LeishMANIAdb
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Associated kinase of Tb14-3-3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Associated kinase of Tb14-3-3
Gene product:
Associated kinase of Tb14-3-3, putative
Species:
Leishmania mexicana
UniProt:
E9ARW5_LEIMU
TriTrypDb:
LmxM.19.0140
Length:
626

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9ARW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARW5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 18
GO:0006793 phosphorus metabolic process 3 18
GO:0006796 phosphate-containing compound metabolic process 4 18
GO:0006807 nitrogen compound metabolic process 2 18
GO:0008152 metabolic process 1 18
GO:0009987 cellular process 1 18
GO:0016310 phosphorylation 5 18
GO:0019538 protein metabolic process 3 18
GO:0036211 protein modification process 4 18
GO:0043170 macromolecule metabolic process 3 18
GO:0043412 macromolecule modification 4 18
GO:0044237 cellular metabolic process 2 18
GO:0044238 primary metabolic process 2 18
GO:0071704 organic substance metabolic process 2 18
GO:1901564 organonitrogen compound metabolic process 3 18
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 18
GO:0003824 catalytic activity 1 18
GO:0004672 protein kinase activity 3 18
GO:0005488 binding 1 18
GO:0005524 ATP binding 5 18
GO:0016301 kinase activity 4 18
GO:0016740 transferase activity 2 18
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 18
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 18
GO:0017076 purine nucleotide binding 4 18
GO:0030554 adenyl nucleotide binding 5 18
GO:0032553 ribonucleotide binding 3 18
GO:0032555 purine ribonucleotide binding 4 18
GO:0032559 adenyl ribonucleotide binding 5 18
GO:0035639 purine ribonucleoside triphosphate binding 4 18
GO:0036094 small molecule binding 2 18
GO:0043167 ion binding 2 18
GO:0043168 anion binding 3 18
GO:0097159 organic cyclic compound binding 2 18
GO:0097367 carbohydrate derivative binding 2 18
GO:0140096 catalytic activity, acting on a protein 2 18
GO:1901265 nucleoside phosphate binding 3 18
GO:1901363 heterocyclic compound binding 2 18
GO:0004674 protein serine/threonine kinase activity 4 7
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1
GO:0015631 tubulin binding 4 1
GO:0042802 identical protein binding 3 1
GO:0042803 protein homodimerization activity 4 1
GO:0046983 protein dimerization activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.511
CLV_NRD_NRD_1 364 366 PF00675 0.513
CLV_NRD_NRD_1 403 405 PF00675 0.582
