Proline-rich protein 36-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARV4_LEIMU

TriTrypDb:

LmxM.19.0020

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	37	39	PF00675	0.664
CLV_NRD_NRD_1	43	45	PF00675	0.666
CLV_NRD_NRD_1	58	60	PF00675	0.782
CLV_NRD_NRD_1	69	71	PF00675	0.613
CLV_PCSK_FUR_1	67	71	PF00082	0.670
CLV_PCSK_KEX2_1	36	38	PF00082	0.666
CLV_PCSK_KEX2_1	43	45	PF00082	0.666
CLV_PCSK_KEX2_1	58	60	PF00082	0.673
CLV_PCSK_KEX2_1	69	71	PF00082	0.640
CLV_PCSK_PC7_1	33	39	PF00082	0.662
CLV_PCSK_SKI1_1	20	24	PF00082	0.563
DEG_SCF_FBW7_1	246	252	PF00400	0.617
DEG_SPOP_SBC_1	24	28	PF00917	0.563
DOC_CKS1_1	147	152	PF01111	0.622
DOC_CKS1_1	246	251	PF01111	0.551
DOC_MAPK_MEF2A_6	216	224	PF00069	0.391
DOC_MAPK_MEF2A_6	354	361	PF00069	0.468
DOC_MAPK_MEF2A_6	89	97	PF00069	0.633
DOC_USP7_MATH_1	102	106	PF00917	0.633
DOC_USP7_MATH_1	155	159	PF00917	0.502
DOC_USP7_MATH_1	171	175	PF00917	0.709
DOC_USP7_MATH_1	24	28	PF00917	0.673
DOC_USP7_MATH_1	288	292	PF00917	0.705
DOC_USP7_MATH_1	319	323	PF00917	0.682
DOC_USP7_MATH_1	79	83	PF00917	0.628
DOC_WW_Pin1_4	133	138	PF00397	0.703
DOC_WW_Pin1_4	146	151	PF00397	0.724
DOC_WW_Pin1_4	15	20	PF00397	0.553
DOC_WW_Pin1_4	245	250	PF00397	0.550
LIG_14-3-3_CanoR_1	121	131	PF00244	0.622
LIG_14-3-3_CanoR_1	216	221	PF00244	0.584
LIG_14-3-3_CanoR_1	269	274	PF00244	0.671
LIG_14-3-3_CanoR_1	342	349	PF00244	0.658
LIG_Actin_WH2_2	210	227	PF00022	0.391
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BRCT_BRCA1_1	307	311	PF00533	0.701
LIG_BRCT_BRCA1_1	357	361	PF00533	0.495
LIG_FHA_1	261	267	PF00498	0.682
LIG_FHA_2	83	89	PF00498	0.557
LIG_Integrin_RGD_1	49	51	PF01839	0.555
LIG_Integrin_RGD_1	55	57	PF01839	0.563
LIG_LIR_Gen_1	115	120	PF02991	0.469
LIG_Pex14_2	339	343	PF04695	0.684
LIG_SH2_GRB2like	297	300	PF00017	0.604
LIG_SH2_STAT5	210	213	PF00017	0.512
LIG_SH3_1	354	360	PF00018	0.465
LIG_SH3_3	144	150	PF00018	0.812
LIG_SH3_3	181	187	PF00018	0.668
LIG_SH3_3	193	199	PF00018	0.424
LIG_SH3_3	202	208	PF00018	0.555
LIG_SH3_3	217	223	PF00018	0.400
LIG_SH3_3	243	249	PF00018	0.559
LIG_SH3_3	255	261	PF00018	0.588
LIG_SH3_3	354	360	PF00018	0.628
LIG_SH3_3	65	71	PF00018	0.672
LIG_SH3_CIN85_PxpxPR_1	5	10	PF14604	0.534
LIG_SUMO_SIM_par_1	210	215	PF11976	0.509
LIG_TRAF2_1	174	177	PF00917	0.681
LIG_TRAF2_1	85	88	PF00917	0.699
