40S ribosomal protein S2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S2

Species:

Leishmania mexicana

UniProt:

E9ARV7_LEIMU

TriTrypDb:

LmxM.19.0060

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	14
GO:0032991	protein-containing complex	1	14
GO:0044391	ribosomal subunit	3	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV7

PDB structure(s): 6az1_F

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	162	168	PF00089	0.379
CLV_NRD_NRD_1	189	191	PF00675	0.436
CLV_NRD_NRD_1	267	269	PF00675	0.379
CLV_NRD_NRD_1	33	35	PF00675	0.504
CLV_PCSK_KEX2_1	189	191	PF00082	0.436
CLV_PCSK_SKI1_1	234	238	PF00082	0.413
CLV_PCSK_SKI1_1	90	94	PF00082	0.449
DEG_SPOP_SBC_1	245	249	PF00917	0.379
DOC_CKS1_1	273	278	PF01111	0.379
DOC_CYCLIN_RxL_1	232	243	PF00134	0.379
DOC_MAPK_gen_1	165	174	PF00069	0.379
DOC_MAPK_HePTP_8	162	174	PF00069	0.379
DOC_MAPK_MEF2A_6	165	174	PF00069	0.379
DOC_MAPK_MEF2A_6	210	218	PF00069	0.379
DOC_PP1_RVXF_1	233	240	PF00149	0.376
DOC_PP4_FxxP_1	106	109	PF00568	0.467
DOC_PP4_FxxP_1	273	276	PF00568	0.379
DOC_USP7_MATH_1	3	7	PF00917	0.465
DOC_USP7_UBL2_3	206	210	PF12436	0.470
DOC_WW_Pin1_4	272	277	PF00397	0.379
LIG_14-3-3_CanoR_1	175	179	PF00244	0.379
LIG_14-3-3_CanoR_1	268	272	PF00244	0.379
LIG_AP2alpha_2	10	12	PF02296	0.467
LIG_FHA_1	223	229	PF00498	0.413
LIG_FHA_1	25	31	PF00498	0.465
LIG_FHA_1	273	279	PF00498	0.359
LIG_FHA_2	96	102	PF00498	0.456
LIG_LIR_Apic_2	270	276	PF02991	0.379
LIG_LIR_Nem_3	145	150	PF02991	0.379
LIG_LIR_Nem_3	238	242	PF02991	0.387
LIG_LIR_Nem_3	263	267	PF02991	0.379
LIG_LIR_Nem_3	270	274	PF02991	0.379
LIG_PCNA_yPIPBox_3	252	265	PF02747	0.379
LIG_PDZ_Class_1	297	302	PF00595	0.681
LIG_SH2_CRK	271	275	PF00017	0.379
LIG_SH2_STAT3	133	136	PF00017	0.513
LIG_SH2_STAT5	246	249	PF00017	0.353
LIG_SH3_3	216	222	PF00018	0.365
LIG_SH3_3	225	231	PF00018	0.336
LIG_TRAF2_1	43	46	PF00917	0.735
LIG_TRAF2_1	76	79	PF00917	0.728
LIG_TRAF2_1	99	102	PF00917	0.454
LIG_UBA3_1	105	111	PF00899	0.467
LIG_UBA3_1	129	137	PF00899	0.413
LIG_WRC_WIRS_1	261	266	PF05994	0.379
MOD_CK2_1	95	101	PF00069	0.464
MOD_GlcNHglycan	139	142	PF01048	0.379
MOD_GSK3_1	12	19	PF00069	0.454
MOD_GSK3_1	24	31	PF00069	0.453
MOD_GSK3_1	246	253	PF00069	0.363
MOD_GSK3_1	282	289	PF00069	0.520
MOD_NEK2_1	104	109	PF00069	0.468
MOD_NEK2_1	12	17	PF00069	0.458
MOD_NEK2_1	205	210	PF00069	0.549
MOD_NEK2_1	267	272	PF00069	0.379
MOD_NEK2_1	38	43	PF00069	0.612
MOD_PIKK_1	16	22	PF00454	0.452
MOD_PIKK_1	38	44	PF00454	0.613
MOD_PK_1	210	216	PF00069	0.379
MOD_PKA_2	174	180	PF00069	0.379
MOD_PKA_2	222	228	PF00069	0.413
MOD_PKA_2	267	273	PF00069	0.379
MOD_Plk_1	168	174	PF00069	0.379
MOD_Plk_1	28	34	PF00069	0.468
MOD_Plk_4	115	121	PF00069	0.604
MOD_Plk_4	174	180	PF00069	0.379
MOD_Plk_4	260	266	PF00069	0.379
MOD_ProDKin_1	272	278	PF00069	0.379
TRG_DiLeu_BaEn_1	291	296	PF01217	0.656
TRG_ENDOCYTIC_2	271	274	PF00928	0.379
TRG_ER_diArg_1	144	147	PF00400	0.379
TRG_ER_diArg_1	188	190	PF00400	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IWW3	Bodo saltans	84%	100%
A0A1X0P6Q2	Trypanosomatidae	91%	100%
A0A3Q8IED5	Leishmania donovani	99%	100%
A0A3S7X558	Leishmania donovani	97%	100%
A2BMD9	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	46%	100%
A4H9W3	Leishmania braziliensis	93%	100%
A4HK25	Leishmania braziliensis	92%	100%
A4I7K9	Leishmania infantum	97%	100%
A4YCY6	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	45%	100%
A8AC00	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	47%	100%
C3NH89	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	44%	100%
D0A0B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	89%	100%
E9AGQ8	Leishmania infantum	100%	100%
E9B2G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O05641	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	43%	100%
O18789	Bos taurus	62%	100%
O43992	Leishmania amazonensis	99%	100%
O59439	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	43%	100%
O74892	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
P15880	Homo sapiens	62%	100%
P25443	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	100%
P25444	Mus musculus	62%	100%
P27685	Dictyostelium discoideum	60%	100%
P27952	Rattus norvegicus	62%	100%
P31009	Drosophila melanogaster	61%	100%
P49154	Urechis caupo	62%	100%
P49688	Arabidopsis thaliana	65%	100%
P51403	Caenorhabditis elegans	61%	100%
Q12ZT1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	44%	100%
Q4Q5P0	Leishmania major	97%	100%
Q4QDL5	Leishmania major	99%	100%
Q5A900	Candida albicans (strain SC5314 / ATCC MYA-2876)	59%	100%
Q74MD4	Nanoarchaeum equitans (strain Kin4-M)	43%	100%
Q8L8Y0	Arabidopsis thaliana	65%	100%
Q90YS3	Ictalurus punctatus	61%	100%
Q93VB8	Arabidopsis thaliana	65%	100%
Q975K0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	46%	100%
Q9SCM3	Arabidopsis thaliana	64%	100%
Q9UX87	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	43%	100%
Q9V1V5	Pyrococcus abyssi (strain GE5 / Orsay)	42%	100%
Q9YF95	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	47%	100%