Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9ARV2_LEIMU

TriTrypDb:

LmxM.18.1670

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.871
CLV_NRD_NRD_1	261	263	PF00675	0.716
CLV_NRD_NRD_1	79	81	PF00675	0.677
CLV_PCSK_FUR_1	14	18	PF00082	0.544
CLV_PCSK_KEX2_1	16	18	PF00082	0.548
CLV_PCSK_KEX2_1	261	263	PF00082	0.738
CLV_PCSK_KEX2_1	290	292	PF00082	0.596
CLV_PCSK_KEX2_1	79	81	PF00082	0.666
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.548
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.596
CLV_PCSK_SKI1_1	119	123	PF00082	0.667
CLV_PCSK_SKI1_1	17	21	PF00082	0.622
CLV_PCSK_SKI1_1	358	362	PF00082	0.744
CLV_PCSK_SKI1_1	385	389	PF00082	0.477
CLV_PCSK_SKI1_1	89	93	PF00082	0.675
DEG_APCC_DBOX_1	353	361	PF00400	0.770
DEG_APCC_DBOX_1	384	392	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DOC_CKS1_1	111	116	PF01111	0.634
DOC_MAPK_gen_1	14	21	PF00069	0.540
DOC_MAPK_gen_1	267	277	PF00069	0.582
DOC_MAPK_MEF2A_6	179	187	PF00069	0.628
DOC_MAPK_MEF2A_6	267	275	PF00069	0.579
DOC_PP1_RVXF_1	15	22	PF00149	0.540
DOC_PP1_RVXF_1	164	171	PF00149	0.667
DOC_PP2B_LxvP_1	360	363	PF13499	0.581
DOC_PP4_FxxP_1	162	165	PF00568	0.523
DOC_PP4_FxxP_1	210	213	PF00568	0.726
DOC_USP7_MATH_1	106	110	PF00917	0.784
DOC_USP7_MATH_1	190	194	PF00917	0.806
DOC_USP7_MATH_1	245	249	PF00917	0.719
DOC_USP7_MATH_1	319	323	PF00917	0.778
DOC_USP7_MATH_1	417	421	PF00917	0.617
DOC_USP7_MATH_1	85	89	PF00917	0.688
DOC_WW_Pin1_4	110	115	PF00397	0.704
DOC_WW_Pin1_4	211	216	PF00397	0.728
DOC_WW_Pin1_4	247	252	PF00397	0.598
DOC_WW_Pin1_4	301	306	PF00397	0.766
DOC_WW_Pin1_4	403	408	PF00397	0.505
DOC_WW_Pin1_4	73	78	PF00397	0.721
LIG_14-3-3_CanoR_1	123	129	PF00244	0.656
LIG_14-3-3_CanoR_1	17	22	PF00244	0.537
LIG_14-3-3_CanoR_1	270	276	PF00244	0.583
LIG_14-3-3_CanoR_1	354	358	PF00244	0.575
LIG_14-3-3_CanoR_1	37	41	PF00244	0.701
LIG_14-3-3_CanoR_1	44	52	PF00244	0.597
LIG_14-3-3_CanoR_1	89	96	PF00244	0.519
LIG_Actin_WH2_2	331	348	PF00022	0.542
LIG_Clathr_ClatBox_1	373	377	PF01394	0.687
LIG_CtBP_PxDLS_1	252	256	PF00389	0.580
LIG_CtBP_PxDLS_1	342	346	PF00389	0.549
LIG_deltaCOP1_diTrp_1	139	144	PF00928	0.495
LIG_FHA_1	248	254	PF00498	0.772
LIG_FHA_1	270	276	PF00498	0.583
LIG_FHA_1	47	53	PF00498	0.503
LIG_FHA_1	66	72	PF00498	0.504
LIG_FHA_2	125	131	PF00498	0.654
LIG_FHA_2	159	165	PF00498	0.540
LIG_FHA_2	90	96	PF00498	0.518
LIG_LIR_Apic_2	109	114	PF02991	0.762
LIG_LIR_Apic_2	161	165	PF02991	0.523
LIG_LIR_Apic_2	209	213	PF02991	0.707
LIG_LIR_Apic_2	322	328	PF02991	0.720
LIG_LIR_Gen_1	204	215	PF02991	0.608
LIG_LIR_Nem_3	204	210	PF02991	0.643
LIG_MAD2	157	165	PF02301	0.521
LIG_PDZ_Class_1	417	422	PF00595	0.513
LIG_Pex14_2	138	142	PF04695	0.499
LIG_PTAP_UEV_1	57	62	PF05743	0.700
LIG_SH2_CRK	111	115	PF00017	0.508
