697	PF00018	0.716
LIG_SH3_3	719	725	PF00018	0.638
LIG_SH3_3	80	86	PF00018	0.395
LIG_SH3_3	856	862	PF00018	0.370
LIG_SH3_3	92	98	PF00018	0.320
LIG_SH3_4	648	655	PF00018	0.405
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.448
LIG_SUMO_SIM_par_1	242	247	PF11976	0.475
LIG_SUMO_SIM_par_1	557	562	PF11976	0.424
LIG_SUMO_SIM_par_1	607	613	PF11976	0.377
LIG_TRAF2_1	227	230	PF00917	0.440
LIG_TRAF2_1	325	328	PF00917	0.736
LIG_TRAF2_1	716	719	PF00917	0.628
LIG_TRAF2_1	87	90	PF00917	0.393
LIG_TYR_ITIM	471	476	PF00017	0.339
LIG_TYR_ITIM	740	745	PF00017	0.503
LIG_UBA3_1	736	744	PF00899	0.306
LIG_WRC_WIRS_1	583	588	PF05994	0.434
LIG_WW_3	334	338	PF00397	0.477
MOD_CDK_SPxxK_3	306	313	PF00069	0.469
MOD_CK1_1	199	205	PF00069	0.496
MOD_CK1_1	293	299	PF00069	0.551
MOD_CK1_1	320	326	PF00069	0.653
MOD_CK1_1	360	366	PF00069	0.745
MOD_CK1_1	410	416	PF00069	0.520
MOD_CK1_1	461	467	PF00069	0.390
MOD_CK1_1	494	500	PF00069	0.499
MOD_CK1_1	604	610	PF00069	0.372
MOD_CK1_1	638	644	PF00069	0.457
MOD_CK1_1	693	699	PF00069	0.651
MOD_CK1_1	701	707	PF00069	0.675
MOD_CK1_1	73	79	PF00069	0.273
MOD_CK2_1	18	24	PF00069	0.421
MOD_CK2_1	735	741	PF00069	0.432
MOD_CK2_1	754	760	PF00069	0.413
MOD_CK2_1	792	798	PF00069	0.376
MOD_CK2_1	84	90	PF00069	0.419
MOD_GlcNHglycan	298	301	PF01048	0.665
MOD_GlcNHglycan	493	496	PF01048	0.342
MOD_GlcNHglycan	507	510	PF01048	0.405
MOD_GlcNHglycan	569	572	PF01048	0.406
MOD_GlcNHglycan	640	643	PF01048	0.447
MOD_GlcNHglycan	768	771	PF01048	0.454
MOD_GSK3_1	317	324	PF00069	0.617
MOD_GSK3_1	370	377	PF00069	0.699
MOD_GSK3_1	458	465	PF00069	0.381
MOD_GSK3_1	689	696	PF00069	0.515
MOD_GSK3_1	698	705	PF00069	0.481
MOD_GSK3_1	70	77	PF00069	0.278
MOD_LATS_1	163	169	PF00433	0.218
MOD_N-GLC_1	330	335	PF02516	0.750
MOD_N-GLC_1	374	379	PF02516	0.559
MOD_N-GLC_1	70	75	PF02516	0.245
MOD_N-GLC_1	754	759	PF02516	0.444
MOD_NEK2_1	472	477	PF00069	0.382
MOD_NEK2_1	527	532	PF00069	0.411
MOD_NEK2_1	582	587	PF00069	0.210
MOD_NEK2_1	62	67	PF00069	0.472
MOD_NEK2_1	689	694	PF00069	0.630
MOD_PIKK_1	370	376	PF00454	0.479
MOD_PIKK_1	696	702	PF00454	0.484
MOD_PK_1	569	575	PF00069	0.447
MOD_PKA_1	400	406	PF00069	0.474
MOD_PKA_1	674	680	PF00069	0.575
MOD_PKA_2	184	190	PF00069	0.439
MOD_PKA_2	207	213	PF00069	0.622
MOD_PKA_2	215	221	PF00069	0.459
MOD_PKA_2	400	406	PF00069	0.474
MOD_PKA_2	813	819	PF00069	0.396
MOD_Plk_1	754	760	PF00069	0.455
MOD_Plk_4	132	138	PF00069	0.431
MOD_Plk_4	419	425	PF00069	0.227
MOD_Plk_4	582	588	PF00069	0.318
MOD_Plk_4	604	610	PF00069	0.380
MOD_ProDKin_1	173	179	PF00069	0.475
MOD_ProDKin_1	199	205	PF00069	0.657
MOD_ProDKin_1	306	312	PF00069	0.623
MOD_ProDKin_1	317	323	PF00069	0.639
MOD_ProDKin_1	407	413	PF00069	0.445
MOD_ProDKin_1	545	551	PF00069	0.459
MOD_ProDKin_1	690	696	PF00069	0.616
MOD_ProDKin_1	855	861	PF00069	0.391
MOD_SUMO_rev_2	118	128	PF00179	0.405
MOD_SUMO_rev_2	641	650	PF00179	0.469
MOD_SUMO_rev_2	713	722	PF00179	0.460
TRG_DiLeu_BaEn_1	798	803	PF01217	0.374
TRG_ENDOCYTIC_2	136	139	PF00928	0.287
TRG_ENDOCYTIC_2	149	152	PF00928	0.373
TRG_ENDOCYTIC_2	356	359	PF00928	0.543
TRG_ENDOCYTIC_2	473	476	PF00928	0.315
TRG_ENDOCYTIC_2	742	745	PF00928	0.511
TRG_ER_diArg_1	553	555	PF00400	0.492
TRG_ER_diArg_1	707	710	PF00400	0.558
TRG_ER_diArg_1	800	802	PF00400	0.423
TRG_NES_CRM1_1	274	287	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	800	805	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K1	Leptomonas seymouri	62%	99%
A0A0S4ILQ6	Bodo saltans	27%	88%
A0A1X0P6E5	Trypanosomatidae	39%	100%
A0A3R7MW28	Trypanosoma rangeli	38%	100%
A0A3S7WVF9	Leishmania donovani	89%	100%
A0A3S7X6A2	Leishmania donovani	25%	100%
A4H9Y2	Leishmania braziliensis	76%	100%
A4HL43	Leishmania braziliensis	25%	100%
A4HY47	Leishmania infantum	89%	100%
A4I8M3	Leishmania infantum	25%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
D3Z8X7	Rattus norvegicus	26%	95%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O60308	Homo sapiens	26%	95%
Q4Q4L6	Leishmania major	24%	100%
Q4QDJ6	Leishmania major	89%	100%
Q80V31	Mus musculus	25%	94%
V5DTJ3	Trypanosoma cruzi	39%	100%