LeishMANIAdb
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GN3L_Grn1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
GN3L_Grn1 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ARX5_LEIMU
TriTrypDb:
LmxM.19.0240
Length:
671

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ARX5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.677
CLV_C14_Caspase3-7 152 156 PF00656 0.505
CLV_C14_Caspase3-7 182 186 PF00656 0.523
CLV_C14_Caspase3-7 514 518 PF00656 0.640
CLV_NRD_NRD_1 117 119 PF00675 0.691
CLV_NRD_NRD_1 197 199 PF00675 0.454
CLV_NRD_NRD_1 21 23 PF00675 0.537
CLV_NRD_NRD_1 296 298 PF00675 0.474
CLV_NRD_NRD_1 437 439 PF00675 0.532
CLV_NRD_NRD_1 89 91 PF00675 0.639
CLV_PCSK_FUR_1 22 26 PF00082 0.512
CLV_PCSK_KEX2_1 10 12 PF00082 0.573
CLV_PCSK_KEX2_1 117 119 PF00082 0.691
CLV_PCSK_KEX2_1 24 26 PF00082 0.551
CLV_PCSK_KEX2_1 28 30 PF00082 0.532
CLV_PCSK_KEX2_1 296 298 PF00082 0.474
CLV_PCSK_KEX2_1 437 439 PF00082 0.552
CLV_PCSK_KEX2_1 46 48 PF00082 0.598
CLV_PCSK_KEX2_1 572 574 PF00082 0.530
CLV_PCSK_KEX2_1 89 91 PF00082 0.633
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.573
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.551
CLV_PCSK_PC1ET2_1 28 30 PF00082 0.532
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.598
CLV_PCSK_PC1ET2_1 572 574 PF00082 0.533
CLV_PCSK_SKI1_1 118 122 PF00082 0.578
CLV_PCSK_SKI1_1 137 141 PF00082 0.579
CLV_PCSK_SKI1_1 198 202 PF00082 0.380
CLV_PCSK_SKI1_1 256 260 PF00082 0.504
CLV_PCSK_SKI1_1 29 33 PF00082 0.589
CLV_PCSK_SKI1_1 346 350 PF00082 0.608
CLV_PCSK_SKI1_1 36 40 PF00082 0.539
CLV_PCSK_SKI1_1 527 531 PF00082 0.538
CLV_PCSK_SKI1_1 56 60 PF00082 0.359
CLV_PCSK_SKI1_1 83 87 PF00082 0.601
DEG_APCC_DBOX_1 116 124 PF00400 0.671
DEG_APCC_DBOX_1 255 263 PF00400 0.551
DEG_APCC_DBOX_1 526 534 PF00400 0.544
DEG_SPOP_SBC_1 458 462 PF00917 0.673
DOC_CKS1_1 363 368 PF01111 0.653
DOC_CKS1_1 615 620 PF01111 0.586
DOC_CYCLIN_RxL_1 371 380 PF00134 0.615
DOC_CYCLIN_yCln2_LP_2 142 148 PF00134 0.553
DOC_CYCLIN_yCln2_LP_2 159 165 PF00134 0.601
DOC_MAPK_gen_1 117 123 PF00069 0.567
DOC_MAPK_gen_1 198 204 PF00069 0.397
DOC_MAPK_gen_1 253 261 PF00069 0.460
DOC_MAPK_gen_1 49 59 PF00069 0.560
DOC_MAPK_MEF2A_6 52 61 PF00069 0.552
DOC_PP1_RVXF_1 130 136 PF00149 0.596
DOC_PP1_RVXF_1 372 379 PF00149 0.617
DOC_PP2B_LxvP_1 159 162 PF13499 0.607
DOC_PP2B_LxvP_1 616 619 PF13499 0.646
DOC_PP4_FxxP_1 340 343 PF00568 0.633
DOC_PP4_FxxP_1 406 409 PF00568 0.501
DOC_PP4_FxxP_1 615 618 PF00568 0.666
DOC_SPAK_OSR1_1 173 177 PF12202 0.496
DOC_USP7_MATH_1 112 116 PF00917 0.664
DOC_USP7_MATH_1 125 129 PF00917 0.660
DOC_USP7_MATH_1 175 179 PF00917 0.436
DOC_USP7_MATH_1 216 220 PF00917 0.459
DOC_USP7_MATH_1 307 311 PF00917 0.683
DOC_USP7_MATH_1 45 49 PF00917 0.633
