t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania mexicana

UniProt:

E9ARW3_LEIMU

TriTrypDb:

LmxM.19.0120

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9ARW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARW3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0016192	vesicle-mediated transport	4	5

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.248
CLV_NRD_NRD_1	202	204	PF00675	0.258
CLV_NRD_NRD_1	43	45	PF00675	0.317
CLV_NRD_NRD_1	90	92	PF00675	0.382
CLV_PCSK_FUR_1	41	45	PF00082	0.376
CLV_PCSK_KEX2_1	197	199	PF00082	0.242
CLV_PCSK_KEX2_1	43	45	PF00082	0.402
CLV_PCSK_KEX2_1	90	92	PF00082	0.409
CLV_PCSK_PC7_1	39	45	PF00082	0.400
CLV_PCSK_SKI1_1	78	82	PF00082	0.425
DOC_MAPK_gen_1	41	49	PF00069	0.554
DOC_USP7_MATH_1	63	67	PF00917	0.543
LIG_14-3-3_CanoR_1	197	203	PF00244	0.537
LIG_14-3-3_CanoR_1	93	97	PF00244	0.643
LIG_BIR_III_2	62	66	PF00653	0.639
LIG_CaM_IQ_9	20	36	PF13499	0.513
LIG_FHA_1	173	179	PF00498	0.472
LIG_FHA_1	209	215	PF00498	0.347
LIG_FHA_1	43	49	PF00498	0.556
LIG_FHA_2	115	121	PF00498	0.723
LIG_FHA_2	154	160	PF00498	0.559
LIG_FHA_2	87	93	PF00498	0.613
LIG_LIR_Gen_1	156	164	PF02991	0.586
LIG_LIR_Nem_3	156	160	PF02991	0.580
LIG_LIR_Nem_3	201	205	PF02991	0.522
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.582
LIG_SH2_CRK	202	206	PF00017	0.425
LIG_SH2_STAT3	74	77	PF00017	0.582
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.538
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.352
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.399
LIG_SUMO_SIM_par_1	216	222	PF11976	0.418
LIG_TRAF2_1	156	159	PF00917	0.642
MOD_CK1_1	114	120	PF00069	0.699
MOD_CK1_1	66	72	PF00069	0.588
MOD_CK2_1	100	106	PF00069	0.690
MOD_CK2_1	114	120	PF00069	0.721
MOD_CK2_1	139	145	PF00069	0.701
MOD_CK2_1	153	159	PF00069	0.576
MOD_CK2_1	180	186	PF00069	0.472
MOD_CK2_1	23	29	PF00069	0.632
MOD_CK2_1	51	57	PF00069	0.536
MOD_CK2_1	58	64	PF00069	0.593
MOD_CK2_1	86	92	PF00069	0.621
MOD_GlcNHglycan	141	144	PF01048	0.529
MOD_GlcNHglycan	208	211	PF01048	0.456
MOD_GSK3_1	124	131	PF00069	0.627
MOD_GSK3_1	172	179	PF00069	0.476
MOD_GSK3_1	18	25	PF00069	0.585
MOD_GSK3_1	92	99	PF00069	0.630
MOD_N-GLC_1	124	129	PF02516	0.475
MOD_N-GLC_1	176	181	PF02516	0.289
MOD_NEK2_1	153	158	PF00069	0.557
MOD_NEK2_1	42	47	PF00069	0.494
MOD_PIKK_1	111	117	PF00454	0.660
MOD_PKA_2	172	178	PF00069	0.509
MOD_PKA_2	42	48	PF00069	0.545
MOD_PKA_2	92	98	PF00069	0.620
MOD_Plk_2-3	100	106	PF00069	0.685
MOD_Plk_2-3	128	134	PF00069	0.677
MOD_Plk_2-3	180	186	PF00069	0.538
MOD_Plk_2-3	58	64	PF00069	0.621
MOD_Plk_4	159	165	PF00069	0.625
MOD_Plk_4	208	214	PF00069	0.318
MOD_SUMO_rev_2	147	156	PF00179	0.652
TRG_DiLeu_BaEn_1	159	164	PF01217	0.574
TRG_DiLeu_BaEn_1	180	185	PF01217	0.538
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.562
TRG_ENDOCYTIC_2	157	160	PF00928	0.588
TRG_ENDOCYTIC_2	202	205	PF00928	0.425
TRG_ER_diArg_1	197	200	PF00400	0.496
TRG_ER_diArg_1	41	44	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K8	Leptomonas seymouri	74%	100%
A0A0S4IVI2	Bodo saltans	37%	93%
A0A1X0P7H4	Trypanosomatidae	43%	95%
A0A3Q8IJV6	Leishmania donovani	93%	100%
A0A422ND16	Trypanosoma rangeli	43%	96%
A4H9W9	Leishmania braziliensis	79%	100%
E9AGR4	Leishmania infantum	93%	100%
O64791	Arabidopsis thaliana	24%	75%
Q4QDK9	Leishmania major	92%	100%
V5BBT6	Trypanosoma cruzi	48%	96%