Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania mexicana

UniProt:

E9ARX4_LEIMU

TriTrypDb:

LmxM.19.0230

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	11
GO:0030964	NADH dehydrogenase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0045271	respiratory chain complex I	4	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:1902495	transmembrane transporter complex	3	11
GO:1990204	oxidoreductase complex	3	11
GO:1990351	transporter complex	2	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.558
CLV_C14_Caspase3-7	64	68	PF00656	0.619
CLV_C14_Caspase3-7	79	83	PF00656	0.552
CLV_NRD_NRD_1	149	151	PF00675	0.714
CLV_NRD_NRD_1	235	237	PF00675	0.465
CLV_NRD_NRD_1	277	279	PF00675	0.581
CLV_NRD_NRD_1	3	5	PF00675	0.547
CLV_NRD_NRD_1	348	350	PF00675	0.599
CLV_NRD_NRD_1	370	372	PF00675	0.579
CLV_NRD_NRD_1	374	376	PF00675	0.562
CLV_NRD_NRD_1	547	549	PF00675	0.587
CLV_NRD_NRD_1	599	601	PF00675	0.567
CLV_NRD_NRD_1	635	637	PF00675	0.467
CLV_NRD_NRD_1	645	647	PF00675	0.484
CLV_PCSK_FUR_1	557	561	PF00082	0.539
CLV_PCSK_KEX2_1	115	117	PF00082	0.732
CLV_PCSK_KEX2_1	149	151	PF00082	0.622
CLV_PCSK_KEX2_1	235	237	PF00082	0.465
CLV_PCSK_KEX2_1	277	279	PF00082	0.581
CLV_PCSK_KEX2_1	3	5	PF00082	0.547
CLV_PCSK_KEX2_1	348	350	PF00082	0.618
CLV_PCSK_KEX2_1	370	372	PF00082	0.579
CLV_PCSK_KEX2_1	374	376	PF00082	0.562
CLV_PCSK_KEX2_1	547	549	PF00082	0.570
CLV_PCSK_KEX2_1	559	561	PF00082	0.524
CLV_PCSK_KEX2_1	599	601	PF00082	0.567
CLV_PCSK_KEX2_1	645	647	PF00082	0.504
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.732
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.543
CLV_PCSK_PC7_1	344	350	PF00082	0.610
CLV_PCSK_PC7_1	370	376	PF00082	0.572
CLV_PCSK_SKI1_1	175	179	PF00082	0.447
CLV_PCSK_SKI1_1	218	222	PF00082	0.348
CLV_PCSK_SKI1_1	295	299	PF00082	0.544
CLV_PCSK_SKI1_1	375	379	PF00082	0.550
CLV_PCSK_SKI1_1	437	441	PF00082	0.550
CLV_PCSK_SKI1_1	462	466	PF00082	0.570
DEG_APCC_DBOX_1	174	182	PF00400	0.355
DEG_APCC_DBOX_1	461	469	PF00400	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_ODPH_VHL_1	465	477	PF01847	0.565
DOC_CDC14_PxL_1	39	47	PF14671	0.672
DOC_CKS1_1	130	135	PF01111	0.752
DOC_CKS1_1	84	89	PF01111	0.766
DOC_CYCLIN_RxL_1	459	469	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.459
DOC_MAPK_gen_1	198	205	PF00069	0.480
DOC_MAPK_gen_1	3	11	PF00069	0.517