CLV_NRD_NRD_1 436 438 PF00675 0.601
CLV_NRD_NRD_1 451 453 PF00675 0.631
CLV_NRD_NRD_1 472 474 PF00675 0.573
CLV_PCSK_KEX2_1 186 188 PF00082 0.289
CLV_PCSK_KEX2_1 219 221 PF00082 0.251
CLV_PCSK_KEX2_1 315 317 PF00082 0.240
CLV_PCSK_KEX2_1 364 366 PF00082 0.513
CLV_PCSK_KEX2_1 403 405 PF00082 0.596
CLV_PCSK_KEX2_1 436 438 PF00082 0.601
CLV_PCSK_KEX2_1 451 453 PF00082 0.631
CLV_PCSK_KEX2_1 472 474 PF00082 0.573
CLV_PCSK_KEX2_1 83 85 PF00082 0.270
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.289
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.269
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.254
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.242
CLV_PCSK_PC7_1 215 221 PF00082 0.269
CLV_PCSK_SKI1_1 109 113 PF00082 0.332
CLV_PCSK_SKI1_1 149 153 PF00082 0.305
CLV_PCSK_SKI1_1 162 166 PF00082 0.318
CLV_PCSK_SKI1_1 280 284 PF00082 0.240
CLV_PCSK_SKI1_1 486 490 PF00082 0.728
CLV_PCSK_SKI1_1 509 513 PF00082 0.666
CLV_PCSK_SKI1_1 515 519 PF00082 0.643
CLV_PCSK_SKI1_1 613 617 PF00082 0.243
DEG_Nend_UBRbox_3 1 3 PF02207 0.718
DOC_CKS1_1 227 232 PF01111 0.285
DOC_CKS1_1 287 292 PF01111 0.329
DOC_CKS1_1 39 44 PF01111 0.343
DOC_CYCLIN_yCln2_LP_2 323 329 PF00134 0.358
DOC_MAPK_gen_1 162 171 PF00069 0.320
DOC_MAPK_gen_1 563 571 PF00069 0.238
DOC_MAPK_JIP1_4 165 171 PF00069 0.280
DOC_PP2B_LxvP_1 206 209 PF13499 0.294
DOC_PP4_FxxP_1 607 610 PF00568 0.238
DOC_USP7_MATH_1 185 189 PF00917 0.249
DOC_USP7_MATH_1 484 488 PF00917 0.624
DOC_USP7_MATH_1 513 517 PF00917 0.639
DOC_USP7_MATH_1 519 523 PF00917 0.674
DOC_USP7_MATH_1 530 534 PF00917 0.576
DOC_USP7_UBL2_3 311 315 PF12436 0.278
DOC_USP7_UBL2_3 56 60 PF12436 0.311
DOC_WW_Pin1_4 193 198 PF00397 0.369
DOC_WW_Pin1_4 226 231 PF00397 0.263
DOC_WW_Pin1_4 269 274 PF00397 0.385
DOC_WW_Pin1_4 286 291 PF00397 0.299
DOC_WW_Pin1_4 295 300 PF00397 0.285
DOC_WW_Pin1_4 314 319 PF00397 0.441
DOC_WW_Pin1_4 38 43 PF00397 0.281
DOC_WW_Pin1_4 397 402 PF00397 0.636
DOC_WW_Pin1_4 404 409 PF00397 0.648
DOC_WW_Pin1_4 425 430 PF00397 0.569
DOC_WW_Pin1_4 457 462 PF00397 0.573
DOC_WW_Pin1_4 472 477 PF00397 0.569
DOC_WW_Pin1_4 480 485 PF00397 0.592
DOC_WW_Pin1_4 486 491 PF00397 0.558
DOC_WW_Pin1_4 509 514 PF00397 0.582
DOC_WW_Pin1_4 515 520 PF00397 0.562
DOC_WW_Pin1_4 526 531 PF00397 0.525
LIG_14-3-3_CanoR_1 220 230 PF00244 0.277
LIG_14-3-3_CanoR_1 284 290 PF00244 0.351
LIG_14-3-3_CanoR_1 31 37 PF00244 0.243
LIG_14-3-3_CanoR_1 413 420 PF00244 0.702
LIG_14-3-3_CanoR_1 425 429 PF00244 0.515
LIG_14-3-3_CanoR_1 451 456 PF00244 0.590
