SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 13, putative

Species:

Leishmania mexicana

UniProt:

E9ARV8_LEIMU

TriTrypDb:

LmxM.19.0070

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046860	glycosome membrane	7	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ARV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0009987	cellular process	1	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0043574	peroxisomal transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.536
CLV_NRD_NRD_1	135	137	PF00675	0.635
CLV_NRD_NRD_1	284	286	PF00675	0.507
CLV_NRD_NRD_1	356	358	PF00675	0.428
CLV_NRD_NRD_1	409	411	PF00675	0.314
CLV_PCSK_FUR_1	133	137	PF00082	0.631
CLV_PCSK_FUR_1	282	286	PF00082	0.502
CLV_PCSK_KEX2_1	135	137	PF00082	0.635
CLV_PCSK_KEX2_1	282	284	PF00082	0.518
CLV_PCSK_KEX2_1	356	358	PF00082	0.389
CLV_PCSK_KEX2_1	409	411	PF00082	0.335
CLV_PCSK_SKI1_1	284	288	PF00082	0.547
DEG_APCC_DBOX_1	252	260	PF00400	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.448
DOC_MAPK_gen_1	156	166	PF00069	0.435
DOC_MAPK_gen_1	251	259	PF00069	0.301
DOC_MAPK_MEF2A_6	253	261	PF00069	0.321
DOC_USP7_MATH_1	106	110	PF00917	0.458
DOC_USP7_MATH_1	242	246	PF00917	0.413
DOC_USP7_MATH_1	347	351	PF00917	0.754
DOC_USP7_MATH_1	370	374	PF00917	0.523
DOC_USP7_MATH_1	69	73	PF00917	0.518
DOC_WW_Pin1_4	111	116	PF00397	0.567
DOC_WW_Pin1_4	126	131	PF00397	0.513
LIG_14-3-3_CanoR_1	308	316	PF00244	0.756
LIG_14-3-3_CanoR_1	334	341	PF00244	0.611
LIG_Actin_WH2_2	166	181	PF00022	0.419
LIG_BIR_III_4	292	296	PF00653	0.736
LIG_EH_1	67	71	PF12763	0.371
LIG_eIF4E_1	44	50	PF01652	0.578
LIG_FHA_1	169	175	PF00498	0.426
LIG_FHA_1	353	359	PF00498	0.572
LIG_FHA_1	73	79	PF00498	0.380
LIG_FHA_2	315	321	PF00498	0.754
LIG_FHA_2	324	330	PF00498	0.749
LIG_GBD_Chelix_1	166	174	PF00786	0.662
LIG_LIR_Gen_1	236	244	PF02991	0.369
LIG_LIR_Gen_1	415	424	PF02991	0.649
LIG_LIR_Nem_3	236	241	PF02991	0.451
LIG_LIR_Nem_3	291	297	PF02991	0.763
LIG_LIR_Nem_3	415	420	PF02991	0.562
LIG_PDZ_Class_1	422	427	PF00595	0.646
LIG_Pex14_1	331	335	PF04695	0.748
LIG_Pex14_2	185	189	PF04695	0.363
LIG_PTB_Apo_2	64	71	PF02174	0.452
LIG_SH2_CRK	294	298	PF00017	0.762
LIG_SH2_SRC	388	391	PF00017	0.534
LIG_SH2_STAP1	193	197	PF00017	0.351
LIG_SH2_STAP1	303	307	PF00017	0.736
LIG_SH2_STAP1	363	367	PF00017	0.548
LIG_SH2_STAT3	363	366	PF00017	0.562
LIG_TRAF2_1	129	132	PF00917	0.484
LIG_WRC_WIRS_1	61	66	PF05994	0.731
MOD_CDK_SPxxK_3	126	133	PF00069	0.638
MOD_CK1_1	306	312	PF00069	0.711
MOD_CK1_1	314	320	PF00069	0.715
MOD_CK1_1	373	379	PF00069	0.432
MOD_CK1_1	403	409	PF00069	0.396
MOD_CK1_1	72	78	PF00069	0.729
MOD_CK2_1	126	132	PF00069	0.587
MOD_CK2_1	177	183	PF00069	0.433
MOD_CK2_1	296	302	PF00069	0.632
MOD_CK2_1	307	313	PF00069	0.683
MOD_CK2_1	323	329	PF00069	0.507
MOD_CMANNOS	252	255	PF00535	0.497
MOD_Cter_Amidation	407	410	PF01082	0.428
MOD_GlcNHglycan	179	182	PF01048	0.451
MOD_GlcNHglycan	2	5	PF01048	0.592
MOD_GlcNHglycan	235	238	PF01048	0.630
MOD_GlcNHglycan	245	248	PF01048	0.561
MOD_GlcNHglycan	349	352	PF01048	0.715
MOD_GlcNHglycan	46	49	PF01048	0.656
MOD_GlcNHglycan	57	60	PF01048	0.648
MOD_GSK3_1	303	310	PF00069	0.649
MOD_GSK3_1	51	58	PF00069	0.672
MOD_GSK3_1	83	90	PF00069	0.734
MOD_N-GLC_1	126	131	PF02516	0.658
MOD_N-GLC_1	352	357	PF02516	0.595
MOD_N-GLC_1	72	77	PF02516	0.653
MOD_NEK2_1	12	17	PF00069	0.550
MOD_NEK2_1	50	55	PF00069	0.686
MOD_NEK2_1	96	101	PF00069	0.764
MOD_NEK2_2	303	308	PF00069	0.696
MOD_PIKK_1	225	231	PF00454	0.714
MOD_PIKK_1	296	302	PF00454	0.720
MOD_PIKK_1	341	347	PF00454	0.770
MOD_PIKK_1	88	94	PF00454	0.781
MOD_PKA_1	284	290	PF00069	0.594
MOD_PKA_2	284	290	PF00069	0.623
MOD_PKA_2	307	313	PF00069	0.691
MOD_PKA_2	314	320	PF00069	0.739
MOD_PKB_1	282	290	PF00069	0.606
MOD_Plk_1	303	309	PF00069	0.650
MOD_Plk_1	323	329	PF00069	0.674
MOD_Plk_1	72	78	PF00069	0.655
MOD_Plk_2-3	323	329	PF00069	0.630
MOD_Plk_4	12	18	PF00069	0.538
MOD_Plk_4	188	194	PF00069	0.428
MOD_Plk_4	60	66	PF00069	0.628
MOD_ProDKin_1	111	117	PF00069	0.733
MOD_ProDKin_1	126	132	PF00069	0.655
TRG_ENDOCYTIC_2	192	195	PF00928	0.439
TRG_ENDOCYTIC_2	2	5	PF00928	0.453
TRG_ENDOCYTIC_2	294	297	PF00928	0.729
TRG_ENDOCYTIC_2	359	362	PF00928	0.466
TRG_ER_diArg_1	133	136	PF00400	0.539
TRG_ER_diArg_1	282	285	PF00400	0.715
TRG_ER_diArg_1	356	358	PF00400	0.580
TRG_NES_CRM1_1	165	176	PF08389	0.601
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.633
TRG_PTS1	424	427	PF00515	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9X6	Leptomonas seymouri	71%	100%
A0A0S4J170	Bodo saltans	24%	94%
A0A1X0P6F7	Trypanosomatidae	34%	100%
A0A3S7WV91	Leishmania donovani	87%	100%
A0A422NCY3	Trypanosoma rangeli	32%	100%
A4H9W4	Leishmania braziliensis	79%	100%
D0A0C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AGQ9	Leishmania infantum	90%	100%
Q4QDL4	Leishmania major	90%	100%