DOC_MAPK_gen_1	631	640	PF00069	0.478
DOC_MAPK_MEF2A_6	185	194	PF00069	0.482
DOC_MAPK_MEF2A_6	198	205	PF00069	0.370
DOC_MAPK_MEF2A_6	3	11	PF00069	0.696
DOC_MAPK_MEF2A_6	656	663	PF00069	0.547
DOC_MAPK_NFAT4_5	198	206	PF00069	0.447
DOC_PP1_RVXF_1	200	206	PF00149	0.447
DOC_PP2B_LxvP_1	190	193	PF13499	0.447
DOC_PP2B_LxvP_1	464	467	PF13499	0.526
DOC_PP2B_LxvP_1	5	8	PF13499	0.455
DOC_PP2B_LxvP_1	69	72	PF13499	0.763
DOC_PP4_FxxP_1	234	237	PF00568	0.613
DOC_PP4_FxxP_1	591	594	PF00568	0.650
DOC_PP4_FxxP_1	657	660	PF00568	0.438
DOC_SPAK_OSR1_1	656	660	PF12202	0.540
DOC_USP7_MATH_1	169	173	PF00917	0.355
DOC_USP7_MATH_1	683	687	PF00917	0.609
DOC_USP7_UBL2_3	255	259	PF12436	0.699
DOC_USP7_UBL2_3	295	299	PF12436	0.528
DOC_WW_Pin1_4	129	134	PF00397	0.747
DOC_WW_Pin1_4	405	410	PF00397	0.711
DOC_WW_Pin1_4	83	88	PF00397	0.765
LIG_14-3-3_CanoR_1	17	25	PF00244	0.650
LIG_14-3-3_CanoR_1	236	242	PF00244	0.298
LIG_14-3-3_CanoR_1	303	309	PF00244	0.561
LIG_14-3-3_CanoR_1	450	459	PF00244	0.536
LIG_14-3-3_CanoR_1	636	641	PF00244	0.450
LIG_APCC_ABBA_1	661	666	PF00400	0.536
LIG_BRCT_BRCA1_1	230	234	PF00533	0.515
LIG_BRCT_BRCA1_1	428	432	PF00533	0.524
LIG_BRCT_BRCA1_1	499	503	PF00533	0.438
LIG_FHA_1	152	158	PF00498	0.639
LIG_FHA_1	497	503	PF00498	0.557
LIG_FHA_1	531	537	PF00498	0.497
LIG_FHA_1	71	77	PF00498	0.774
LIG_FHA_2	130	136	PF00498	0.748
LIG_FHA_2	256	262	PF00498	0.565
LIG_FHA_2	35	41	PF00498	0.575
LIG_FHA_2	380	386	PF00498	0.544
LIG_FHA_2	428	434	PF00498	0.550
LIG_FHA_2	51	57	PF00498	0.663
LIG_FHA_2	516	522	PF00498	0.523
LIG_FXI_DFP_1	540	544	PF00024	0.535
LIG_LIR_Apic_2	231	237	PF02991	0.524
LIG_LIR_Apic_2	356	362	PF02991	0.571
LIG_LIR_Apic_2	589	594	PF02991	0.612
LIG_LIR_Apic_2	598	604	PF02991	0.519
LIG_LIR_Apic_2	73	77	PF02991	0.752
LIG_LIR_Gen_1	294	305	PF02991	0.614
LIG_LIR_Gen_1	397	404	PF02991	0.519
LIG_LIR_Gen_1	469	480	PF02991	0.518
LIG_LIR_Gen_1	500	508	PF02991	0.459
LIG_LIR_Gen_1	518	526	PF02991	0.401
LIG_LIR_Gen_1	651	660	PF02991	0.460
LIG_LIR_Nem_3	124	128	PF02991	0.612
LIG_LIR_Nem_3	142	146	PF02991	0.573
LIG_LIR_Nem_3	172	177	PF02991	0.392
LIG_LIR_Nem_3	294	300	PF02991	0.599
LIG_LIR_Nem_3	397	403	PF02991	0.519
LIG_LIR_Nem_3	429	435	PF02991	0.531
LIG_LIR_Nem_3	455	461	PF02991	0.514
LIG_LIR_Nem_3	469	475	PF02991	0.520
LIG_LIR_Nem_3	500	506	PF02991	0.448
