LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ARU9_LEIMU
TriTrypDb:
LmxM.18.1640
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 10
Silverman et al. no yes: 0
Pissara et al. no yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 32
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

E9ARU9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 81 85 PF00656 0.416
CLV_PCSK_SKI1_1 110 114 PF00082 0.413
DOC_PP2B_PxIxI_1 14 20 PF00149 0.368
DOC_USP7_UBL2_3 106 110 PF12436 0.364
DOC_WW_Pin1_4 44 49 PF00397 0.580
LIG_14-3-3_CanoR_1 95 101 PF00244 0.484
LIG_Actin_WH2_2 79 97 PF00022 0.426
LIG_BIR_II_1 1 5 PF00653 0.563
LIG_BRCT_BRCA1_1 75 79 PF00533 0.438
LIG_EVH1_2 57 61 PF00568 0.345
LIG_FHA_1 68 74 PF00498 0.539
LIG_FHA_1 89 95 PF00498 0.353
LIG_LIR_Gen_1 47 57 PF02991 0.552
LIG_LIR_Gen_1 76 86 PF02991 0.417
LIG_LIR_Nem_3 107 112 PF02991 0.440
LIG_LIR_Nem_3 18 23 PF02991 0.523
LIG_LIR_Nem_3 47 52 PF02991 0.533
LIG_LIR_Nem_3 76 82 PF02991 0.415
LIG_PALB2_WD40_1 56 64 PF16756 0.352
LIG_REV1ctd_RIR_1 109 118 PF16727 0.456
LIG_TRAF2_1 85 88 PF00917 0.450
LIG_UBA3_1 19 24 PF00899 0.472
MOD_CK1_1 38 44 PF00069 0.543
MOD_GSK3_1 31 38 PF00069 0.434
MOD_GSK3_1 63 70 PF00069 0.502
MOD_N-GLC_1 104 109 PF02516 0.579
MOD_N-GLC_1 31 36 PF02516 0.459
MOD_N-GLC_1 8 13 PF02516 0.365
MOD_N-GLC_2 37 39 PF02516 0.601
MOD_NEK2_1 31 36 PF00069 0.509
MOD_NEK2_1 78 83 PF00069 0.433
MOD_NEK2_1 94 99 PF00069 0.483
MOD_NEK2_2 15 20 PF00069 0.498
MOD_PIKK_1 63 69 PF00454 0.445
MOD_PKA_2 94 100 PF00069 0.500
MOD_Plk_1 104 110 PF00069 0.489
MOD_Plk_1 24 30 PF00069 0.431
MOD_Plk_1 31 37 PF00069 0.449
MOD_Plk_4 73 79 PF00069 0.481
MOD_ProDKin_1 44 50 PF00069 0.570
TRG_ENDOCYTIC_2 109 112 PF00928 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C7 Leptomonas seymouri 42% 94%
A0A0N1HW96 Leptomonas seymouri 40% 100%
A0A0N1IHI7 Leptomonas seymouri 89% 100%
A0A0S4IPF2 Bodo saltans 39% 100%
A0A0S4IRP9 Bodo saltans 60% 99%
A0A0S4JBB4 Bodo saltans 43% 99%
A0A0S4JFI1 Bodo saltans 36% 100%
A0A1X0NKC2 Trypanosomatidae 31% 99%
A0A1X0P0Q8 Trypanosomatidae 47% 94%
A0A1X0P259 Trypanosomatidae 38% 100%
A0A1X0P760 Trypanosomatidae 64% 100%
A0A3Q8IB96 Leishmania donovani 95% 100%
A0A3R7K0R9 Trypanosoma rangeli 38% 100%
A0A3S7X3W3 Leishmania donovani 37% 100%
A0A3S7X6I1 Leishmania donovani 39% 70%
A0A422N867 Trypanosoma rangeli 45% 94%
A0A422NFX4 Trypanosoma rangeli 31% 98%
A0A422NPM1 Trypanosoma rangeli 62% 100%
A4H9R6 Leishmania braziliensis 86% 100%
A4HIL9 Leishmania braziliensis 39% 100%
A4HLA1 Leishmania braziliensis 39% 100%
A4HY35 Leishmania infantum 95% 100%
A4I5W4 Leishmania infantum 37% 100%
A4I8S7 Leishmania infantum 39% 94%
C9ZR85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A4S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 94%
E9B159 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B3P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 94%
Q4Q707 Leishmania major 37% 100%
Q4QDM4 Leishmania major 95% 100%
V5BMX8 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS