Glutamate--cysteine ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-glutamylcysteine synthetase, putative

Species:

Leishmania mexicana

UniProt:

E9ARV1_LEIMU

TriTrypDb:

LmxM.18.1660

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ARV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV1

Function

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Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	12
GO:0006575	cellular modified amino acid metabolic process	3	12
GO:0006749	glutathione metabolic process	4	12
GO:0006750	glutathione biosynthetic process	5	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019184	nonribosomal peptide biosynthetic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004357	glutamate-cysteine ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	12
GO:0016881	acid-amino acid ligase activity	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.434
CLV_C14_Caspase3-7	413	417	PF00656	0.372
CLV_NRD_NRD_1	122	124	PF00675	0.300
CLV_NRD_NRD_1	189	191	PF00675	0.294
CLV_NRD_NRD_1	384	386	PF00675	0.252
CLV_NRD_NRD_1	556	558	PF00675	0.256
CLV_NRD_NRD_1	632	634	PF00675	0.325
CLV_PCSK_FUR_1	187	191	PF00082	0.294
CLV_PCSK_KEX2_1	122	124	PF00082	0.301
CLV_PCSK_KEX2_1	189	191	PF00082	0.294

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9N5	Leptomonas seymouri	72%	100%
A0A0S4IM75	Bodo saltans	53%	100%
A0A1X0P757	Trypanosomatidae	58%	100%
A0A3S5IRL4	Trypanosoma rangeli	60%	100%
A0A3S7WV51	Leishmania donovani	91%	100%
A4H9R8	Leishmania braziliensis	76%	100%
A4HY37	Leishmania infantum	91%	100%
D0A548	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q09768	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q4QDM2	Leishmania major	89%	100%

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