LIG_LIR_Nem_3	518	522	PF02991	0.426
LIG_LIR_Nem_3	580	584	PF02991	0.517
LIG_LIR_Nem_3	651	655	PF02991	0.466
LIG_NRBOX	460	466	PF00104	0.604
LIG_Pex14_1	519	523	PF04695	0.535
LIG_Pex14_2	522	526	PF04695	0.553
LIG_PTB_Apo_2	651	658	PF02174	0.551
LIG_RPA_C_Fungi	145	157	PF08784	0.696
LIG_SH2_CRK	174	178	PF00017	0.447
LIG_SH2_CRK	359	363	PF00017	0.570
LIG_SH2_CRK	601	605	PF00017	0.551
LIG_SH2_CRK	610	614	PF00017	0.456
LIG_SH2_CRK	74	78	PF00017	0.773
LIG_SH2_GRB2like	584	587	PF00017	0.532
LIG_SH2_STAP1	428	432	PF00017	0.524
LIG_SH2_STAP1	435	439	PF00017	0.537
LIG_SH2_STAP1	498	502	PF00017	0.537
LIG_SH2_STAT3	438	441	PF00017	0.517
LIG_SH2_STAT5	101	104	PF00017	0.608
LIG_SH2_STAT5	244	247	PF00017	0.581
LIG_SH2_STAT5	257	260	PF00017	0.471
LIG_SH2_STAT5	314	317	PF00017	0.573
LIG_SH2_STAT5	336	339	PF00017	0.616
LIG_SH2_STAT5	392	395	PF00017	0.507
LIG_SH2_STAT5	402	405	PF00017	0.539
LIG_SH2_STAT5	438	441	PF00017	0.517
LIG_SH2_STAT5	458	461	PF00017	0.572
LIG_SH2_STAT5	463	466	PF00017	0.535
LIG_SH2_STAT5	498	501	PF00017	0.539
LIG_SH2_STAT5	523	526	PF00017	0.538
LIG_SH2_STAT5	54	57	PF00017	0.585
LIG_SH2_STAT5	573	576	PF00017	0.515
LIG_SH2_STAT5	584	587	PF00017	0.473
LIG_SH3_3	127	133	PF00018	0.678
LIG_SH3_3	189	195	PF00018	0.495
LIG_SH3_3	525	531	PF00018	0.512
LIG_SH3_3	582	588	PF00018	0.540
LIG_SH3_3	659	665	PF00018	0.330
LIG_TRAF2_1	258	261	PF00917	0.585
LIG_TRAF2_1	479	482	PF00917	0.497
LIG_TRFH_1	463	467	PF08558	0.602
LIG_TYR_ITIM	123	128	PF00017	0.607
LIG_UBA3_1	177	185	PF00899	0.402
LIG_UBA3_1	190	198	PF00899	0.249
LIG_UBA3_1	502	510	PF00899	0.484
LIG_ULM_U2AF65_1	547	552	PF00076	0.547
LIG_WW_1	71	74	PF00397	0.778
MOD_CK1_1	20	26	PF00069	0.635
MOD_CK1_1	408	414	PF00069	0.616
MOD_CK1_1	679	685	PF00069	0.502
MOD_CK2_1	129	135	PF00069	0.718
MOD_CK2_1	246	252	PF00069	0.567
MOD_CK2_1	255	261	PF00069	0.543
MOD_CK2_1	263	269	PF00069	0.432
MOD_CK2_1	379	385	PF00069	0.533
MOD_CK2_1	404	410	PF00069	0.580
MOD_CK2_1	427	433	PF00069	0.593
MOD_CK2_1	50	56	PF00069	0.602
MOD_Cter_Amidation	147	150	PF01082	0.600
MOD_GlcNHglycan	102	105	PF01048	0.510
MOD_GlcNHglycan	22	25	PF01048	0.592
MOD_GlcNHglycan	308	311	PF01048	0.432
MOD_GlcNHglycan	356	359	PF01048	0.573
MOD_GlcNHglycan	563	566	PF01048	0.608
MOD_GlcNHglycan	595	598	PF01048	0.567
MOD_GlcNHglycan	685	688	PF01048	0.645
MOD_GSK3_1	169	176	PF00069	0.342
MOD_GSK3_1	304	311	PF00069	0.572
MOD_GSK3_1	379	386	PF00069	0.537
MOD_GSK3_1	404	411	PF00069	0.568
MOD_GSK3_1	679	686	PF00069	0.656
MOD_N-GLC_1	18	23	PF02516	0.566
MOD_N-GLC_1	34	39	PF02516	0.618
MOD_N-GLC_1	89	94	PF02516	0.748
MOD_N-GLC_2	676	678	PF02516	0.606
MOD_NEK2_1	144	149	PF00069	0.647
MOD_NEK2_1	173	178	PF00069	0.447
MOD_NEK2_1	18	23	PF00069	0.601
MOD_NEK2_1	228	233	PF00069	0.465
MOD_NEK2_1	383	388	PF00069	0.553
MOD_NEK2_1	427	432	PF00069	0.537
MOD_NEK2_1	515	520	PF00069	0.513
MOD_NEK2_1	89	94	PF00069	0.676
MOD_NEK2_2	169	174	PF00069	0.335
MOD_PIKK_1	666	672	PF00454	0.439
MOD_PK_1	636	642	PF00069	0.502
MOD_PKA_1	636	642	PF00069	0.494
MOD_PKA_2	237	243	PF00069	0.461
MOD_PKA_2	404	410	PF00069	0.573
MOD_PKA_2	625	631	PF00069	0.571
MOD_Plk_1	384	390	PF00069	0.559
MOD_Plk_1	416	422	PF00069	0.556
MOD_Plk_1	89	95	PF00069	0.622
MOD_Plk_2-3	246	252	PF00069	0.703
MOD_Plk_2-3	379	385	PF00069	0.558
MOD_Plk_2-3	521	527	PF00069	0.604
MOD_Plk_4	151	157	PF00069	0.622
MOD_Plk_4	169	175	PF00069	0.230
MOD_Plk_4	228	234	PF00069	0.508
MOD_Plk_4	379	385	PF00069	0.558
MOD_Plk_4	573	579	PF00069	0.464
MOD_ProDKin_1	129	135	PF00069	0.747
MOD_ProDKin_1	405	411	PF00069	0.710
MOD_ProDKin_1	83	89	PF00069	0.765
MOD_SUMO_rev_2	51	60	PF00179	0.735
MOD_SUMO_rev_2	564	572	PF00179	0.587
TRG_DiLeu_BaEn_2	150	156	PF01217	0.690
TRG_DiLeu_BaEn_4	64	70	PF01217	0.677
TRG_ENDOCYTIC_2	125	128	PF00928	0.609
TRG_ENDOCYTIC_2	174	177	PF00928	0.403
TRG_ENDOCYTIC_2	187	190	PF00928	0.249
TRG_ENDOCYTIC_2	373	376	PF00928	0.566
TRG_ENDOCYTIC_2	458	461	PF00928	0.525
TRG_ENDOCYTIC_2	523	526	PF00928	0.560
TRG_ENDOCYTIC_2	610	613	PF00928	0.435
TRG_ER_diArg_1	2	4	PF00400	0.545
TRG_ER_diArg_1	201	204	PF00400	0.408
TRG_ER_diArg_1	234	236	PF00400	0.468
TRG_ER_diArg_1	373	375	PF00400	0.574
TRG_ER_diArg_1	459	462	PF00400	0.529
TRG_ER_diArg_1	599	601	PF00400	0.568
TRG_ER_diArg_1	645	647	PF00400	0.504
TRG_NES_CRM1_1	608	623	PF08389	0.575
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Q5	Leptomonas seymouri	78%	99%
A0A0S4KEU9	Bodo saltans	59%	85%
A0A1X0P7G4	Trypanosomatidae	71%	98%
A0A3S7WVA4	Leishmania donovani	96%	100%
A4H9Y0	Leishmania braziliensis	91%	100%
A4HY45	Leishmania infantum	96%	100%
D0A0E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	97%
Q4QDJ8	Leishmania major	95%	100%
V5BSA4	Trypanosoma cruzi	70%	100%