Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARU8_LEIMU

TriTrypDb:

LmxM.18.1630

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.586
CLV_NRD_NRD_1	104	106	PF00675	0.531
CLV_NRD_NRD_1	211	213	PF00675	0.593
CLV_NRD_NRD_1	236	238	PF00675	0.504
CLV_NRD_NRD_1	74	76	PF00675	0.435
CLV_NRD_NRD_1	85	87	PF00675	0.463
CLV_NRD_NRD_1	92	94	PF00675	0.465
CLV_PCSK_KEX2_1	211	213	PF00082	0.385
CLV_PCSK_KEX2_1	236	238	PF00082	0.498
CLV_PCSK_KEX2_1	74	76	PF00082	0.442
CLV_PCSK_KEX2_1	80	82	PF00082	0.460
CLV_PCSK_KEX2_1	85	87	PF00082	0.492
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.515
CLV_PCSK_PC7_1	81	87	PF00082	0.499
CLV_PCSK_SKI1_1	154	158	PF00082	0.481
DEG_APCC_DBOX_1	153	161	PF00400	0.539
DEG_APCC_DBOX_1	172	180	PF00400	0.294
DEG_SCF_FBW7_2	122	129	PF00400	0.591
DOC_CKS1_1	187	192	PF01111	0.570
DOC_MAPK_gen_1	93	103	PF00069	0.611
DOC_MAPK_MEF2A_6	62	70	PF00069	0.298
DOC_PP1_RVXF_1	129	136	PF00149	0.383
DOC_PP1_RVXF_1	31	38	PF00149	0.419
DOC_USP7_MATH_1	164	168	PF00917	0.512
DOC_USP7_MATH_1	169	173	PF00917	0.477
DOC_USP7_UBL2_3	106	110	PF12436	0.609
DOC_USP7_UBL2_3	83	87	PF12436	0.615
DOC_WW_Pin1_4	122	127	PF00397	0.591
DOC_WW_Pin1_4	186	191	PF00397	0.526
LIG_14-3-3_CanoR_1	140	146	PF00244	0.503
LIG_14-3-3_CanoR_1	98	102	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_CaM_NSCaTE_8	209	216	PF13499	0.491
LIG_deltaCOP1_diTrp_1	134	138	PF00928	0.336
LIG_FHA_1	12	18	PF00498	0.416
LIG_FHA_1	140	146	PF00498	0.467
LIG_FHA_1	39	45	PF00498	0.500
LIG_FHA_2	123	129	PF00498	0.659
LIG_FHA_2	180	186	PF00498	0.462
LIG_FHA_2	187	193	PF00498	0.463
LIG_FHA_2	219	225	PF00498	0.498
LIG_FHA_2	246	252	PF00498	0.667
LIG_FHA_2	50	56	PF00498	0.417
LIG_LIR_Apic_2	214	220	PF02991	0.485
LIG_LIR_Gen_1	134	139	PF02991	0.333
LIG_LIR_Gen_1	22	32	PF02991	0.412
LIG_LIR_Nem_3	134	138	PF02991	0.336
LIG_LIR_Nem_3	22	28	PF02991	0.385
LIG_PDZ_Class_3	251	256	PF00595	0.580
LIG_Rb_LxCxE_1	134	153	PF01857	0.353
LIG_SH2_NCK_1	18	22	PF00017	0.396
LIG_SH2_PTP2	217	220	PF00017	0.495
LIG_SH2_STAT5	217	220	PF00017	0.495
LIG_SH3_3	109	115	PF00018	0.670
LIG_SH3_3	184	190	PF00018	0.417
LIG_SH3_3	4	10	PF00018	0.617
LIG_SUMO_SIM_par_1	120	125	PF11976	0.567
LIG_SUMO_SIM_par_1	174	182	PF11976	0.539
LIG_TRAF2_1	126	129	PF00917	0.480
LIG_TRAF2_1	220	223	PF00917	0.511
LIG_UBA3_1	24	33	PF00899	0.466
LIG_WRC_WIRS_1	34	39	PF05994	0.398
MOD_CK1_1	104	110	PF00069	0.565
MOD_CK1_1	11	17	PF00069	0.427
MOD_CK2_1	122	128	PF00069	0.587
MOD_CK2_1	186	192	PF00069	0.483
MOD_CK2_1	218	224	PF00069	0.616
MOD_GlcNHglycan	1	4	PF01048	0.510
MOD_GlcNHglycan	166	170	PF01048	0.589
MOD_GSK3_1	165	172	PF00069	0.440
MOD_GSK3_1	8	15	PF00069	0.448
MOD_GSK3_1	97	104	PF00069	0.533
MOD_NEK2_1	38	43	PF00069	0.512
MOD_PIKK_1	218	224	PF00454	0.589
MOD_PKA_2	104	110	PF00069	0.602
MOD_PKA_2	139	145	PF00069	0.424
MOD_PKA_2	245	251	PF00069	0.612
MOD_PKA_2	97	103	PF00069	0.572
MOD_Plk_1	165	171	PF00069	0.413
MOD_Plk_1	38	44	PF00069	0.558
MOD_Plk_4	104	110	PF00069	0.595
MOD_Plk_4	213	219	PF00069	0.432
MOD_Plk_4	33	39	PF00069	0.398
MOD_Plk_4	8	14	PF00069	0.448
MOD_ProDKin_1	122	128	PF00069	0.589
MOD_ProDKin_1	186	192	PF00069	0.524
MOD_SUMO_for_1	79	82	PF00179	0.504
MOD_SUMO_rev_2	123	133	PF00179	0.490
TRG_DiLeu_BaEn_1	192	197	PF01217	0.543
TRG_DiLeu_BaEn_4	152	158	PF01217	0.447
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.405
TRG_ER_diArg_1	211	213	PF00400	0.385
TRG_ER_diArg_1	73	75	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL1	Leptomonas seymouri	74%	100%
A0A0S4IRK8	Bodo saltans	49%	84%
A0A1X0P7F4	Trypanosomatidae	60%	98%
A0A3S7WVC9	Leishmania donovani	94%	100%
A0A422NPY0	Trypanosoma rangeli	57%	99%
A4H9R5	Leishmania braziliensis	84%	100%
A4HY34	Leishmania infantum	94%	100%
D0A550	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	70%
Q4QDM5	Leishmania major	93%	100%
V5D4P1	Trypanosoma cruzi	58%	99%