MOD_CDC14_SPxK_1	138	141	PF00782	0.640
MOD_CDK_SPK_2	15	20	PF00069	0.553
MOD_CDK_SPxK_1	135	141	PF00069	0.640
MOD_CK1_1	103	109	PF00069	0.567
MOD_CK1_1	112	118	PF00069	0.490
MOD_CK1_1	272	278	PF00069	0.622
MOD_CK1_1	322	328	PF00069	0.692
MOD_CK1_1	365	371	PF00069	0.682
MOD_CK1_1	82	88	PF00069	0.545
MOD_CK2_1	155	161	PF00069	0.716
MOD_CK2_1	171	177	PF00069	0.703
MOD_CK2_1	82	88	PF00069	0.561
MOD_GlcNHglycan	1	4	PF01048	0.685
MOD_GlcNHglycan	102	105	PF01048	0.662
MOD_GlcNHglycan	111	114	PF01048	0.671
MOD_GlcNHglycan	124	127	PF01048	0.692
MOD_GlcNHglycan	239	242	PF01048	0.565
MOD_GlcNHglycan	27	30	PF01048	0.703
MOD_GlcNHglycan	290	293	PF01048	0.757
MOD_GlcNHglycan	324	327	PF01048	0.635
MOD_GlcNHglycan	350	353	PF01048	0.601
MOD_GSK3_1	142	149	PF00069	0.742
MOD_GSK3_1	155	162	PF00069	0.788
MOD_GSK3_1	20	27	PF00069	0.586
MOD_GSK3_1	245	252	PF00069	0.610
MOD_GSK3_1	265	272	PF00069	0.674
MOD_N-GLC_1	109	114	PF02516	0.658
MOD_N-GLC_1	24	29	PF02516	0.717
MOD_NEK2_1	224	229	PF00069	0.458
MOD_NEK2_1	311	316	PF00069	0.649
MOD_PIKK_1	142	148	PF00454	0.625
MOD_PIKK_1	155	161	PF00454	0.738
MOD_PIKK_1	224	230	PF00454	0.625
MOD_PIKK_1	290	296	PF00454	0.681
MOD_PIKK_1	311	317	PF00454	0.650
MOD_PIKK_1	362	368	PF00454	0.704
MOD_PK_1	216	222	PF00069	0.629
MOD_PKA_2	122	128	PF00069	0.675
MOD_PKA_2	224	230	PF00069	0.551
MOD_PKA_2	332	338	PF00069	0.749
MOD_PKA_2	343	349	PF00069	0.541
MOD_PKA_2	362	368	PF00069	0.439
MOD_Plk_2-3	172	178	PF00069	0.711
MOD_Plk_4	163	169	PF00069	0.508
MOD_ProDKin_1	133	139	PF00069	0.701
MOD_ProDKin_1	146	152	PF00069	0.720
MOD_ProDKin_1	15	21	PF00069	0.549
MOD_ProDKin_1	245	251	PF00069	0.553
MOD_SUMO_for_1	5	8	PF00179	0.663
MOD_SUMO_rev_2	82	90	PF00179	0.658
TRG_ER_diArg_1	120	123	PF00400	0.674
TRG_ER_diArg_1	13	16	PF00400	0.502
TRG_ER_diArg_1	36	38	PF00400	0.666
TRG_ER_diArg_1	67	70	PF00400	0.723
TRG_NES_CRM1_1	213	228	PF08389	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE1	Leptomonas seymouri	64%	99%
A0A1X0P6F6	Trypanosomatidae	31%	100%
A0A3Q8IB46	Leishmania donovani	91%	100%
A0A3R7JZB4	Trypanosoma rangeli	33%	100%
A4H9V9	Leishmania braziliensis	83%	98%
A4HY41	Leishmania infantum	91%	100%
D0A0C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QDL9	Leishmania major	94%	100%
V5BBT3	Trypanosoma cruzi	31%	100%