Clathrin light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARW2_LEIMU

TriTrypDb:

LmxM.19.0110

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	5
GO:0030118	clathrin coat	4	5
GO:0030120	vesicle coat	4	5
GO:0030125	clathrin vesicle coat	5	5
GO:0030130	clathrin coat of trans-Golgi network vesicle	6	5
GO:0030132	clathrin coat of coated pit	4	5
GO:0032991	protein-containing complex	1	5
GO:0098796	membrane protein complex	2	5
GO:0098797	plasma membrane protein complex	3	5

Expansion

Sequence features

E9ARW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARW2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	5
GO:0008104	protein localization	4	5
GO:0009987	cellular process	1	5
GO:0015031	protein transport	4	5
GO:0016192	vesicle-mediated transport	4	5
GO:0033036	macromolecule localization	2	5
GO:0045184	establishment of protein localization	3	5
GO:0046907	intracellular transport	3	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051641	cellular localization	2	5
GO:0051649	establishment of localization in cell	3	5
GO:0070727	cellular macromolecule localization	3	5
GO:0071702	organic substance transport	4	5
GO:0071705	nitrogen compound transport	4	5

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	76	78	PF00082	0.278
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.259
CLV_PCSK_SKI1_1	132	136	PF00082	0.209
CLV_PCSK_SKI1_1	61	65	PF00082	0.333
CLV_PCSK_SKI1_1	82	86	PF00082	0.186
DEG_APCC_DBOX_1	131	139	PF00400	0.198
DOC_CKS1_1	22	27	PF01111	0.521
DOC_PP4_MxPP_1	1	4	PF00568	0.447
DOC_USP7_MATH_1	84	88	PF00917	0.191
DOC_USP7_MATH_2	25	31	PF00917	0.459
DOC_USP7_UBL2_3	85	89	PF12436	0.409
DOC_WW_Pin1_4	11	16	PF00397	0.665
DOC_WW_Pin1_4	138	143	PF00397	0.184
DOC_WW_Pin1_4	18	23	PF00397	0.541
LIG_14-3-3_CanoR_1	126	134	PF00244	0.197
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_FHA_1	35	41	PF00498	0.398
LIG_FHA_2	22	28	PF00498	0.473
LIG_FHA_2	73	79	PF00498	0.172
LIG_SH2_STAT5	69	72	PF00017	0.385
LIG_SH3_1	20	26	PF00018	0.443
LIG_SH3_2	23	28	PF14604	0.462
LIG_SH3_3	16	22	PF00018	0.509
LIG_SH3_3	23	29	PF00018	0.520
LIG_UBA3_1	114	120	PF00899	0.229
MOD_CDK_SPK_2	15	20	PF00069	0.460
MOD_CDK_SPxK_1	138	144	PF00069	0.184
MOD_CDK_SPxxK_3	138	145	PF00069	0.413
MOD_CDK_SPxxK_3	21	28	PF00069	0.472
MOD_CK1_1	125	131	PF00069	0.198
MOD_CK1_1	18	24	PF00069	0.486
MOD_CK2_1	21	27	PF00069	0.519
MOD_CK2_1	72	78	PF00069	0.172
MOD_CK2_1	84	90	PF00069	0.162
MOD_GlcNHglycan	104	107	PF01048	0.184
MOD_GlcNHglycan	109	112	PF01048	0.178
MOD_GlcNHglycan	29	32	PF01048	0.436
MOD_GSK3_1	11	18	PF00069	0.634
MOD_GSK3_1	130	137	PF00069	0.402
MOD_GSK3_1	57	64	PF00069	0.183
MOD_N-GLC_1	138	143	PF02516	0.203
MOD_N-GLC_1	45	50	PF02516	0.175
MOD_NEK2_1	9	14	PF00069	0.675
MOD_PKA_2	125	131	PF00069	0.184
MOD_ProDKin_1	11	17	PF00069	0.667
MOD_ProDKin_1	138	144	PF00069	0.184
MOD_ProDKin_1	18	24	PF00069	0.541
MOD_SUMO_rev_2	54	63	PF00179	0.209
MOD_SUMO_rev_2	97	105	PF00179	0.197

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NCU7	Trypanosoma rangeli	35%	77%
A4H9W8	Leishmania braziliensis	66%	100%
D0A0D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	77%
Q4QDL0	Leishmania major	83%	100%