Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MG, Family M24

Species:

Leishmania mexicana

UniProt:

E9ARW7_LEIMU

TriTrypDb:

LmxM.19.0160

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARW7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008238	exopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.334
CLV_PCSK_KEX2_1	206	208	PF00082	0.296
CLV_PCSK_KEX2_1	219	221	PF00082	0.296
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.296
CLV_PCSK_SKI1_1	156	160	PF00082	0.364
CLV_PCSK_SKI1_1	285	289	PF00082	0.498
CLV_PCSK_SKI1_1	39	43	PF00082	0.307
CLV_PCSK_SKI1_1	77	81	PF00082	0.319
DEG_APCC_DBOX_1	301	309	PF00400	0.361
DOC_MAPK_gen_1	299	305	PF00069	0.380
DOC_PP1_RVXF_1	83	90	PF00149	0.296
DOC_USP7_MATH_1	104	108	PF00917	0.361
DOC_USP7_UBL2_3	247	251	PF12436	0.376
DOC_USP7_UBL2_3	276	280	PF12436	0.507
DOC_USP7_UBL2_3	376	380	PF12436	0.675
DOC_USP7_UBL2_3	56	60	PF12436	0.311
DOC_USP7_UBL2_3	77	81	PF12436	0.330
DOC_WW_Pin1_4	100	105	PF00397	0.297
DOC_WW_Pin1_4	192	197	PF00397	0.296
LIG_14-3-3_CanoR_1	156	165	PF00244	0.384
LIG_APCC_ABBA_1	125	130	PF00400	0.296
LIG_APCC_ABBA_1	356	361	PF00400	0.440
LIG_BIR_III_2	254	258	PF00653	0.480
LIG_EH1_1	330	338	PF00400	0.335
LIG_eIF4E_1	359	365	PF01652	0.400
LIG_FHA_1	137	143	PF00498	0.296
LIG_FHA_1	180	186	PF00498	0.299
LIG_FHA_1	236	242	PF00498	0.323
LIG_FHA_1	332	338	PF00498	0.321
LIG_FHA_1	365	371	PF00498	0.423
LIG_FHA_1	45	51	PF00498	0.354
LIG_FHA_1	71	77	PF00498	0.317
LIG_FHA_2	109	115	PF00498	0.469
LIG_FHA_2	141	147	PF00498	0.197
LIG_FHA_2	193	199	PF00498	0.309
LIG_LIR_Gen_1	130	140	PF02991	0.441
LIG_LIR_Gen_1	159	169	PF02991	0.390
LIG_LIR_Gen_1	283	293	PF02991	0.368
LIG_LIR_Nem_3	130	135	PF02991	0.441
LIG_LIR_Nem_3	159	165	PF02991	0.355
LIG_LIR_Nem_3	211	216	PF02991	0.296
LIG_LIR_Nem_3	283	289	PF02991	0.376
LIG_LIR_Nem_3	8	13	PF02991	0.577
LIG_LYPXL_yS_3	317	320	PF13949	0.361
LIG_MAD2	49	57	PF02301	0.423
LIG_MYND_1	354	358	PF01753	0.466
LIG_SH2_CRK	132	136	PF00017	0.441
LIG_SH2_CRK	162	166	PF00017	0.330
LIG_SH2_CRK	213	217	PF00017	0.466
LIG_SH2_STAP1	268	272	PF00017	0.405
LIG_SH2_STAP1	359	363	PF00017	0.412
LIG_SH2_STAT5	132	135	PF00017	0.311
LIG_SH2_STAT5	208	211	PF00017	0.296
LIG_SH2_STAT5	359	362	PF00017	0.414
LIG_SH3_4	56	63	PF00018	0.330
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.345
LIG_TRAF2_1	111	114	PF00917	0.335
LIG_TRAF2_1	5	8	PF00917	0.594
LIG_TYR_ITIM	315	320	PF00017	0.391
MOD_CK1_1	266	272	PF00069	0.489
MOD_CK2_1	108	114	PF00069	0.471
MOD_CK2_1	271	277	PF00069	0.395
MOD_GlcNHglycan	244	247	PF01048	0.381
MOD_GlcNHglycan	273	276	PF01048	0.384
MOD_GSK3_1	100	107	PF00069	0.361
MOD_GSK3_1	136	143	PF00069	0.296
MOD_GSK3_1	24	31	PF00069	0.431
MOD_GSK3_1	281	288	PF00069	0.474
MOD_GSK3_1	364	371	PF00069	0.476
MOD_N-GLC_1	266	271	PF02516	0.540
MOD_N-GLC_1	28	33	PF02516	0.401
MOD_N-GLC_1	44	49	PF02516	0.296
MOD_N-GLC_2	96	98	PF02516	0.296
MOD_NEK2_1	331	336	PF00069	0.318
MOD_NEK2_1	364	369	PF00069	0.380
MOD_NEK2_2	174	179	PF00069	0.390
MOD_NEK2_2	44	49	PF00069	0.441
MOD_PIKK_1	108	114	PF00454	0.359
MOD_Plk_1	23	29	PF00069	0.452
MOD_Plk_1	266	272	PF00069	0.493
MOD_Plk_1	44	50	PF00069	0.352
MOD_Plk_1	68	74	PF00069	0.296
MOD_Plk_2-3	357	363	PF00069	0.553
MOD_Plk_4	174	180	PF00069	0.394
MOD_Plk_4	75	81	PF00069	0.373
MOD_ProDKin_1	100	106	PF00069	0.297
MOD_ProDKin_1	192	198	PF00069	0.296
MOD_SUMO_for_1	270	273	PF00179	0.401
MOD_SUMO_rev_2	145	155	PF00179	0.316
MOD_SUMO_rev_2	277	287	PF00179	0.523
MOD_SUMO_rev_2	371	379	PF00179	0.579
TRG_ENDOCYTIC_2	132	135	PF00928	0.441
TRG_ENDOCYTIC_2	162	165	PF00928	0.365
TRG_ENDOCYTIC_2	213	216	PF00928	0.466
TRG_ENDOCYTIC_2	286	289	PF00928	0.409
TRG_ENDOCYTIC_2	317	320	PF00928	0.361
TRG_ER_diArg_1	219	221	PF00400	0.361
TRG_ER_diLys_1	376	380	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W6	Leptomonas seymouri	24%	82%
A0A0N1IIM1	Leptomonas seymouri	89%	99%
A0A0S4IME4	Bodo saltans	23%	85%
A0A0S4J160	Bodo saltans	64%	99%
A0A1X0NPS8	Trypanosomatidae	29%	69%
A0A1X0NXP2	Trypanosomatidae	24%	80%
A0A1X0P6E6	Trypanosomatidae	75%	100%