LIG_14-3-3_CanoR_1 503 513 PF00244 0.664
LIG_14-3-3_CanoR_1 528 537 PF00244 0.526
LIG_14-3-3_CanoR_1 618 625 PF00244 0.247
LIG_Actin_WH2_2 75 92 PF00022 0.309
LIG_APCC_ABBA_1 111 116 PF00400 0.238
LIG_BRCT_BRCA1_1 265 269 PF00533 0.238
LIG_BRCT_BRCA1_1 573 577 PF00533 0.329
LIG_Clathr_ClatBox_1 112 116 PF01394 0.238
LIG_Dynein_DLC8_1 239 245 PF01221 0.251
LIG_FHA_1 142 148 PF00498 0.276
LIG_FHA_1 252 258 PF00498 0.272
LIG_FHA_1 536 542 PF00498 0.736
LIG_FHA_1 543 549 PF00498 0.677
LIG_FHA_2 20 26 PF00498 0.392
LIG_FHA_2 243 249 PF00498 0.238
LIG_FHA_2 98 104 PF00498 0.251
LIG_LIR_Apic_2 229 235 PF02991 0.320
LIG_LIR_Gen_1 108 118 PF02991 0.292
LIG_LIR_Gen_1 144 152 PF02991 0.238
LIG_LIR_Gen_1 236 247 PF02991 0.250
LIG_LIR_Gen_1 261 270 PF02991 0.264
LIG_LIR_Gen_1 317 328 PF02991 0.272
LIG_LIR_Nem_3 100 104 PF02991 0.303
LIG_LIR_Nem_3 108 114 PF02991 0.339
LIG_LIR_Nem_3 144 148 PF02991 0.241
LIG_LIR_Nem_3 236 242 PF02991 0.239
LIG_LIR_Nem_3 245 250 PF02991 0.326
LIG_LIR_Nem_3 261 265 PF02991 0.253
LIG_LIR_Nem_3 281 286 PF02991 0.228
LIG_LIR_Nem_3 317 323 PF02991 0.272
LIG_Pex14_2 111 115 PF04695 0.244
LIG_Pex14_2 238 242 PF04695 0.238
LIG_REV1ctd_RIR_1 112 121 PF16727 0.385
LIG_SH2_CRK 145 149 PF00017 0.238
LIG_SH2_CRK 320 324 PF00017 0.269
LIG_SH2_CRK 34 38 PF00017 0.417
LIG_SH2_PTP2 262 265 PF00017 0.335
LIG_SH2_PTP2 46 49 PF00017 0.385
LIG_SH2_SRC 145 148 PF00017 0.242
LIG_SH2_SRC 46 49 PF00017 0.269
LIG_SH2_SRC 66 69 PF00017 0.232
LIG_SH2_STAP1 143 147 PF00017 0.251
LIG_SH2_STAT3 143 146 PF00017 0.238
LIG_SH2_STAT3 21 24 PF00017 0.316
LIG_SH2_STAT5 104 107 PF00017 0.315
LIG_SH2_STAT5 143 146 PF00017 0.269
LIG_SH2_STAT5 21 24 PF00017 0.327
LIG_SH2_STAT5 262 265 PF00017 0.321
LIG_SH2_STAT5 46 49 PF00017 0.294
LIG_SH2_STAT5 57 60 PF00017 0.159
LIG_SH2_STAT5 606 609 PF00017 0.238
LIG_SH2_STAT5 66 69 PF00017 0.210
LIG_SH3_3 194 200 PF00018 0.357
LIG_SH3_3 267 273 PF00018 0.385
LIG_SH3_3 36 42 PF00018 0.248
LIG_SH3_3 387 393 PF00018 0.508
LIG_SH3_3 423 429 PF00018 0.593
LIG_SUMO_SIM_anti_2 85 90 PF11976 0.268
LIG_SUMO_SIM_par_1 199 204 PF11976 0.325
LIG_TRAF2_1 394 397 PF00917 0.730
LIG_TYR_ITIM 260 265 PF00017 0.335
LIG_UBA3_1 67 72 PF00899 0.269
LIG_WRC_WIRS_1 98 103 PF05994 0.251
MOD_CDC14_SPxK_1 428 431 PF00782 0.554
MOD_CDK_SPK_2 193 198 PF00069 0.230
MOD_CDK_SPK_2 226 231 PF00069 0.238
MOD_CDK_SPxK_1 397 403 PF00069 0.562
MOD_CDK_SPxK_1 425 431 PF00069 0.557
MOD_CDK_SPxK_1 472 478 PF00069 0.572
MOD_CDK_SPxK_1 480 486 PF00069 0.583
MOD_CDK_SPxK_1 509 515 PF00069 0.601