DOC_USP7_MATH_1 488 492 PF00917 0.631
DOC_USP7_MATH_1 6 10 PF00917 0.683
DOC_USP7_MATH_1 657 661 PF00917 0.817
DOC_USP7_UBL2_3 15 19 PF12436 0.562
DOC_USP7_UBL2_3 24 28 PF12436 0.509
DOC_USP7_UBL2_3 32 36 PF12436 0.479
DOC_USP7_UBL2_3 335 339 PF12436 0.715
DOC_USP7_UBL2_3 423 427 PF12436 0.548
DOC_USP7_UBL2_3 46 50 PF12436 0.568
DOC_USP7_UBL2_3 502 506 PF12436 0.644
DOC_USP7_UBL2_3 56 60 PF12436 0.524
DOC_WW_Pin1_4 242 247 PF00397 0.510
DOC_WW_Pin1_4 362 367 PF00397 0.624
DOC_WW_Pin1_4 442 447 PF00397 0.472
DOC_WW_Pin1_4 486 491 PF00397 0.591
DOC_WW_Pin1_4 550 555 PF00397 0.621
DOC_WW_Pin1_4 609 614 PF00397 0.551
LIG_14-3-3_CanoR_1 137 145 PF00244 0.601
LIG_14-3-3_CanoR_1 296 300 PF00244 0.452
LIG_14-3-3_CanoR_1 326 336 PF00244 0.689
LIG_14-3-3_CanoR_1 419 423 PF00244 0.483
LIG_14-3-3_CanoR_1 475 481 PF00244 0.569
LIG_APCC_ABBA_1 247 252 PF00400 0.560
LIG_BRCT_BRCA1_1 127 131 PF00533 0.526
LIG_BRCT_BRCA1_1 374 378 PF00533 0.603
LIG_BRCT_BRCA1_1 444 448 PF00533 0.496
LIG_BRCT_BRCA1_1 560 564 PF00533 0.416
LIG_BRCT_BRCA1_1 611 615 PF00533 0.554
LIG_FHA_1 138 144 PF00498 0.578
LIG_FHA_1 156 162 PF00498 0.513
LIG_FHA_1 312 318 PF00498 0.649
LIG_FHA_1 575 581 PF00498 0.609
LIG_FHA_1 79 85 PF00498 0.661
LIG_FHA_2 147 153 PF00498 0.648
LIG_FHA_2 180 186 PF00498 0.488
LIG_FHA_2 205 211 PF00498 0.401
LIG_FHA_2 328 334 PF00498 0.660
LIG_FHA_2 631 637 PF00498 0.727
LIG_FHA_2 93 99 PF00498 0.688
LIG_LIR_Apic_2 338 343 PF02991 0.671
LIG_LIR_Apic_2 612 618 PF02991 0.654
LIG_LIR_Gen_1 178 188 PF02991 0.455
LIG_LIR_Gen_1 508 518 PF02991 0.677
LIG_LIR_Nem_3 178 184 PF02991 0.453
LIG_LIR_Nem_3 370 376 PF02991 0.479
LIG_LIR_Nem_3 508 513 PF02991 0.665
LIG_PCNA_yPIPBox_3 132 143 PF02747 0.567
LIG_Pex14_2 131 135 PF04695 0.482
LIG_PTB_Apo_2 479 486 PF02174 0.673
LIG_PTB_Phospho_1 479 485 PF10480 0.677
LIG_SH2_CRK 510 514 PF00017 0.680
LIG_SH2_GRB2like 485 488 PF00017 0.638
LIG_SH2_NCK_1 485 489 PF00017 0.663
LIG_SH2_STAT5 122 125 PF00017 0.581
LIG_SH2_STAT5 166 169 PF00017 0.391
LIG_SH2_STAT5 194 197 PF00017 0.556
LIG_SH3_3 209 215 PF00018 0.505
LIG_SH3_3 348 354 PF00018 0.664
LIG_SH3_3 599 605 PF00018 0.540
LIG_SUMO_SIM_anti_2 219 225 PF11976 0.447
LIG_SUMO_SIM_par_1 166 171 PF11976 0.393
LIG_SUMO_SIM_par_1 199 205 PF11976 0.491
LIG_TRAF2_1 330 333 PF00917 0.686
LIG_TRAF2_1 629 632 PF00917 0.727
LIG_TRAF2_1 652 655 PF00917 0.748
LIG_UBA3_1 120 126 PF00899 0.648
LIG_UBA3_1 202 208 PF00899 0.368
LIG_WW_1 618 621 PF00397 0.693
MOD_CDK_SPxK_1 486 492 PF00069 0.589
MOD_CK1_1 248 254 PF00069 0.547
MOD_CK1_1 310 316 PF00069 0.570
MOD_CK1_1 327 333 PF00069 0.687
MOD_CK1_1 461 467 PF00069 0.651
MOD_CK1_1 476 482 PF00069 0.601
MOD_CK1_1 48 54 PF00069 0.606
MOD_CK1_1 486 492 PF00069 0.554
MOD_CK2_1 327 333 PF00069 0.687