A0A3Q8IBA7	Leishmania donovani	99%	100%
A0A3Q8IBP5	Leishmania donovani	32%	66%
A0A3R7KN75	Trypanosoma rangeli	29%	74%
A0A3R7MCJ4	Trypanosoma rangeli	23%	81%
A0A3S7WWI2	Leishmania donovani	25%	82%
A0A422NCW7	Trypanosoma rangeli	74%	100%
A1CCP2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	79%
A1CH02	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	87%
A1CXT5	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	86%
A1CYM1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	82%
A1DA84	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	85%
A2QAF9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	80%
A2QHX0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	88%
A4H757	Leishmania braziliensis	31%	100%
A4H9X3	Leishmania braziliensis	92%	100%
A4HBT2	Leishmania braziliensis	24%	82%
A4HVJ6	Leishmania infantum	32%	66%
A4HZM5	Leishmania infantum	25%	82%
A4RDI6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	86%
A5DR89	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	23%	83%
A5E5I9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	24%	80%
A6RGC8	Ajellomyces capsulatus (strain NAm1 / WU24)	25%	82%
A6RTU0	Botryotinia fuckeliana (strain B05.10)	23%	85%
A6ZKL2	Saccharomyces cerevisiae (strain YJM789)	26%	90%
A7EZ86	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	23%	85%
A8QBZ2	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	24%	85%
B0CRL4	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	25%	100%
B0XTJ7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	78%
B0Y5N4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	81%
B0YAX5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	85%
B2B738	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	25%	85%
B2VW14	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	26%	83%
B2W1N6	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	24%	84%
B3LNM2	Saccharomyces cerevisiae (strain RM11-1a)	26%	90%
B5VDQ0	Saccharomyces cerevisiae (strain AWRI1631)	26%	90%
B6H5L5	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	24%	82%
B6HTQ4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	87%
B6Q1N3	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	23%	86%
B6QD96	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	26%	82%
B6YTG0	Thermococcus onnurineus (strain NA1)	29%	100%
B8LUH2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	24%	86%
B8M990	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	82%
B8NA06	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	22%	85%
B8NLL0	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	23%	81%
B9WJA2	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	84%
C0NIQ4	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	24%	85%
C0NX86	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	25%	82%
C0SIM8	Paracoccidioides brasiliensis (strain Pb03)	24%	85%
C1GLM4	Paracoccidioides brasiliensis (strain Pb18)	24%	85%
C1HAB2	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	24%	85%
C4JSX6	Uncinocarpus reesii (strain UAMH 1704)	24%	84%
C4R2P3	Komagataella phaffii (strain GS115 / ATCC 20864)	23%	85%
C4Y1F8	Clavispora lusitaniae (strain ATCC 42720)	26%	87%
C4YSA9	Candida albicans (strain WO-1)	23%	85%
C5DE35	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	24%	90%
C5FEJ1	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	26%	82%
C5FF46	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	23%	85%
C5GCN0	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	24%	85%
C5GLJ6	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	27%	82%
C5JW60	Blastomyces gilchristii (strain SLH14081)	24%	85%
C5JYZ5	Blastomyces gilchristii (strain SLH14081)	27%	82%
C5M8M4	Candida tropicalis (strain ATCC MYA-3404 / T1)	24%	88%
C5P8Q4	Coccidioides posadasii (strain C735)	24%	84%
C6HI66	Ajellomyces capsulatus (strain H143)	25%	86%
C7GSF3	Saccharomyces cerevisiae (strain JAY291)	26%	90%
C7YS77	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	24%	85%
C7Z7V7	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	24%	84%