MOD_CDK_SPxxK_3 286 293 PF00069 0.392
MOD_CDK_SPxxK_3 397 404 PF00069 0.657
MOD_CDK_SPxxK_3 457 464 PF00069 0.573
MOD_CK1_1 272 278 PF00069 0.385
MOD_CK1_1 314 320 PF00069 0.442
MOD_CK1_1 409 415 PF00069 0.653
MOD_CK1_1 440 446 PF00069 0.688
MOD_CK1_1 491 497 PF00069 0.576
MOD_CK1_1 539 545 PF00069 0.538
MOD_CK2_1 275 281 PF00069 0.329
MOD_CK2_1 97 103 PF00069 0.251
MOD_Cter_Amidation 217 220 PF01082 0.251
MOD_DYRK1A_RPxSP_1 404 408 PF00069 0.569
MOD_DYRK1A_RPxSP_1 425 429 PF00069 0.608
MOD_DYRK1A_RPxSP_1 486 490 PF00069 0.588
MOD_DYRK1A_RPxSP_1 515 519 PF00069 0.581
MOD_DYRK1A_RPxSP_1 526 530 PF00069 0.588
MOD_GlcNHglycan 131 134 PF01048 0.394
MOD_GlcNHglycan 265 268 PF01048 0.294
MOD_GlcNHglycan 348 351 PF01048 0.548
MOD_GlcNHglycan 353 356 PF01048 0.548
MOD_GlcNHglycan 408 411 PF01048 0.686
MOD_GlcNHglycan 421 424 PF01048 0.614
MOD_GlcNHglycan 444 447 PF01048 0.657
MOD_GlcNHglycan 453 456 PF01048 0.562
MOD_GlcNHglycan 464 467 PF01048 0.529
MOD_GlcNHglycan 486 489 PF01048 0.610
MOD_GlcNHglycan 497 500 PF01048 0.504
MOD_GlcNHglycan 515 518 PF01048 0.667
MOD_GlcNHglycan 521 524 PF01048 0.681
MOD_GlcNHglycan 532 535 PF01048 0.556
MOD_GlcNHglycan 538 541 PF01048 0.572
MOD_GSK3_1 129 136 PF00069 0.306
MOD_GSK3_1 137 144 PF00069 0.277
MOD_GSK3_1 261 268 PF00069 0.250
MOD_GSK3_1 282 289 PF00069 0.282
MOD_GSK3_1 409 416 PF00069 0.675
MOD_GSK3_1 431 438 PF00069 0.695
MOD_GSK3_1 441 448 PF00069 0.678
MOD_GSK3_1 480 487 PF00069 0.763
MOD_GSK3_1 491 498 PF00069 0.510
MOD_GSK3_1 505 512 PF00069 0.618
MOD_GSK3_1 515 522 PF00069 0.559
MOD_GSK3_1 526 533 PF00069 0.579
MOD_GSK3_1 535 542 PF00069 0.559
MOD_GSK3_1 591 598 PF00069 0.238
MOD_LATS_1 435 441 PF00433 0.598
MOD_N-GLC_1 275 280 PF02516 0.354
MOD_N-GLC_1 571 576 PF02516 0.329
MOD_NEK2_1 128 133 PF00069 0.392
MOD_NEK2_1 201 206 PF00069 0.387
MOD_NEK2_1 242 247 PF00069 0.282
MOD_NEK2_1 265 270 PF00069 0.251
MOD_NEK2_1 304 309 PF00069 0.345
MOD_NEK2_1 395 400 PF00069 0.729
MOD_NEK2_1 462 467 PF00069 0.574
MOD_NEK2_1 505 510 PF00069 0.705
MOD_NEK2_1 571 576 PF00069 0.368
MOD_PIKK_1 240 246 PF00454 0.292
MOD_PIKK_1 617 623 PF00454 0.238
MOD_PKA_1 451 457 PF00069 0.628
MOD_PKA_2 334 340 PF00069 0.513
MOD_PKA_2 414 420 PF00069 0.698
MOD_PKA_2 424 430 PF00069 0.596
MOD_PKA_2 435 441 PF00069 0.608
MOD_PKA_2 451 457 PF00069 0.591
MOD_PKA_2 491 497 PF00069 0.603
MOD_PKA_2 617 623 PF00069 0.238
MOD_Plk_1 201 207 PF00069 0.415
MOD_Plk_2-3 596 602 PF00069 0.238
MOD_Plk_4 258 264 PF00069 0.281
MOD_Plk_4 304 310 PF00069 0.340
MOD_Plk_4 32 38 PF00069 0.369