MOD_CK2_1 649 655 PF00069 0.784
MOD_CK2_1 92 98 PF00069 0.638
MOD_Cter_Amidation 196 199 PF01082 0.518
MOD_Cter_Amidation 294 297 PF01082 0.444
MOD_Cter_Amidation 570 573 PF01082 0.508
MOD_GlcNHglycan 123 126 PF01048 0.679
MOD_GlcNHglycan 212 215 PF01048 0.551
MOD_GlcNHglycan 326 329 PF01048 0.613
MOD_GlcNHglycan 470 473 PF01048 0.693
MOD_GSK3_1 121 128 PF00069 0.629
MOD_GSK3_1 175 182 PF00069 0.469
MOD_GSK3_1 291 298 PF00069 0.450
MOD_GSK3_1 307 314 PF00069 0.376
MOD_GSK3_1 447 454 PF00069 0.528
MOD_GSK3_1 457 464 PF00069 0.617
MOD_GSK3_1 558 565 PF00069 0.547
MOD_GSK3_1 6 13 PF00069 0.572
MOD_GSK3_1 649 656 PF00069 0.535
MOD_GSK3_1 92 99 PF00069 0.717
MOD_N-GLC_1 307 312 PF02516 0.648
MOD_N-GLC_1 481 486 PF02516 0.656
MOD_N-GLC_1 548 553 PF02516 0.466
MOD_NEK2_1 121 126 PF00069 0.666
MOD_NEK2_1 202 207 PF00069 0.358
MOD_NEK2_1 299 304 PF00069 0.536
MOD_NEK2_1 324 329 PF00069 0.685
MOD_NEK2_1 372 377 PF00069 0.537
MOD_NEK2_1 38 43 PF00069 0.597
MOD_NEK2_1 481 486 PF00069 0.667
MOD_NEK2_1 59 64 PF00069 0.544
MOD_PIKK_1 216 222 PF00454 0.380
MOD_PIKK_1 251 257 PF00454 0.590
MOD_PIKK_1 473 479 PF00454 0.631
MOD_PKA_1 10 16 PF00069 0.575
MOD_PKA_1 92 98 PF00069 0.720
MOD_PKA_2 10 16 PF00069 0.575
MOD_PKA_2 295 301 PF00069 0.470
MOD_PKA_2 418 424 PF00069 0.536
MOD_PKA_2 78 84 PF00069 0.661
MOD_PKB_1 90 98 PF00069 0.666
MOD_Plk_1 307 313 PF00069 0.571
MOD_Plk_1 397 403 PF00069 0.526
MOD_Plk_1 481 487 PF00069 0.595
MOD_Plk_1 548 554 PF00069 0.586
MOD_Plk_2-3 155 161 PF00069 0.603
MOD_Plk_4 346 352 PF00069 0.618
MOD_Plk_4 476 482 PF00069 0.626
MOD_ProDKin_1 242 248 PF00069 0.511
MOD_ProDKin_1 362 368 PF00069 0.613
MOD_ProDKin_1 442 448 PF00069 0.470
MOD_ProDKin_1 486 492 PF00069 0.589
MOD_ProDKin_1 550 556 PF00069 0.617
MOD_ProDKin_1 609 615 PF00069 0.556
MOD_SUMO_for_1 85 88 PF00179 0.656
MOD_SUMO_rev_2 26 34 PF00179 0.642
MOD_SUMO_rev_2 327 336 PF00179 0.696
MOD_SUMO_rev_2 565 574 PF00179 0.568
MOD_SUMO_rev_2 578 583 PF00179 0.565
TRG_ENDOCYTIC_2 510 513 PF00928 0.672
TRG_ER_diArg_1 436 438 PF00400 0.497
TRG_ER_diArg_1 89 92 PF00400 0.720
TRG_NLS_Bipartite_1 28 50 PF00514 0.583
TRG_NLS_MonoExtC_3 45 50 PF00514 0.615
TRG_NLS_MonoExtN_4 45 50 PF00514 0.615
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 301 306 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I322 Leptomonas seymouri 79% 100%
A0A0S4KI95 Bodo saltans 42% 94%
A0A1X0P6K8 Trypanosomatidae 49% 97%
A0A3S7WV83 Leishmania donovani 95% 100%
A0A422NCV7 Trypanosoma rangeli 46% 98%
A4H9Y1 Leishmania braziliensis 88% 100%
A4HY46 Leishmania infantum 95% 100%
D0A0E3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 93%
Q4QDJ7 Leishmania major 94% 100%
V5BBU4 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS