Putative polyprenyl synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyprenyl synthase, putative

Species:

Leishmania mexicana

UniProt:

E9ARX3_LEIMU

TriTrypDb:

LmxM.19.0220

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARX3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008299	isoprenoid biosynthetic process	4	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004659	prenyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.380
CLV_C14_Caspase3-7	406	410	PF00656	0.575
CLV_C14_Caspase3-7	488	492	PF00656	0.391
CLV_C14_Caspase3-7	576	580	PF00656	0.293
CLV_C14_Caspase3-7	647	651	PF00656	0.274
CLV_C14_Caspase3-7	694	698	PF00656	0.258
CLV_NRD_NRD_1	166	168	PF00675	0.280
CLV_NRD_NRD_1	496	498	PF00675	0.274
CLV_PCSK_KEX2_1	166	168	PF00082	0.315
CLV_PCSK_KEX2_1	223	225	PF00082	0.302
CLV_PCSK_KEX2_1	375	377	PF00082	0.431
CLV_PCSK_KEX2_1	496	498	PF00082	0.274
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.302
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.431
CLV_PCSK_SKI1_1	134	138	PF00082	0.319
CLV_PCSK_SKI1_1	220	224	PF00082	0.497
CLV_PCSK_SKI1_1	369	373	PF00082	0.410
CLV_PCSK_SKI1_1	669	673	PF00082	0.177
DEG_APCC_DBOX_1	668	676	PF00400	0.336
DEG_APCC_DBOX_1	706	714	PF00400	0.379
DOC_MAPK_gen_1	445	455	PF00069	0.310
DOC_MAPK_gen_1	496	504	PF00069	0.298
DOC_MAPK_gen_1	535	544	PF00069	0.298
DOC_MAPK_gen_1	649	659	PF00069	0.279
DOC_MAPK_HePTP_8	108	120	PF00069	0.302
DOC_MAPK_MEF2A_6	111	120	PF00069	0.302
DOC_MAPK_MEF2A_6	616	625	PF00069	0.482
DOC_MAPK_MEF2A_6	652	661	PF00069	0.471
DOC_MAPK_NFAT4_5	616	624	PF00069	0.336
DOC_PP1_RVXF_1	449	456	PF00149	0.177
DOC_PP1_RVXF_1	539	545	PF00149	0.227
DOC_PP4_FxxP_1	520	523	PF00568	0.370
DOC_PP4_FxxP_1	716	719	PF00568	0.235
DOC_USP7_MATH_1	209	213	PF00917	0.315
DOC_USP7_MATH_1	287	291	PF00917	0.302
DOC_USP7_MATH_1	407	411	PF00917	0.418
DOC_USP7_MATH_1	438	442	PF00917	0.298
DOC_USP7_MATH_1	595	599	PF00917	0.321
DOC_USP7_MATH_2	532	538	PF00917	0.336
DOC_USP7_UBL2_3	42	46	PF12436	0.177
DOC_WW_Pin1_4	603	608	PF00397	0.177
LIG_14-3-3_CanoR_1	166	171	PF00244	0.311
LIG_14-3-3_CanoR_1	319	327	PF00244	0.413
LIG_14-3-3_CanoR_1	445	451	PF00244	0.405
LIG_14-3-3_CanoR_1	616	622	PF00244	0.177
LIG_14-3-3_CanoR_1	731	737	PF00244	0.354
LIG_Actin_WH2_2	109	127	PF00022	0.336
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	289	293	PF00533	0.177
LIG_BRCT_BRCA1_1	451	455	PF00533	0.292
LIG_BRCT_BRCA1_1	47	51	PF00533	0.412
LIG_BRCT_BRCA1_1	699	703	PF00533	0.341
LIG_Clathr_ClatBox_1	78	82	PF01394	0.333
LIG_deltaCOP1_diTrp_1	3	9	PF00928	0.452
LIG_deltaCOP1_diTrp_1	712	716	PF00928	0.232
LIG_eIF4E_1	559	565	PF01652	0.391
LIG_FHA_1	212	218	PF00498	0.399
LIG_FHA_1	340	346	PF00498	0.461
LIG_FHA_1	382	388	PF00498	0.419
LIG_FHA_1	572	578	PF00498	0.227
LIG_FHA_1	604	610	PF00498	0.349
LIG_FHA_1	618	624	PF00498	0.196
LIG_FHA_1	652	658	PF00498	0.246
LIG_FHA_2	148	154	PF00498	0.211
LIG_FHA_2	185	191	PF00498	0.298
LIG_FHA_2	271	277	PF00498	0.302
LIG_FHA_2	283	289	PF00498	0.335
LIG_FHA_2	404	410	PF00498	0.462
LIG_FHA_2	574	580	PF00498	0.336