MOD_Plk_4 334 340 PF00069 0.515
MOD_Plk_4 596 602 PF00069 0.250
MOD_Plk_4 97 103 PF00069 0.251
MOD_ProDKin_1 193 199 PF00069 0.369
MOD_ProDKin_1 226 232 PF00069 0.263
MOD_ProDKin_1 269 275 PF00069 0.385
MOD_ProDKin_1 286 292 PF00069 0.299
MOD_ProDKin_1 295 301 PF00069 0.285
MOD_ProDKin_1 314 320 PF00069 0.441
MOD_ProDKin_1 38 44 PF00069 0.281
MOD_ProDKin_1 397 403 PF00069 0.639
MOD_ProDKin_1 404 410 PF00069 0.649
MOD_ProDKin_1 425 431 PF00069 0.572
MOD_ProDKin_1 457 463 PF00069 0.571
MOD_ProDKin_1 472 478 PF00069 0.572
MOD_ProDKin_1 480 486 PF00069 0.583
MOD_ProDKin_1 509 515 PF00069 0.583
MOD_ProDKin_1 526 532 PF00069 0.524
MOD_SUMO_for_1 164 167 PF00179 0.320
MOD_SUMO_for_1 82 85 PF00179 0.238
MOD_SUMO_rev_2 131 140 PF00179 0.272
MOD_SUMO_rev_2 158 166 PF00179 0.238
TRG_DiLeu_BaEn_1 108 113 PF01217 0.251
TRG_DiLeu_BaEn_1 63 68 PF01217 0.251
TRG_DiLeu_BaEn_4 137 143 PF01217 0.329
TRG_DiLeu_BaEn_4 361 367 PF01217 0.569
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.269
TRG_ENDOCYTIC_2 145 148 PF00928 0.238
TRG_ENDOCYTIC_2 239 242 PF00928 0.244
TRG_ENDOCYTIC_2 247 250 PF00928 0.340
TRG_ENDOCYTIC_2 262 265 PF00928 0.392
TRG_ENDOCYTIC_2 320 323 PF00928 0.307
TRG_ENDOCYTIC_2 34 37 PF00928 0.422
TRG_ER_diArg_1 364 367 PF00400 0.480
TRG_ER_diArg_1 450 452 PF00400 0.617
TRG_ER_diArg_1 456 459 PF00400 0.602
TRG_ER_diArg_1 471 473 PF00400 0.543
TRG_ER_diLys_1 623 626 PF00400 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M7 Leptomonas seymouri 82% 97%
A0A0S4IX25 Bodo saltans 47% 96%
A0A0S4J320 Bodo saltans 24% 100%
A0A0S4J3J3 Bodo saltans 25% 72%
A0A0S4JVD7 Bodo saltans 25% 100%
A0A1X0P6L8 Trypanosomatidae 68% 100%
A0A3R7LU08 Trypanosoma rangeli 65% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S7WV74 Leishmania donovani 98% 99%
A0A3S7WY10 Leishmania donovani 26% 100%
A0A3S7X8Z8 Leishmania donovani 25% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 27% 100%
A4H9X1 Leishmania braziliensis 92% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4HSE2 Leishmania infantum 28% 100%
A4IB02 Leishmania infantum 26% 100%
D0A0D2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 98%
E9AET0 Leishmania major 25% 100%
E9AGR6 Leishmania infantum 98% 99%
E9AH34 Leishmania infantum 26% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q19469 Caenorhabditis elegans 27% 68%
Q4QAV8 Leishmania major 27% 100%
Q4QDK7 Leishmania major 97% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 27% 100%
V5DTI3 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS