Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania mexicana

UniProt:

E9ARV0_LEIMU

TriTrypDb:

LmxM.18.1650

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	482	486	PF00656	0.405
CLV_NRD_NRD_1	192	194	PF00675	0.501
CLV_NRD_NRD_1	207	209	PF00675	0.251
CLV_NRD_NRD_1	62	64	PF00675	0.644
CLV_NRD_NRD_1	66	68	PF00675	0.606
CLV_PCSK_KEX2_1	192	194	PF00082	0.501
CLV_PCSK_KEX2_1	207	209	PF00082	0.251
CLV_PCSK_KEX2_1	577	579	PF00082	0.493
CLV_PCSK_KEX2_1	61	63	PF00082	0.646
CLV_PCSK_KEX2_1	66	68	PF00082	0.601
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.493
CLV_PCSK_PC7_1	62	68	PF00082	0.674
CLV_PCSK_SKI1_1	192	196	PF00082	0.562
CLV_PCSK_SKI1_1	357	361	PF00082	0.447
CLV_PCSK_SKI1_1	471	475	PF00082	0.519
DEG_APCC_DBOX_1	309	317	PF00400	0.252
DOC_CKS1_1	335	340	PF01111	0.459
DOC_CYCLIN_RxL_1	279	287	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.422
DOC_MAPK_gen_1	207	214	PF00069	0.435
DOC_MAPK_gen_1	535	543	PF00069	0.329
DOC_MAPK_MEF2A_6	207	214	PF00069	0.402
DOC_MAPK_MEF2A_6	259	268	PF00069	0.349
DOC_MAPK_MEF2A_6	430	437	PF00069	0.448
DOC_MAPK_NFAT4_5	430	438	PF00069	0.444
DOC_PP2B_LxvP_1	523	526	PF13499	0.277
DOC_USP7_MATH_1	244	248	PF00917	0.456
DOC_USP7_MATH_1	260	264	PF00917	0.301
DOC_USP7_MATH_1	37	41	PF00917	0.674
DOC_USP7_MATH_1	49	53	PF00917	0.634
DOC_USP7_MATH_1	97	101	PF00917	0.633
DOC_USP7_UBL2_3	496	500	PF12436	0.646
DOC_WW_Pin1_4	164	169	PF00397	0.444
DOC_WW_Pin1_4	334	339	PF00397	0.440
DOC_WW_Pin1_4	495	500	PF00397	0.702
DOC_WW_Pin1_4	506	511	PF00397	0.697
DOC_WW_Pin1_4	95	100	PF00397	0.628
LIG_14-3-3_CanoR_1	211	219	PF00244	0.393
LIG_14-3-3_CanoR_1	282	287	PF00244	0.476
LIG_14-3-3_CanoR_1	301	311	PF00244	0.207
LIG_14-3-3_CanoR_1	347	353	PF00244	0.276
LIG_14-3-3_CanoR_1	419	424	PF00244	0.483
LIG_14-3-3_CanoR_1	430	434	PF00244	0.362
LIG_14-3-3_CanoR_1	527	534	PF00244	0.233
LIG_14-3-3_CanoR_1	549	558	PF00244	0.411
LIG_14-3-3_CterR_2	578	580	PF00244	0.371
LIG_APCC_ABBA_1	226	231	PF00400	0.437
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.450
LIG_BH_BH3_1	73	89	PF00452	0.476
LIG_BRCT_BRCA1_1	314	318	PF00533	0.360
LIG_Clathr_ClatBox_1	283	287	PF01394	0.350
LIG_DLG_GKlike_1	419	427	PF00625	0.327
LIG_FHA_1	11	17	PF00498	0.554
LIG_FHA_1	165	171	PF00498	0.469
LIG_FHA_1	189	195	PF00498	0.479
LIG_FHA_1	378	384	PF00498	0.388
LIG_FHA_1	422	428	PF00498	0.427
LIG_FHA_1	520	526	PF00498	0.365
LIG_FHA_2	128	134	PF00498	0.464
LIG_FHA_2	303	309	PF00498	0.508
LIG_FHA_2	480	486	PF00498	0.388
LIG_FHA_2	81	87	PF00498	0.602
LIG_LIR_Gen_1	247	254	PF02991	0.434
LIG_LIR_Gen_1	315	325	PF02991	0.385
LIG_LIR_Gen_1	358	366	PF02991	0.472
LIG_LIR_Gen_1	409	416	PF02991	0.434
LIG_LIR_Gen_1	71	81	PF02991	0.546
LIG_LIR_Nem_3	247	251	PF02991	0.376
LIG_LIR_Nem_3	315	321	PF02991	0.396
LIG_LIR_Nem_3	343	349	PF02991	0.444
LIG_LIR_Nem_3	358	363	PF02991	0.317
LIG_LIR_Nem_3	409	414	PF02991	0.436
LIG_LIR_Nem_3	517	523	PF02991	0.323
LIG_LIR_Nem_3	537	541	PF02991	0.156
LIG_LIR_Nem_3	562	568	PF02991	0.283
LIG_LIR_Nem_3	71	77	PF02991	0.444
LIG_NRBOX	326	332	PF00104	0.475
LIG_Pex14_1	314	318	PF04695	0.438
LIG_SH2_CRK	520	524	PF00017	0.294
LIG_SH2_CRK	538	542	PF00017	0.205
LIG_SH2_GRB2like	248	251	PF00017	0.472
LIG_SH2_SRC	572	575	PF00017	0.329
LIG_SH2_STAP1	147	151	PF00017	0.328
LIG_SH2_STAP1	248	252	PF00017	0.395
LIG_SH2_STAP1	257	261	PF00017	0.399
LIG_SH2_STAP1	303	307	PF00017	0.298
LIG_SH2_STAP1	423	427	PF00017	0.534
LIG_SH2_STAP1	572	576	PF00017	0.277
LIG_SH2_STAT3	295	298	PF00017	0.387
LIG_SH2_STAT5	248	251	PF00017	0.452
LIG_SH2_STAT5	352	355	PF00017	0.267
LIG_SH2_STAT5	423	426	PF00017	0.475
LIG_SH3_3	103	109	PF00018	0.523
LIG_SH3_3	383	389	PF00018	0.509
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.355
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.350
LIG_SUMO_SIM_par_1	193	198	PF11976	0.505
LIG_SUMO_SIM_par_1	282	287	PF11976	0.366
LIG_TRAF2_1	571	574	PF00917	0.428
LIG_TYR_ITIM	344	349	PF00017	0.251
LIG_TYR_ITIM	518	523	PF00017	0.407
MOD_CDK_SPK_2	495	500	PF00069	0.769
MOD_CDK_SPxxK_3	334	341	PF00069	0.457
MOD_CDK_SPxxK_3	495	502	PF00069	0.605
MOD_CDK_SPxxK_3	506	513	PF00069	0.544
MOD_CK1_1	156	162	PF00069	0.363
MOD_CK1_1	320	326	PF00069	0.488
MOD_CK1_1	495	501	PF00069	0.711
MOD_CK1_1	509	515	PF00069	0.587
MOD_CK2_1	182	188	PF00069	0.299
MOD_CK2_1	302	308	PF00069	0.530
MOD_CK2_1	419	425	PF00069	0.447
MOD_CK2_1	527	533	PF00069	0.169
MOD_GlcNHglycan	158	161	PF01048	0.480
MOD_GlcNHglycan	184	187	PF01048	0.430
MOD_GlcNHglycan	204	207	PF01048	0.505
MOD_GlcNHglycan	305	308	PF01048	0.326
MOD_GlcNHglycan	529	532	PF01048	0.348
MOD_GlcNHglycan	551	554	PF01048	0.323
MOD_GSK3_1	39	46	PF00069	0.703
MOD_GSK3_1	421	428	PF00069	0.495
MOD_GSK3_1	486	493	PF00069	0.707
MOD_GSK3_1	560	567	PF00069	0.443
MOD_GSK3_1	95	102	PF00069	0.519
MOD_LATS_1	519	525	PF00433	0.329
MOD_N-GLC_1	527	532	PF02516	0.169
MOD_N-GLC_1	90	95	PF02516	0.429
MOD_NEK2_1	127	132	PF00069	0.455
MOD_NEK2_1	155	160	PF00069	0.544
MOD_NEK2_1	414	419	PF00069	0.435
MOD_NEK2_1	429	434	PF00069	0.241
MOD_NEK2_1	50	55	PF00069	0.529
MOD_NEK2_2	314	319	PF00069	0.441
MOD_NEK2_2	561	566	PF00069	0.443
MOD_PIKK_1	10	16	PF00454	0.695
MOD_PIKK_1	127	133	PF00454	0.317
MOD_PIKK_1	212	218	PF00454	0.390
MOD_PIKK_1	37	43	PF00454	0.698
MOD_PIKK_1	377	383	PF00454	0.540
MOD_PKA_2	429	435	PF00069	0.487
MOD_PKA_2	487	493	PF00069	0.525
MOD_Plk_1	454	460	PF00069	0.400
MOD_Plk_1	561	567	PF00069	0.329
MOD_Plk_1	90	96	PF00069	0.432
MOD_Plk_4	326	332	PF00069	0.349
MOD_Plk_4	374	380	PF00069	0.457
MOD_Plk_4	406	412	PF00069	0.542
MOD_Plk_4	429	435	PF00069	0.299
MOD_ProDKin_1	164	170	PF00069	0.434
MOD_ProDKin_1	334	340	PF00069	0.447
MOD_ProDKin_1	495	501	PF00069	0.700
MOD_ProDKin_1	506	512	PF00069	0.691
MOD_ProDKin_1	95	101	PF00069	0.625
MOD_SUMO_rev_2	530	537	PF00179	0.313
TRG_AP2beta_CARGO_1	358	367	PF09066	0.326
TRG_DiLeu_BaEn_1	64	69	PF01217	0.576
TRG_DiLeu_BaEn_2	373	379	PF01217	0.387
TRG_DiLeu_BaEn_4	455	461	PF01217	0.328
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.454
TRG_ENDOCYTIC_2	248	251	PF00928	0.368
TRG_ENDOCYTIC_2	346	349	PF00928	0.333
TRG_ENDOCYTIC_2	411	414	PF00928	0.352
TRG_ENDOCYTIC_2	520	523	PF00928	0.277
TRG_ENDOCYTIC_2	538	541	PF00928	0.277
TRG_ENDOCYTIC_2	572	575	PF00928	0.262
TRG_ER_diArg_1	192	194	PF00400	0.512
TRG_ER_diArg_1	207	209	PF00400	0.285
TRG_ER_diArg_1	60	63	PF00400	0.695
TRG_ER_diArg_1	65	67	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HST8	Leptomonas seymouri	45%	99%
A0A1X0P804	Trypanosomatidae	27%	97%
A0A3Q8IB64	Leishmania donovani	87%	100%
A0A3R7KJ25	Trypanosoma rangeli	28%	94%
A4HY36	Leishmania infantum	88%	100%
D0A549	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QDM3	Leishmania major	89%	100%
V5B4A5	Trypanosoma cruzi	28%	100%
V5DRP2	Trypanosoma cruzi	24%	79%