LIG_FHA_2	692	698	PF00498	0.484
LIG_KLC1_Yacidic_2	177	182	PF13176	0.245
LIG_LIR_Apic_2	562	566	PF02991	0.391
LIG_LIR_Gen_1	177	185	PF02991	0.384
LIG_LIR_Gen_1	19	27	PF02991	0.381
LIG_LIR_Gen_1	214	222	PF02991	0.336
LIG_LIR_Gen_1	252	261	PF02991	0.303
LIG_LIR_Gen_1	304	312	PF02991	0.284
LIG_LIR_Gen_1	470	479	PF02991	0.183
LIG_LIR_Gen_1	712	721	PF02991	0.354
LIG_LIR_Gen_1	732	738	PF02991	0.174
LIG_LIR_Nem_3	177	183	PF02991	0.325
LIG_LIR_Nem_3	19	24	PF02991	0.511
LIG_LIR_Nem_3	214	219	PF02991	0.376
LIG_LIR_Nem_3	252	256	PF02991	0.297
LIG_LIR_Nem_3	304	308	PF02991	0.284
LIG_LIR_Nem_3	310	314	PF02991	0.288
LIG_LIR_Nem_3	433	439	PF02991	0.274
LIG_LIR_Nem_3	449	453	PF02991	0.274
LIG_LIR_Nem_3	470	475	PF02991	0.182
LIG_LIR_Nem_3	537	543	PF02991	0.380
LIG_LIR_Nem_3	712	717	PF02991	0.326
LIG_LIR_Nem_3	722	728	PF02991	0.314
LIG_LIR_Nem_3	732	736	PF02991	0.173
LIG_NRBOX	119	125	PF00104	0.336
LIG_Pex14_1	5	9	PF04695	0.483
LIG_Pex14_2	51	55	PF04695	0.276
LIG_PTB_Apo_2	198	205	PF02174	0.183
LIG_PTB_Apo_2	80	87	PF02174	0.177
LIG_PTB_Phospho_1	198	204	PF10480	0.227
LIG_PTB_Phospho_1	80	86	PF10480	0.177
LIG_REV1ctd_RIR_1	53	61	PF16727	0.333
LIG_SH2_GRB2like	34	37	PF00017	0.274
LIG_SH2_GRB2like	381	384	PF00017	0.236
LIG_SH2_PTP2	180	183	PF00017	0.279
LIG_SH2_PTP2	216	219	PF00017	0.302
LIG_SH2_PTP2	472	475	PF00017	0.298
LIG_SH2_SRC	180	183	PF00017	0.347
LIG_SH2_SRC	34	37	PF00017	0.336
LIG_SH2_SRC	87	90	PF00017	0.333
LIG_SH2_STAP1	168	172	PF00017	0.431
LIG_SH2_STAP1	21	25	PF00017	0.392
LIG_SH2_STAP1	232	236	PF00017	0.274
LIG_SH2_STAP1	381	385	PF00017	0.241
LIG_SH2_STAP1	71	75	PF00017	0.440
LIG_SH2_STAP1	87	91	PF00017	0.248
LIG_SH2_STAT3	142	145	PF00017	0.352
LIG_SH2_STAT3	4	7	PF00017	0.296
LIG_SH2_STAT5	142	145	PF00017	0.336
LIG_SH2_STAT5	168	171	PF00017	0.329
LIG_SH2_STAT5	180	183	PF00017	0.339
LIG_SH2_STAT5	207	210	PF00017	0.352
LIG_SH2_STAT5	216	219	PF00017	0.371
LIG_SH2_STAT5	394	397	PF00017	0.434
LIG_SH2_STAT5	466	469	PF00017	0.307
LIG_SH2_STAT5	472	475	PF00017	0.286
LIG_SH2_STAT5	519	522	PF00017	0.298
LIG_SH2_STAT5	543	546	PF00017	0.274
LIG_SH2_STAT5	563	566	PF00017	0.155
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.302
LIG_SUMO_SIM_anti_2	384	389	PF11976	0.285
LIG_SUMO_SIM_par_1	77	82	PF11976	0.228
LIG_TRAF2_1	187	190	PF00917	0.177
LIG_TRAF2_1	336	339	PF00917	0.333
LIG_TRAF2_1	398	401	PF00917	0.509
LIG_UBA3_1	120	126	PF00899	0.391
LIG_UBA3_1	78	85	PF00899	0.336
LIG_WRC_WIRS_1	308	313	PF05994	0.298
LIG_WRC_WIRS_1	52	57	PF05994	0.333
LIG_WRC_WIRS_1	730	735	PF05994	0.311
LIG_WW_3	9	13	PF00397	0.428
MOD_CK1_1	252	258	PF00069	0.321
MOD_CK1_1	259	265	PF00069	0.273
MOD_CK1_1	26	32	PF00069	0.423
MOD_CK1_1	270	276	PF00069	0.215
MOD_CK1_1	307	313	PF00069	0.270
MOD_CK1_1	410	416	PF00069	0.405
MOD_CK1_1	449	455	PF00069	0.391
MOD_CK2_1	184	190	PF00069	0.177
MOD_CK2_1	236	242	PF00069	0.484
MOD_CK2_1	270	276	PF00069	0.263
MOD_GlcNHglycan	25	28	PF01048	0.562
MOD_GlcNHglycan	269	272	PF01048	0.457
MOD_GlcNHglycan	321	324	PF01048	0.336
MOD_GlcNHglycan	356	360	PF01048	0.456
MOD_GlcNHglycan	515	518	PF01048	0.330
MOD_GlcNHglycan	89	92	PF01048	0.452
MOD_GSK3_1	147	154	PF00069	0.257
MOD_GSK3_1	166	173	PF00069	0.302
MOD_GSK3_1	207	214	PF00069	0.328
MOD_GSK3_1	252	259	PF00069	0.324
MOD_GSK3_1	303	310	PF00069	0.282
MOD_GSK3_1	403	410	PF00069	0.557
MOD_GSK3_1	568	575	PF00069	0.336
MOD_N-GLC_1	249	254	PF02516	0.257
MOD_N-GLC_1	259	264	PF02516	0.324
MOD_N-GLC_1	301	306	PF02516	0.383
MOD_NEK2_1	151	156	PF00069	0.336
MOD_NEK2_1	170	175	PF00069	0.346
MOD_NEK2_1	211	216	PF00069	0.336
MOD_NEK2_1	236	241	PF00069	0.426
MOD_NEK2_1	256	261	PF00069	0.292
MOD_NEK2_1	282	287	PF00069	0.292
MOD_NEK2_1	327	332	PF00069	0.407
MOD_NEK2_1	467	472	PF00069	0.198
MOD_NEK2_1	51	56	PF00069	0.298
MOD_NEK2_1	617	622	PF00069	0.292
MOD_NEK2_1	721	726	PF00069	0.385
MOD_NEK2_1	729	734	PF00069	0.303
MOD_NEK2_2	287	292	PF00069	0.177
MOD_NEK2_2	37	42	PF00069	0.302
MOD_PIKK_1	140	146	PF00454	0.391
MOD_PIKK_1	184	190	PF00454	0.336
MOD_PIKK_1	259	265	PF00454	0.391
MOD_PKA_1	166	172	PF00069	0.374
MOD_PKA_2	166	172	PF00069	0.433
MOD_PKA_2	244	250	PF00069	0.449
MOD_Plk_1	151	157	PF00069	0.378
MOD_Plk_1	249	255	PF00069	0.357
MOD_Plk_1	259	265	PF00069	0.334
MOD_Plk_1	301	307	PF00069	0.402
MOD_Plk_1	327	333	PF00069	0.336
MOD_Plk_1	44	50	PF00069	0.294
MOD_Plk_1	467	473	PF00069	0.177
MOD_Plk_1	490	496	PF00069	0.298
MOD_Plk_1	572	578	PF00069	0.336
MOD_Plk_1	721	727	PF00069	0.421
MOD_Plk_2-3	573	579	PF00069	0.336
MOD_Plk_2-3	93	99	PF00069	0.336
MOD_Plk_4	262	268	PF00069	0.321
MOD_Plk_4	304	310	PF00069	0.277
MOD_Plk_4	339	345	PF00069	0.267
MOD_Plk_4	390	396	PF00069	0.428
MOD_Plk_4	407	413	PF00069	0.360
MOD_Plk_4	431	437	PF00069	0.274
MOD_Plk_4	480	486	PF00069	0.274
MOD_Plk_4	490	496	PF00069	0.274
MOD_Plk_4	51	57	PF00069	0.274
MOD_Plk_4	573	579	PF00069	0.438
MOD_Plk_4	605	611	PF00069	0.302
MOD_Plk_4	732	738	PF00069	0.409
MOD_ProDKin_1	603	609	PF00069	0.177
MOD_SUMO_for_1	222	225	PF00179	0.336
MOD_SUMO_for_1	41	44	PF00179	0.336
MOD_SUMO_for_1	641	644	PF00179	0.302
MOD_SUMO_rev_2	644	654	PF00179	0.296
TRG_DiLeu_BaEn_2	711	717	PF01217	0.226
TRG_DiLeu_BaEn_4	400	406	PF01217	0.420
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.460
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.386
TRG_ENDOCYTIC_2	180	183	PF00928	0.328
TRG_ENDOCYTIC_2	205	208	PF00928	0.302
TRG_ENDOCYTIC_2	21	24	PF00928	0.359
TRG_ENDOCYTIC_2	216	219	PF00928	0.289
TRG_ENDOCYTIC_2	351	354	PF00928	0.407
TRG_ENDOCYTIC_2	472	475	PF00928	0.298
TRG_ENDOCYTIC_2	543	546	PF00928	0.274
TRG_ER_diArg_1	166	168	PF00400	0.315
TRG_ER_diArg_1	495	497	PF00400	0.274
TRG_ER_FFAT_2	19	29	PF00635	0.307
TRG_NES_CRM1_1	477	488	PF08389	0.274
TRG_NES_CRM1_1	612	626	PF08389	0.177
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.177
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRK5	Bodo saltans	49%	94%
A0A1X0P7U9	Trypanosomatidae	49%	100%
A0A3S7WV99	Leishmania donovani	90%	100%
A0A422ND06	Trypanosoma rangeli	51%	99%
A4H9X9	Leishmania braziliensis	79%	100%
A4HY44	Leishmania infantum	90%	100%
Q4QDJ9	Leishmania major	88%	100%
V5C1S4	Trypanosoma cruzi	43%	99%