LIG_SH2_NCK_1	325	329	PF00017	0.713
LIG_SH2_SRC	56	59	PF00017	0.695
LIG_SH2_STAP1	413	417	PF00017	0.523
LIG_SH2_STAT5	325	328	PF00017	0.716
LIG_SH3_2	174	179	PF14604	0.686
LIG_SH3_2	58	63	PF14604	0.706
LIG_SH3_3	16	22	PF00018	0.539
LIG_SH3_3	171	177	PF00018	0.799
LIG_SH3_3	178	184	PF00018	0.705
LIG_SH3_3	404	410	PF00018	0.653
LIG_SH3_3	55	61	PF00018	0.692
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.532
LIG_SUMO_SIM_par_1	250	258	PF11976	0.578
LIG_TRAF2_1	127	130	PF00917	0.653
LIG_TRFH_1	102	106	PF08558	0.675
LIG_WRC_WIRS_1	159	164	PF05994	0.525
LIG_WRC_WIRS_1	207	212	PF05994	0.620
MOD_CDC14_SPxK_1	76	79	PF00782	0.555
MOD_CDK_SPxK_1	73	79	PF00069	0.689
MOD_CDK_SPxxK_3	73	80	PF00069	0.721
MOD_CK1_1	110	116	PF00069	0.664
MOD_CK1_1	131	137	PF00069	0.790
MOD_CK1_1	193	199	PF00069	0.690
MOD_CK1_1	211	217	PF00069	0.539
MOD_CK1_1	311	317	PF00069	0.647
MOD_CK1_1	353	359	PF00069	0.678
MOD_CK1_1	48	54	PF00069	0.508
MOD_CK2_1	124	130	PF00069	0.656
MOD_CK2_1	158	164	PF00069	0.540
MOD_CK2_1	193	199	PF00069	0.770
MOD_CK2_1	234	240	PF00069	0.714
MOD_Cter_Amidation	77	80	PF01082	0.686
MOD_GlcNHglycan	247	250	PF01048	0.679
MOD_GlcNHglycan	58	61	PF01048	0.576
MOD_GSK3_1	106	113	PF00069	0.663
MOD_GSK3_1	124	131	PF00069	0.457
MOD_GSK3_1	193	200	PF00069	0.692
MOD_GSK3_1	24	31	PF00069	0.660
MOD_GSK3_1	241	248	PF00069	0.747
MOD_GSK3_1	271	278	PF00069	0.588
MOD_GSK3_1	307	314	PF00069	0.690
MOD_GSK3_1	319	326	PF00069	0.764
MOD_GSK3_1	32	39	PF00069	0.544
MOD_GSK3_1	352	359	PF00069	0.656
MOD_GSK3_1	44	51	PF00069	0.462
MOD_GSK3_1	85	92	PF00069	0.523
MOD_N-GLC_1	234	239	PF02516	0.745
MOD_N-GLC_1	65	70	PF02516	0.724
MOD_NEK2_1	107	112	PF00069	0.743
MOD_NEK2_1	122	127	PF00069	0.516
MOD_NEK2_1	307	312	PF00069	0.796
MOD_NEK2_1	45	50	PF00069	0.639
MOD_NEK2_2	67	72	PF00069	0.570
MOD_PIKK_1	122	128	PF00454	0.698
MOD_PKA_2	122	128	PF00069	0.498
MOD_PKA_2	269	275	PF00069	0.580
MOD_PKA_2	353	359	PF00069	0.575
MOD_PKA_2	36	42	PF00069	0.654
MOD_PKA_2	62	68	PF00069	0.720
MOD_Plk_1	234	240	PF00069	0.688
MOD_Plk_1	24	30	PF00069	0.526
MOD_Plk_1	308	314	PF00069	0.579
MOD_ProDKin_1	110	116	PF00069	0.702
MOD_ProDKin_1	211	217	PF00069	0.728
MOD_ProDKin_1	247	253	PF00069	0.599
MOD_ProDKin_1	301	307	PF00069	0.767
MOD_ProDKin_1	403	409	PF00069	0.505
MOD_ProDKin_1	73	79	PF00069	0.721
MOD_SUMO_for_1	136	139	PF00179	0.791
MOD_SUMO_rev_2	193	202	PF00179	0.695
TRG_DiLeu_BaEn_2	181	187	PF01217	0.520
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.600
TRG_ENDOCYTIC_2	102	105	PF00928	0.706
TRG_ENDOCYTIC_2	191	194	PF00928	0.650
TRG_ENDOCYTIC_2	207	210	PF00928	0.625
TRG_ER_diArg_1	261	263	PF00400	0.716
TRG_ER_diArg_1	79	81	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9R9	Leishmania braziliensis	40%	70%
Q4QDM1	Leishmania major	71%	100%