C8Z3V4	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	26%	90%
C9SB49	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	26%	86%
D0A0D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
D0A1D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	82%
D0A6Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	71%
D1ZEN1	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	26%	87%
D4B2G3	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	24%	85%
D4DE65	Trichophyton verrucosum (strain HKI 0517)	24%	85%
D8PR70	Schizophyllum commune (strain H4-8 / FGSC 9210)	26%	90%
E3L3Q8	Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)	23%	83%
E3QDQ4	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	24%	82%
E3QW41	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	24%	86%
E3RCY7	Pyrenophora teres f. teres (strain 0-1)	24%	84%
E3RD74	Pyrenophora teres f. teres (strain 0-1)	27%	83%
E4ZYY3	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	26%	83%
E5R278	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	25%	81%
E5R3Z8	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	24%	85%
E5R4J3	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	24%	84%
E9AGR8	Leishmania infantum	99%	100%
E9AP92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AV56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
H1UBK1	Caenorhabditis elegans	23%	81%
M1CZC0	Solanum tuberosum	39%	98%
O08663	Mus musculus	24%	79%
O27355	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O28438	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O58362	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	100%
O60085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	89%
O60180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	91%
P38062	Rattus norvegicus	23%	79%
P38174	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	90%
P50579	Homo sapiens	23%	79%
P50580	Mus musculus	37%	96%
P56218	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
P95963	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q09184	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q0C838	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	23%	84%
Q0CL94	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	22%	85%
Q0UTI9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	87%
Q1ZXG4	Dictyostelium discoideum	40%	99%
Q2GSJ7	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	26%	87%
Q2GYA8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	26%	87%
Q2U6H2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	81%
Q3ZC89	Bos taurus	23%	80%
Q4QCC5	Leishmania major	24%	100%
Q4QDK5	Leishmania major	98%	100%
Q4QG86	Leishmania major	30%	66%
Q4WAY7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	85%
Q4WII3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	78%
Q4WNT9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	81%
Q55C21	Dictyostelium discoideum	23%	87%
Q56Y85	Arabidopsis thaliana	24%	87%
Q58725	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q59LF9	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	85%
Q5B4X6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	85%
Q5BGG1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	83%
Q5JGD1	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	100%
Q6AYD3	Rattus norvegicus	37%	96%
Q6BVB8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	20%	91%
Q6CA79	Yarrowia lipolytica (strain CLIB 122 / E 150)	21%	81%
Q6CCY2	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	79%
Q6CP80	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	91%
Q6XMH6	Encephalitozoon hellem (strain ATCC 50504)	23%	100%
Q6XMH7	Encephalitozoon intestinalis (strain ATCC 50506)	23%	100%
Q7S7L7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	87%
Q8SR45	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q96327	Arabidopsis thaliana	38%	97%
Q9FV49	Arabidopsis thaliana	24%	86%
Q9UQ80	Homo sapiens	37%	96%
Q9UYT4	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
V5BFG1	Trypanosoma cruzi	29%	72%
V5BMW9	Trypanosoma cruzi	25%	80%
V5BS99	Trypanosoma cruzi	72%	100%